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Article Open Access

Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells

  • Authors:
    • Jiandi Wu
    • Jingjing Liang
    • Meijun Li
    • Mingzhuo Lin
    • Linlin Mai
    • Xiaohui Huang
    • Jianqiu Liang
    • Yunzhao Hu
    • Yuli Huang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Affiliated Foshan Hospital, Southern Medical University, Foshan, Guangdong 528308, P.R. China, Department of Cardiology, Shunde Hospital, Southern Medical University, Foshan, Guangdong 528308, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2150-2160
    |
    Published online on: October 13, 2020
       https://doi.org/10.3892/ijmm.2020.4753
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Abstract

Vitamin C plays a protective role in oxidative damage by blocking the effects of free radicals. The present study investigated the mechanisms through which vitamin C partly mediates anti‑apoptotic and antioxidant functions via the regulation of microRNAs (miRNAs or miRs). For this purpose, a global miRNA expression analysis on human umbilical vein endothelial cells (HUVECs) treated with vitamin C was conducted using microarrays containing human precursor and mature miRNA probes. The results revealed that there were 42 identical miRNAs among the differentially expressed miRNAs in the HUVEC group and H2O2 + vitamin C‑treated HUVEC group compared to the H2O2‑exposed HUVEC group, including 41 upregulated miRNAs and 1 down‑regulated miRNA. Using bioinformatics analysis, differentially expressed miRNAs were investigated to identify novel target mRNAs and signaling pathways. Pathway enrichment analyses revealed that apoptosis, the mitogen‑activated protein kinase (MAPK) signaling pathway, phosphoinositide 3‑kinase (PI3K)/Akt signaling pathway and oxidative phosphorylation were significantly enriched. The results from western blot analysis demonstrated that the interleukin (IL)10, matrix metalloproteinase (MMP)2, cAMP‑response element binding protein (CREB) and p‑CREB protein expression levels in HUVECs transfected with hsa‑miR‑3928‑5p and induced by H2O2 were significantly downregulated; the MAPK9, caspase‑3 (CASP3) and p‑CASP3 protein expression levels in HUVECs transfected with hsa‑miR‑323a‑5p and induced by H2O2 were significantly downregulated. The present study therefore demonstrates that vitamin C partly exerts protective effects on HUVECs through the regulation of miRNA/mRNA axis expression.
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1 

Ruano L, Portaccio E, Goretti B, Niccolai C, Severo M, Patti F, Cilia S, Gallo P, Grossi P, Ghezzi A, et al: Age and disability drive cognitive impairment in multiple sclerosis across disease subtypes. Mult Scler. 23:1258–1267. 2017. View Article : Google Scholar

2 

Sies H: Oxidative stress: Oxidants and antioxidants. Exp Physiol. 82:291–295. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Zhou C, Yong H and Przedborski S: Oxidative stress in Parkinson's disease: A mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci. 1147:93–104. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Markesbery WR: Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med. 23:134–147. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Federico A, Morgillo F, Tuccillo C, Ciardiello F and Loguercio C: Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer. 121:2381–2386. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Tsutsui H, Kinugawa S and Matsushima S: Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol. 301:H2181–H2190. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Palade F, Alexa ID, Azoicăi D, Panaghiu L and Ungureanu G: Oxidative stress in atherosclerosis. Rev Med Chir Soc Med Nat Iasi. 107:502–511. 2003.In Romanian.

8 

Kubrak OI, Husak VV, Rovenko BM, Poigner H, Mazepa MA, Kriews M, Abele D and Lushchak VI: Tissue specificity in nickel uptake and induction of oxidative stress in kidney and spleen of goldfish carassius auratus, exposed to waterborne nickel. Aquat Toxicol. 118-119:88–96. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H and Lleonart ME: Oxidative stress and cancer: An overview. Ageing Res Rev. 12:376–390. 2013. View Article : Google Scholar

10 

Fiaschi T and Chiarugi P: Oxidative stress, tumor microenvironment, and metabolic reprogramming: A diabolic liaison. Int J Cell Biol. 2012:7628252012. View Article : Google Scholar : PubMed/NCBI

11 

Halliwell B and Gutteridge J: Free radicals in biology and medicine. J Free Radical Biol Med. 1:331–332. 2007. View Article : Google Scholar

12 

Gibbons GH and Dzau VJ: Molecular therapies for vascular diseases. Science. 272:689–693. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Tang X, Luo YX, Chen HZ and Liu DP: Mitochondria, endothelial cell function, and vascular diseases. Front Physiol. 5:1752014. View Article : Google Scholar : PubMed/NCBI

14 

Schinzari F, Tesauro M and Cardillo C: Endothelial and perivascular adipose tissue abnormalities in obesity-related vascular dysfunction: Novel targets for treatment. J Cardiovasc Pharmacol. 69:360–368. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Yang M and Vousden KH: Serine and one-carbon metabolism in cancer. Nat Rev Cancer. 16:650–662. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Zhang J, Xia L, Zhang F, Zhu D, Xin C, Wang H, Zhang F, Guo X, Lee Y, Zhang L, et al: A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation. Biochim Biophys Acta Mol Basis Dis. 1863:1556–1567. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW and Feng Y: The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci. 16:26087–26124. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Ahmad KA, Yuan Yuan D, Nawaz W, Ze H, Zhuo CX, Talal B, Taleb A, Mais E and Qilong D: Antioxidant therapy for management of oxidative stress induced hypertension. Free Radic Res. 51:428–438. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Chen AY, Lü JM, Yao Q and Chen C: Entacapone is an antioxidant more potent than vitamin C and vitamin E for scavenging of hypochlorous acid and peroxynitrite, and the inhibition of oxidative stress-induced cell death. Med Sci Monit. 22:687–696. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Ryan MJ, Dudash HJ, Docherty M, Geronilla KB, Baker BA, Haff GG, Cutlip RG and Always SE: Vitamin E and C supple-mentation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats. Exp Gerontol. 45:882–895. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Monacelli F, Acquarone E, Giannotti C, Borghi R and Nencioni A: Vitamin C, aging and Alzheimer's disease. Nutrients. 9:6902017.

22 

Linster CL and Van Schaftingen E: Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J. 274:1–22. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Carr AC and Maggini S: Vitamin C and immune function. Nutrients. 9:12112017. View Article : Google Scholar :

24 

Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, et al: Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 350:1391–1396. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Uetaki M, Tabata S, Nakasuka F, Soga T and Tomita M: Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress. Sci Rep. 5:138962015. View Article : Google Scholar : PubMed/NCBI

26 

Yin B, Tang S, Sun J, Zhang X, Xu J, Di L, Li Z, Hu Y and Bao E: Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress. Cell Stress Chaperones. 23:735–748. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Ting HH, Timimi FK, Haley EA, Roddy MA, Ganz P and Creager MA: Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hyper-cholesterolemia. Circulation. 95:2617–2622. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Karajibani M, Hashemi M, Montazerifar F and Dikshit M: Effect of vitamin E and C supplements on antioxidant defense system in cardiovascular disease patients in Zahedan, southeast Iran. J Nutr Sci Vitaminol (Tokyo). 56:436–440. 2010. View Article : Google Scholar

29 

Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R and Pasquinelli AE: Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell. 122:553–563. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Gao Y, Schug J, McKenna LB, Le Lay J, Kaestner KH and Greenbaum LE: Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues. Nucleic Acids Res. 39:454–463. 2011. View Article : Google Scholar :

31 

Xie Q, Chen C, Li H, Xu J, Wu L, Yu Y, Ren S, Li H, Hua X, Yan H, et al: miR-3687 overexpression promotes bladder cancer cell growth by inhibiting the negative effect of FOXP1 on cyclin E2 transcription. Mol Ther. 27:1028–1038. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Kolhe R, Mondal AK, Pundkar C, Periyasamy-Thandavan S, Mendhe B, Hunter M, Isales CM, Hill WD, Hamrick MW and Fulzele S: Modulation of miRNAs by vitamin C in human bone marrow stromal cells. Nutrients. 10:1862018. View Article : Google Scholar :

33 

Xu C, Chen Y, Zhang H, Chen Y, Shen X, Shi C, Liu Y and Yuan W: Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing. Sci Rep. 6:215802016. View Article : Google Scholar : PubMed/NCBI

34 

Lee S, Woo J, Kim YS and Im HI: Integrated miRNA-mRNA analysis in the habenula nuclei of mice intravenously self-administering nicotine. Sci Rep. 5:129092015. View Article : Google Scholar : PubMed/NCBI

35 

Chambers JC, McGregor A, Jean-Marie J, Obeid OA and Kooner JS: Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: An effect reversible with vitamin C therapy. Circulation. 99:1156–1160. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Heitzer T, Finckh B, Albers S, Krohn K, Kohlschütter A and Meinertz T: Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: Relation to parameters of oxidative stress. Free Radic Biol Med. 31:53–61. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Huang J, Agus DB, Winfree CJ, Kiss S, Mack WJ, McTaggart RA, Choudhri TF, Kim LJ, Mocco J, Pinsky DJ, et al: Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc Natl Acad Sci USA. 98:11720–11724. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Oshima T and Chayama K: Endothelial function and oxidative stress in reno-vascular hypertension. N Engl J Med. 346:1954–1962. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Gao Y, Han Z, Li Q, Wu Y, Shi X, Ai Z, Du J, Li W, Guo Z and Zhang Y: Vitamin C induces a pluripotent state in mouse embryonic stem cells by modulating microRNA expression. FEBS J. 282:685–699. 2015. View Article : Google Scholar

40 

Kim SM, Lim SM, Yoo JA, Woo MJ and Cho KH: Consumption of high-dose vitamin C (1250 mg per day) enhances functional and structural properties of serum lipoprotein to improve anti-oxidant, anti-atherosclerotic, and anti-aging effects via regulation of anti-inflammatory microRNA. Food Funct. 6:3604–3612. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Kim YJ, Ku SY, Rosenwaks Z, Liu HC, Chi SW, Kang JS, Lee WJ, Jung KC, Kim SH, Choi YM, et al: MicroRNA expression profiles are altered by gonadotropins and vitamin C status during in vitro follicular growth. Reprod Sci. 17:1081–1089. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Park WH: MAPK inhibitors, particularly the JNK inhibitor, increase cell death effects in H2O2-treated lung cancer cells via increased superoxide anion and glutathione depletion. Oncol Rep. 39:860–870. 2018.

43 

Samakova A, Gazova A, Sabova N, Valaskova S, Jurikova M and Kyselovic J: The PI3k/Akt pathway is associated with angiogenesis, oxidative stress and survival of mesenchymal stem cells in pathophysiologic condition in ischemia. Physiol Res. 68(Suppl 2): S131–S138. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Yao Y, Wang Y, Zhang Y and Liu C: Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways. Lipids Health Dis. 16:772017. View Article : Google Scholar : PubMed/NCBI

45 

He Z, Li Z, Zhang X, Yin K, Wang W, Xu Z, Li B, Zhang L, Xu J, Sun G, et al: MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer. Cell Death Dis. 9:5052018. View Article : Google Scholar : PubMed/NCBI

46 

Ge L, Habiel DM, Hansbro PM, Kim RY, Gharib SA, Edelman JD, Königshoff M, Parimon T, Brauer R, Huang Y, et al: miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways. JCI Insight. 1:e903012016. View Article : Google Scholar : PubMed/NCBI

47 

Wang JK, Guo Q, Zhang XW, Wang LC, Liu Q, Tu PF, Jiang Y and Zeng KW: Aglaia odorata Lour. extract inhibit ischemic neuronal injury potentially via suppressing p53/Puma-mediated mitochondrial apoptosis pathway. J Ethnopharmacol. 248:1123362020. View Article : Google Scholar

48 

Cai ZJ, Lee YK, Lau YM, Ho JC, Lai WH, Wong NL, Huang D, Hai JJ, Ng KM, Tse HF, et al: Expression of Lmna-R225X nonsense mutation results in dilated cardiomyopathy and conduction disorders (DCM-CD) in mice: Impact of exercise training. Int J Cardiol. 298:85–92. 2020. View Article : Google Scholar

49 

Ibrahim RY, Mansour SM and Elkady WM: Phytochemical profile and protective effect of Ocimum basilicum aqueous extract in doxorubicin/irradiation-induced testicular injury. J Pharm Pharmacol. 72:101–110. 2020. View Article : Google Scholar

50 

Hirai T, Konishi Y, Mizuno S, Rui Z, Sun Y and Nishiwaki K: Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines. J Anesth. 34:47–57. 2020. View Article : Google Scholar

51 

Tang Y, Liu J, Yan Y, Fang H, Guo C, Xie R and Liu Q: 1-25-dihydroxyvitamin-D3 promotes neutrophil apoptosis in periodontitis with type 2 diabetes mellitus patients via the p38/MAPK pathway. Medicine (Baltimore). 97:e139032018. View Article : Google Scholar

52 

Li L, Zhang M, Chen W, Wang R, Ye Z, Wang Y, Li X and Cai C: LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125. Acta Biochim Biophys Sin (Shanghai). 50:996–1006. 2018. View Article : Google Scholar

53 

Blascke de Mello MM, Parente JM, Schulz R and Castro MM: Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension. Vascul Pharmacol. 116:36–44. 2019. View Article : Google Scholar

54 

Kim SJ, Park YS, Paik HD and Chang HI: Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers. Br J Nutr. 106:1792–1801. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Iyer SS and Cheng G: Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 32:23–63. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Herkel J, Schrader J, Erez N, Lohse AW and Cohen IR: Activation of the Akt-CREB signalling axis by a proline-rich heptapeptide confers resistance to stress–induced cell death and inflammation. Immunology. 151:474–480. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Liang J, Li M, Lin M, Mai L, Huang X, Liang J, Hu Y and Huang Y: Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells. Int J Mol Med 46: 2150-2160, 2020.
APA
Wu, J., Liang, J., Li, M., Lin, M., Mai, L., Huang, X. ... Huang, Y. (2020). Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells. International Journal of Molecular Medicine, 46, 2150-2160. https://doi.org/10.3892/ijmm.2020.4753
MLA
Wu, J., Liang, J., Li, M., Lin, M., Mai, L., Huang, X., Liang, J., Hu, Y., Huang, Y."Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells". International Journal of Molecular Medicine 46.6 (2020): 2150-2160.
Chicago
Wu, J., Liang, J., Li, M., Lin, M., Mai, L., Huang, X., Liang, J., Hu, Y., Huang, Y."Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells". International Journal of Molecular Medicine 46, no. 6 (2020): 2150-2160. https://doi.org/10.3892/ijmm.2020.4753
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Liang J, Li M, Lin M, Mai L, Huang X, Liang J, Hu Y and Huang Y: Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells. Int J Mol Med 46: 2150-2160, 2020.
APA
Wu, J., Liang, J., Li, M., Lin, M., Mai, L., Huang, X. ... Huang, Y. (2020). Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells. International Journal of Molecular Medicine, 46, 2150-2160. https://doi.org/10.3892/ijmm.2020.4753
MLA
Wu, J., Liang, J., Li, M., Lin, M., Mai, L., Huang, X., Liang, J., Hu, Y., Huang, Y."Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells". International Journal of Molecular Medicine 46.6 (2020): 2150-2160.
Chicago
Wu, J., Liang, J., Li, M., Lin, M., Mai, L., Huang, X., Liang, J., Hu, Y., Huang, Y."Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells". International Journal of Molecular Medicine 46, no. 6 (2020): 2150-2160. https://doi.org/10.3892/ijmm.2020.4753
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