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Article Open Access

PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway

  • Authors:
    • Zhong Lv
    • Aikeremujiang Muheremu
    • Xiaochun Bai
    • Xuenong Zou
    • Tao Lin
    • Bailing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong 510080, P.R. China, Department of Orthopedics, Peking University Third Hospital, Beijing 100191, P.R. China, Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510280, P.R. China
    Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2089-2101
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    Published online on: October 13, 2020
       https://doi.org/10.3892/ijmm.2020.4754
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Abstract

The ability of intermittent parathyroid hormone (1‑34) [PTH(1‑34)] treatment to enhance bone‑implant osseointegration was recently demonstrated in vivo. However, the mechanisms through which PTH (1‑34) regulates bone marrow‑derived stromal cells (BMSCs) remain unclear. The present study thus aimed to investigate the effects of PTH(1‑34) on the migration and adhesion of, and rictor/mammalian target of rapamycin complex 2 (mTORC2) signaling in BMSCs. In the present study, BMSCs were isolated from Sprague‑Dawley rats treated with various concentrations of PTH(1‑34) for different periods of time. PTH(1‑34) treatment was performed with or without an mTORC1 inhibitor (20 nM rapamycin) and mTORC1/2 inhibitor (10 µM PP242). Cell migration was assessed by Transwell cell migration assays and wound healing assays. Cell adhesion and related mRNA expression were investigated through adhesion assays and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), respectively. The protein expression of chemokine receptors (CXCR4 and CCR2) and adhesion factors [intercellular adhesion molecule 1 (ICAM‑1), fibronectin and integrin β1] was examined by western blot analysis. The results revealed that various concentrations (1, 10, 20, 50 and 100 nM) of PTH(1‑34) significantly increased the migration and adhesion of BMSCs, as well as the expression of CXCR4, CCR2, ICAM‑1, fibronectin and integrin β1. In addition, the p‑Akt and p‑S6 levels were also upregulated by PTH(1‑34). BMSCs subjected to mTORC1/2 signaling pathway inhibition or rictor silencing exhibited a markedly reduced PTH‑induced migration and adhesion, while no such effect was observed for the BMSCs subjected to mTORC1 pathway inhibition or raptor silencing. These results indicate that PTH(1‑34) promotes BMSC migration and adhesion through rictor/mTORC2 signaling in vitro. Taken together, the results of the present study reveal an important mechanism for the therapeutic effects of PTH(1‑34) on bone‑implant osseointegration and suggest a potential treatment strategy based on the effect of PTH(1‑34) on BMSCs.
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View References

1 

Ponnusamy KE, Iyer S, Gupta G and Khanna AJ: Instrumentation of the osteoporotic spine: Biomechanical and clinical consider-ations. Spine J. 11:54–63. 2011. View Article : Google Scholar

2 

Dvorak G, Arnhart S, Heuberer C, Huber G, Watzek R and Gruber R: Peri-implantitis and late implant failures in postmenopausal women: A cross-sectional study. J Clin Periodontol. 38:950–955. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Cameron P, Travers C, Chander T, Buckland C, Campion B and Noble B: Directed osteogenic differentiation of human mesen-chymal stem/precursor cells on silicate substituted calcium phosphate. J Biomed Mater Res A. 101:13–22. 2013. View Article : Google Scholar

4 

Mavrogenis AF, Dimitriou R, Parvizi J and Babis GC: Biology of implant osseointegration. J Musculoskelet Neuronal Interact. 9:61–71. 2009.PubMed/NCBI

5 

Davies JE: Understanding peri-implant endosseous healing. J Dent Educ. 67:932–949. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Olivares-Navarrete R, Hyzy SL, Hutton DL, Erdman CP, Wieland M, Boyan BD and Schwartz Z: Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage. Biomaterials. 31:2728–2735. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Puleo DA and Nanci A: Understanding and controlling the bone-implant interface. Biomaterials. 20:2311–2321. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Özdal-Kurt F, Tuğlu I, Vatansever HS, Tong S, Şen BH and Deliloğlu-Gürhan SI: The effect of different implant biomaterials on the behavior of canine bone marrow stromal cells during their differentiation into osteoblasts. Biotech Histochem. 91:412–422. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Kaback LA, Soung DY, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ and Drissi H: Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J Cell Biochem. 105:219–226. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Jiang L, Zhang W, Wei L, Zhou Q, Yang G, Qian N, Tang Y, Gao Y and Jiang X: Early effects of parathyroid hormone on vascularized bone regeneration and implant osseointegration in aged rats. Biomaterials. 179:15–28. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Ohkawa Y, Tokunaga K and Endo N: Intermittent administration of human parathyroid hormone (1-34) increases new bone formation on the interface of hydroxyapatitecoated titanium rods implanted into ovariectomized rat femora. J Orthop Sci. 13:533–542. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Du L, Feng R and Ge S: PTH/SDF-1α cotherapy promotes proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells. Cell Prolif. 49:599–608. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Sengupta S, Peterson TR and Sabatini DM: Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell. 40:310–322. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Zoncu R, Efeyan A and Sabatini DM: mTOR: From growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 12:21–35. 2011. View Article : Google Scholar

15 

Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA and Weiner OD: Membrane tension acts through PLD2 and mTORC2 to limit actin network assembly during neutrophil migration. PLoS Biol. 14:e10024742016. View Article : Google Scholar : PubMed/NCBI

16 

Wang H, Shao X, He Q, Wang C, Xia L, Yue D, Qin G, Jia C and Chen R: Quantitative proteomics implicates rictor/mTORC2 in cell adhesion. J Proteome Res. 17:3360–3369. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Huang L, Zhang Y, Xu C, Gu X, Niu L, Wang J, Sun X, Bai X, Xuan X, Li Q, et al: Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin. PLoS Biol. 15:e20017502017. View Article : Google Scholar : PubMed/NCBI

18 

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RA, Erdjument-Bromage H, Tempst P and Sabatini DM: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 14:1296–1302. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Sen B, Xie Z, Case N, Thompson WR, Uze G, Styner M and Rubin J: mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow-derived mesenchymal stem cells. J Bone Miner Res. 29:78–89. 2014. View Article : Google Scholar

20 

Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M, Lee EY, Weiss HL, O'Connor KL, Gao T and Evers BM: mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res. 71:3246–3256. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Wang X, Lai P, Zhang Z, Huang M, Wang L, Yin M, Jin D, Zhou R and Bai X: Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis. Oncol Rep. 32:382–388. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Hau AM, Leivo MZ, Gilder AS, Hu JJ, Gonias SL and Hansel DE: mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer. Cell Signal. 29:96–106. 2017. View Article : Google Scholar

23 

Maniatopoulos C, Sodek J and Melcher AH: Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res. 254:317–330. 1988. View Article : Google Scholar : PubMed/NCBI

24 

Smajilagić A, Aljičević M, Redžić A, Filipović S and Lagumdžija A: Rat bone marrow stem cells isolation and culture as a bone formative experimental system. Bosn J Basic Med Sci. 13:27–30. 2013. View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expres-sion data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

26 

Alghamdi HS, Bosco R, Both SK, Iafisco M, Leeuwenburgh SC, Jansen JA and van den Beucken JJ: Synergistic effects of bisphos-phonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats. Biomaterials. 35:5482–5490. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Zhu D, Su Y, Young ML, Ma J, Zheng Y and Tang L: Biological responses and mechanisms of human bone marrow mesenchymal stem cells to Zn and Mg biomaterials. ACS Appl Mater Interfaces. 9:27453–27461. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Petrie TA, Raynor JE, Dumbauld DW, Lee TT, Jagtap S, Templeman KL, Collard DM and Garcia AJ: Multivalent integrin-specific ligands enhance tissue healing and biomaterial integration. Sci Transl Med. 2:45r–60r. 2010. View Article : Google Scholar

29 

Misof BM, Roschger P, Dempster DW, Zhou H, Bilezikian JP, Klaushofer K and Rubin MR: PTH(1-84) administration in hypo-parathyroidism transiently reduces bone matrix mineralization. J Bone Miner Res. 31:180–189. 2016. View Article : Google Scholar

30 

Morgan EF, Mason ZD, Bishop G, Davis AD, Wigner NA, Gerstenfeld LC and Einhorn TA: Combined effects of recombi-nant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing. Bone. 43:1031–1038. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Sheyn D, Shapiro G, Tawackoli W, Jun DS, Koh Y, Kang KB, Su S, Da X, Ben-David S, Bez M, et al: PTH induces systemically administered mesenchymal stem cells to migrate to and regenerate spine injuries. Mol Ther. 24:318–330. 2016. View Article : Google Scholar :

32 

Kitaori T, Ito H, Schwarz ME, Tsutsumi R, Yoshitomi H, Oishi S, Nakano M, Fujii N, Nagasawa T and Nakamura T: Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum. 60:813–823. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Wang LL, Chen D, Lee J, Gu X, Alaaeddine G, Li J, Wei L and Yu SP: Mobilization of endogenous bone marrow derived endothelial progenitor cells and therapeutic potential of parathyroid hormone after ischemic stroke in mice. PLoS One. 9:e872842014. View Article : Google Scholar : PubMed/NCBI

34 

Ryan CM, Brown JA, Bourke E, Prendergast M, Kavanagh C, Liu Z, Owens P, Shaw G, Kolch W, O'Brien T and Barry FP: ROCK activity and the Gβg complex mediate chemotactic migration of mouse bone marrow-derived stromal cells. Stem Cell Res Ther. 6:1362015. View Article : Google Scholar

35 

Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R and Luscinskas W: ICAM-1 regulates neutrophil adhesion and trans-cellular migration of TNF-alpha-activated vascular endothelium under flow. Blood. 106:584–592. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Pendegrass CJ, El-Husseiny M and Blunn GW: The development of fibronectin-functionalised hydroxyapatite coatings to improve dermal fibroblast attachment in vitro. J Bone Joint Surg Br. 94:564–569. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Davies T and Chambers TJ: Parathyroid hormone activates adhesion in bone marrow stromal precursor cells. J Endocrinol. 180:505–513. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA and O'Keefe RJ: Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. J Orthop Res. 33:17–24. 2015. View Article : Google Scholar

39 

Okada Y, Morimoto I, Ura K, Watanabe K, Eto S, Kumegawa M, Raisz L, Pilbeam C and Tanaka Y: Cell-to-cell adhesion via inter-cellular adhesion molecule-1 and leukocyte function-associated antigen-1 pathway is involved in 1alpha,25(OH)2D3, PTH and IL-1alpha-induced osteoclast differentiation and bone resorption. Endocr J. 49:483–495. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Yin Y, Hua H, Li M, Liu S, Kong Q, Shao T, Wang J, Luo Y, Wang Q, Luo T and Jiang Y: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. Cell Res. 26:46–65. 2016. View Article : Google Scholar :

41 

Chantaravisoot N, Wongkongkathep P, Loo JA, Mischel PS and Tamanoi F: Significance of filamin A in mTORC2 function in glioblastoma. Mol Cancer. 14:1272015. View Article : Google Scholar : PubMed/NCBI

42 

Rosner M and Hengstschläger M: Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: Rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. Hum Mol Genet. 17:2934–2948. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Akcakanat A, Singh G, Hung MC and Meric-Bernstam F: Rapamycin regulates the phosphorylation of rictor. Biochem Biophys Res Commun. 362:330–333. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G and Pober JS: Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. J Exp Med. 211:395–404. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima R, et al: Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 335:1638–1643. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lv Z, Muheremu A, Bai X, Zou X, Lin T and Chen B: PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway. Int J Mol Med 46: 2089-2101, 2020.
APA
Lv, Z., Muheremu, A., Bai, X., Zou, X., Lin, T., & Chen, B. (2020). PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway. International Journal of Molecular Medicine, 46, 2089-2101. https://doi.org/10.3892/ijmm.2020.4754
MLA
Lv, Z., Muheremu, A., Bai, X., Zou, X., Lin, T., Chen, B."PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway". International Journal of Molecular Medicine 46.6 (2020): 2089-2101.
Chicago
Lv, Z., Muheremu, A., Bai, X., Zou, X., Lin, T., Chen, B."PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway". International Journal of Molecular Medicine 46, no. 6 (2020): 2089-2101. https://doi.org/10.3892/ijmm.2020.4754
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Z, Muheremu A, Bai X, Zou X, Lin T and Chen B: PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway. Int J Mol Med 46: 2089-2101, 2020.
APA
Lv, Z., Muheremu, A., Bai, X., Zou, X., Lin, T., & Chen, B. (2020). PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway. International Journal of Molecular Medicine, 46, 2089-2101. https://doi.org/10.3892/ijmm.2020.4754
MLA
Lv, Z., Muheremu, A., Bai, X., Zou, X., Lin, T., Chen, B."PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway". International Journal of Molecular Medicine 46.6 (2020): 2089-2101.
Chicago
Lv, Z., Muheremu, A., Bai, X., Zou, X., Lin, T., Chen, B."PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway". International Journal of Molecular Medicine 46, no. 6 (2020): 2089-2101. https://doi.org/10.3892/ijmm.2020.4754
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