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Review

Transcription factor PU.1 and immune cell differentiation (Review)

  • Authors:
    • Guanglan Li
    • Wenke Hao
    • Wenxue Hu
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 1943-1950
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    Published online on: October 21, 2020
       https://doi.org/10.3892/ijmm.2020.4763
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Abstract

The transcription factor PU.1, an important member of the ETS family, plays a significant role in the differentiation of immune cells, which include macrophages, neutrophils, dendritic cells, T lymphoid cells, B lymphoid cells and so on. Immune cells are involved in the occurrence and development of diseases, including inflammatory diseases, neoplastic diseases and immune diseases. Therefore, it is particularly crucial to elucidate the roles and mechanisms of PU.1 in immune cells. The elucidation of these mechanisms may lead to the development of more effective therapeutic strategies for the treatment of inflammatory diseases and immune‑mediated diseases mediated by various immune cells. With the development of molecular biology, the mechanisms of PU.1 in immune cell differentiation have been further explained. Different levels of PU.1 expression determine the type of immune cell differentiation. PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews and discusses the effects of the transcription factor PU.1 on immune cell differentiation.
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1 

Karim FD, Urness LD, Thummel CS, Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA, Gunther CV, Nye JA, et al: The ETS-domain: A new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes Dev. 4:1451–1453. 1990. View Article : Google Scholar : PubMed/NCBI

2 

Moreau-Gachelin F, Tavitian A and Tambourin P: Spi1 is a putative oncogene in virally induced murine erythroleukaemias. Nature. 331:277–280. 1988. View Article : Google Scholar : PubMed/NCBI

3 

Gupta P, Gurudutta GU, Saluja D and Tripathi RP: PU.1 and partners: Regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis. J Cell Mol Med. 13:4349–4363. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Ueno N, Nishimura N, Ueno S, Endo S, Tatetsu H, Hirata S, Hata H, Matsuoka M, Mitsuya H and Okuno Y: PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4. Oncogene. 36:4481–4497. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Tenen DG, Hromas R, Licht JD and Zhang DE: Transcription factors, normal myeloid development, and leukemia. Blood. 90:489–519. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Batista CR, Lim M, Laramée AS, Abu-Sardanah F, Xu LS, Hossain R, Bell GL, Hess DA and DeKoter RP: Driver mutations in Janus kinases in a mouse model of B-cell leukemia induced by deletion of PU.1 and Spi-B. Blood Adv. 2:2798–2810. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Dozmorov MG, Wren JD and Alarcón-Riquelme ME: Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes. Epigenetics. 9:276–285. 2014. View Article : Google Scholar :

8 

Alivernini S, Kurowska-Stolarska M, Tolusso B, Benvenuto R, Elmesmari A, Canestri S, Petricca L, Mangoni A, Fedele AL, Di Mario C, et al: MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nat Commun. 7:129702016. View Article : Google Scholar : PubMed/NCBI

9 

Turkistany SA and DeKoter RP: The transcription factor PU.1 is a critical regulator of cellular communication in the immune system. Arch Immunol Ther Exp (Warsz). 59:431–440. 2011. View Article : Google Scholar

10 

Pospíšil V, Krsmanovic P, Chramostová K, Vokurka K, Laslo P and Stopka T: Graded PU.1 levels activate granulocyte vs macrophage genes via multiple(super) enhancer elements. Exp Hematol. 76(Suppl): S822019. View Article : Google Scholar

11 

Nutt SL, Metcalf D, D'Amico A, Polli M and Wu L: Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. Exp Med. 201:221–231. 2005. View Article : Google Scholar

12 

Yashiro T, Takeuchi H, Kasakura K and Nishiyama C: PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4+ T cells. FEBS Open Bio. 10:1115–1121. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Anderson MK, Weiss AH, Hernandez-Hoyos G, Dionne CJ and Rothenberg EV: Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Immunity. 16:285–296. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Yashiro T, Nakano S, Nomura K, Uchida Y, Kasakura K and Nishiyama C: A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages. Sci Rep. 9:11612019. View Article : Google Scholar : PubMed/NCBI

15 

Lloberas J, Soler C and Celada A: The key role of PU.1/SPI-1 in B cells, myeloid cells and macrophages. Immunol Today. 20:184–189. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Petrovick MS, Hiebert SW, Friedman AD, Hetherington CJ, Tenen DG and Zhang DE: Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1. Mol Cell Biol. 18:3915–3925. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Marecki S and Fenton MJ: PU.1/interferon regulatory factor interactions: Mechanisms of transcriptional regulation. Cell Biochem Biophys. 33:127–148. 2000. View Article : Google Scholar

18 

Behre G, Whitmarsh AJ, Coghlan MP, Hoang T, Carpenter CL, Zhang DE, Davis RJ and Tenen DG: c-Jun is a JNK-independent coactivator of the PU.1 transcription factor. J Biol Chem. 274:4939–4946. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Zhang P, Zhang X, Iwama A, Yu C, Smith KA, Mueller BU, Narravula S, Torbett BE, Orkin SH and Tenen DG: PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 96:2641–2648. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Rekhtman N, Choe KS, Matushansky I, Murray S, Stopka T and Skoultchi AI: PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation. Mol Cell Biol. 23:7460–7474. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Stopka T, Amanatullah DF, Papetti M and Skoultchi AI: PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure. EMBO J. 24:3712–3723. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Burda P, Laslo P and Stopka T: The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis. Leukemia. 24:1249–1257. 2010. View Article : Google Scholar : PubMed/NCBI

23 

O'Neill LA and Pearce EJ: Immunometabolism governs dendritic cell and macrophage function. J Exp Med. 213:15–23. 2016. View Article : Google Scholar :

24 

Tarique AA, Logan J, Thomas E, Holt PG, Sly PD and Fantino E: Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages. Am J Respir Cell Mol Biol. 53:676–688. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Nair MG, Gallagher IJ, Taylor MD, Loke P, Coulson PS, Wilson RA, Maizels RM and Allen JE: Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Infect Immun. 73:385–394. 2005. View Article : Google Scholar :

26 

Wang N, Liang H and Zen K: Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front Immunol. 5:6142014. View Article : Google Scholar : PubMed/NCBI

27 

Juhas U, Ryba-Stanisławowska M, Szargiej P and Myśliwska J: Different pathways of macrophage activation and polarization. Postepy Hig Med Dosw (Online). 69:496–502. 2015. View Article : Google Scholar

28 

Karpurapu M, Wang X, Deng J, Park H, Xiao L, Sadikot RT, Frey RS, Maus UA, Park GY, Scott EW and Christman JW: Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia. Blood. 118:5255–5266. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Qian F, Deng J, Lee YG, Zhu J, Karpurapu M, Chung S, Zheng JN, Xiao L, Park GY and Christman JW: The transcription factor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammation. J Mol Cell Biol. 7:557–567. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Tagore M, McAndrew MJ, Gjidoda A and Floer M: The lineage-specific transcription factor PU.1 prevents polycomb-mediated heterochromatin formation at macrophage-specific genes. Mol Cell Biol. 35:2610–2625. 2015. View Article : Google Scholar : PubMed/NCBI

31 

van Oevelen C, Collombet S, Vicent G, Hoogenkamp M, Lepoivre C, Badeaux A, Bussmann L, Sardina JL, Thieffry D, Beato M, et al: C/EBPα activates pre-existing and de novo macrophage enhancers during induced Pre-B cell transdifferentiation and myelopoiesis. Stem Cell Reports. 5:232–247. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Solomon LA, Podder S, He J, Jackson-Chornenki NL, Gibson K, Ziliotto RG, Rhee J and DeKoter RP: Coordination of myeloid differentiation with reduced cell cycle progression by PU.1 induction of MicroRNAs targeting cell cycle regulators and lipid anabolism. Mol Cell Biol. 37:e00013–17. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Denechaud PD, Lopez-Mejia IC, Giralt A, Lai Q, Blanchet E, Delacuisine B, Nicolay BN, Dyson NJ, Bonner C, Pattou F, et al: E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Invest. 126:137–150. 2016. View Article : Google Scholar :

34 

Eguchi J, Kong X, Tenta M, Wang X, Kang S and Rosen ED: Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes. 62:3394–3403. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Shen C, Chen MT, Zhang XH, Yin XL, Ning HM, Su R, Lin HS, Song L, Wang F, Ma YN, et al: The PU.1-modulated MicroRNA-22 is a regulator of monocyte/macrophage differentiation and acute myeloid leukemia. PLoS Genet. 12:e10062592016. View Article : Google Scholar :

36 

Shakerian L, Ghorbani S, Talebi F and Noorbakhsh F: MicroRNA-150 targets PU.1 and regulates macrophage differentiation and function in experimental autoimmune encephalomyelitis. J Neuroimmunol. 323:167–174. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Kruger P, Saffarzadeh M, Weber AN, Rieber N, Radsak M, von Bernuth H, Benarafa C, Roos D, Skokowa J and Hartl D: Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS Pathog. 11:e10046512015. View Article : Google Scholar : PubMed/NCBI

38 

Mantovani A, Cassatella MA, Costantini C and Jaillon S: Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 11:519–531. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Haimovici A, Brigger D, Torbett BE, Fey MF and Tschan MP: Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation. Leuk Res. 38:1041–1047. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Humbert M, Federzoni EA, Britschgi A, Schläfli AM, Valk PJ, Kaufmann T, Haferlach T, Behre G, Simon HU, Torbett BE, et al: The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL. J Leukoc Biol. 95:83–93. 2014. View Article : Google Scholar :

41 

Bialik S and Kimchi A: The death-associated protein kinases: Structure, function, and beyond. Annu Rev Biochem. 75:189–210. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Malu K, Garhwal R, Pelletier MG, Gotur D, Halene S, Zwerger M, Yang ZF, Rosmarin AG and Gaines P: Cooperative activity of GABP with PU.1 or C/EBPε regulates lamin B receptor gene expression, implicating their roles in granulocyte nuclear maturation. J Immunol. 197:910–922. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Keightley MC, Carradice DP, Layton JE, Pase L, Bertrand JY, Wittig JG, Dakic A, Badrock AP, Cole NJ, Traver D, et al: The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger. Nat Commun. 8:149112017. View Article : Google Scholar : PubMed/NCBI

44 

Federzoni EA, Valk PJ, Torbett BE, Haferlach T, Löwenberg B, Fey MF and Tschan MP: PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells. Blood. 119:4963–4970. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Batliner J, Buehrer E, Federzoni EA, Jenal M, Tobler A, Torbett BE, Fey MF and Tschan MP: Transcriptional regulation of MIR29B by PU.1 (SPI1) and MYC during neutrophil differentiation of acute promyelocytic leukaemia cells. Br J Haematol. 157:270–274. 2012. View Article : Google Scholar

46 

Fontana MF, Baccarella A, Pancholi N, Pufall MA, Herbert DR and Kim CC: JUNB is a key transcriptional modulator of macrophage activation. J Immunol. 194:177–186. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Fischer J, Walter C, Tönges A, Aleth H, Jordão MJC, Leddin M, Gröning V, Erdmann T, Lenz G, Roth J, et al: Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils. Nat Immunol. 20:546–558. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Guilliams M, Ginhoux F, Jakubzick C, Naik SH, Onai N, Schraml BU, Segura E, Tussiwand R and Yona S: Dendritic cells, monocytes and macrophages: A unified nomenclature based on ontogeny. Nat Rev Immunol. 14:571–578. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Belz GT and Nutt SL: Transcriptional programming of the dendritic cell network. Nat Rev Immunol. 12:101–113. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Carotta S, Dakic A, D'Amico A, Pang SH, Greig KT, Nutt SL and Wu L: The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity. 32:628–641. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Lapko N, Zawadka M, Polosak J, Worthen GS, Danet-Desnoyers G, Puzianowska-Kuźnicka M and Laudanski K: Long-term monocyte dysfunction after sepsis in humanized mice is related to persisted activation of macrophage-colony stimulation factor (M-CSF) and demethylation of PU.1, and it can be reversed by blocking M-CSF in vitro or by transplanting naïve autologous stem cells in vivo. Front Immunol. 8:4012017. View Article : Google Scholar

52 

Hamdorf M, Berger A, Schüle S, Reinhardt J and Flory E: PKCδ-induced PU.1 phosphorylation promotes hematopoietic stem cell differentiation to dendritic cells. Stem Cells. 29:297–306. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Yashiro T, Kasakura K, Oda Y, Kitamura N, Inoue A, Nakamura S, Yokoyama H, Fukuyama K, Hara M, Ogawa H, et al: The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c. Int Immunol. 29:87–94. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Zhu XJ, Yang ZF, Chen Y, Wang J and Rosmarin AG: PU.1 is essential for CD11c expression in CD8(+)/CD8(-) lymphoid and monocyte-derived dendritic cells during GM-CSF or FLT3L-induced differentiation. PLoS One. 7:e521412017. View Article : Google Scholar

55 

Kanada S, Nishiyama C, Nakano N, Suzuki R, Maeda K, Hara M, Kitamura N, Ogawa H and Okumura K: Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells. Blood. 117:2211–2222. 2011. View Article : Google Scholar

56 

Yashiro T, Hara M, Ogawa H, Okumura K and Nishiyama C: Critical role of transcription factor PU.1 in the function of the OX40L/TNFSF4 promoter in dendritic cells. Sci Rep. 6:348252016. View Article : Google Scholar : PubMed/NCBI

57 

Yashiro T, Yamaguchi M, Watanuki Y, Kasakura K and Nishiyama C: The transcription factors PU.1 and IRF4 determine dendritic cell-specific expression of RALDH2. J Immunol. 201:3677–3682. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, et al: Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells. J Allergy Clin Immunol. 129:814–824.e6. 2012. View Article : Google Scholar

59 

Miura R, Kasakura K, Nakano N, Hara M, Maeda K, Okumura K, Ogawa H, Yashiro T and Nishiyama C: Role of PU.1 in MHC class II expression via CIITA transcription in plasmacytoid dendritic cells. PLoS One. 11:e01540942016. View Article : Google Scholar : PubMed/NCBI

60 

Yashiro T, Kubo M, Ogawa H, Okumura K and Nishiyama C: PU.1 suppresses Th2 cytokine expression via silencing of GATA3 transcription in dendritic cells. PLoS One. 10:e01376992015. View Article : Google Scholar : PubMed/NCBI

61 

Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, Nishiyama M, Okumura K and Ogawa H: Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood. 109:4846–4855. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Yui MA and Rothenberg EV: Developmental gene networks: A triathlon on the course to T cell identity. Nat Rev Immunol. 14:529–545. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Heinz S, Romanoski CE, Benner C, Allison KA, Kaikkonen MU, Orozco LD and Glass CK: Effect of natural genetic variation on enhancer selection and function. Nature. 503:487–492. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Natoli G, Ghisletti S and Barozzi I: The genomic landscapes of inflammation. Genes Dev. 25:101–106. 2011. View Article : Google Scholar : PubMed/NCBI

65 

Hosokawa H, Ungerbäck J, Wang X, Matsumoto M, Nakayama KI, Cohen SM, Tanaka T and Rothenberg EV: Transcription factor PU.1 represses and activates gene expression in early T cells by redirecting partner transcription factor binding. Immunity. 49:7822018. View Article : Google Scholar : PubMed/NCBI

66 

Rothenberg EV, Hosokawa H and Ungerbäck J: Mechanisms of action of hematopoietic transcription factor PU.1 in initiation of T-cell development. Front Immunol. 10:2282019. View Article : Google Scholar : PubMed/NCBI

67 

Ungerbäck J, Hosokawa H, Wang X, Strid T, Williams BA, Sigvardsson M and Rothenberg EV: Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1). Genome Res. 28:1508–1519. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Champhekar A, Damle SS, Freedman G, Carotta S, Nutt SL and Rothenberg EV: Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1. Genes Dev. 29:832–848. 2015. View Article : Google Scholar : PubMed/NCBI

69 

Ramming A, Druzd D, Leipe J, Schulze-Koops H and Skapenko A: Maturation-related histone modifications in the PU.1 promoter regulate Th9-cell development. Blood. 119:4665–4674. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Goswami R and Kaplan MH: Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. J Immunol. 189:3026–3033. 2012. View Article : Google Scholar : PubMed/NCBI

71 

Rivera Vargas T, Cai Z, Shen Y, Dosset M, Benoit-Lizon I, Martin T, Roussey A, Flavell RA, Ghiringhelli F and Apetoh L: Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells. Nat Commun. 8:5592017. View Article : Google Scholar :

72 

Goodnow CC, Vinuesa CG, Randall KL, Mackay F and Brink R: Control systems and decision making for antibody production. Nat Immunol. 11:681–688. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Carotta S, Willis SN, Hasbold J, Inouye M, Pang SH, Emslie D, Light A, Chopin M, Shi W, Wang H, et al: The transcription factors IRF8 and PU.1 negatively regulate plasma cell differen-tiation. J Exp Med. 211:2169–2181. 2014. View Article : Google Scholar : PubMed/NCBI

74 

Willis SN, Tellier J, Liao Y, Trezise S, Light A, O'Donnell K, Garrett- Sinha LA, Shi W, Tarlinton DM and Nutt SL: Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB. Nat Commun. 8:14262017. View Article : Google Scholar : PubMed/NCBI

75 

Batista CR, Li SK, Xu LS, Solomon LA and DeKoter RP: PU.1 regulates Ig light chain transcription and rearrangement in Pre-B cells during B cell development. J Immunol. 198:1565–1574. 2017. View Article : Google Scholar : PubMed/NCBI

76 

Ochiai K, Maienschein-Cline M, Simonetti G, Chen J, Rosenthal R, Brink R, Chong AS, Klein U, Dinner AR, Singh H and Sciammas R: Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity. 38:918–929. 2013. View Article : Google Scholar : PubMed/NCBI

77 

Pang SH, Minnich M, Gangatirkar P, Zheng Z, Ebert A, Song G, Dickins RA, Corcoran LM, Mullighan CG, Busslinger M, et al: PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia. Leukemia. 30:1375–1387. 2016. View Article : Google Scholar : PubMed/NCBI

78 

Scialdone A, Khazaei S, Hasni MS, Lennartsson A, Gullberg U and Drott K: Depletion of the transcriptional coactivators CREB-binding protein or EP300 downregulates CD20 in diffuse large B-cell lymphoma cells and impairs the cytotoxic effects of anti-CD20 antibodies. Exp Hematol. 79:35–46.e1. 2019. View Article : Google Scholar : PubMed/NCBI

79 

Soodgupta D, White LS, Yang W, Johnston R, Andrews JM, Kohyama M, Murphy KM, Mosammaparast N, Payton JE and Bednarski JJ: RAG-mediated DNA breaks attenuate PU.1 activity in early B cells through activation of a SPIC-BCLAF1 complex. Cell Rep. 29:829–843.e5. 2019. View Article : Google Scholar : PubMed/NCBI

80 

Rogers JH, Owens KS, Kurkewich J, Klopfenstein N, Iyer SR, Simon MC and Dahl R: E2A antagonizes PU.1 activity through inhibition of DNA binding. Biomed Res Int. 2016:39836862016. View Article : Google Scholar : PubMed/NCBI

81 

Laslo P, Spooner CJ, Warmflash A, Lanck DW, Lee HJ, Sciammas R, Gantner BN, Dinner AR and Singh H: Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 126:755–766. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li G, Hao W and Hu W: Transcription factor PU.1 and immune cell differentiation (Review). Int J Mol Med 46: 1943-1950, 2020.
APA
Li, G., Hao, W., & Hu, W. (2020). Transcription factor PU.1 and immune cell differentiation (Review). International Journal of Molecular Medicine, 46, 1943-1950. https://doi.org/10.3892/ijmm.2020.4763
MLA
Li, G., Hao, W., Hu, W."Transcription factor PU.1 and immune cell differentiation (Review)". International Journal of Molecular Medicine 46.6 (2020): 1943-1950.
Chicago
Li, G., Hao, W., Hu, W."Transcription factor PU.1 and immune cell differentiation (Review)". International Journal of Molecular Medicine 46, no. 6 (2020): 1943-1950. https://doi.org/10.3892/ijmm.2020.4763
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Hao W and Hu W: Transcription factor PU.1 and immune cell differentiation (Review). Int J Mol Med 46: 1943-1950, 2020.
APA
Li, G., Hao, W., & Hu, W. (2020). Transcription factor PU.1 and immune cell differentiation (Review). International Journal of Molecular Medicine, 46, 1943-1950. https://doi.org/10.3892/ijmm.2020.4763
MLA
Li, G., Hao, W., Hu, W."Transcription factor PU.1 and immune cell differentiation (Review)". International Journal of Molecular Medicine 46.6 (2020): 1943-1950.
Chicago
Li, G., Hao, W., Hu, W."Transcription factor PU.1 and immune cell differentiation (Review)". International Journal of Molecular Medicine 46, no. 6 (2020): 1943-1950. https://doi.org/10.3892/ijmm.2020.4763
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