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Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review)

  • Authors:
    • Wenjing Gong
    • Tracey A. Martin
    • Andrew J. Sanders
    • Aihua Jiang
    • Ping Sun
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Yantai Yuhuangding Hospital, Medical College, Qingdao University, Yantai, Shandong 264000, P.R. China, Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff CF14 4XN, UK, Department of Anaesthesiology, Yantai Yuhuangding Hospital, Medical College, Qingdao University, Yantai, Shandong 264000, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 435-443
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    Published online on: December 4, 2020
       https://doi.org/10.3892/ijmm.2020.4811
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Abstract

Despite improvements in therapy and management, cancer represents and remains a major cause of mortality and morbidity worldwide. Although genetics serve an important role in tumorigenesis and tumour progression, the tumour microenvironment (TME) in solid tumours is also important and has been indicated to contribute to these processes. Stromal cell‑derived factors (SDFs) represent an important family within the TME. The family includes SDF‑1, SDF‑2, SDF2‑like 1 (SDF2L1), SDF‑3, SDF‑4 and SDF‑5. SDF‑1 has been demonstrated to act as a positive regulator in a number of types of tumour, such as oesophago‑gastric, pancreatic, lung, breast, colorectal and ovarian cancer, while the biology and functions of other members of the SDF family, including SDF‑2, SDF2L1, SDF‑4 and SDF‑5, in cancer are different, complex and controversial, and remain mainly unknown. Full identification and understanding of the SDFs across multiple types of cancer is required to elucidate their function and establish potential key targets in cancer.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Micke P and Ostman A: Tumour-stroma interaction: Cancer-associated fibroblasts as novel targets in anti-cancer therapy? Lung Cancer. 45(Suppl 2): S163–S175. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Kang H, Escudero-Esparza A, Douglas-Jones A, Mansel RE and Jiang WG: Transcript analyses of stromal cell derived factors (SDFs): SDF-2, SDF-4 and SDF-5 reveal a different pattern of expression and prognostic association in human breast cancer. Int J Oncol. 35:205–211. 2009.PubMed/NCBI

4 

Wang M, Lin T, Wang Y, Gao S, Yang Z, Hong X and Chen G: CXCL12 suppresses cisplatin-induced apoptosis through activation of JAK2/STAT3 signaling in human non-small-cell lung cancer cells. Onco Targets Ther. 10:3215–3224. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Miller MC and Mayo KH: Chemokines from a structural perspective. Int J Mol Sci. 18:20882017. View Article : Google Scholar :

6 

Mélik-Parsadaniantz S and Rostène W: Chemokines and neuro-modulation. J Neuroimmunol. 198:62–68. 2008. View Article : Google Scholar

7 

Samarendra H, Jones K, Petrinic T, Silva MA, Reddy S, Soonawalla Z and Gordon-Weeks A: A meta-analysis of CXCL12 expression for cancer prognosis. Br J Cancer. 117:124–135. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Ling X, Spaeth E, Chen Y, Shi Y, Zhang W, Schober W, Hail N Jr, Konopleva M and Andreeff M: The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo. PLoS One. 8:e584262013. View Article : Google Scholar : PubMed/NCBI

9 

Kollmar O, Rupertus K, Scheuer C, Junker B, Tilton B, Schilling MK and Menger MD: Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis. Neoplasia. 9:862–870. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Kryczek I, Wei S, Keller E, Liu R and Zou W: Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis. Am J Physiol Cell Physiol. 292:C987–C995. 2007. View Article : Google Scholar

11 

Wu M, Chen Q, Li D, Li X, Li X, Huang C, Tang Y, Zhou Y, Wang D, Tang K, et al: LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways. J Cell Biochem. 103:245–255. 2008. View Article : Google Scholar

12 

Dehghani M, Kianpour S, Zangeneh A and Mostafavi-Pour Z: CXCL12 modulates prostate cancer cell adhesion by altering the levels or activities of β1-containing integrins. Int J Cell Biol. 2014:9817502014. View Article : Google Scholar

13 

Shen X, Wang S, Wang H, Liang M, Xiao L and Wang Z: The role of SDF-1/CXCR4 axis in ovarian cancer metastasis. J Huazhong Univ Sci Technolog Med Sci. 29:363–367. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Zhou W, Guo S, Liu M, Burow ME and Wang G: Targeting CXCL12/CXCR4 axis in tumor immunotherapy. Curr Med Chem. 26:3026–3041. 2019. View Article : Google Scholar

15 

Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, et al: CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. Hepatology. 61:1591–1602. 2015. View Article : Google Scholar :

16 

Wald O: CXCR4 based therapeutics for non-small cell lung cancer (NSCLC). J Clin Med. 7:3032018. View Article : Google Scholar :

17 

Otsuka S and Bebb G: The CXCR4/SDF-1 chemokine receptor axis: A new target therapeutic for non-small cell lung cancer. J Thorac Oncol. 3:1379–1383. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Wang B, Wang W, Niu W, Liu E, Liu X, Wang J, Peng C, Liu S, Xu L, Wang L and Niu J: SDF-1/CXCR4 axis promotes directional migration of colorectal cancer cells through upregulation of integrin alphavbeta6. Carcinogenesis. 35:282–291. 2014. View Article : Google Scholar

19 

Walentowicz-Sadlecka M, Sadlecki P, Bodnar M, Marszalek A, Walentowicz P, Sokup A, Wilińska-Jankowska A and Grabiec M: Stromal derived factor-1 (SDF-1) and its receptors CXCR4 and CXCR7 in endometrial cancer patients. PLoS One. 9:e846292014. View Article : Google Scholar : PubMed/NCBI

20 

Mao W, Yi X, Qin J, Tian M and Jin G: CXCL12/CXCR4 axis improves migration of neuroblasts along corpus callosum by stimulating MMP-2 secretion after traumatic brain injury in rats. Neurochem Res. 41:1315–1322. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Ahirwar DK, Nasser MW, Ouseph MM, Elbaz M, Cuitiño MC, Kladney RD, Varikuti S, Kaul K, Satoskar AR, Ramaswamy B, et al: Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation. Oncogene. 37:4428–4442. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Lang J, Zhao X, Qi Y, Zhang Y, Han X, Ding Y, Guan J, Ji T, Zhao Y and Nie G: Reshaping prostate tumor microenvironment To suppress metastasis via cancer-associated fibroblast inactivation with peptide-assembly-based nanosystem. ACS Nano. 13:12357–12371. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Mahadevan D and Von Hoff DD: Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 6:1186–1197. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O, Levis M, Rubin JB, Negrin RR, Estey EH, et al: Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood. 113:6215–6224. 2009. View Article : Google Scholar :

25 

Kong L, Guo S, Liu C, Zhao Y, Feng C, Liu Y, Wang T and Li C: Overexpression of SDF-1 activates the NF-kappaB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells. Int J Oncol. 48:1085–1094. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Kim SY, Lee CH, Midura BV, Yeung C, Mendoza A, Hong SH, Ren L, Wong D, Korz W, Merzouk A, et al: Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases. Clin Exp Metastasis. 25:201–211. 2008. View Article : Google Scholar

27 

Meng W, Xue S and Chen Y: The role of CXCL12 in tumor microenvironment. Gene. 641:105–110. 2018. View Article : Google Scholar

28 

Conley-LaComb MK, Semaan L, Singareddy R, Li Y, Heath EI, Kim S, Cher ML and Chinni SR: Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis. Mol Cancer. 15:682016. View Article : Google Scholar : PubMed/NCBI

29 

Ray P, Lewin SA, Mihalko LA, Schmidt BT, Luker KE and Luker GD: Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4. Neoplasia. 13:1152–1161. 2011. View Article : Google Scholar

30 

Li H, Chen Y, Xu N, Yu M, Tu X, Chen Z, Lin M, Xie B, Fu J and Han L: AMD3100 inhibits brain-specific metastasis in lung cancer via suppressing the SDF-1/CXCR4 axis and protecting blood-brain barrier. Am J Transl Res. 9:5259–5274. 2017.

31 

Tong X, Ma Y, Deng H, Wang X, Liu S, Yan Z, Peng S and Fan H: The SDF-1 rs1801157 polymorphism is associated with cancer risk: An update pooled analysis and FPRP test of 17,876 participants. Sci Rep. 6:274662016. View Article : Google Scholar : PubMed/NCBI

32 

Ponting CP: Novel repeats in ryanodine and IP3 receptors and protein O-mannosyltransferases. Trends Biochem Sci. 25:48–50. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Hamada T, Tashiro K, Tada H, Inazawa J, Shirozu M, Shibahara K, Nakamura T, Martina N, Nakano T and Honjo T: Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method. Gene. 176:211–214. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Vendrell E, Ribas M, Valls J, Solé X, Grau M, Moreno V, Capellà G and Peinado MA: Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. Int J Oncol. 30:1099–1107. 2007.PubMed/NCBI

35 

Fukuda S, Sumii M, Masuda Y, Takahashi M, Koike N, Teishima J, Yasumoto H, Itamoto T, Asahara T, Dohi K and Kamiya K: Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family. Biochem Biophys Res Commun. 280:407–414. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Lorenzon-Ojea AR, Caldeira W, Ribeiro AF, Fisher SJ, Guzzo CR and Bevilacqua E: Stromal cell derived factor-2 (Sdf2): A novel protein expressed in mouse. Int J Biochem Cell Biol. 53:262–270. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Lorenzon-Ojea AR, Yung HW, Burton GJ and Bevilacqua E: The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset. Biochim Biophys Acta Mol Basis Dis. 1866:1653862020. View Article : Google Scholar

38 

Walter P and Ron D: The unfolded protein response: From stress pathway to homeostatic regulation. Science. 334:1081–1086. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Schott A, Ravaud S, Keller S, Radzimanowski J, Viotti C, Hillmer S, Sinning I and Strahl S: Arabidopsis stromal-derived Factor2 (SDF2) is a crucial target of the unfolded protein response in the endoplasmic reticulum. J Biol Chem. 285:18113–18121. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Willis S, Villalobos VM, Gevaert O, Abramovitz M, Williams C, Sikic BI and Leyland-Jones B: Single gene prognostic biomarkers in ovarian cancer: A meta-analysis. PLoS One. 11:e01491832016. View Article : Google Scholar : PubMed/NCBI

41 

Giulianelli S, Herschkowitz JI, Patel V, Lamb CA, Gutkind JS, Molinolo A, Perou CM and Lanari C: MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Res Treat. 129:49–67. 2011. View Article : Google Scholar

42 

Takahashi K, Tanaka M, Yashiro M, Matsumoto M, Ohtsuka A, Nakayama KI, Izumi Y, Nagayama K, Miura K, Iwao H and Shiota M: Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells. Cancer Lett. 378:8–15. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Honoré B: The rapidly expanding CREC protein family: Members, localization, function, and role in disease. Bioessays. 31:262–277. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Luo J, Li Z, Zhu H, Wang C, Zheng W, He Y, Song J, Wang W, Zhou X, Lu X, et al: A novel role of Cab45-G in mediating cell migration in cancer cells. Int J Biol Sci. 12:677–687. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Honoré B and Vorum H: The CREC family, a novel family of multiple EF-hand, low-affinity Ca(2+)-binding proteins localised to the secretory pathway of mammalian cells. FEBS Lett. 466:11–18. 2000. View Article : Google Scholar : PubMed/NCBI

46 

Scherer PE, Lederkremer GZ, Williams S, Fogliano M, Baldini G and Lodish HF: Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen. J Cell Biol. 133:257–268. 1996. View Article : Google Scholar : PubMed/NCBI

47 

Chen L, Xu S, Xu Y, Lu W, Liu L, Yue D, Teng J and Chen J: Cab45S promotes cell proliferation through SERCA2b inhibition and Ca2+ signaling. Oncogene. 35:35–46. 2016. View Article : Google Scholar

48 

Lam PP, Hyvärinen K, Kauppi M, Cosen-Binker L, Laitinen S, Keränen S, Gaisano HY and Olkkonen VM: A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Mol Biol Cell. 18:2473–2480. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Grønborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, et al: Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol Cell Proteomics. 5:157–171. 2006. View Article : Google Scholar

50 

Ji H, Greening DW, Kapp EA, Moritz RL and Simpson RJ: Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells. Proteomics Clin Appl. 3:433–451. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Blank B and von Blume J: Cab45-Unraveling key features of a novel secretory cargo sorter at the trans-Golgi network. Eur J Cell Biol. 96:383–390. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Mittal V: Epithelial mesenchymal transition in tumor metastasis. Annu Rev Pathol. 13:395–412. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Gialeli C, Theocharis AD and Karamanos NK: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J. 278:16–27. 2011. View Article : Google Scholar

54 

Bisel B, Wang Y, Wei JH, Xiang Y, Tang D, Miron-Mendoza M, Yoshimura S, Nakamura N and Seemann J: ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65. J Cell Biol. 182:837–843. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Prigozhina NL and Waterman-Storer CM: Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility. Curr Biol. 14:88–98. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Kienzle C and von Blume J: Secretory cargo sorting at the trans-Golgi network. Trends Cell Biol. 24:584–593. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Weiss H, Amberger A, Widschwendter M, Margreiter R, Ofner D and Dietl P: Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells. Int J Cancer. 92:877–882. 2001. View Article : Google Scholar : PubMed/NCBI

58 

Yilmaz M and Christofori G: EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28:15–33. 2009. View Article : Google Scholar : PubMed/NCBI

59 

Kessenbrock K, Plaks V and Werb Z: Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell. 141:52–67. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Merchant N, Nagaraju GP, Rajitha B, Lammata S, Jella KK, Buchwald ZS, Lakka SS and Ali AN: Matrix metalloproteinases: Their functional role in lung cancer. Carcinogenesis. 38:766–780. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Shirozu M, Tada H, Tashiro K, Nakamura T, Lopez ND, Nazarea M, Hamada T, Sato T, Nakano T and Honjo T: Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 37:273–280. 1996. View Article : Google Scholar : PubMed/NCBI

62 

Shi Y, He B, You L and Jablons DM: Roles of secreted frizzled-related proteins in cancer. Acta Pharmacol Sin. 28:1499–1504. 2007. View Article : Google Scholar : PubMed/NCBI

63 

Liu Y, Zhou Q, Zhou D, Huang C, Meng X and Li J: Secreted frizzled-related protein 2-mediated cancer events: Friend or foe? Pharmacol Rep. 69:403–408. 2017. View Article : Google Scholar : PubMed/NCBI

64 

Arce L, Yokoyama NN and Waterman ML: Diversity of LEF/TCF action in development and disease. Oncogene. 25:7492–7504. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Zhang X, Rong X, Chen Y and Su L: Methylation-mediated loss of SFRP2 enhances invasiveness of non-small cell lung cancer cells. Hum Exp Toxicol. 37:155–162. 2018. View Article : Google Scholar : PubMed/NCBI

66 

Li P, Zhao S and Hu Y: SFRP2 modulates nonsmall cell lung cancer A549 cell apoptosis and metastasis by regulating mitochondrial fission via Wnt pathways. Mol Med Rep. 20:1925–1932. 2019.PubMed/NCBI

67 

Zeng X, Zhang Y, Xu H, Zhang T, Xue Y and An R: Secreted frizzled related protein 2modulates epithelial-mesenchymal transition and stemness via Wnt/β-catenin signaling in chorio-carcinoma. Cell Physiol Biochem. 50:1815–1831. 2018. View Article : Google Scholar

68 

Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK and Leung WK: Frequent epigenetic inactivation of secreted frizzled-related protein 2(SFRP2) by promoter methylation in human gastric cancer. Br J Cancer. 97:895–901. 2007. View Article : Google Scholar : PubMed/NCBI

69 

Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, et al: Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer. Int J Cancer. 132:1771–1780. 2013. View Article : Google Scholar

70 

Bhangu JS, Beer A, Mittlböck M, Tamandl D, Pulverer W, Schönthaler S, Taghizadeh H, Stremitzer S, Kaczirek K, Gruenberger T, et al: Circulating free methylated tumor DNA markers for sensitive assessment of tumor burden and early response monitoring in patients receiving systemic chemotherapy for colorectal cancer liver metastasis. Ann Surg. 268:894–902. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Luo X, Wei B, Chen A, Zhao H, Huang K and Chen J: Methylation-mediated loss of SFRP2 enhances melanoma cell invasion via Wnt signaling. Am J Transl Res. 8:1502–1509. 2016.PubMed/NCBI

72 

Liu S, Chen X, Chen R, Wang J, Zhu G, Jiang J, Wang H, Duan S and Huang J: Diagnostic role of Wnt pathway gene promoter methylation in non small cell lung cancer. Oncotarget. 8:36354–36367. 2017. View Article : Google Scholar : PubMed/NCBI

73 

Shih YL, Hsieh CB, Yan MD, Tsao CM, Hsieh TY, Liu CH and Lin YW: Frequent concomitant epigenetic silencing of SOX1 and secreted frizzled-related proteins (SFRPs) in human hepatocel-lular carcinoma. J Gastroenterol Hepatol. 28:551–559. 2013. View Article : Google Scholar

74 

Yang Q, Huang T, Ye G, Wang B and Zhang X: Methylation of SFRP2 gene as a promising noninvasive biomarker using feces in colorectal cancer diagnosis: A systematic meta-analysis. Sci Rep. 6:333392016. View Article : Google Scholar : PubMed/NCBI

75 

Lee JL, Lin CT, Chueh LL and Chang CJ: Autocrine/paracrine secreted Frizzled-related protein 2induces cellular resistance to apoptosis: A possible mechanism of mammary tumorigenesis. J Biol Chem. 279:14602–14609. 2004. View Article : Google Scholar : PubMed/NCBI

76 

Courtwright A, Siamakpour-Reihani S, Arbiser JL, Banet N, Hilliard E, Fried L, Livasy C, Ketelsen D, Nepal DB, Perou CM, et al: Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res. 69:4621–4628. 2009. View Article : Google Scholar : PubMed/NCBI

77 

Lee JL, Chang CJ, Chueh LL and Lin CT: Secreted frizzled related protein 2(sFRP2) decreases susceptibility to UV-induced apoptosis in primary culture of canine mammary gland tumors by NF-kappaB activation or JNK suppression. Breast Cancer Res Treat. 100:49–58. 2006. View Article : Google Scholar : PubMed/NCBI

78 

Lee JL, Chang CJ, Wu SY, Sargan DR and Lin CT: Secreted frizzled-related protein 2(SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands. Breast Cancer Res Treat. 84:139–149. 2004. View Article : Google Scholar : PubMed/NCBI

79 

Viros A, Girotti MR and Marais R: So you can teach old fibro-blasts new tricks. Cancer Discov. 6:581–583. 2016. View Article : Google Scholar

80 

Fontenot E, Rossi E, Mumper R, Snyder S, Siamakpour-Reihani S, Ma P, Hilliard E, Bone B, Ketelsen D, Santos C, et al: A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth. Mol Cancer Ther. 12:685–695. 2013. View Article : Google Scholar : PubMed/NCBI

81 

Xiao X, Xiao Y, Wen R, Zhang Y, Li X, Wang H, Huang J, Liu J, Long T and Tang J: Promoting roles of the secreted frizzled-related protein 2as a Wnt agonist in lung cancer cells. Oncol Rep. 34:2259–2266. 2015. View Article : Google Scholar : PubMed/NCBI

82 

Zhang Y, Li Q and Chen H: DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development. Carcinogenesis. 34:1756–1763. 2013. View Article : Google Scholar : PubMed/NCBI

83 

Wang WA, Groenendyk J and Michalak M: Endoplasmic reticulum stress associated responses in cancer. Biochim Biophys Acta. 1843:2143–2149. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gong W, Martin TA, Sanders AJ, Jiang A, Sun P and Jiang WG: Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review). Int J Mol Med 47: 435-443, 2021.
APA
Gong, W., Martin, T.A., Sanders, A.J., Jiang, A., Sun, P., & Jiang, W.G. (2021). Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review). International Journal of Molecular Medicine, 47, 435-443. https://doi.org/10.3892/ijmm.2020.4811
MLA
Gong, W., Martin, T. A., Sanders, A. J., Jiang, A., Sun, P., Jiang, W. G."Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review)". International Journal of Molecular Medicine 47.2 (2021): 435-443.
Chicago
Gong, W., Martin, T. A., Sanders, A. J., Jiang, A., Sun, P., Jiang, W. G."Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review)". International Journal of Molecular Medicine 47, no. 2 (2021): 435-443. https://doi.org/10.3892/ijmm.2020.4811
Copy and paste a formatted citation
x
Spandidos Publications style
Gong W, Martin TA, Sanders AJ, Jiang A, Sun P and Jiang WG: Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review). Int J Mol Med 47: 435-443, 2021.
APA
Gong, W., Martin, T.A., Sanders, A.J., Jiang, A., Sun, P., & Jiang, W.G. (2021). Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review). International Journal of Molecular Medicine, 47, 435-443. https://doi.org/10.3892/ijmm.2020.4811
MLA
Gong, W., Martin, T. A., Sanders, A. J., Jiang, A., Sun, P., Jiang, W. G."Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review)". International Journal of Molecular Medicine 47.2 (2021): 435-443.
Chicago
Gong, W., Martin, T. A., Sanders, A. J., Jiang, A., Sun, P., Jiang, W. G."Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review)". International Journal of Molecular Medicine 47, no. 2 (2021): 435-443. https://doi.org/10.3892/ijmm.2020.4811
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