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EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions

  • Authors:
    • Guibin Chen
    • Yanhong Yang
    • Wanwan Liu
    • Li Huang
    • Lanxiang Yang
    • Yuting Lei
    • Huijuan Wu
    • Zili Lei
    • Jiao Guo
  • View Affiliations / Copyright

    Affiliations: Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine and Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China and Institute of Chinese Medicine, Guangdong Pharmaceutical University and Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou, Guangdong 510006, P.R. China, The First Affiliated Hospital (School of Clinical Medicine), Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 621-632
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    Published online on: December 10, 2020
       https://doi.org/10.3892/ijmm.2020.4815
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Abstract

Epithelial cell adhesion molecule (EpCAM) is highly expressed in mammalian intestines, and is essential for maintaining the homeostasis of the intestinal epithelium. EpCAM protein is localized at tight junctions and the basolateral membrane of the intestinal epithelium, where it interacts with many cell adhesion molecules. To explore the molecular functions of EpCAM in regulating adherens junctions in the intestinal epithelium, EpCAM knockout embryos and newborn pups were analyzed. Hematoxylin and eosin staining was used to assess the histology of the duodenum, jejunum, ileum and colon from wild-type and EpCAM‑/‑ mice at E18.5, P0 and P3. The expression and localization of adherens junction‑associated genes and genes that encode the proteins that participate in the assembly of adherens junctions were measured at the mRNA and protein levels using qPCR, western blot analysis and immunofluorescence staining. The results showed that although there was no significant damage to the intestines of EpCAM‑/‑ mice at E18.5 and P0, they were significantly damaged at P3 in mutant mice. The expression of adherens junction‑associated genes in EpCAM mutant mice was normal at the mRNA level from E18.5 to P3, but their protein levels were gradually reduced and mislocalized from E18.5 to P3. The expression of nectin 1, which can regulate the assembly and adhesion activity of E‑cadherin, was also gradually reduced at both the mRNA and protein levels in the intestinal epithelium of EpCAM mutant mice from E18.5 to P3. In summary, the loss of EpCAM may cause the reduction and mislocalization of proteins that compose adherens junctions partly via the downregulation of nectin 1 in the intestines.
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1 

Balzar M, Winter MJ, de Boer CJ and Litvinov SV: The biology of the 17-1A antigen (Ep-CAM). J Mol Med (Berl). 77:699–712. 1999. View Article : Google Scholar

2 

Huang L, Yang Y, Yang F, Liu S, Zhu Z, Lei Z and Guo J: Functions of EpCAM in physiological processes and diseases (Review). Int J Mol Med. 42:1771–1785. 2018.PubMed/NCBI

3 

Schnell U, Cirulli V and Giepmans BN: EpCAM: Structure and function in health and disease. Biochim Biophys Acta. 1828:1989–2001. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Slanchev K, Carney TJ, Stemmler MP, Koschorz B, Amsterdam A, Schwarz H and Hammerschmidt M: The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genet. 5:e10005632009. View Article : Google Scholar : PubMed/NCBI

5 

Kamimoto K, Kaneko K, Kok CY, Okada H, Miyajima A and Itoh T: Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling. Elife. 5:e150342016. View Article : Google Scholar : PubMed/NCBI

6 

Schmelzer E, Zhang L, Bruce A, Wauthier E, Ludlow J, Yao HL, Moss N, Melhem A, McClelland R, Turner W, et al: Human hepatic stem cells from fetal and postnatal donors. J Exp Med. 204:1973–1987. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Carneiro FP, Muniz-Junqueira MI, De Vasconcelos Carneiro M, De Araújo Oliveira Í, Soares AC, De Vargas Haar N, Takano GHS, De Sousa Vianna LM, De Carvalho Caldas G, Vieira DLM, et al: Anti-EpCAM antibodies for detection of metastatic carcinoma in effusions and peritoneal wash. Oncol Lett. 18:2019–2024. 2019.PubMed/NCBI

8 

Sivagnanam M, Mueller JL, Lee H, Chen Z, Nelson SF, Turner D, Zlotkin SH, Pencharz PB, Ngan BY, Libiger O, et al: Identification of EpCAM as the gene for congenital tufting enteropathy. Gastroenterology. 135:429–437. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Guerra E, Lattanzio R, La Sorda R, Dini F, Tiboni GM, Piantelli M and Alberti S: mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin/β-catenin. PLoS One. 7:e493022012. View Article : Google Scholar

10 

Lei Z, Maeda T, Tamura A, Nakamura T, Yamazaki Y, Shiratori H, Yashiro K, Tsukita S and Hamada H: EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 371:136–145. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Mueller JL, McGeough MD, Peña CA and Sivagnanam M: Functional consequences of EpCam mutation in mice and men. Am J Physiol Gastrointest Liver Physiol. 306:G278–G288. 2014. View Article : Google Scholar :

12 

Ng V, Ang S, Chan J and Choo A: Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells. Stem Cells. 28:29–35. 2010. View Article : Google Scholar

13 

Gerlach J, Foka H, Thompson R, Gridelli B and Schmelzer E: Epithelial cell adhesion molecule fragments and signaling in primary human liver cells. J Cell Physiol. 233:4841–4851. 2018. View Article : Google Scholar

14 

Nagao K, Zhu J, Heneghan M, Hanson J, Morasso M, Tessarollo L, Mackem S and Udey MC: Abnormal placental development and early embryonic lethality in EpCAM-null mice. PLoS One. 4:e85432009. View Article : Google Scholar :

15 

Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, et al: Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development. 142:2147–2162. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Wu CJ, Mannan P, Lu M and Udey MC: Epithelial cell adhesion molecule (EpCAM) regulates claudin dynamics and tight junctions. J Biol Chem. 288:12253–12268. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Litvinov SV, Balzar M, Winter MJ, Bakker HA, Briaire-de Bruijn IH, Prins F, Fleuren GJ and Warnaar SO: Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins. J Cell Biol. 139:1337–1348. 1997. View Article : Google Scholar

18 

Winter MJ, Nagelkerken B, Mertens AE, Rees-Bakker HA, Briaire-de Bruijn IH and Litvinov SV: Expression of Ep-CAM shifts the state of cadherin-mediated adhesions from strong to weak. Exp Cell Res. 285:50–58. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Maghzal N, Kayali HA, Rohani N, Kajava AV and Fagotto F: EpCAM controls actomyosin contractility and cell adhesion by direct inhibition of PKC. Dev Cell. 27:263–277. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Salomon J, Gaston C, Magescas J, Duvauchelle B, Canioni D, Sengmanivong L, Mayeux A, Michaux G, Campeotto F, Lemale J, et al: Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity. Nat Commun. 8:139982017. View Article : Google Scholar : PubMed/NCBI

21 

Patey N, Scoazec JY, Cuenod-Jabri B, Canioni D, Kedinger M, Goulet O and Brousse N: Distribution of cell adhesion molecules in infants with intestinal epithelial dysplasia (tufting enter-opathy). Gastroenterology. 113:833–843. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Yang Y, Liu S, Lei Z, Chen G, Huang L, Yang F, Lei Y, Liu Y, Yang L, Liu W, et al: Circular RNA profile in liver tissue of EpCAM knockout mice. Int J Mol Med. 44:1063–1077. 2019.PubMed/NCBI

23 

Sato T, Fujita N, Yamada A, Ooshio T, Okamoto R, Irie K and Takai Y: Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby canine kidney cells. J Biol Chem. 281:5288–5299. 2006. View Article : Google Scholar

24 

Pathak SJ, Mueller JL, Okamoto K, Das B, Hertecant J, Greenhalgh L, Cole T, Pinsk V, Yerushalmi B, Gurkan OE, et al: EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome. Hum Mutat. 40:142–161. 2019. View Article : Google Scholar :

25 

Sherman PM, Mitchell DJ and Cutz E: Neonatal enteropathies: Defining the causes of protracted diarrhea of infancy. J Pediatr Gastroenterol Nutr. 38:16–26. 2004. View Article : Google Scholar

26 

Schneider MR, Dahlhoff M, Horst D, Hirschi B, Trülzsch K, Müller-Höcker J, Vogelmann R, Allgäuer M, Gerhard M, Steininger S, et al: A key role for E-cadherin in intestinal homeo-stasis and Paneth cell maturation. PLoS One. 5:e143252010. View Article : Google Scholar

27 

Bondow BJ, Faber ML, Wojta KJ, Walker EM and Battle MA: E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 371:1–12. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Gloushankova NA, Rubtsova SN and Zhitnyak IY: Cadherin-mediated cell-cell interactions in normal and cancer cells. Tissue Barriers. 5:e13569002017. View Article : Google Scholar : PubMed/NCBI

29 

Hermiston ML and Gordon JI: Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science. 270:1203–1207. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Hermiston ML, Wong MH and Gordon JI: Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. Genes Dev. 10:985–996. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Smalley-Freed WG, Efimov A, Short SP, Jia P, Zhao Z, Washington MK, Robine S, Coffey RJ and Reynolds AB: Adenoma formation following limited ablation of p120-catenin in the mouse intestine. PLoS One. 6:e198802011. View Article : Google Scholar : PubMed/NCBI

32 

Smalley-Freed WG, Efimov A, Burnett PE, Short SP, Davis MA, Gumucio DL, Washington MK, Coffey RJ and Reynolds AB: p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest. 120:1824–1835. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Short SP, Kondo J, Smalley-Freed WG, Takeda H, Dohn MR, Powell AE, Carnahan RH, Washington MK, Tripathi M, Payne DM, et al: p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia. J Clin Invest. 127:4462–4476. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Nusse R and Clevers H: Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 169:985–999. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Chiacchiera F, Rossi A, Jammula S, Piunti A, Scelfo A, Ordóñez-Morán P, Huelsken J, Koseki H and Pasini D: Polycomb complex PRC1 preserves intestinal stem cell identity by sustaining Wnt/β-catenin transcriptional activity. Cell Stem Cell. 18:91–103. 2016. View Article : Google Scholar

36 

Ahmad R, Kumar B, Chen Z, Chen X, Müller D, Lele SM, Washington MK, Batra SK, Dhawan P and Singh AB: Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling. Oncogene. 36:6592–6604. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Janeckova L, Fafilek B, Krausova M, Horazna M, Vojtechova M, Alberich-Jorda M, Sloncova E, Galuskova K, Sedlacek R, Anderova M and Korinek V: Wnt signaling inhibition deprives small intestinal stem cells of clonogenic capacity. Genesis. 54:101–114. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Sun X, Yao L, Liang H, Wang D, He Y, Wei Y, Ye L, Wang K, Li L, Chen J, et al: Intestinal epithelial PKM2 serves as a safeguard against experimental colitis via activating β-catenin signaling. Mucosal Immunol. 12:1280–1290. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Kobielak A and Fuchs E: Alpha-catenin: At the junction of inter-cellular adhesion and actin dynamics. Nat Rev Mol Cell Biol. 5:614–625. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Shimono Y, Rikitake Y, Mandai K, Mori M and Takai Y: Immunoglobulin superfamily receptors and adherens junctions. Subcell Biochem. 60:137–170. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Takai Y, Ikeda W, Ogita H and Rikitake Y: The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin. Annu Rev Cell Dev Biol. 24:309–342. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Martinez-Rico C, Pincet F, Perez E, Thiery JP, Shimizu K, Takai Y and Dufour S: Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3. J Biol Chem. 280:4753–4760. 2005. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chen G, Yang Y, Liu W, Huang L, Yang L, Lei Y, Wu H, Lei Z and Guo J: EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions. Int J Mol Med 47: 621-632, 2021.
APA
Chen, G., Yang, Y., Liu, W., Huang, L., Yang, L., Lei, Y. ... Guo, J. (2021). EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions. International Journal of Molecular Medicine, 47, 621-632. https://doi.org/10.3892/ijmm.2020.4815
MLA
Chen, G., Yang, Y., Liu, W., Huang, L., Yang, L., Lei, Y., Wu, H., Lei, Z., Guo, J."EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions". International Journal of Molecular Medicine 47.2 (2021): 621-632.
Chicago
Chen, G., Yang, Y., Liu, W., Huang, L., Yang, L., Lei, Y., Wu, H., Lei, Z., Guo, J."EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions". International Journal of Molecular Medicine 47, no. 2 (2021): 621-632. https://doi.org/10.3892/ijmm.2020.4815
Copy and paste a formatted citation
x
Spandidos Publications style
Chen G, Yang Y, Liu W, Huang L, Yang L, Lei Y, Wu H, Lei Z and Guo J: EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions. Int J Mol Med 47: 621-632, 2021.
APA
Chen, G., Yang, Y., Liu, W., Huang, L., Yang, L., Lei, Y. ... Guo, J. (2021). EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions. International Journal of Molecular Medicine, 47, 621-632. https://doi.org/10.3892/ijmm.2020.4815
MLA
Chen, G., Yang, Y., Liu, W., Huang, L., Yang, L., Lei, Y., Wu, H., Lei, Z., Guo, J."EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions". International Journal of Molecular Medicine 47.2 (2021): 621-632.
Chicago
Chen, G., Yang, Y., Liu, W., Huang, L., Yang, L., Lei, Y., Wu, H., Lei, Z., Guo, J."EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose adherens junctions". International Journal of Molecular Medicine 47, no. 2 (2021): 621-632. https://doi.org/10.3892/ijmm.2020.4815
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