Open Access

ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy

  • Authors:
    • Wenjun Zou
    • Shasha Luo
    • Zhengwei Zhang
    • Libo Cheng
    • Xiaoli Huang
    • Nannan Ding
    • Ying Pan
    • Zhifeng Wu
  • View Affiliations

  • Published online on: December 24, 2020     https://doi.org/10.3892/ijmm.2020.4833
  • Pages: 732-740
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetic retinopathy (DR) is the leading cause of blindness among the working‑age population in several countries. Despite the available treatments, some patients are diagnosed at the late stages of the disease when treatment is more difficult. Hence, it is crucial that novel targets are identified in order to improve the clinical therapy of DR. In the present study, an animal model of DR and a cell model using primary human retinal microvascular endothelial cells exposed to high glucose were constructed to examine the association between apoptosis signal‑regulating kinase 1 (ASK1)/p38 and NLR family pyrin domain containing 3 (NLRP3) in DR. The results revealed that DR induced inflammatory response and microvascular cell proliferation. NLRP3 contributed to DR‑mediated inflammatory development and progression, which promoted the expression of inflammatory‑related cytokines. In addition, NLRP3 promoted the tube formation of retinal microvascular endothelial cells and angiogenesis. Moreover, further research indicated that the NLRP3‑mediated aberrant retinal angiogenesis in DR was regulated by ASK1 and p38. It was thus suggested that ASK1/p38 may be novel target for the treatment of DR.
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February-2021
Volume 47 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zou W, Luo S, Zhang Z, Cheng L, Huang X, Ding N, Pan Y and Wu Z: ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy. Int J Mol Med 47: 732-740, 2021
APA
Zou, W., Luo, S., Zhang, Z., Cheng, L., Huang, X., Ding, N. ... Wu, Z. (2021). ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy. International Journal of Molecular Medicine, 47, 732-740. https://doi.org/10.3892/ijmm.2020.4833
MLA
Zou, W., Luo, S., Zhang, Z., Cheng, L., Huang, X., Ding, N., Pan, Y., Wu, Z."ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy". International Journal of Molecular Medicine 47.2 (2021): 732-740.
Chicago
Zou, W., Luo, S., Zhang, Z., Cheng, L., Huang, X., Ding, N., Pan, Y., Wu, Z."ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy". International Journal of Molecular Medicine 47, no. 2 (2021): 732-740. https://doi.org/10.3892/ijmm.2020.4833