Long non‑coding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma

Ye,Hui; Mulmi Shrestha,Sachin; Zhu,Jie; Ding,Yan; Shi,Ruihua

doi:10.3892/ijmm.2021.4866

Long non‑coding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma

Authors:
- Hui Ye
- Sachin Mulmi Shrestha
- Jie Zhu
- Yan Ding
- Ruihua Shi
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Affiliations: School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Gastroenterology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, P.R. China
Published online on: February 2, 2021 https://doi.org/10.3892/ijmm.2021.4866
Article Number: 33
Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor in the human digestive system, which affects the physical and mental health of the patient. Long non‑coding (lnc)RNAs have been revealed to play an important role in human malignant tumors. Moreover, long intergenic non‑protein coding RNA 491 (LINC00491) is a newly discovered lncRNA that can affect the prognosis of cancer. The present study aimed to explore the expression of LINC00491 in ESCC tissues and cells. The reverse transcription‑quantitative PCR results suggested that LINC00491 was upregulated in ESCC tissues and cells. LINC00491 expression in esophageal squamous cell carcinoma cells were knocked down. Cell Counting Kit‑8, wound healing, Transwell and apoptosis assays were performed to detect the effects of LINC00491 knockdown on cell biological behavior. The results showed that lower expression of LINC00491 resulted in decreased cell proliferation and migration and increased the apoptosis rate. Therefore, the present results indicated that lncRNA LINC00491 promoted the biological processes of ESCC, and thus LINC00491 may be a potential therapeutic target for ESCC.

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