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Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review)

  • Authors:
    • Qi Li
    • Zhuqing Li
    • Zhixing Fan
    • Ying Yang
    • Chengzhi Lu
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Nankai University, Tianjin 300071, P.R. China, Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443000, P.R. China, Department of Cardiology, Beijing Tsinghua Changgeng Hospital, School of Clinical Medicine, Tsinghua University, Beijing 100084, P.R. China
  • Article Number: 42
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    Published online on: February 5, 2021
       https://doi.org/10.3892/ijmm.2021.4875
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Abstract

Myocardial ischemia/reperfusion injury (MIRI) may cause myocardial stunning, reperfusion arrhythmia, no‑reflow phenomenon and lethal reperfusion injury, which has a significant effect on the prognosis of patients undergoing thrombolytic agent therapy and percutaneous coronary intervention. Increasing evidence suggests that apoptosis, innate inflammation, oxidative stress, calcium overload and autophagy are involved in the pathogenesis of MIRI. Recent advancements in RNA sequencing technologies and genome‑wide analyses led to the finding of small non‑coding RNAs (ncRNAs). ncRNAs modulate cellular processes such as signal transduction, transcription, chromatin remodeling and post‑transcriptional modification. The effects of ncRNAs on cellular biology is more considerable than initially expected, and thus ncRNAs have gained increasing attention and focus in modern medical research. There are several types of ncRNAs, such as microRNAs (miRNAs), long non‑coding RNAs (lncRNAs) and circular RNAs (circRNAs), which have been shown to regulate gene expression at the transcription, post‑transcription and epigenetic levels. Dysregulation of ncRNAs, including miRNAs, lncRNAs and circRNAs, may participate in the molecular mechanisms of MIRI. The present review summarizes the characteristics and biological roles of miRNAs, lncRNAs and circRNAs, with particular emphasis on their role in MIRI, which show the novel complexity of ischemic hearts and may offer valuable insights into the pathogenesis of MIRI.
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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Li Z, Fan Z, Yang Y and Lu C: Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review). Int J Mol Med 47: 42, 2021.
APA
Li, Q., Li, Z., Fan, Z., Yang, Y., & Lu, C. (2021). Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review). International Journal of Molecular Medicine, 47, 42. https://doi.org/10.3892/ijmm.2021.4875
MLA
Li, Q., Li, Z., Fan, Z., Yang, Y., Lu, C."Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review)". International Journal of Molecular Medicine 47.4 (2021): 42.
Chicago
Li, Q., Li, Z., Fan, Z., Yang, Y., Lu, C."Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review)". International Journal of Molecular Medicine 47, no. 4 (2021): 42. https://doi.org/10.3892/ijmm.2021.4875
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Li Z, Fan Z, Yang Y and Lu C: Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review). Int J Mol Med 47: 42, 2021.
APA
Li, Q., Li, Z., Fan, Z., Yang, Y., & Lu, C. (2021). Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review). International Journal of Molecular Medicine, 47, 42. https://doi.org/10.3892/ijmm.2021.4875
MLA
Li, Q., Li, Z., Fan, Z., Yang, Y., Lu, C."Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review)". International Journal of Molecular Medicine 47.4 (2021): 42.
Chicago
Li, Q., Li, Z., Fan, Z., Yang, Y., Lu, C."Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review)". International Journal of Molecular Medicine 47, no. 4 (2021): 42. https://doi.org/10.3892/ijmm.2021.4875
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