Open Access

Determining available strategies for prevention and therapy: Exploring COVID‑19 from the perspective of ACE2 (Review)

  • Authors:
    • Liyang Cai
    • Xi Guo
    • Yuchen Cao
    • Peixi Ying
    • Libing Hong
    • Yuxi Zhang
    • Guoguo Yi
    • Min Fu
  • View Affiliations

  • Published online on: February 8, 2021     https://doi.org/10.3892/ijmm.2021.4876
  • Article Number: 43
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Coronavirus disease 2019 (COVID‑19) is an acute infectious pneumonia caused by a novel type of coronavirus infection. There are currently no clinically available specific drugs for the treatment of this virus. The process of host invasion is the key to viral infection, and it is a mechanism that needs to be considered when exploring antiviral drugs. At present, studies have confirmed that angiotensin‑converting enzyme II (ACE2) is the main functional receptor through which severe acute respiratory syndrome coronavirus (SARS‑CoV‑2) invades host cells. Therefore, a number of studies have focused on this field. However, as ACE2 may play a dual role in mediating susceptibility and immunity to SARS‑CoV‑2 infection, the role of ACE2 in viral infection is controversial. Beginning with the physiological function of ACE2, the present review article summarizes the influence of the ACE2 content on the susceptibility to the virus and acute lung injury. Drug mechanisms were taken as the starting point, combined with the results of clinical trials, specifically elaborating upon and analyzing the efficacy of several ACE2‑centered therapeutic drugs and their potential effects. In addition, the current status of ACE2 as a targeted therapy for COVID‑19 is discussed in order to provide new insight into the clinical prevention and treatment of COVID‑19.
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April-2021
Volume 47 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Cai L, Guo X, Cao Y, Ying P, Hong L, Zhang Y, Yi G and Fu M: Determining available strategies for prevention and therapy: Exploring COVID‑19 from the perspective of ACE2 (Review). Int J Mol Med 47: 43, 2021
APA
Cai, L., Guo, X., Cao, Y., Ying, P., Hong, L., Zhang, Y. ... Fu, M. (2021). Determining available strategies for prevention and therapy: Exploring COVID‑19 from the perspective of ACE2 (Review). International Journal of Molecular Medicine, 47, 43. https://doi.org/10.3892/ijmm.2021.4876
MLA
Cai, L., Guo, X., Cao, Y., Ying, P., Hong, L., Zhang, Y., Yi, G., Fu, M."Determining available strategies for prevention and therapy: Exploring COVID‑19 from the perspective of ACE2 (Review)". International Journal of Molecular Medicine 47.4 (2021): 43.
Chicago
Cai, L., Guo, X., Cao, Y., Ying, P., Hong, L., Zhang, Y., Yi, G., Fu, M."Determining available strategies for prevention and therapy: Exploring COVID‑19 from the perspective of ACE2 (Review)". International Journal of Molecular Medicine 47, no. 4 (2021): 43. https://doi.org/10.3892/ijmm.2021.4876