Curcumin protects BEAS‑2B cells from PM2.5‑induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways

  • Authors:
    • Shuo Yang
    • Xiao-Long Huang
    • Jin Chen
    • Li-Na Mao
    • Xu Liu
    • Wen-Sheng Yuan
    • Xiao-Jie Wu
    • Guang-Wei Luo
  • View Affiliations

  • Published online on: February 8, 2021     https://doi.org/10.3892/ijmm.2021.4878
  • Article Number: 45
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Abstract

Fine particulate matter (PM2.5) with an average aerodynamic diameter of <2.5 µm can cause severe lung injury. Oxidative stress and inflammation are considered the main outcomes of PM2.5 exposure. Curcumin is a well‑known antioxidant; however, its effect on PM2.5‑induced oxidative injury in airway epithelial cells remains unclear. In the present study, it was demonstrated that pre‑treatment with curcumin significantly reduced the PM2.5‑induced apoptosis of BEAS‑2B human bronchial epithelial cells by decreasing the level of intercellular reactive oxygen species. Western blot analysis revealed that curcumin increased the expression of nuclear factor erythroid 2‑related factor 2 (NRF2) and regulated the transcription of downstream genes, particularly those encoding antioxidant enzymes. Moreover, curcumin reduced the PM2.5‑induced expression and production of inflammatory factors, and induced the expression of the anti‑inflammatory factors, interleukin (IL)‑5 and IL‑13. Taken together, the present study demonstrates that curcumin protects BEAS‑2B cells against PM2.5‑induced oxidative damage and inflammation, and prevents cell apoptosis by increasing the activation of NRF2‑related pathways. It is thus suggested that curcumin may be a potential compound for use in the prevention of PM2.5‑induced tissue injury.
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April-2021
Volume 47 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yang S, Huang X, Chen J, Mao L, Liu X, Yuan W, Wu X and Luo G: Curcumin protects BEAS‑2B cells from PM<sub>2.5</sub>‑induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways. Int J Mol Med 47: 45, 2021
APA
Yang, S., Huang, X., Chen, J., Mao, L., Liu, X., Yuan, W. ... Luo, G. (2021). Curcumin protects BEAS‑2B cells from PM<sub>2.5</sub>‑induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways. International Journal of Molecular Medicine, 47, 45. https://doi.org/10.3892/ijmm.2021.4878
MLA
Yang, S., Huang, X., Chen, J., Mao, L., Liu, X., Yuan, W., Wu, X., Luo, G."Curcumin protects BEAS‑2B cells from PM<sub>2.5</sub>‑induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways". International Journal of Molecular Medicine 47.4 (2021): 45.
Chicago
Yang, S., Huang, X., Chen, J., Mao, L., Liu, X., Yuan, W., Wu, X., Luo, G."Curcumin protects BEAS‑2B cells from PM<sub>2.5</sub>‑induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways". International Journal of Molecular Medicine 47, no. 4 (2021): 45. https://doi.org/10.3892/ijmm.2021.4878