Open Access

Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review)

  • Authors:
    • Junmin Wang
    • Hongjiao Xiang
    • Yifei Lu
    • Tao Wu
  • View Affiliations

  • Published online on: February 15, 2021     https://doi.org/10.3892/ijmm.2021.4888
  • Article Number: 55
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The appearance and growth of malignant tumors is a complicated process that is regulated by a number of genes. In recent years, studies have revealed that the transforming growth factor‑β (TGF‑β) signaling pathway serves an important role in cell cycle regulation, growth and development, differentiation, extracellular matrix synthesis and immune response. Notably, two members of the TGF‑β signaling pathway, TGF‑β1 and TGF‑β receptor 1 (TGF‑βR1), are highly expressed in a variety of tumors, such as breast cancer, colon cancer, gastric cancer and hepatocellular carcinoma. Moreover, an increasing number of studies have demonstrated that TGF‑β1 and TGF‑βR1 promote proliferation, migration and epithelial‑mesenchymal transition of tumor cells by activating other signaling pathways, signaling molecules or microRNAs (miRs), such as the NF‑κB signaling pathway and miR‑133b. In addition, some inhibitors targeting TGF‑β1 and TGF‑βR1 have exhibited positive effects in in vitro experiments. The present review discusses the association between TGF‑β1 or TGF‑βR1 and tumors, and the development of some inhibitors, hoping to provide more approaches to help identify novel tumor markers to restrain and cure tumors.
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April-2021
Volume 47 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Xiang H, Lu Y and Wu T: Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review). Int J Mol Med 47: 55, 2021
APA
Wang, J., Xiang, H., Lu, Y., & Wu, T. (2021). Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review). International Journal of Molecular Medicine, 47, 55. https://doi.org/10.3892/ijmm.2021.4888
MLA
Wang, J., Xiang, H., Lu, Y., Wu, T."Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review)". International Journal of Molecular Medicine 47.4 (2021): 55.
Chicago
Wang, J., Xiang, H., Lu, Y., Wu, T."Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors (Review)". International Journal of Molecular Medicine 47, no. 4 (2021): 55. https://doi.org/10.3892/ijmm.2021.4888