Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2021 Volume 47 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 47 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis

Retraction in: /10.3892/ijmm.2023.5218
  • Authors:
    • Lei Chen
    • Qiang Chen
    • Yongyou Wu
    • Minggao Zhu
    • Jia Hu
    • Zhixiang Zhuang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of Genetics and Bioinformatics, College of Basic Medicine and Biological Sciences of Soochow University, Suzhou, Jiangsu 215004, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 65
    |
    Published online on: February 26, 2021
       https://doi.org/10.3892/ijmm.2021.4898
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The liver is the most common site of metastasis for colorectal cancer (CRC). Metastasis suppressor 1 (MTSS1), a potential tumor suppressor gene associated with tumor metastasis, has been reported to play an important role in cancer development. The present study aimed to investigate the effects and underlying mechanisms of MTSS1 on the biological behavior of CRC cells both in vitro and in vivo. A CRC mouse model with a high liver metastatic potential was established by injecting mice with SW1116 cells, and the association between MTSS1 expression levels and the metastatic potential of forming liver metastasis lesions was subsequently analyzed. MTSS1 gain‑ and loss‑of‑function experiments were performed by transfecting the CRC cell lines, SW1116 and DLD‑1, with Plvx‑IRES‑ZsGreen1‑MTSS1 plasmid and short hairpin RNA, respectively. Cell proliferation, migration, invasion and cell cycle distribution were analyzed by MTT, Transwell and flow cytometric assays, respectively. To further determine the underlying mechanisms of MTSS1 in CRC, the expression levels of cell surface chemokine C‑X‑C receptor 4 (CXCR4) and its downstream signaling factors, Rac and cell division cycle 42 (CDC42), were analyzed with or without C‑X‑C motif chemokine ligand 12 (CXCL12) stimulation. The results revealed that as the CRC metastatic potential increased, the expression levels of MTSS1 decreased. The overexpression of MTSS1 exerted an inhibitory effect on cell proliferation, migration and invasion, while the knockdown of MTSS1 exerted the opposite effects in vitro. Flow cytometric analysis and western blot analysis demonstrated that MTSS1 negatively regulated the expression levels of cell surface CXCR4 and its downstream signaling pathway activation. On the whole, the results of the present study indicate that MTSS1 may play an important negative role in CRC metastasis and the underlying mechanisms may involve the downregulation of the CXCR4/CXCL12 signaling axis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Lee WS, Yun SH, Chun HK, Lee WY, Yun HR, Kim J, Kim K and Shim YM: Pulmonary resection for metastases from colorectal cancer: Prognostic factors and survival. Int J Colorectal Dis. 22:699–704. 2007. View Article : Google Scholar

3 

Van Cutsem E, Nordlinger B, Adam R, Köhne CH, Pozzo C, Poston G, Ychou M and Rougier P; European Colorectal Metastases Treatment Group: Towards a pan European consensus on the treatment of patients with colorectal liver metastases. Eur J Cancer. 42:2212–2221. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Yoo PS, Lopez-Soler RI, Longo WE and Cha CH: Liver resection for metastatic colorectal cancer in the age of neoadjuvant chemotherapy and bevacizumab. Clin Colorectal Cancer. 6:202–207. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Dawood O, Mahadevan A and Goodman KA: Stereotactic body radiation therapy for liver metastases. Eur J Cancer. 45:2947–2959. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Kemeny N: Management of liver metastases from colorectal cancer. Oncology (Williston Park). 20:1161–1176; discussion 1179-1180, 1185-1186. 2006.

7 

Lee YG, Macoska JA, Korenchuk S and Pienta KJ: MIM, a potential metastasis suppressor gene in bladder cancer. Neoplasia. 4:291–294. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Nixdorf S, Grimm MO, Loberg R, Marreiros A, Russell PJ, Pienta KJ and Jackson P: Expression and regulation of MIM (missing in metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. Cancer Lett. 215:209–220. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Xie F, Ye L, Chen J, Wu N, Zhang Z, Yang Y, Zhang L and Jiang WG: The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance. J Transl Med. 9:952011. View Article : Google Scholar : PubMed/NCBI

10 

Zhou L, Li J, Shao QQ, Guo JC, Liang ZY, Zhou WX, Zhang TP, You L and Zhao YP: Expression and significances of MTSS1 in pancreatic cancer. Pathol Oncol Res. 22:7–14. 2016. View Article : Google Scholar

11 

Liu K, Jiao XD, Hao JL, Qin BD, Wu Y, Chen W, Liu J, He X and Zang YS: MTSS1 inhibits metastatic potential and induces G2/M phase cell cycle arrest in gastric cancer. Onco Targets Ther. 12:5143–5152. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Xu M and Xu T: Expression and clinical significance of miR-23a and MTSS1 in diffuse large B-cell lymphoma. Oncol Lett. 16:371–377. 2018.PubMed/NCBI

13 

Mertz KD, Pathria G, Wagner C, Saarikangas J, Sboner A, Romanov J, Gschaider M, Lenz F, Neumann F, Schreiner W, et al: MTSS1 is a metastasis driver in a subset of human melanomas. Nat Commun. 5:3465–3474. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Huang XY, Huang ZL, Xu B, Chen Z, Re TJ, Zheng Q, Tang ZY and Huang XY: Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma. J Exp Clin Cancer Res. 35:85–98. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Dawson JC, Timpson P, Kalna G and Machesky LM: Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells. Oncogene. 31:1781–1793. 2012. View Article : Google Scholar

16 

Ling DJ, Chen ZS, Liao QD, Feng JX, Zhang XY and Yin TY: Differential effects of MTSS1 on invasion and proliferation in subtypes of non-small cell lung cancer cells. Exp Ther Med. 12:1225–1231. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Agarwal E, Robb CM, Smith LM, Brattain MG, Wang J, Black JD and Chowdhury S: Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis. Oncogene. 36:3104–3118. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Wang D, Xu MR, Wang T, Li T and Zhu Jw: MTSS1 overexpression correlates with poor prognosis in colorectal cancer. J Gastrointest Surg. 15:1205–1212. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Zhan T, Cao C, Li L, Gu N, Civin CI and Zhan X: MIM regulates the trafficking of bone marrow cells via modulating surface expression of CXCR4. Leukemia. 30:1327–1334. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Chen K, Bao Z, Tang P, Gong W, Yoshimura T and Wang JM: Chemokines in homeostasis and diseases. Cell Mol Immunol. 15:324–334. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Fernandis AZ, Prasad A, Band H, Klösel R and Ganju RK: Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene. 23:157–167. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J and Ratajczak MZ: Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis. Stem Cells. 23:879–894. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Furusato B, Mohamed A, Uhlén M and Rhim JS: CXCR4 and cancer. Pathol Int. 60:497–505. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Li L, Baxter SS, Gu N, Ji M and Zhan X: Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci. 130:1475–1485. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Yu D, Zhan XH, Zhao XF, Williams MS, Carey GB, Smith E, Scott D, Zhu J, Guo Y, Cherukuri S, et al: Mice deficient in MIM expression are predisposed to lymphomagenesis. Oncogene. 31:3561–3568. 2012. View Article : Google Scholar :

26 

McCormick PJ, Segarra M, Gasperini P, Gulino AV and Tosato G: Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor. PLoS One. 4:e81022009. View Article : Google Scholar : PubMed/NCBI

27 

Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T and Honjo T: Structure and chromosomal localization of the human stromal cell-derived factor 1(SDF1) gene. Genomics. 28:495–500. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Rousseau S, Dolado I, Beardmore V, Shpiro N, Marquez R, Nebreda AR, Arthur JS, Case LM, Tessier-Lavigne M, Gaestel M, et al: CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal. 18:1897–1905. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Bendall LJ, Baraz R, Juarez J, Shen W and Bradstock KF: Defective p38 mitogen- activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia. Cancer Res. 65:3290–3298. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Petrov P, Sarapulov AV, Eöry L, Scielzo C, Scarfò L, Smith J, Burt DW and Mattila PK: Computational analysis of the evolutionarily conserved missing in metastasis/metastasis suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control. Sci Rep. 9:4155–4171. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Mattila PK, Pykäläinen A, Saarikangas J, Paavilainen VO, Vihinen H, Jokitalo E and Lappalainen P: Missing-in-metastasis and IRSp53 deform PI (4,5)P2-rich membranes by an inverse BAR domain-like mechanism. J Cell Biol. 176:953–964. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Yamagishi A, Masuda M, Ohki T, Onishi H and Mochizuki N: A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. J Biol Chem. 279:14929–14936. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Bompard G, Sharp SJ, Freiss G and Machesky LM: Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. J Cell Sci. 118:5393–5403. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Callahan CA, Ofstad T, Horng L, Wang JK, Zhen HH, Coulombe PA and Oro AE: MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev. 18:2724–2729. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Scarlett KA, White EZ, Coke CJ, Carter JR, Bryant LK and Hinton CV: Agonist induced CXCR4 and CB2 heterodimerization inhibits Gα13/RhoA-mediated migration. Mol Cancer Res. 16:728–739. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Cancelas JA and Williams DA: Rho GTPases in hematopoietic stem cell functions. Curr Opin Hematol. 16:249–254. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Xu C, Zhao H, Chen H and Yao Q: CXCR4 in breast cancer: Oncogenic role and therapeutic targeting. Drug Des Devel Ther. 9:4953–4964. 2015.PubMed/NCBI

38 

Kodama J, Hasengaowa, Kusumoto T, Seki N, Matsuo T, Ojima Y, Nakamura K, Hongo A and Hiramatsu Y: Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancer. Ann Oncol. 18:70–76. 2007. View Article : Google Scholar

39 

Lv S, Yang Y, Kwon S, Han M, Zhao F, Kang H, Dai C and Wang R: The association of CXCR4 expression with prognosis and clinicopathological indicators in colorectal carcinoma patients: A meta-analysis. Histopathology. 64:701–712. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Gangadhar T, Nandi S and Salgia R: The role of chemokine receptor CXCR4 in lung cancer. Cancer Biol Ther. 9:409–416. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Benedicto A, Romayor I and Arteta B: CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver. Oncol Rep. 39:2022–2030. 2018.PubMed/NCBI

42 

Haga RB and Ridley AJ: Small GTPases: Regulation and roles in cancer cell biology. Small GTPases. 7:207–221. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen L, Chen Q, Wu Y, Zhu M, Hu J and Zhuang Z: MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis Retraction in /10.3892/ijmm.2023.5218. Int J Mol Med 47: 65, 2021.
APA
Chen, L., Chen, Q., Wu, Y., Zhu, M., Hu, J., & Zhuang, Z. (2021). MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis Retraction in /10.3892/ijmm.2023.5218. International Journal of Molecular Medicine, 47, 65. https://doi.org/10.3892/ijmm.2021.4898
MLA
Chen, L., Chen, Q., Wu, Y., Zhu, M., Hu, J., Zhuang, Z."MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis Retraction in /10.3892/ijmm.2023.5218". International Journal of Molecular Medicine 47.5 (2021): 65.
Chicago
Chen, L., Chen, Q., Wu, Y., Zhu, M., Hu, J., Zhuang, Z."MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis Retraction in /10.3892/ijmm.2023.5218". International Journal of Molecular Medicine 47, no. 5 (2021): 65. https://doi.org/10.3892/ijmm.2021.4898
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Chen Q, Wu Y, Zhu M, Hu J and Zhuang Z: MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis Retraction in /10.3892/ijmm.2023.5218. Int J Mol Med 47: 65, 2021.
APA
Chen, L., Chen, Q., Wu, Y., Zhu, M., Hu, J., & Zhuang, Z. (2021). MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis Retraction in /10.3892/ijmm.2023.5218. International Journal of Molecular Medicine, 47, 65. https://doi.org/10.3892/ijmm.2021.4898
MLA
Chen, L., Chen, Q., Wu, Y., Zhu, M., Hu, J., Zhuang, Z."MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis Retraction in /10.3892/ijmm.2023.5218". International Journal of Molecular Medicine 47.5 (2021): 65.
Chicago
Chen, L., Chen, Q., Wu, Y., Zhu, M., Hu, J., Zhuang, Z."MTSS1 inhibits colorectal cancer metastasis by regulating the CXCR4/CXCL12 signaling axis Retraction in /10.3892/ijmm.2023.5218". International Journal of Molecular Medicine 47, no. 5 (2021): 65. https://doi.org/10.3892/ijmm.2021.4898
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team