|
1
|
WRITING GROUP MEMBERS; Lloyd-Jones D,
Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB,
Ford E, Furie K, et al: Heart disease and stroke statistics-2010
Update: A report from the American Heart Association. Circulation.
121:e46–e215. 2010.
|
|
2
|
Gwathmey JK, Copelas L, MacKinnon R,
Schoen FJ, Feldman MD, Grossman W and Morgan JP: Abnormal
intracellular calcium handling in myocardium from patients with
end-stage heart failure. Circ Res. 61:70–76. 1987. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Hasenfuss G, Reinecke H, Studer R, Meyer
M, Pieske B, Holtz J, Holubarsch C, Posival H, Just H and Drexler
H: Relation between myocardial function and expression of
sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing
human myocardium. Circ Res. 75:434–442. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Meyer M, Schillinger W, Pieske B,
Holubarsch C, Heilmann C, Posival H, Kuwajima G, Mikoshiba K, Just
H, Hasenfuss G, et al: Alterations of sarcoplasmic reticulum
proteins in failing human dilated cardiomyopathy. Circulation.
92:778–784. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Hajjar RJ, Kang JX, Gwathmey JK and
Rosenzweig A: Physiological effects of adenoviral gene transfer of
sarcoplasmic reticulum calcium ATPase in isolated rat myocytes.
Circulation. 95:423–429. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi
Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, et al: Reversal
of cardiac dysfunction after long-term expression of SERCA2a by
gene transfer in a pre-clinical model of heart failure. J Am Coll
Cardiol. 51:1112–1119. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
He H, Giordano FJ, Hilal-Dandan R, Choi
DJ, Rockman HA, McDonough PM, Bluhm WF, Meyer M, Sayen MR, Swanson
E, et al: Overexpression of the rat sarcoplasmic reticulum
Ca2+ ATPase gene in the heart of transgenic mice
accelerates calcium transients and cardiac relaxation. J Clin
Invest. 100:380–389. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Baker DL, Hashimoto K, Grupp IL, Ji Y,
Reed T, Loukianov E, Grupp G, Bhagwhat A, Hoit B, Walsh R, et al:
Targeted overexpression of the sarcoplasmic reticulum
Ca2+-ATPase increases cardiac contractility in
transgenic mouse hearts. Circ Res. 83:1205–1214. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Dillmann WH: Influences of increased
expression of the Ca2+ ATPase of the sarcoplasmic
reticulum by a transgenic approach on cardiac contractility. Ann N
Y Acad Sci. 853:43–48. 1998. View Article : Google Scholar
|
|
10
|
Maier LS, Wahl-Schott C, Horn W, Weichert
S, Pagel C, Wagner S, Dybkova N, Müller OJ, Näbauer M, Franz WM and
Pieske B: Increased SR Ca2+ cycling contributes to
improved contractile performance in SERCA2a-overexpres sing
transgenic rats. Cardiovasc Res. 67:636–646. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Müller OJ, Lange M, Rattunde H, Lorenzen
HP, Müller M, Frey N, Bittner C, Simonides W, Katus HA and Franz
WM: Transgenic rat hearts overexpressing SERCA2a show improved
contractility under baseline conditions and pressure overload.
Cardiovasc Res. 59:380–389. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Suarez J, Gloss B, Belke DD, Hu Y, Scott
B, Dieterle T, Kim YK, Valencik ML, McDonald JA and Dillmann WH:
Doxycycline inducible expression of SERCA2a improves calcium
handling and reverts cardiac dysfunction in pressure
overload-induced cardiac hypertrophy. Am J Physiol Heart Circ
Physiol. 287:H2164–H2172. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
del Monte F, Williams E, Lebeche D,
Schmidt U, Rosenzweig A, Gwathmey JK, Lewandowski ED and Hajjar RJ:
Improvement in survival and cardiac metabolism after gene transfer
of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart
failure. Circulation. 104:1424–1429. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Sakata S, Lebeche D, Sakata N, Sakata Y,
Chemaly ER, Liang LF, Tsuji T, Takewa Y, del Monte F, Peluso R, et
al: Restoration of mechanical and energetic function in failing
aortic-banded rat hearts by gene transfer of calcium cycling
proteins. J Mol Cell Cardiol. 42:852–861. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Mitsuyama S, Takeshita D, Obata K, Zhang
GX and Takaki M: Left ventricular mechanical and energetic changes
in long-term isoproterenol-induced hypertrophied hearts of SERCA2a
transgenic rats. J Mol Cell Cardiol. 59:95–106. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Davia K, Bernobich E, Ranu HK, del Monte
F, Terracciano CM, MacLeod KT, Adamson DL, Chaudhri B, Hajjar RJ
and Harding SE: SERCA2A overexpression decreases the incidence of
aftercontractions in adult rabbit ventricular myocytes. J Mol Cell
Cardiol. 33:1005–1015. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Cutler MJ, Wan X, Plummer BN, Liu H,
Deschenes I, Laurita KR, Hajjar RJ and Rosenbaum DS: Targeted
sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore
electrical stability in the failing heart. Circulation.
126:2095–2104. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Lyon AR, Bannister ML, Collins T, Pearce
E, Sepehripour AH, Dubb SS, Garcia E, O'Gara P, Liang L,
Kohlbrenner E, et al: SERCA2a gene transfer decreases sarcoplasmic
reticulum calcium leak and reduces ventricular arrhythmias in a
model of chronic heart failure. Circ Arrhythm Electrophysiol.
4:362–372. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Prunier F, Kawase Y, Gianni D, Scapin C,
Danik SB, Ellinor PT, Hajjar RJ and Del Monte F: Prevention of
ventricular arrhythmias with sarcoplasmic reticulum Ca2+
ATPase pump overexpression in a porcine model of ischemia
reperfusion. Circulation. 118:614–624. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
del Monte F, Lebeche D, Guerrero JL, Tsuji
T, Doye AA, Gwathmey JK and Hajjar RJ: Abrogation of ventricular
arrhythmias in a model of ischemia and reperfusion by targeting
myocardial calcium cycling. Proc Natl Acad Sci USA. 101:5622–5627.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Cutler MJ, Wan X, Laurita KR, Hajjar RJ
and Rosenbaum DS: Targeted SERCA2a gene expression identifies
molecular mechanism and therapeutic target for arrhythmogenic
cardiac alternans. Circ Arrhythm Electrophysiol. 2:686–694. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Hadri L, Bobe R, Kawase Y, Ladage D,
Ishikawa K, Atassi F, Lebeche D, Kranias EG, Leopold JA, Lompré AM,
et al: SERCA2a gene transfer enhances eNOS expression and activity
in endothelial cells. Mol Ther. 18:1284–1292. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Jaski BE, Jessup ML, Mancini DM, Cappola
TP, Pauly DF, Greenberg B, Borow K, Dittrich H, Zsebo KM and Hajjar
RJ: Calcium upregulation by percutaneous administration of gene
therapy in cardiac disease (CUPID Trial), a first-in-human phase
1/2 clinical trial. J Card Fail. 15:171–181. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Jessup M, Greenberg B, Mancini D, Cappola
T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H and
Hajjar RJ; Calcium Upregulation by Percutaneous Administration of
Gene Therapy in Cardiac Disease (CUPID) Investigators: Calcium
upregulation by percutaneous administration of gene therapy in
cardiac disease (CUPID) A phase 2 trial of intracoronary gene
therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with
advanced heart failure. Circulation. 124:304–313. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zsebo K, Yaroshinsky A, Rudy JJ, Wagner K,
Greenberg B, Jessup M and Hajjar RJ: Long-term effects of
AAV1/SERCA2a gene transfer in patients with severe heart failure
analysis of recurrent cardiovascular events and mortality. Circ
Res. 114:101–108. 2014. View Article : Google Scholar
|
|
26
|
Greenberg B, Butler J, Felker GM,
Ponikowski P, Voors AA, Desai AS, Barnard D, Bouchard A, Jaski B,
Lyon AR, et al: Calcium upregulation by percutaneous administration
of gene therapy in patients with cardiac disease (CUPID 2): A
randomised, multinational, double-blind, placebo-controlled, phase
2b trial. Lancet. 387:1178–1186. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Zhang K and Kaufman RJ: From
endoplasmic-reticulum stress to the inflammatory response. Nature.
454:455–462. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Schmitz ML, Shaban MS, Albert BV, Goekcen
A and Kracht M: The crosstalk of endoplasmic reticulum (ER) stress
pathways with NF-κB: Complex mechanisms relevant for cancer,
inflammation and infection. Biomedicines. 6:582018. View Article : Google Scholar
|
|
29
|
Liu XH, Zhang ZY, Andersson KB, Husberg C,
Enger UH, Ræder MG, Christensen G and Louch WE:
Cardiomyocyte-specific disruption of Serca2 in adult mice causes
sarco(endo) plasmic reticulum stress and apoptosis. Cell Calcium.
49:201–207. 2011. View Article : Google Scholar
|
|
30
|
Xin W, Lu X, Li X, Niu K and Cai J:
Attenuation of endoplasmic reticulum stress-related myocardial
apoptosis by SERCA2a gene delivery in ischemic heart disease. Mol
Med. 17:201–210. 2011. View Article : Google Scholar
|
|
31
|
National Research Council (U.S.):
Committee for the Update of the Guide for the Care and Use of
Laboratory Animals. Guide for the Care and Use of Laboratory
Animals. 8th edition. Washington DC: National Academies Press;
2011
|
|
32
|
O'Donnell JM, Sumbilla CM, Ma H, Farrance
IK, Cavagna M, Klein MG and Inesi G: Tight control of exogenous
SERCA expression is required to obtain acceleration of calcium
transients with minimal cytotoxic effects in cardiac myocytes. Circ
Res. 88:415–421. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Hamid T, Guo SZ, Kingery JR, Xiang X, Dawn
B and Prabhu SD: Cardiomyocyte NF-κB p65 promotes adverse
remodelling, apoptosis, and endoplasmic reticulum stress in heart
failure. Cardiovasc Res. 89:129–138. 2011. View Article : Google Scholar
|
|
34
|
Pahl HL: Signal transduction from the
endoplasmic reticulum to the cell nucleus. Physiol Rev. 79:683–701.
1999. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Pahl HL and Baeuerle PA: Expression of
influenza virus hemagglutinin activates transcription factor
NF-kappa B. J Virol. 69:1480–1484. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Meyer M, Caselmann WH, Schluter V, Schreck
R, Hofschneider PH and Baeuerle PA: Hepatitis B virus
transactivator MHBst: Activation of NF-kappa B, selective
inhibition by antioxidants and integral membrane localization. EMBO
J. 11:2991–3001. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Pahl HL, Sester M, Burgert HG and Baeuerle
PA: Activation of transcription factor NF-kappaB by the adenovirus
E3/19K protein requires its ER retention. J Cell Biol. 132:511–522.
1996. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Gong G, Waris G, Tanveer R and Siddiqui A:
Human hepatitis C virus NS5A protein alters intracellular calcium
levels, induces oxidative stress, and activates STAT-3 and NF-kappa
B. Proc Natl Acad Sci USA. 98:9599–9604. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Ma TS: Sarcoplasmic reticulum calcium
ATPase overexpression induces cellular calcium overload and cell
death. Ann NY Acad Sci. 853:325–328. 1998. View Article : Google Scholar
|
|
40
|
Wu GM, Long XL and Marin-Garcia J:
Adenoviral SERCA1 overexpression triggers an apoptotic response in
cultured neonatal but not in adult rat cardiomyocytes. Mol Cell
Biochem. 267:123–132. 2004. View Article : Google Scholar
|
|
41
|
Hu P, Han Z, Couvillon AD, Kaufman RJ and
Exton JH: Autocrine tumor necrosis factor alpha links endoplasmic
reticulum stress to the membrane death receptor pathway through
IRE1 alpha-mediated NF-kappa B activation and down-regulation of
TRAF2 expression. Mol Cell Biol. 26:3071–3084. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Hamid T, Gu Y, Ortines RV, Bhattacharya C,
Wang G, Xuan YT and Prabhu SD: Divergent tumor necrosis factor
receptor-related remodeling responses in heart failure role of
nuclear factor-kappa B and inflammatory activation. Circulation.
119:1386–1397. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Perkins ND: Post-translational
modifications regulating the activity and function of the nuclear
factor kappa B pathway. Oncogene. 25:6717–6730. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Zwergal A, Quirling M, Saugel B, Huth KC,
Sydlik C, Poli V, Neumeier D, Ziegler-Heitbrock HW and Brand K:
C/EBP beta blocks p65 phosphorylation and thereby NF-kappa
B-mediated transcription in TNF-tolerant cells. J Immunol.
177:665–672. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Kitamura M: Biphasic, bidirectional
regulation of NF-kappaB by endoplasmic reticulum stress. Antioxid
Redox Signal. 11:2353–2364. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Nakajima S and Kitamura M: Bidirectional
regulation of NF-κB by reactive oxygen species: A role of unfolded
protein response. Free Radic Biol Med. 65:162–174. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Gupta D, Palma J, Molina E, Gaughan JP,
Long W, Houser S and Macha M: Improved exercise capacity and
reduced systemic inflammation after adenoviral-mediated SERCA-2a
gene transfer. J Surg Res. 145:257–265. 2008. View Article : Google Scholar : PubMed/NCBI
|
