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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2021 Volume 47 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

MicroRNA‑101 inhibits renal tubular epithelial‑to‑mesenchymal transition by targeting TGF‑β1 type I receptor

Qinglan Wang, Yanyan Tao, Hongdong Xie, Chenghai Liu, Ping Liu
Article Number: 119
Published online on: 29 April 2021

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An update on genetic basis of generalized pustular psoriasis (Review)

Jiahong Zhou, Qing Luo, Yang Cheng, Xia Wen, Jinbo Liu
Article Number: 118
Published online on: 28 April 2021

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Overexpression of microRNA‑486 affects the proliferation and chemosensitivity of mesothelioma cell lines by targeting PIM1

Silvana Pinelli, Rossella Alinovi, Diana Poli, Massimo Corradi, Giorgio Pelosi, Marcello Tiseo, Matteo Goldoni, Delia Cavallo, Paola Mozzoni
Article Number: 117
Published online on: 28 April 2021

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FGF21 attenuates hypoxia‑induced dysfunction and inflammation in HPAECs via the microRNA‑27b‑mediated PPARγ pathway

Dan Yao, Qinlian He, Junwei Sun, Luqiong Cai, Jinqiu Wei, Gexiang Cai, Jingjing Liu, Yinuo Lin, Liangxing Wang, Xiaoying Huang
Article Number: 116
Published online on: 27 April 2021

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Demetra Application: An integrated genotype analysis web server for clinical genomics in endometriosis

Louis Papageorgiou, Maria I. Zervou, Dimitrios Vlachakis, Michail Matalliotakis, Ioannis Matalliotakis, Demetrios A. Spandidos, George N. Goulielmos, Elias Eliopoulos
Article Number: 115
Published online on: 27 April 2021

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Role of 2‑series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non‑alcoholic fatty liver disease (Review)

Weixuan Wang, Xin Zhong, Jiao Guo
Article Number: 114
Published online on: 26 April 2021

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Attenuation of the upregulation of NF‑κB and AP‑1 DNA‑binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression

Zhigang Qu, Xiaochun Lu, Yan Qu, Tianqi Tao, Xiuhua Liu, Xiaoying Li
Article Number: 113
Published online on: 22 April 2021

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Exosomal microRNAs in colorectal cancer: Overcoming barriers of the metastatic cascade (Review)

Joshua Miguel C. Danac, Aileen Geobee G. Uy, Reynaldo L. Garcia
Article Number: 112
Published online on: 21 April 2021

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Article

Circular RNA 0004904 promotes autophagy and regulates the fused in sarcoma/vascular endothelial growth factor axis in preeclampsia

Wei Dai, Xinghui Liu
Article Number: 111
Published online on: 21 April 2021

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Article

L‑carnitine attenuates TGF‑β1‑induced EMT in retinal pigment epithelial cells via a PPARγ‑dependent mechanism

Min Li, Hui Li, Shuai Yang, Xin Liao, Chun Zhao, Fang Wang
Article Number: 110
Published online on: 20 April 2021

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Upregulation of NFKBIZ affects bladder cancer progression via the PTEN/PI3K/Akt signaling pathway

Tao Xu, Ting Rao, Wei-Ming Yu, Jin-Zhuo Ning, Xi Yu, Shao-Ming Zhu, Kang Yang, Tao Bai, Fan Cheng
Article Number: 109
Published online on: 19 April 2021

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Article

Advanced oxidation protein products aggravate age‑related bone loss by increasing sclerostin expression in osteocytes via ROS‑dependent downregulation of Sirt1

Jihuan Zeng, Qiang Xiao, Xiaodan Li, Jianting Chen
Article Number: 108
Published online on: 19 April 2021

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Interleukin‑6 signalling as a valuable cornerstone for molecular medicine (Review)

Maria Trovato, Salvatore Sciacchitano, Alessio Facciolà, Andrea Valenti, Giuseppa Visalli, Angela Di Pietro
Article Number: 107
Published online on: 16 April 2021

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Sonic Hedgehog signaling pathway in gynecological and genitourinary cancer (Review)

Anna Kotulak‑Chrząszcz, Zbigniew Kmieć, Piotr M. Wierzbicki
Article Number: 106
Published online on: 16 April 2021

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Article Open Access

DNAJC12 promotes lung cancer growth by regulating the activation of β‑catenin

Yun Li, Meng Li, Fengqi Jin, Jianbo Liu, Minghui Chen, Jingjing Yin
Article Number: 105
Published online on: 16 April 2021

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IRF1 regulates the progression of colorectal cancer via interferon‑induced proteins

Xiaohui Xu, Yong Wu, Ke Yi, Yan Hu, Weiqun Ding, Chungen Xing
Article Number: 104
Published online on: 15 April 2021

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Genotoxicity of chloroacetamide herbicides and their metabolites in vitro and in vivo Retraction in /10.3892/ijmm.2025.5511

Xinyan Ma, Ying Zhang, Mingyang Guan, Weidong Zhang, Huifang Tian, Caixiao Jiang, Xiaoxin Tan, Weijun Kang
Article Number: 103
Published online on: 15 April 2021

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Article

Naringin protects H9C2 cardiomyocytes from chemical hypoxia‑induced injury by promoting the autophagic flux via the activation of the HIF‑1α/BNIP3 signaling pathway

Shanghai Li, Jiamei Jiang, Junyu Fang, Xingyue Li, Chunyan Huang, Weijun Liang, Keng Wu
Article Number: 102
Published online on: 15 April 2021

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Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway

Heting Liu, Yanghui Xiu, Qing Zhang, Yuxin Xu, Qianqian Wan, Liming Tao
Article Number: 101
Published online on: 14 April 2021

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Current and innovative methods for the diagnosis of COVID‑19 infection (Review)

Luca Falzone, Giuseppe Gattuso, Aristidis Tsatsakis, Demetrios A. Spandidos, Massimo Libra
Article Number: 100
Published online on: 12 April 2021

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KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265

Pengyi Zheng, Kaijie Wu, Zhongwei Gao, Huibing Li, Wensheng Li, Xiaohui Wang, Zhenguo Shi, Fei Xiao, Kaixuan Wang, Zhijun Li, Qingjiang Han
Article Number: 99
Published online on: 09 April 2021

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Mechanisms of microRNA‑142 in mitochondrial autophagy and hippocampal damage in a rat model of epilepsy

Du Xiao, Jingdan Lv, Zhigang Zheng, Yi Liu, Yonggen Zhang, Cuizhu Luo, Liu Qi, Bing Qin, Chao Liu
Article Number: 98
Published online on: 08 April 2021

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Challenges and perspectives for immunotherapy in oesophageal cancer: A look to the future (Review)

Andrea Lampis, Margherita Ratti, Michele Ghidini, Milko B. Mirchev, Ali Fuat Okuducu, Nicola Valeri, Jens Claus Hahne
Article Number: 97
Published online on: 08 April 2021

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Retraction Open Access

[Retracted] Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade

Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Liu
Article Number: 96
Published online on: 07 April 2021

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Role of the central renin‑angiotensin system in hypertension (Review)

Chuanxin Su, Jinhua Xue, Chao Ye, Aidong Chen
Article Number: 95
Published online on: 07 April 2021

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Article Open Access

Wnt7a promotes the osteogenic differentiation of human mesenchymal stem cells

Leiluo Yang, Qing Li, Junhong Zhang, Pengcheng Li, Pingjiang An, Chunqing Wang, Pingsheng Hu, Xue Zou, Xiaowei Dou, Lixin Zhu
Article Number: 94
Published online on: 06 April 2021

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Knockdown of lncRNA MIR4435‑2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/β‑catenin signaling pathway

Pengyi Xing, Ye Wang, Li Zhang, Chao Ma, Jianping Lu
Article Number: 93
Published online on: 01 April 2021

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review)

Wenyu Wu, Nuoran Li, Guoshu Deng, Suyi Yang, Ruifeng Zeng, Rui Chen, Jun Li
Article Number: 264
Published online on: 22 July 2026

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Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

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Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

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Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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Article Open Access

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Article Open Access

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Review Open Access

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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Journal Cover
October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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