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Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps

  • Authors:
    • Zhuohui Liu
    • Haoyu Liu
    • Deshun Yu
    • Jingyu Gao
    • Biao Ruan
    • Ruiqing Long
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Otolaryngology, The First People's Hospital of Qujing, Qujing, Yunnan 655000, P.R. China, Department of Otolaryngology, Affiliated Hospital of Dali University, Dali, Yunnan 671000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 126
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    Published online on: May 12, 2021
       https://doi.org/10.3892/ijmm.2021.4959
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Abstract

Matrix metalloproteinase (MMP)‑9 is a key enzyme responsible for extracellular matrix degradation and contributes to the progressive histological changes observed in lower respiratory tract infections. Integrin β1 and α‑tubulin are potential MMP‑9‑interacting proteins, and microRNA (miR)‑29b‑3p can regulate MMP‑9 expression. MMP‑9 is highly expressed in chronic rhinosinusitis with nasal polyps (CRSwNPs), regardless of its effects on miR‑29b‑3p, integrin β1 and α‑tubulin expression. In the present study, samples from 100 patients with CRSwNPs were examined via reverse transcription‑quantitative PCR to assess the mRNA expression of miR‑29b‑3p, and western blotting was performed to assess the protein expression of MMP‑2, MMP‑9, acetyl‑α‑tubulin, integrin β1 and tissue inhibitor of metalloproteinase 1 (TIMP‑1). A dual‑luciferase reporter assay was used to verify the direct binding of miR‑29b‑3p and MMP‑2/MMP‑9. Co‑immunoprecipitation (Co‑IP) and GST pull‑down assays showed that integrin β1 and α‑tubulin were MMP‑9‑interacting proteins. Cell viability, apoptosis and inflammatory cytokine levels were determined via a Cell Counting Kit‑8 assay, flow cytometry and ELISA, respectively. miR‑29b‑3p expression was found to be positively correlated with MMP‑2 and MMP‑9 expression. Whereas, TIMP‑1 expression was negatively correlated with MMP‑2 and MMP‑9 expression. The dual‑luciferase assay revealed that miR‑29b‑3p targeted the 3' untranslated region of MMP‑2/MMP‑9. The Co‑IP and GST pull‑down assays showed that MMP‑9 could directly bind to integrin β1 and indirectly bind to α‑tubulin. Finally, the overexpression of miR‑29b‑3p decreased the expression of MMP‑9 and increased the levels of acetyl‑α‑tubulin. By contrast, the knockdown of miR‑29b‑3p increased the expression of MMP‑9 and decreased the levels of acetyl‑α‑tubulin. Additionally, MMP‑9 expression was found to be negatively correlated with acetyl‑α‑tubulin expression. Of note, the expression of integrin β1 did not change following the overexpression and knockdown of MMP‑9. Finally, the overexpression of miR‑29b‑3p not only decreased MMP‑9 expression, but also alleviated lipopolysaccharide‑induced inflammation in NP69 cells. The results showed that the downregulation of miR‑29b‑3p promoted α‑tubulin deacetylation by increasing the number of MMP‑9‑integrin β1 complexes in CRSwNPs, thus targeting miR‑29b‑3p/MMP‑9 may be a potential novel strategy for the clinical treatment of CRSwNPs.
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1 

Sarig-Nadir O and Seliktar D: The role of matrix metalloproteinases in regulating neuronal and nonneuronal cell invasion into PEGylated fibrinogen hydrogels. Biomaterials. 31:6411–6416. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Fang CY, Zhang J, Yang HL, Peng LL, Wang K, Wang YJ, Zhao X, Liu HJ, Dou CH, Shi LH, et al: Leucine aminopeptidase 3promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases-2/9 expression. J Cell Biochem. 120:3611–3620. 2019. View Article : Google Scholar

3 

Gerwien H, Hermann S, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, et al: Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci Transl Med. 8:364ra1522016. View Article : Google Scholar : PubMed/NCBI

4 

Eifan AO, Orban NT, Jacobson MR and Durham SR: Severe persistent allergic rhinitis. Inflammation but no histologic features of structural upper airway remodeling. Am J Respir Crit Care Med. 192:1431–1439. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Kahveci OK, Derekoy FS, Yilmaz M, Serteser M and Altuntas A: The role of MMP-9 and TIMP-1 in nasal polyp formation. Swiss Med Wkly. 138:684–688. 2008.PubMed/NCBI

6 

Kelly EA, Busse WW and Jarjour NN: Increased matrix metalloproteinase-9 in the airway after allergen challenge. Am J Respir Crit Care Med. 162:1157–1161. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Chen Y, Peng W, Raffetto JD and Khalil RA: Matrix metalloproteinases in remodeling of lower extremity veins and chronic venous disease. Prog Mol Biol Transl Sci. 147:267–299. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Pinet K and McLaughlin K: Mechanisms of physiological tissue remodeling in animals: Manipulating tissue, organ, and organism morphology. Dev Biol. 451:134–145. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Alaseem A, Alhazzani K, Dondapati P, Alobid S, Bishayee A and Rathinavelu A: Matrix metalloproteinases: A challenging paradigm of cancer management. Semin Cancer Biol. 56:100–115. 2019. View Article : Google Scholar

10 

Can IH, Ceylan K, Caydere M, Samim EE, Ustun H and Karasoy DS: The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis. Otolaryngol Head Neck Surg. 139:211–215. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Wang JH, Kwon HJ and Jang YJ: Staphylococcus aureus increases cytokine and matrix metalloproteinase expression in nasal mucosae of patients with chronic rhinosinusitis and nasal polyps. Am J Rhinol Allergy. 24:422–427. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Li X, Meng J, Qiao X, Liu Y, Liu F, Zhang N, Zhang J, Holtappels G, Luo B, Zhou P, et al: Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis. J Allergy Clin Immunol. 125:1061–1068. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Guerra G, Testa D, Salzano F, Tafuri D, Hay E, Schettino BA, Iovine R, Marcuccio G and Motta G: Expression of matrix metalloproteinases and their tissue inhibitors in chronic rhinosinusitis with nasal polyps: Etiopathogenesis and recurrence. Ear Nose Yhroat J. 145561319896635:2020.

14 

Yigit O, Acioğlu E, Gelişgen R, Server EA, Azizli E and Uzun H: The effect of corticosteroid on metalloproteinase levels of nasal polyposis. Laryngoscope. 121:667–673. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Wang C, Lou H, Wang X, Wang Y, Fan E, Li Y, Wang H, Bachert C and Zhang L: Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 135:922–929.e926. 2015. View Article : Google Scholar

16 

Song Y and Brady S: Post-translational modifications of tubulin: Pathways to functional diversity of microtubules. Trends Cell Biol. 25:125–136. 2015. View Article : Google Scholar

17 

Janke C and Bulinski JC: Post-translational regulation of the microtubule cytoskeleton: Mechanisms and functions. Nat Rev Mol Cell Biol. 12:773–786. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Wloga D and Gaertig J: Post-translational modifications of microtubules. J Cell Sci. 123:3447–3455. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Vo NT and Bols NC: Demonstration of primary cilia and acetylated α-tubulin in fish endothelial, epithelial and fibroblast cell lines. Fish Physiol Biochem. 42:29–38. 2016. View Article : Google Scholar

20 

Lee CC, Cheng YC, Chang CY, Lin CM and Chang JY: Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption. Sci Rep. 8:174772018. View Article : Google Scholar : PubMed/NCBI

21 

Gu S, Liu Y, Zhu B, Ding K, Yao TP, Chen F, Zhan L, Xu P, Ehrlich M, Liang T, et al: Loss of α-Tubulin acetylation is associated with TGF-β-induced epithelial-mesenchymal transition. J Biol Chem. 291:5396–5405. 2016. View Article : Google Scholar : PubMed/NCBI

22 

McGraw M, Rioux J, Garlick R, Rancourt R, White C and Veress L: From the cover: Impaired proliferation and differentiation of the conducting airway epithelium associated with bronchiolitis obliterans after sulfur mustard inhalation injury in rats. Toxicol Sci. 157:399–409. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Lee HN, Bosompra OA and Coller HA: RECK isoforms differentially regulate fibroblast migration by modulating tubulin post-translational modifications. Biochem Biophys Res Commun. 510:211–218. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Smith AC: A glitch in the matrix: Aberrant extracellular matrix proteolysis contributes to alcohol seeking. Biol Psychiatry. 81:900–902. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Yin L, Li FQ, Li J, Yang XR, Xie XY, Xue LY, Li YL and Zhang C: Chronic intermittent ethanol exposure induces upregulation of matrix metalloproteinase-9 in the rat medial prefrontal cortex and hippocampus. Neurochem Res. 44:1593–1601. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Wang W, Yang C, Wang X, Zhou LY, Lao GJ, Liu D, Wang C, Hu MD, Zeng TT, Yan L and Ren M: MicroRNA-129 and -335 promote diabetic wound healing by inhibiting sp1-Mediated MMP-9 expression. Diabetes. 67:1627–1638. 2018. View Article : Google Scholar : PubMed/NCBI

27 

del Campo SEM, Latchana N, Levine KM, Grignol VP, Fairchild ET, Jaime-Ramirez AC, Dao TV, Karpa VI, Carson M, Ganju A, et al: MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: In vivo effects of MiR-21 inhibitor. PLoS One. 10:e01159192015. View Article : Google Scholar

28 

Chen KC, Wang YS, Hu CY, Chang WC, Liao YC, Dai CY and Juo SH: OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: A novel mechanism for cardiovascular diseases. FASEB J. 25:1718–1728. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Chen Z, Wei H, Zhao X, Xin X, Peng L, Ning Y, Wang YP, Lan YL and Zhang QH: Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMPand MMPvia H19/miRb and AKT/mTOR/autophagy signaling pathways. J Cell Physiol. 234:19964–19976. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Callejas-Díaz B, Fernandez G, Fuentes M, Martínez-Antón A, Alobid I, Roca-Ferrer J, Picado C, Tubita V and Mullol J: Integrated mRNA and microRNA transcriptome profiling during differentiation of human nasal polyp epithelium reveals an altered ciliogenesis. Allergy. 75:2548–2561. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Zhang T, Zhou Y, You B, You YW, Yan YB, Zhang J, Pei Y, Zhang W and Chen J: miR-30a-5p inhibits epithelial-to-mesenchymal transition by targeting CDK6 in nasal polyps. Am J Rhinol Allergy. 35:152–163. 2021. View Article : Google Scholar

32 

Yang P, Chen S, Zhong G, Kong W and Wang Y: Agonist of PPAR-γ reduced epithelial-mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps via inhibition of high mobility group box 1. Int J Med Sci. 16:1631–1641. 2019. View Article : Google Scholar :

33 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

34 

Zhang L, Zhao D, Jin M, Song MZ, Liu SC, Guo KK and Zhang YM: Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells. Virulence. 11:489–501. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Pommier A, Varilh J, Bleuse S, Delétang K, Bonini J, Bergougnoux A, Brochiero E, Koenig M, Claustres M and Taulan-Cadars M: miRNA repertoires of cystic fibrosis ex vivo models highlight miR-181a and miR-101 that regulate WISP1 expression. J Pathol. 253:186–197. 2021. View Article : Google Scholar

36 

Mudd P, Katial R, Alam R, Hohensee S, Ramakrishnan V and Kingdom T: Variations in expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in nasal mucosa of aspirin-sensitive versus aspirin-tolerant patients with nasal polyposis. Ann Allergy Asthma Immunol. 107:353–359. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Chen Y, Langhammer T, Westhofen M and Lorenzen J: Relationship between matrix metalloproteinases MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinases-1 and IL-5, IL-8 in nasal polyps. Allergy. 62:66–72. 2007. View Article : Google Scholar

38 

Yeo N, Eom D, Oh M, Lim H and Song Y: Expression of matrix metalloproteinase 2 and 9 and tissue inhibitor of metalloproteinase 1 in nonrecurrent vs recurrent nasal polyps. Ann Allergy Asthma Immunol. 111:205–210. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Karadag A, Fedarko N and Fisher L: Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44. Cancer Res. 65:11545–11552. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Redondo-Muñoz J and Ugarte-Berzal E: Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain. Cancer Cell. 17:160–172. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Ugarte-Berzal E, Bailón E, Amigo-Jiménez I, Vituri CL, del Cerro MH, Terol MJ, Albar JP, Rivas G, García-Marco JA and García-Pardo A: A 17-residue sequence from the matrix metalloproteinase-9 (MMP-9) hemopexin domain binds α4β1 integrin and inhibits MMP-9-induced functions in chronic lymphocytic leukemia B cells. J Biol Chem. 287:27601–27613. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Alford V, Kamath A, Ren X, Kumar K, Gan Q, Awwa M, Tong M, Seeliger MA, Cao J, Ojima I and Sampson NS: Targeting the hemopexin-like domain of latent matrix metalloproteinase-9 (proMMP-9) with a small molecule inhibitor prevents the formation of focal adhesion junctions. ACS Chem Biol. 12:2788–2803. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Chen S, Owens GC, Makarenkova H and Edelman DB: HDAC6 regulates mitochondrial transport in hippocampal neurons. PLoS One. 5:e108482010. View Article : Google Scholar : PubMed/NCBI

44 

Tan HF and Tan SM: The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining α-tubulin acetylation. J Biol Chem. 295:5928–5943. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Bouvard D, Pouwels J, De Franceschi N and Ivaska J: Integrin inactivators: Balancing cellular functions in vitro and in vivo. Nat Rev Mol Cell Biol. 14:430–442. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Mudd PA, Katial RK, Alam R, Hohensee S, Ramakrishnan V and Kingdom TT: Variations in expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in nasal mucosa of aspirin-sensitive versus aspirin-tolerant patients with nasal polyposis. Ann Allergy Asthma Immunol. 107:353–359. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Kovacs-Kasa A, Kovacs L, Cherian-Shaw M, Patel V, Meadows M, Fulton D, Su YC and Verin AD: Inhibition of class IIa HDACs improves endothelial barrier function in endotoxin-induced acute lung injury. J Cell Physiol. 236:2893–2905. 2021. View Article : Google Scholar

48 

Zheng Y, Chen Y, Lu X, Weng QH, Dai GL, Yu Y, Yu KH and Gao WY: Inhibition of histone deacetylase 6 by Tubastatin a attenuates the progress of osteoarthritis via improving mitochondrial function. Am J Pathol. 190:2376–2386. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Liu H, Yu D, Gao J, Ruan B and Long R: Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps. Int J Mol Med 48: 126, 2021.
APA
Liu, Z., Liu, H., Yu, D., Gao, J., Ruan, B., & Long, R. (2021). Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps. International Journal of Molecular Medicine, 48, 126. https://doi.org/10.3892/ijmm.2021.4959
MLA
Liu, Z., Liu, H., Yu, D., Gao, J., Ruan, B., Long, R."Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps". International Journal of Molecular Medicine 48.1 (2021): 126.
Chicago
Liu, Z., Liu, H., Yu, D., Gao, J., Ruan, B., Long, R."Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps". International Journal of Molecular Medicine 48, no. 1 (2021): 126. https://doi.org/10.3892/ijmm.2021.4959
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Liu H, Yu D, Gao J, Ruan B and Long R: Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps. Int J Mol Med 48: 126, 2021.
APA
Liu, Z., Liu, H., Yu, D., Gao, J., Ruan, B., & Long, R. (2021). Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps. International Journal of Molecular Medicine, 48, 126. https://doi.org/10.3892/ijmm.2021.4959
MLA
Liu, Z., Liu, H., Yu, D., Gao, J., Ruan, B., Long, R."Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps". International Journal of Molecular Medicine 48.1 (2021): 126.
Chicago
Liu, Z., Liu, H., Yu, D., Gao, J., Ruan, B., Long, R."Downregulation of miR‑29b‑3p promotes α‑tubulin deacetylation by targeting the interaction of matrix metalloproteinase‑9 with integrin β1 in nasal polyps". International Journal of Molecular Medicine 48, no. 1 (2021): 126. https://doi.org/10.3892/ijmm.2021.4959
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