Open Access

Long noncoding RNA network: Novel insight into hepatocellular carcinoma metastasis (Review)

  • Authors:
    • Xiuming Zhu
    • Hongming Pan
    • Lili Liu
  • View Affiliations

  • Published online on: May 19, 2021     https://doi.org/10.3892/ijmm.2021.4967
  • Article Number: 134
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hepatocellular carcinoma (HCC) is one of the most common, aggressive malignancies with poor prognosis and high mortality. Although great progress has been made in recent decades, overall survival of HCC patients remains unsatisfactory due to high recurrence and metastasis. Accordingly, understanding and clarifying the underlying molecular mechanisms of metastasis has become increasingly important. Recently, accumulated reports have supported that long noncoding RNAs (lncRNAs) are dysregulated in HCC and are involved in various pivotal biological processes, including metastasis. The aim of this review was to investigate the dysregulation of lncRNAs in HCC and their function as oncogenes or tumour suppressors. Furthermore, reciprocal regulatory networks between lncRNAs and various molecules that were identified in HCC metastasis, including regulating epithelial‑mesenchymal transition (EMT), controlling metastasis‑associated genes, and regulating tumour angiogenesis were examined. Numerous reports and information on lncRNAs may help identify lncRNAs that are potential novel diagnostic markers, prognostic markers and therapeutic targets.
View Figures
View References

Related Articles

Journal Cover

July-2021
Volume 48 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Pan H and Liu L: Long noncoding RNA network: Novel insight into hepatocellular carcinoma metastasis (Review). Int J Mol Med 48: 134, 2021
APA
Zhu, X., Pan, H., & Liu, L. (2021). Long noncoding RNA network: Novel insight into hepatocellular carcinoma metastasis (Review). International Journal of Molecular Medicine, 48, 134. https://doi.org/10.3892/ijmm.2021.4967
MLA
Zhu, X., Pan, H., Liu, L."Long noncoding RNA network: Novel insight into hepatocellular carcinoma metastasis (Review)". International Journal of Molecular Medicine 48.1 (2021): 134.
Chicago
Zhu, X., Pan, H., Liu, L."Long noncoding RNA network: Novel insight into hepatocellular carcinoma metastasis (Review)". International Journal of Molecular Medicine 48, no. 1 (2021): 134. https://doi.org/10.3892/ijmm.2021.4967