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Review

Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review)

  • Authors:
    • Alessandra Magenta
    • Maria Cristina Florio
    • Massimo Ruggeri
    • Sergio Furgiuele
  • View Affiliations / Copyright

    Affiliations: Experimental Immunology Laboratory, IDI‑IRCCS, I‑00167 Rome, Italy, Laboratory of Cardiovascular Science, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD 21224, USA, Department of Vascular Surgery, San Camillo de Lellis Hospital, I‑02100 Rieti, Italy, Swiss Stem Cell Foundation, 6900 Lugano, Switzerland
  • Article Number: 173
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    Published online on: July 13, 2021
       https://doi.org/10.3892/ijmm.2021.5006
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Abstract

Cell therapy is becoming an attractive alternative for the treatment of patients with no‑option critical limb ischemia (CLI). The main benefits of cell therapy are the induction of therapeutic angiogenesis and neovascularization that lead to an increase in blood flow in the ischemic limb and tissue regeneration in non‑healing cutaneous trophic lesions. In the present review, the current state of the art of strategies in the cell therapy field are summarized, focusing on intra‑operative autologous cell concentrates in diabetic patients with CLI, examining different sources of cell concentrates and their mechanisms of action. The present study underlined the detrimental effects of the diabetic condition on different sources of autologous cells used in cell therapy, and also in delaying wound healing capacity. Moreover, relevant clinical trials and critical issues arising from cell therapy trials are discussed. Finally, the new concept of cell therapy as an adjuvant therapy to increase wound healing in revascularized diabetic patients is introduced.
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Copy and paste a formatted citation
Spandidos Publications style
Magenta A, Florio MC, Ruggeri M and Furgiuele S: Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review). Int J Mol Med 48: 173, 2021.
APA
Magenta, A., Florio, M.C., Ruggeri, M., & Furgiuele, S. (2021). Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review). International Journal of Molecular Medicine, 48, 173. https://doi.org/10.3892/ijmm.2021.5006
MLA
Magenta, A., Florio, M. C., Ruggeri, M., Furgiuele, S."Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review)". International Journal of Molecular Medicine 48.3 (2021): 173.
Chicago
Magenta, A., Florio, M. C., Ruggeri, M., Furgiuele, S."Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review)". International Journal of Molecular Medicine 48, no. 3 (2021): 173. https://doi.org/10.3892/ijmm.2021.5006
Copy and paste a formatted citation
x
Spandidos Publications style
Magenta A, Florio MC, Ruggeri M and Furgiuele S: Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review). Int J Mol Med 48: 173, 2021.
APA
Magenta, A., Florio, M.C., Ruggeri, M., & Furgiuele, S. (2021). Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review). International Journal of Molecular Medicine, 48, 173. https://doi.org/10.3892/ijmm.2021.5006
MLA
Magenta, A., Florio, M. C., Ruggeri, M., Furgiuele, S."Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review)". International Journal of Molecular Medicine 48.3 (2021): 173.
Chicago
Magenta, A., Florio, M. C., Ruggeri, M., Furgiuele, S."Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review)". International Journal of Molecular Medicine 48, no. 3 (2021): 173. https://doi.org/10.3892/ijmm.2021.5006
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