Open Access

MEIS1 and its potential as a cancer therapeutic target (Review)

  • Authors:
    • Maozhong Yao
    • Yong Gu
    • Zhaoxin Yang
    • Keyan Zhong
    • Zhanjuan Chen
  • View Affiliations

  • Published online on: July 28, 2021     https://doi.org/10.3892/ijmm.2021.5014
  • Article Number: 181
  • Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Meis homeobox 1 (Meis1) was initially discovered in 1995 as a factor involved in leukemia in an animal model. Subsequently, 2 years later, MEIS1, the human homolog, was cloned in the liver and cerebellum, and was found to be highly expressed in myeloid leukemia cells. The MEIS1 gene, located on chromosome 2p14, encodes a 390‑amino acid protein with six domains. The expression of homeobox protein MEIS1 is affected by cell type, age and environmental conditions, as well as the pathological state. Certain types of modifications of MEIS1 and its protein interaction with homeobox or pre‑B‑cell leukemia homeobox proteins have been described. As a transcription factor, MEIS1 protein is involved in cell proliferation in leukemia and some solid tumors. The present review article discusses the molecular biology, modifications, protein‑protein interactions, as well as the role of MEIS1 in cell proliferation of cancer cells and MEIS1 inhibitors. It is suggested by the available literature MEIS1 has potential to become a cancer therapeutic target.
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September-2021
Volume 48 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Yao M, Gu Y, Yang Z, Zhong K and Chen Z: MEIS1 and its potential as a cancer therapeutic target (Review). Int J Mol Med 48: 181, 2021
APA
Yao, M., Gu, Y., Yang, Z., Zhong, K., & Chen, Z. (2021). MEIS1 and its potential as a cancer therapeutic target (Review). International Journal of Molecular Medicine, 48, 181. https://doi.org/10.3892/ijmm.2021.5014
MLA
Yao, M., Gu, Y., Yang, Z., Zhong, K., Chen, Z."MEIS1 and its potential as a cancer therapeutic target (Review)". International Journal of Molecular Medicine 48.3 (2021): 181.
Chicago
Yao, M., Gu, Y., Yang, Z., Zhong, K., Chen, Z."MEIS1 and its potential as a cancer therapeutic target (Review)". International Journal of Molecular Medicine 48, no. 3 (2021): 181. https://doi.org/10.3892/ijmm.2021.5014