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Review Open Access

MEIS1 and its potential as a cancer therapeutic target (Review)

  • Authors:
    • Maozhong Yao
    • Yong Gu
    • Zhaoxin Yang
    • Keyan Zhong
    • Zhanjuan Chen
  • View Affiliations / Copyright

    Affiliations: Clinical Research Center, Hainan Provincial Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Haikou, Hainan 570203, P.R. China, Teaching Experimental Animal Center, Research Center for Drug Safety Evaluation of Hainan Province, Hainan Medical University, Haikou, Hainan 571199, P.R. China, Chemical Experiment Teaching Center, College of Pharmacy, Hainan Medical University, Haikou, Hainan 571199, P.R. China
    Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 181
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    Published online on: July 28, 2021
       https://doi.org/10.3892/ijmm.2021.5014
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Abstract

Meis homeobox 1 (Meis1) was initially discovered in 1995 as a factor involved in leukemia in an animal model. Subsequently, 2 years later, MEIS1, the human homolog, was cloned in the liver and cerebellum, and was found to be highly expressed in myeloid leukemia cells. The MEIS1 gene, located on chromosome 2p14, encodes a 390‑amino acid protein with six domains. The expression of homeobox protein MEIS1 is affected by cell type, age and environmental conditions, as well as the pathological state. Certain types of modifications of MEIS1 and its protein interaction with homeobox or pre‑B‑cell leukemia homeobox proteins have been described. As a transcription factor, MEIS1 protein is involved in cell proliferation in leukemia and some solid tumors. The present review article discusses the molecular biology, modifications, protein‑protein interactions, as well as the role of MEIS1 in cell proliferation of cancer cells and MEIS1 inhibitors. It is suggested by the available literature MEIS1 has potential to become a cancer therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Yao M, Gu Y, Yang Z, Zhong K and Chen Z: MEIS1 and its potential as a cancer therapeutic target (Review). Int J Mol Med 48: 181, 2021.
APA
Yao, M., Gu, Y., Yang, Z., Zhong, K., & Chen, Z. (2021). MEIS1 and its potential as a cancer therapeutic target (Review). International Journal of Molecular Medicine, 48, 181. https://doi.org/10.3892/ijmm.2021.5014
MLA
Yao, M., Gu, Y., Yang, Z., Zhong, K., Chen, Z."MEIS1 and its potential as a cancer therapeutic target (Review)". International Journal of Molecular Medicine 48.3 (2021): 181.
Chicago
Yao, M., Gu, Y., Yang, Z., Zhong, K., Chen, Z."MEIS1 and its potential as a cancer therapeutic target (Review)". International Journal of Molecular Medicine 48, no. 3 (2021): 181. https://doi.org/10.3892/ijmm.2021.5014
Copy and paste a formatted citation
x
Spandidos Publications style
Yao M, Gu Y, Yang Z, Zhong K and Chen Z: MEIS1 and its potential as a cancer therapeutic target (Review). Int J Mol Med 48: 181, 2021.
APA
Yao, M., Gu, Y., Yang, Z., Zhong, K., & Chen, Z. (2021). MEIS1 and its potential as a cancer therapeutic target (Review). International Journal of Molecular Medicine, 48, 181. https://doi.org/10.3892/ijmm.2021.5014
MLA
Yao, M., Gu, Y., Yang, Z., Zhong, K., Chen, Z."MEIS1 and its potential as a cancer therapeutic target (Review)". International Journal of Molecular Medicine 48.3 (2021): 181.
Chicago
Yao, M., Gu, Y., Yang, Z., Zhong, K., Chen, Z."MEIS1 and its potential as a cancer therapeutic target (Review)". International Journal of Molecular Medicine 48, no. 3 (2021): 181. https://doi.org/10.3892/ijmm.2021.5014
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