Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October-2021 Volume 48 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2021 Volume 48 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice

  • Authors:
    • Xiao Yang
    • Yifan Zhou
    • Zhiqian Chen
    • Chen Chen
    • Chen Han
    • Xunlin Li
    • Haijun Tian
    • Xiaofei Cheng
    • Kai Zhang
    • Tangjun Zhou
    • Jie Zhao
  • View Affiliations / Copyright

    Affiliations: Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 192
    |
    Published online on: August 20, 2021
       https://doi.org/10.3892/ijmm.2021.5025
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

At present, an increasing number of individuals are affected by osteoarthritis (OA), resulting in a heavy socioeconomic burden. OA in knee joints is caused by the release of inflammatory cytokines and subsequent biomechanical and structural deterioration. To determine its anti‑inflammatory function, the current study investigated the use of the plant‑derived medicine, curcumenol, in OA treatment. Curcumenol was not cytotoxic to ATDC5 chondrocytes and primary chondrocytes, as determined using a cell viability test. When these cells were treated with TNF‑α and IL‑1β to induce inflammation, curcumenol treatment inhibited the progression of inflammation by inactivating the NF‑κB and MAPK signaling pathways, as well as decreasing the expression levels of MMP3 (as indicated by reverse transcription‑quantitative PCR and western blotting). Moreover, to analyze metabolic and catabolic status in high‑density and pellet culture, catalytic changes and the degradation of the extracellular matrix induced by TNF‑α and IL‑1β, were evaluated by alcian blue staining. These catalytic deteriorations were ameliorated by curcumenol. Using curcumenol in disease management, the mechanical and metabolic disruption of cartilage caused in the destabilization of medial meniscus (DMM) model was prevented in vivo. Thus, curcumenol mitigated inflammation in ATDC5 chondrocytes and primary mice chondrocytes, and also ameliorated OA in a DMM‑induced mouse model.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H and Carr AJ: Osteoarthritis. Lancet. 386:376–387. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Zhang Z, Huang C, Jiang Q, Zheng Y, Liu Y, Liu S, Chen Y, Mei Y, Ding C, Chen M, et al: Guidelines for the diagnosis and treatment of osteoarthritis in China (2019 edition). Ann Transl Med. 8:12132020. View Article : Google Scholar

3 

Hiligsmann M, Cooper C, Arden N, Boers M, Branco JC, Luisa Brandi M, Bruyère O, Guillemin F, Hochberg MC, Hunter DJ, et al: Health economics in the field of osteoarthritis: An expert's consensus paper from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO). Semin Arthritis Rheum. 43:303–313. 2013. View Article : Google Scholar

4 

Agricola R, Heijboer MP, Roze RH, Reijman M, Bierma-Zeinstra SMA, Verhaar JAN, Weinans H and Waarsing JH: Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: Acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK). Osteoarthritis Cartilage. 21:1514–1521. 2013. View Article : Google Scholar

5 

Tsuchiya H, Ota M, Sumitomo S, Ishigaki K, Suzuki A, Sakata T, Tsuchida Y, Inui H, Hirose J, Kochi Y, et al: Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis. Ann Rheum Dis. Nov 2–2020.Epub ahead of print.

6 

Myers J, Wielage RC, Han B, Price K, Gahn J, Paget MA and Happich M: The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: A systematic literature review and meta-analysis. BMC Musculoskelet Disord. 15:762014. View Article : Google Scholar : PubMed/NCBI

7 

McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, et al: OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 22:363–388. 2014. View Article : Google Scholar

8 

Pas HI, Winters M, Haisma HJ, Koenis MJ, Tol JL and Moen MH: Stem cell injections in knee osteoarthritis: A systematic review of the literature. Br J Sports Med. 51:1125–1133. 2017. View Article : Google Scholar

9 

Hached F, Vinatier C, Le Visage C, Gondé H, Guicheux J, Grimandi G and Billon-Chabaud A: Biomaterial-assisted cell therapy in osteoarthritis: From mesenchymal stem cells to cell encapsulation. Best Pract Res Clin Rheumatol. 31:730–745. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Liao T, Wan C, Yang X, Zhao J, Fu R, Yao Z, Huang Y, Shi Y, Chang G, et al: Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale. PeerJ. 6:e61432019. View Article : Google Scholar : PubMed/NCBI

11 

Hikino H, Sakurai Y, Numabe S and Takemoto T: Structure of curcumenol. Chem Pharm Bull (Tokyo). 16:39–42. 1968. View Article : Google Scholar

12 

Xu J, Ji F, Kang J, Wang H, Li S, Jin DQ, Zhang Q, Sun H and Guo Y: Absolute configurations and NO inhibitory activities of terpenoids from curcuma longa. J Agric Food Chem. 63:5805–5812. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Assis A, Brito V, Bittencourt M, Silva L, Oliveira F and Oliveira R: Essential oils composition of four Piper species from Brazil. J Essential Oil Res. 25:203–209. 2013. View Article : Google Scholar

14 

Saikia AK, Sarma SK, Strano T and Ruberto G: Essential oil from piper pedicellatum C. DC. Collected in North-East India. J Essential Oil Bearing Plants. 18:314–319. 2015. View Article : Google Scholar

15 

Sun DX, Fang ZZ, Zhang YY, Cao YF, Yang L and Yin J: Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 24:1213–1216. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Pintatum A, Maneerat W, Logie E, Tuenter E, Sakavitsi ME, Pieters L, Berghe WV, Sripisut T, Deachathai S and Laphookhieo S: In Vitro anti-inflammatory, anti-oxidant, and cytotoxic activities of four species and the isolation of compounds from rhizome. Biomolecules. 10:7992020. View Article : Google Scholar

17 

Oh CD, Im HJ, Suh J, Chee A, An H and Chen D: Rho-associated kinase inhibitor immortalizes rat nucleus pulposus and annulus fibrosus cells: Establishment of intervertebral disc cell lines with novel approaches. Spine (Plila Pa 1976). 41:E255–E261. 2016. View Article : Google Scholar

18 

Johnson M, Zaretskaya I, Raytselis Y, Merezhuk Y, McGinnis S and Madden TL: NCBI BLAST: A better web interface. Nucleic Acids Res. 36(Web Server issue): W5–W9. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

20 

Shi JW, Zhang TT, Liu W, Yang J, Lin XL, Jia JS, Shen HF, Wang SC, Li J, Zhao WT, et al: Direct conversion of pig fibroblasts to chondrocyte-like cells by c-Myc. Cell Death Discov. 5:552019. View Article : Google Scholar : PubMed/NCBI

21 

Glasson SS, Blanchet TJ and Morris EA: The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage. 15:1061–1069. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Wang M, Sampson ER, Jin H, Li J, Ke QH, Im HJ and Chen D: MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther. 15:R52013. View Article : Google Scholar : PubMed/NCBI

23 

Loeser RF, Kelley KL, Armstrong A, Collins JA, Diekman BO and Carlson CS: Deletion of JNK enhances senescence in joint tissues and increases the severity of age-related osteoarthritis in mice. Arthritis Rheumatol. 72:1679–1688. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Sohara Y, Shimada H, Scadeng M, Pollack H, Yamada S, Ye W, Reynolds CP and DeClerck YA: Lytic bone lesions in human neuroblastoma xenograft involve osteoclast recruitment and are inhibited by bisphosphonate. Cancer Res. 63:3026–3031. 2003.PubMed/NCBI

25 

Sharma L: Osteoarthritis of the knee. N Engl J Med. 384:51–59. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Thorlund JB, Juhl CB, Roos EM and Lohmander LS: Arthroscopic surgery for degenerative knee: Systematic review and meta-analysis of benefits and harms. BMJ. 350:h27472015. View Article : Google Scholar : PubMed/NCBI

27 

Rasmussen-Barr E, Held U, Grooten WJA, Roelofs PDDM, Koes BW, van Tulder MW and Wertli MM: Nonsteroidal anti-inflammatory drugs for sciatica: An updated cochrane review. Spine (Phila Pa 1976). 42:586–594. 2017. View Article : Google Scholar

28 

Derry S, Wiffen PJ, Kalso EA, Bell RF, Aldington D, Phillips T, Gaskell H and Moore RA: Topical analgesics for acute and chronic pain in adults-an overview of cochrane reviews. Cochrane Database Syst Rev. 5:CD0086092017.

29 

Marmon P, Owen SF and Margiotta-Casaluci L: Pharmacology-informed prediction of the risk posed to fish by mixtures of non-steroidal anti-inflammatory drugs (NSAIDs) in the environment. Environ Int. 146:1062222021. View Article : Google Scholar :

30 

Chen J, Xuan J, Gu YT, Shi KS, Xie JJ, Chen JX, Zheng ZM, Chen Y, Chen XB, Wu YS, et al: Celastrol reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo. Biomed Pharmacother. 91:208–219. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Liu Y, Deng SJ, Zhang Z, Gu Y, Xia SN, Bao XY, Cao X and Xu Y: 6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway. Eur J Pharmacol. 883:1732942020. View Article : Google Scholar : PubMed/NCBI

32 

Li Y, Lin S, Liu P, Huang J, Qiu J, Wen Z, Yuan J, Qiu H, Liu Y, Liu Q, et al: Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis. J Cell Physiol. 236:1950–1966. 2021. View Article : Google Scholar

33 

Lo JY, Kamarudin MNA, Hamdi OAA, Awang K and Kadir HA: Curcumenol isolated from curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 6:3550–3559. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Wang Z, Jones G, Winzenberg T, Cai G, Laslett LL, Aitken D, Hopper I, Singh A, Jones R, Fripp J, et al: Effectiveness of extract for the treatment of symptoms and effusion-synovitis of knee osteoarthritis : A randomized trial. Ann Intern Med. 173:861–869. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP and Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 7:33–42. 2011. View Article : Google Scholar

36 

Rodriguez-Trillo A, Mosquera N, Pena C, Rivas-Tobío F, Mera-Varela A, Gonzalez A and Conde C: Non-Canonical WNT5A signaling through RYK contributes to aggressive phenotype of the rheumatoid fibroblast-like synoviocytes. Front Immunol. 11:5552452020. View Article : Google Scholar : PubMed/NCBI

37 

Zhao X, Meng F, Hu S, Yang Z, Huang H, Pang R, Wen X, Kang Y and Zhang Z: The synovium attenuates cartilage degeneration in KOA through activation of the Smad2/3-Runx1 cascade and chondrogenesis-related miRNAs. Mol Ther Nucleic Acids. 22:832–845. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Baker RG, Hayden MS and Ghosh S: NF-κB, inflammation, and metabolic disease. Cell Metab. 13:11–22. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Moqbel SAA, Xu K, Chen Z, Xu L, He Y, Wu Z, Ma C, Ran J, Wu L and Xiong Y: Tectorigenin alleviates inflammation, apoptosis, and ossification in rat tendon-derived stem cells modulating NF-Kappa B and MAPK pathways. Front Cell Dev Biol. 8:5688942020. View Article : Google Scholar

40 

Zhang Q, Lenardo MJ and Baltimore D: 30 Years of NF-κB: A blossoming of relevance to human pathobiology. Cell. 168:37–57. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Zhongyi S, Sai Z, Chao L and Jiwei T: Effects of nuclear factor kappa B signaling pathway in human intervertebral disc degeneration. Spine (Phila Pa 1976). 40:224–232. 2015. View Article : Google Scholar

42 

Baldwin AS: The NF-kappa B and I kappa B proteins: New discoveries and insights. Annu Rev Immunol. 14:649–683. 1996. View Article : Google Scholar : PubMed/NCBI

43 

Sun Z, Yin Z, Liu C, Liang H, Jiang M and Tian J: IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc. J Orthop Surg Res. 10:1592015. View Article : Google Scholar

44 

Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W and Yang C: Simvastatin inhibits IL-1β-induced apoptosis and extracellular matrix degradation by suppressing the NF-kB and MAPK pathways in nucleus pulposus cells. Inflammation. 40:725–734. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Chen J, Garssen J and Redegeld F: The efficacy of bortezomib in human multiple myeloma cells is enhanced by combination with omega-3 fatty acids DHA and EPA: Timing is essential. Clin Nutr. 40:1942–1953. 2021. View Article : Google Scholar

46 

Pham TH, Hagenbeek TJ, Lee HJ, Li J, Rose CM, Lin E, Yu M, Martin SE, Piskol R, Lacap JA, et al: Machine learning and chemico-genomics approach defines and predicts cross-talk of Hippo and MAPK pathways. Cancer Discov. 11:778–793. 2021. View Article : Google Scholar

47 

Cao C, Wu F, Niu X, Hu X, Cheng J, Zhang Y, Li C, Duan X, Fu X, Zhang J, et al: Cadherin-11 cooperates with inflammatory factors to promote the migration and invasion of fibroblast-like synoviocytes in pigmented villonodular synovitis. Theranostics. 10:10573–10588. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Séguin CA, Bojarski M, Pilliar RM, Roughley PJ and Kandel RA: Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration. Matrix Biol. 25:409–418. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Wang G, Chen S, Xie Z, Shen S, Xu W, Chen W, Li X, Wu Y, Li L, Liu B, et al: TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination. Ann Rheum Dis. 79:1111–1120. 2020. View Article : Google Scholar : PubMed/NCBI

50 

He L, He T, Xing J, Zhou Q, Fan L, Liu C, Chen Y, Wu D, Tian Z, Liu B and Rong L: Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Res Ther. 11:2762020. View Article : Google Scholar : PubMed/NCBI

51 

Inoue R, Ishibashi Y, Tsuda E, Yamamoto Y, Matsuzaka M, Takahashi I, Danjo K, Umeda T, Nakaji S and Toh S: Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population. Osteoarthritis Cartilage. 19:51–57. 2011. View Article : Google Scholar

52 

Lamo-Espinosa JM, Blanco JF, Sánchez M, Moreno V, Granero-Moltó F, Sánchez-Guijo F, Crespo-Cullel I, Mora G, Vicente DDS, Pompei-Fernández O, et al: Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis. J Transl Med. 18:3562020. View Article : Google Scholar : PubMed/NCBI

53 

Hubbard JS, Chen PH and Boyd KL: Effects of repeated intraperitoneal injection of pharmaceutical-grade and nonpharmaceutical-grade corn oil in female C57BL/6J mice. J Am Assoc Lab Anim Sci. 56:779–785. 2017.PubMed/NCBI

54 

Alsina-Sanchis E, Mülfarth R, Moll I, Mogler C, Rodriguez-Vita J and Fischer A: Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages. Mol Cancer Res. 19:288–300. 2021. View Article : Google Scholar

55 

Wang S, Ma Q, Xie Z, Shen Y, Zheng B, Jiang C, Yuan P, An Q, Fan S and Jie Z: An antioxidant sesquiterpene inhibits osteoclastogenesis via blocking IPMK/TRAF6 and counteracts OVX-induced osteoporosis in mice. J Bone Miner Res. May 6–2021.Epub ahead of print. View Article : Google Scholar

56 

Kompel AJ, Roemer FW, Murakami AM, Diaz LE, Crema MD and Guermazi A: Intra-articular corticosteroid injections in the hip and knee: Perhaps not as safe as we thought? Radiology. 293:656–663. 2019. View Article : Google Scholar : PubMed/NCBI

57 

Mehta PN and Ghadially FN: Articular cartilage in corn oil-induced lipoarthrosis. Ann Rheum Dis. 32:75–82. 1973. View Article : Google Scholar : PubMed/NCBI

58 

Bagi CM, Berryman ER, Teo S and Lane NE: Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis Cartilage. 25:2080–2090. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Runhaar J, Rozendaal RM, van Middelkoop M, Bijlsma HJW, Doherty M, Dziedzic KS, Lohmander LS, McAlindon T, Zhang W and Zeinstra SB: Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: A systematic review and individual patient data meta-analysis from the OA trial bank. Ann Rheum Dis. 76:1862–1869. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang X, Zhou Y, Chen Z, Chen C, Han C, Li X, Tian H, Cheng X, Zhang K, Zhou T, Zhou T, et al: Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice. Int J Mol Med 48: 192, 2021.
APA
Yang, X., Zhou, Y., Chen, Z., Chen, C., Han, C., Li, X. ... Zhao, J. (2021). Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice. International Journal of Molecular Medicine, 48, 192. https://doi.org/10.3892/ijmm.2021.5025
MLA
Yang, X., Zhou, Y., Chen, Z., Chen, C., Han, C., Li, X., Tian, H., Cheng, X., Zhang, K., Zhou, T., Zhao, J."Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice". International Journal of Molecular Medicine 48.4 (2021): 192.
Chicago
Yang, X., Zhou, Y., Chen, Z., Chen, C., Han, C., Li, X., Tian, H., Cheng, X., Zhang, K., Zhou, T., Zhao, J."Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice". International Journal of Molecular Medicine 48, no. 4 (2021): 192. https://doi.org/10.3892/ijmm.2021.5025
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Zhou Y, Chen Z, Chen C, Han C, Li X, Tian H, Cheng X, Zhang K, Zhou T, Zhou T, et al: Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice. Int J Mol Med 48: 192, 2021.
APA
Yang, X., Zhou, Y., Chen, Z., Chen, C., Han, C., Li, X. ... Zhao, J. (2021). Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice. International Journal of Molecular Medicine, 48, 192. https://doi.org/10.3892/ijmm.2021.5025
MLA
Yang, X., Zhou, Y., Chen, Z., Chen, C., Han, C., Li, X., Tian, H., Cheng, X., Zhang, K., Zhou, T., Zhao, J."Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice". International Journal of Molecular Medicine 48.4 (2021): 192.
Chicago
Yang, X., Zhou, Y., Chen, Z., Chen, C., Han, C., Li, X., Tian, H., Cheng, X., Zhang, K., Zhou, T., Zhao, J."Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice". International Journal of Molecular Medicine 48, no. 4 (2021): 192. https://doi.org/10.3892/ijmm.2021.5025
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team