|
1
|
Lobstein T and Baur L: Obesity in children
and young people: A crisis in public health. Obes Rev. 5(Suppl 1):
S4–S104. 2004. View Article : Google Scholar
|
|
2
|
Nutrition Global Targets 2025. Geneva:
WHO; 2018, http://www.who.int/nutrition/global-target-2025/en/.
Accessed April 2, 2020.
|
|
3
|
NCD Risk Factor Collaboration (NCD-RisC):
Worldwide trends in body-mass index, underweight, overweight, and
obesity from 1975 to 2016: A pooled analysis of 2416
population-based measurement studies in 1289 million children,
adolescents, and adults. Lancet. 390:2627–2642. 2017. View Article : Google Scholar
|
|
4
|
Roberto CA, Swinburn B, Hawkes C, Huang
TT, Costa SA, Ashe M, Zwicker L, Cawley JH and Brownell KD: Patchy
progress on obesity prevention: Emerging examples, entrenched
barriers, and new thinking. Lancet. 385:2400–2409. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Templin T, Cravo Oliveira Hashiguchi T,
Thomson B, Dieleman J and Bendavid E: The overweight and obesity
transition from the wealthy to the poor in low- and middle-income
countries: A survey of household data from 103 countries. PLoS Med.
16:e10029682019. View Article : Google Scholar
|
|
6
|
González-Muniesa P, Mártinez-González MA,
Hu FB, Després JP, Matsuzawa Y, Loos RJF, Moreno LA, Bray GA and
Martinez JA: Obesity. Nat Rev Dis Primers. 3:170342017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Tremmel M, Gerdtham UG, Nilsson PM and
Saha S: Economic burden of obesity: A systematic literature review.
Int J Environ Res Public Health. 14:4352017. View Article : Google Scholar :
|
|
8
|
WHO fact sheet 311. https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight.
Accessed April 2, 2020.
|
|
9
|
Sahoo K, Sahoo B, Choudhury AK, Sofi NY,
Kumar R and Bhadoria AS: Childhood obesity: Causes and
consequences. J Family Med Prim Care. 4:187–192. 2015. View Article : Google Scholar :
|
|
10
|
Frayling TM, Timpson NJ, Weedon MN,
Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H,
Rayner NW, et al: A common variant in the FTO gene is associated
with body mass index and predisposes to childhood and adult
obesity. Science. 316:889–894. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Loos RJ, Lindgren CM, Li S, Wheeler E,
Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann
JS, et al: Common variants near MC4R are associated with fat mass,
weight and risk of obesity. Nat Genet. 40:768–775. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Speliotes EK, Willer CJ, Berndt SI, Monda
KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Mägi
R, et al: Association analyses of 249,796 individuals reveal 18 new
loci associated with body mass index. Nat Genet. 42:937–948. 2010.
View Article : Google Scholar
|
|
13
|
Saeed S, Bonnefond A, Tamanini F, Mirza
MU, Manzoor J, Janjua QM, Din SM, Gaitan J, Milochau A, Durand E,
et al: Loss-of-function mutations in ADCY3 cause monogenic severe
obesity. Nat Genet. 50:175–179. 2018. View Article : Google Scholar
|
|
14
|
Ludwig MG and Seuwen K: Characterization
of the human adenylyl cyclase gene family: cDNA, gene structure,
and tissue distribution of the nine isoforms. J Recept Signal
Transduct Res. 22:79–110. 2002. View Article : Google Scholar
|
|
15
|
Wang H, Wu M, Zhu W, Shen J, Shi X, Yang
J, Zhao Q, Ni C, Xu Y, Shen H, et al: Evaluation of the association
between the AC3 genetic polymorphisms and obesity in a Chinese Han
population. PLoS One. 5:e138512010. View Article : Google Scholar :
|
|
16
|
Nordman S, Abulaiti A, Hilding A, Långberg
EC, Humphreys K, Ostenson CG, Efendic S and Gu HF: Genetic
variation of the adenylyl cyclase 3 (AC3) locus and its influence
on type 2 diabetes and obesity susceptibility in Swedish men. Int J
Obes (Lond). 32:407–412. 2008. View Article : Google Scholar
|
|
17
|
Pitman JL, Wheeler MC, Lloyd DJ, Walker
JR, Glynne RJ and Gekakis N: A gain-of-function mutation in
adenylate cyclase 3 protects mice from diet-induced obesity. PLoS
One. 9:e1102262014. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Hurtado del Pozo C, Vesperinas-García G,
Rubio MÁ, Corripio-Sánchez R, Torres-García AJ, Obregon MJ and
Calvo RM: ChREBP expression in the liver, adipose tissue and
differentiated preadipocytes in human obesity. Biochim Biophys
Acta. 1811:1194–1200. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wu L, Shen C, Seed Ahmed M, Östenson CG
and Gu HF: Adenylate cyclase 3: A new target for anti-obesity drug
development. Obes Rev. 17:907–914. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Siljee JE, Wang Y, Bernard AA, Ersoy BA,
Zhang S, Marley A, Von Zastrow M, Reiter JF and Vaisse C:
Subcellular localization of MC4R with ADCY3 at neuronal primary
cilia underlies a common pathway for genetic predisposition to
obesity. Nat Genet. 50:180–185. 2018. View Article : Google Scholar :
|
|
21
|
Gu C, Sorkin A and Cooper DM: Persistent
interactions between the two transmembrane clusters dictate the
targeting and functional assembly of adenylyl cyclase. Curr Biol.
11:185–190. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Cooper DM: Regulation and organization of
adenylyl cyclases and cAMP. Biochem J. 375:517–529. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Valverde I, Vandermeers A, Anjaneyulu R
and Malaisse WJ: Calmodulin activation of adenylate cyclase in
pancreatic islets. Science. 206:225–227. 1979. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wong ST, Trinh K, Hacker B, Chan GC, Lowe
G, Gaggar A, Xia Z, Gold GH and Storm DR: Disruption of the type
III adenylyl cyclase gene leads to peripheral and behavioral
anosmia in transgenic mice. Neuron. 27:487–497. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Tong T, Shen Y, Lee HW, Yu R and Park T:
Adenylyl cyclase 3 haploinsufficiency confers susceptibility to
diet-induced obesity and insulin resistance in mice. Sci Rep.
6:341792016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Meng Y, Guan Y, Zhang W, Wu YE, Jia H,
Zhang Y, Zhang X, Du H and Wang X: RNA-seq analysis of the
hypothalamic transcriptome reveals the networks regulating
physiopathological progress in the diabetic GK rat. Sci Rep.
6:341382016. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Xu TR, Yang Y, Ward R, Gao L and Liu Y:
Orexin receptors: Multi-functional therapeutic targets for sleeping
disorders, eating disorders, drug addiction, cancers and other
physiological disorders. Cell Signal. 25:2413–2423. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Wheeler MB, Lu M, Dillon JS, Leng XH, Chen
C and Boyd AE III: Functional expression of the rat glucagon-like
peptide-I receptor, evidence for coupling to both adenylyl cyclase
and phospholipase-C. Endocrinology. 133:57–62. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Wang Z, Li V, Chan GC, Phan T, Nudelman
AS, Xia Z and Storm DR: Adult type 3 adenylyl cyclase-deficient
mice are obese. PLoS One. 4:e69792009. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Seed Ahmed M, Kovoor A, Nordman S, Abu
Seman N, Gu T, Efendic S, Brismar K, Östenson CG and Gu HF:
Increased expression of adenylyl cyclase 3 in pancreatic islets and
central nervous system of diabetic Goto-Kakizaki rats: A possible
regulatory role in glucose homeostasis. Islets. 4:343–348. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Andersen MK and Hansen T: Genetics of
metabolic traits in Greenlanders: Lessons from an isolated
population. J Intern Med. 284:464–477. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Goni L, Riezu-Boj JI, Milagro FI, Corrales
FJ, Ortiz L, Cuervo M and Martínez JA: Interaction between an ADCY3
genetic variant and two weight-lowering diets affecting body
fatness and body composition outcomes depending on macronutrient
distribution: A randomized trial. Nutrients. 10:7892018. View Article : Google Scholar :
|
|
33
|
Loid P, Mustila T, Mäkitie RE, Viljakainen
H, Kämpe A, Tossavainen P, Lipsanen-Nyman M, Pekkinen M and Mäkitie
O: Rare variants in genes linked to appetite control and
hypothalamic development in early-onset severe obesity. Front
Endocrinol (Lausanne). 11:812020. View Article : Google Scholar
|
|
34
|
Grarup N, Moltke I, Andersen MK, Dalby M,
Vitting-Seerup K, Kern T, Mahendran Y, Jørsboe E, Larsen CVL,
Dahl-Petersen IK, et al: Loss-of-function variants in ADCY3
increase risk of obesity and type 2 diabetes. Nat Genet.
50:172–174. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Wen W, Cho YS, Zheng W, Dorajoo R, Kato N,
Qi L, Chen CH, Delahanty RJ, Okada Y, Tabara Y, et al:
Meta-analysis identifies common variants associated with body mass
index in east Asians. Nat Genet. 44:307–311. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Stergiakouli E, Gaillard R, Tavaré JM,
Balthasar N, Loos RJ, Taal HR, Evans DM, Rivadeneira F, St Pourcain
B, Uitterlinden AG, et al: Genome-wide association study of
height-adjusted BMI in childhood identifies functional variant in
ADCY3. Obesity (Silver Spring). 22:2252–2259. 2014. View Article : Google Scholar
|
|
37
|
Warrington NM, Howe LD, Paternoster L,
Kaakinen M, Herrala S, Huikari V, Wu YY, Kemp JP, Timpson NJ, St
Pourcain B, et al: A genome-wide association study of body mass
index across early life and childhood. Int J Epidemiol. 44:700–712.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Lee JS, Cheong HS and Shin HD: BMI
prediction within a Korean population. PeerJ. 5:e35102017.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Neocleous V, Shammas C, Phelan MM, Fanis
P, Pantelidou M, Skordis N, Mantzoros C, Phylactou LA and Toumba M:
A novel MC4R deletion coexisting with FTO and MC1R gene variants,
causes severe early onset obesity. Hormones (Athens). 15:445–452.
2016.
|
|
40
|
Voisin S, Almén MS, Zheleznyakova GY,
Lundberg L, Zarei S, Castillo S, Eriksson FE, Nilsson EK, Blüher M,
Böttcher Y, et al: Many obesity-associated SNPs strongly associate
with DNA methylation changes at proximal promoters and enhancers.
Genome Med. 7:1032015. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Volkov P, Olsson AH, Gillberg L, Jørgensen
SW, Brøns C, Eriksson KF, Groop L, Jansson PA, Nilsson E, Rönn T,
et al: A genome-wide mQTL analysis in human adipose tissue
identifies genetic variants associated with DNA methylation, gene
expression and metabolic traits. PLoS One. 11:e01577762016.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Monda KL, Chen GK, Taylor KC, Palmer C,
Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, et
al: A meta-analysis identifies new loci associated with body mass
index in individuals of African ancestry. Nat Genet. 45:690–696.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Locke AE, Kahali B, Berndt SI, Justice AE,
Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, et
al: Genetic studies of body mass index yield new insights for
obesity biology. Nature. 518:197–206. 2015. View Article : Google Scholar : PubMed/NCBI
|
