Open Access

Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)

  • Authors:
    • Yunfei Zhao
    • Xiaojing Zhang
    • Xinye Chen
    • Yun Wei
  • View Affiliations

  • Published online on: December 8, 2021     https://doi.org/10.3892/ijmm.2021.5070
  • Article Number: 15
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral tissue death and focal neuronal damage. The infarct size and neurological severity after ischemic stroke episodes depends on the time period since occurrence, the severity of ischemia, systemic blood pressure, vein systems and location of infarcts, amongst others. Ischemic stroke is a complex disease, and neuronal injuries after ischemic strokes have been the focus of current studies. The present review will provide a basic pathological background of ischemic stroke and cerebral infarcts. Moreover, the major mechanisms underlying ischemic stroke and neuronal injuries are summarized. This review will also briefly summarize some representative clinical trials and up‑to‑date treatments that have been applied to stroke and brain infarcts.
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February-2022
Volume 49 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao Y, Zhang X, Chen X and Wei Y: Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review). Int J Mol Med 49: 15, 2022
APA
Zhao, Y., Zhang, X., Chen, X., & Wei, Y. (2022). Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review). International Journal of Molecular Medicine, 49, 15. https://doi.org/10.3892/ijmm.2021.5070
MLA
Zhao, Y., Zhang, X., Chen, X., Wei, Y."Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)". International Journal of Molecular Medicine 49.2 (2022): 15.
Chicago
Zhao, Y., Zhang, X., Chen, X., Wei, Y."Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)". International Journal of Molecular Medicine 49, no. 2 (2022): 15. https://doi.org/10.3892/ijmm.2021.5070