|
1
|
Bray F, Ferlay J, Soerjomataram I, Siegel
RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN
estimates of incidence and mortality worldwide for 36 cancers in
185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Devesa SS, Bray F, Vizcaino AP and Parkin
DM: International lung cancer trends by histologic type:
Male:Female differences diminishing and adenocarcinoma rates
rising. Int J Cancer. 117:294–299. 2005. View Article : Google Scholar
|
|
3
|
Chan BA and Hughes BG: Targeted therapy
for non-small cell lung cancer: Current standards and the promise
of the future. Transl Lung Cancer Res. 4:36–54. 2015.PubMed/NCBI
|
|
4
|
Senft D and Ronai ZA: UPR, autophagy, and
mitochondria crosstalk underlies the ER stress response. Trends
Biochem Sci. 40:141–148. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Brenning G, Simonsson B, Kallander C and
Ahre A: Pretreatment serum beta 2-microglobulin in multiple
myeloma. Br J Haematol. 62:85–93. 1986. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Shinya S, Kadokura H, Imagawa Y, Inoue M,
Yanagitani K and Kohno K: Reconstitution and characterization of
the unconventional splicing of XBP1u mRNA in vitro. Nucleic Acids
Res. 39:5245–5254. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Chen S, Chen J, Hua X, Sun Y, Cui R, Sha J
and Zhu X: The emerging role of XBP1 in cancer. Biomed
Pharmacother. 127:1100692020. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Sheng X, Nenseth HZ, Qu S, Kuzu OF,
Frahnow T, Simon L, Greene S, Zeng Q, Fazli L, Rennie PS, et al:
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC
signaling. Nat Commun. 10:3232019. View Article : Google Scholar
|
|
9
|
Song M, Sandoval TA, Chae CS, Chopra S,
Tan C, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, et
al: IRE1α-XBP1 controls T cell function in ovarian cancer by
regulating mitochondrial activity. Nature. 562:423–428. 2018.
View Article : Google Scholar :
|
|
10
|
Chen X, Iliopoulos D, Zhang Q, Tang Q,
Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, et
al: XBP1 promotes triple-negative breast cancer by controlling the
HIF1α pathway. Nature. 508:103–107. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Luo Q, Shi W, Dou B, Wang J, Peng W, Liu
X, Zhao D, Tang F, Wu Y, Li X, et al: XBP1-IGFBP3 signaling pathway
promotes NSCLC invasion and metastasis. Front Oncol. 11:6549952021.
View Article : Google Scholar
|
|
12
|
Kim EK and Choi EJ: Compromised MAPK
signaling in human diseases: An update. Arch Toxicol. 89:867–882.
2015. View Article : Google Scholar
|
|
13
|
Cicchini M, Buza EL, Sagal KM, Gudiel AA,
Durham AC and Feldser DM: Context-dependent effects of amplified
MAPK signaling during lung adenocarcinoma initiation and
progression. Cell Rep. 18:1958–1969. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Stutvoet TS, Kol A, de Vries EG, de Bruyn
M, Fehrmann RS, Terwisscha van Scheltinga AG and de Jong S: MAPK
pathway activity plays a key role in PD-L1 expression of lung
adenocarcinoma cells. J Pathol. 249:52–64. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Cao X, Fang X, Malik WS, He Y, Li X, Xie
M, Sun W, Xu Y and Liu X: TRB3 interacts with ERK and JNK and
contributes to the proliferation, apoptosis, and migration of lung
adenocarcinoma cells. J Cell Physiol. 235:538–547. 2020. View Article : Google Scholar
|
|
16
|
Shen H, Liu J, Wang Y, Lian H, Wang J,
Xing L, Yan X, Wang J and Zhang X: Aflatoxin G1-induced oxidative
stress causes DNA damage and triggers apoptosis through MAPK
signaling pathway in A549 cells. Food Chem Toxicol. 62:661–669.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Du X, Wang S, Liu X, He T, Lin X, Wu S,
Wang D, Li J, Huang W and Yang H: MiR-1307-5p targeting TRAF3
upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma
proliferation. Cancer Cell Int. 20:5022020. View Article : Google Scholar
|
|
18
|
Ong JY, Yong PV, Lim YM and Ho AS:
2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung
adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK
signaling pathways. Life Sci. 135:158–164. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Hou XM, Zhang T, Da Z and Wu XA: CHPF
promotes lung adenocarcinoma proliferation and anti-apoptosis via
the MAPK pathway. Pathol Res Pract. 215:988–994. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Chen YY, Liu FC, Chou PY, Chien YC, Chang
WS, Huang GJ, Wu CH and Sheu MJ: Ethanol extracts of fruiting
bodies of Antrodia cinnamomea suppress CL1-5 human lung
adenocarcinoma cells migration by inhibiting matrix
metalloproteinase-2/9 through ERK, JNK, p38, and PI3K/Akt signaling
pathways. Evid Based Complement Alternat Med. 2012:3784152012.
|
|
21
|
Rhodes DR, Kalyana-Sundaram S, Mahavisno
V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ,
Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: Genes, pathways,
and networks in a collection of 18,000 cancer gene expression
profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar :
|
|
22
|
Li T, Fan J, Wang B, Traugh N, Chen Q, Liu
JS, Li B and Liu XS: TIMER: A web server for comprehensive analysis
of tumor-infiltrating immune cells. Cancer Res. 77:e108–e110. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Chandrashekar DS, Bashel B, Balasubramanya
SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and
Varambally S: UALCAN: A portal for facilitating tumor subgroup gene
expression and survival analyses. Neoplasia. 19:649–658. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Vasaikar SV, Straub P, Wang J and Zhang B:
LinkedOmics: Analyzing multi-omics data within and across 32 cancer
types. Nucleic Acids Res. 46:D956–D963. 2018. View Article : Google Scholar :
|
|
25
|
Kanehisa M, Sato Y and Kawashima M: KEGG
mapping tools for uncovering hidden features in biological data.
Protein Sci. 31:47–53. 2022. View Article : Google Scholar
|
|
26
|
Tang Z, Li C, Kang B, Gao G, Li C and
Zhang Z: GEPIA: A web server for cancer and normal gene expression
profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
28
|
Yoshida H, Matsui T, Yamamoto A, Okada T
and Mori K: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in
response to ER stress to produce a highly active transcription
factor. Cell. 107:881–891. 2001. View Article : Google Scholar
|
|
29
|
Huang CH, Chong KY and Lei KF: Analysis of
the internal hypoxic environment in solid tumor tissue using a
folding paper system. ACS Appl Mater Interfaces. 13:33885–33893.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Jin X, Zhai B, Fang T, Guo X and Xu L:
FXR1 is elevated in colorectal cancer and acts as an oncogene.
Tumour Biol. 37:2683–2690. 2016. View Article : Google Scholar
|
|
31
|
Goldar S, Khaniani MS, Derakhshan SM and
Baradaran B: Molecular mechanisms of apoptosis and roles in cancer
development and treatment. Asian Pac J Cancer Prev. 16:2129–2144.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Drosten M and Barbacid M: Targeting the
MAPK pathway in KRAS-Driven tumors. Cancer Cell. 37:543–550. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Xia Z, Wu S, Wei X, Liao Y, Yi P, Liu Y
and Liu J and Liu J: Hypoxic ER stress suppresses β-catenin
expression and promotes cooperation between the transcription
factors XBP1 and HIF1α for cell survival. J Biol Chem.
294:13811–13821. 2019. View Article : Google Scholar :
|
|
34
|
Cubillos-Ruiz JR, Silberman PC, Rutkowski
MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE,
Gupta D, Holcomb K, et al: ER stress sensor XBP1 controls
anti-tumor immunity by disrupting dendritic cell homeostasis. Cell.
161:1527–1538. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Pommier A, Anaparthy N, Memos N, Kelley
ZL, Gouronnec A, Yan R, Auffray C, Albrengues J, Egeblad M,
Iacobuzio-Donahue CA, et al: Unresolved endoplasmic reticulum
stress engenders immune-resistant, latent pancreatic cancer
metastases. Science. 360:eaao49082018. View Article : Google Scholar
|
|
36
|
Sheng X, Arnoldussen YJ, Storm M, Tesikova
M, Nenseth HZ, Zhao S, Fazli L, Rennie P, Risberg B, Wæhre H, et
al: Divergent androgen regulation of unfolded protein response
pathways drives prostate cancer. EMBO Mol Med. 7:788–801. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Niederreiter L, Fritz TM, Adolph TE,
Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S,
Tomczak MF, Kaneider NC, et al: ER stress transcription factor Xbp1
suppresses intestinal tumorigenesis and directs intestinal stem
cells. J Exp Med. 210:2041–2056. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Lhomond S, Avril T, Dejeans N, Voutetakis
K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan
F, et al: Dual IRE1 RNase functions dictate glioblastoma
development. EMBO Mol Med. 10:e79292018. View Article : Google Scholar :
|
|
39
|
Zhao N, Cao J, Xu L, Tang Q, Dobrolecki
LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, et al: Pharmacological
targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven
breast cancer. J Clin Invest. 128:1283–1299. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Clarke HJ, Chambers JE, Liniker E and
Marciniak SJ: Endoplasmic reticulum stress in malignancy. Cancer
Cell. 25:563–573. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Cubillos-Ruiz JR, Bettigole SE and
Glimcher LH: Tumorigenic and immunosuppressive effects of
endoplasmic reticulum stress in cancer. Cell. 168:692–706. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Wang M and Kaufman RJ: The impact of the
endoplasmic reticulum protein-folding environment on cancer
development. Nat Rev Cancer. 14:581–597. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Hetz C, Axten JM and Patterson JB:
Pharmacological targeting of the unfolded protein response for
disease intervention. Nat Chem Biol. 15:764–775. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Mimura N, Fulciniti M, Gorgun G, Tai YT,
Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, et al:
Blockade of XBP1 splicing by inhibition of IRE1alpha is a promising
therapeutic option in multiple myeloma. Blood. 119:5772–5781. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Liu P, Wang H, Liang Y, Hu A, Xing R,
Jiang L, Yi L and Dong J: LINC00852 promotes lung adenocarcinoma
spinal metastasis by targeting S100A9. J Cancer. 9:4139–4149. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Sato H, Schoenfeld AJ, Siau E, Lu YC, Tai
H, Suzawa K, Kubota D, Lui AJW, Qeriqi B, Mattar M, et al: mapk
pathway alterations correlate with poor survival and drive
resistance to therapy in patients with lung cancers driven by ROS1
fusions. Clin Cancer Res. 26:2932–2945. 2020. View Article : Google Scholar
|
|
47
|
Zhou Q, Gui S, Zhou Q and Wang Y:
Melatonin inhibits the migration of human lung adenocarcinoma A549
cell lines involving JNK/MAPK pathway. PLoS One. 9:e1011322014.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Liu T, Wu L, Wang D, Wang H, Chen J, Yang
C, Bao J and Wu C: Role of reactive oxygen species-mediated MAPK
and NF-κB activation in polygonatum cyrtonema lectin-induced
apoptosis and autophagy in human lung adenocarcinoma A549 cells. J
Biochem. 160:315–324. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
QuickGO: Term GO:0001934. https://www.ebi.ac.uk/QuickGO/term/GO:0001934.
Accessed July 20, 2021.
|
|
50
|
Urano F, Wang X, Bertolotti A, Zhang Y,
Chung P, Harding HP and Ron D: Coupling of stress in the ER to
activation of JNK protein kinases by transmembrane protein kinase
IRE1. Science. 287:664–666. 2000. View Article : Google Scholar : PubMed/NCBI
|
