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Review Open Access

Talin‑1 interaction network in cellular mechanotransduction (Review)

  • Authors:
    • Ye Zhao
    • Nikita Lykov
    • Chimeng Tzeng
  • View Affiliations / Copyright

    Affiliations: School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, Jiangsu 211800, P.R. China, Translational Medicine Research Center‑Key Laboratory for Cancer T‑Cell Theragnostic and Clinical Translation, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian 361005, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 60
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    Published online on: March 9, 2022
       https://doi.org/10.3892/ijmm.2022.5116
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Abstract

The mechanical signals within the extracellular matrix (ECM) regulate cell growth, proliferation and differentiation, and integrins function as the hub between the ECM and cellular actin. Focal adhesions (FAs) are multi‑protein, integrin‑containing complexes, acting as tension‑sensing anchoring points that bond cells to the extracellular microenvironment. Talin‑1 serves as the central protein of FAs that participates in the activation of integrins and connects them with the actin cytoskeleton. As a cytoplasmic protein, Talin‑1 consists of a globular head domain and a long rod comprised of a series of α‑helical bundles. The unique structure of the Talin‑1 rod domain permits folding and unfolding in response to the mechanical stress, revealing various binding sites. Thus, conformation changes of the Talin‑1 rod domain enable the cell to convert mechanical signals into chemical through multiple signaling pathways. The present review discusses the binding partners of Talin‑1, their interactions, effects on the cellular processes, and their possible roles in diseases.
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Spandidos Publications style
Zhao Y, Lykov N and Tzeng C: Talin‑1 interaction network in cellular mechanotransduction (Review). Int J Mol Med 49: 60, 2022.
APA
Zhao, Y., Lykov, N., & Tzeng, C. (2022). Talin‑1 interaction network in cellular mechanotransduction (Review). International Journal of Molecular Medicine, 49, 60. https://doi.org/10.3892/ijmm.2022.5116
MLA
Zhao, Y., Lykov, N., Tzeng, C."Talin‑1 interaction network in cellular mechanotransduction (Review)". International Journal of Molecular Medicine 49.5 (2022): 60.
Chicago
Zhao, Y., Lykov, N., Tzeng, C."Talin‑1 interaction network in cellular mechanotransduction (Review)". International Journal of Molecular Medicine 49, no. 5 (2022): 60. https://doi.org/10.3892/ijmm.2022.5116
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Spandidos Publications style
Zhao Y, Lykov N and Tzeng C: Talin‑1 interaction network in cellular mechanotransduction (Review). Int J Mol Med 49: 60, 2022.
APA
Zhao, Y., Lykov, N., & Tzeng, C. (2022). Talin‑1 interaction network in cellular mechanotransduction (Review). International Journal of Molecular Medicine, 49, 60. https://doi.org/10.3892/ijmm.2022.5116
MLA
Zhao, Y., Lykov, N., Tzeng, C."Talin‑1 interaction network in cellular mechanotransduction (Review)". International Journal of Molecular Medicine 49.5 (2022): 60.
Chicago
Zhao, Y., Lykov, N., Tzeng, C."Talin‑1 interaction network in cellular mechanotransduction (Review)". International Journal of Molecular Medicine 49, no. 5 (2022): 60. https://doi.org/10.3892/ijmm.2022.5116
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