Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)
- Authors:
- Xiaolu Zhang
- Wenyun Zeng
- Yue Zhang
- Qun Yu
- Miao Zeng
- Jiali Gan
- Wenlan Zhang
- Xijuan Jiang
- Huhu Li
-
Affiliations: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P.R. China - Published online on: April 7, 2022 https://doi.org/10.3892/ijmm.2022.5130
- Article Number: 74
-
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Wang H, Wang Z, Wu Q, Yuan Y, Cao W and Zhang X: Regulatory T cells in ischemic stroke. CNS Neurosci Ther. 27:643–651. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lu M, Guo J, Wu B, Zhou Y, Wu M, Farzaneh M and Khoshnam SE: Mesenchymal stem cell-mediated mitochondrial transfer: A therapeutic approach for ischemic stroke. Transl Stroke Res. 12:212–229. 2021. View Article : Google Scholar | |
Feng L, Han CX, Cao SY, Zhang HM and Wu GY: Deficits in motor and cognitive functions in an adult mouse model of hypoxia-ischemia induced stroke. Sci Rep. 10:206462020. View Article : Google Scholar : PubMed/NCBI | |
Barrington J, Lemarchand E and Allan SM: A brain in flame; do inflammasomes and pyroptosis influence stroke pathology? Brain Pathol. 27:205–212. 2017. View Article : Google Scholar | |
Lambertsen KL, Finsen B and Clausen BH: Post-stroke inflammation-target or tool for therapy? Acta Neuropathol. 137:693–714. 2019. View Article : Google Scholar | |
Andrabi SS, Parvez S and Tabassum H: Ischemic stroke and mitochondria: Mechanisms and targets. Protoplasma. 257:335–343. 2020. View Article : Google Scholar | |
Li X, Huang Z, Liu S, Zeng X, Xie J, Liu C, Xiao H, Liu R, Li L and Zeng J: 3′-Daidzein sulfonate sodium provides neuroprotection by promoting the expression of the alpha7 nicotinic acetylcholine receptor and suppressing inflammatory responses in a rat model of focal cerebral ischemia. Am J Transl Res. 10:3455–3464. 2018. | |
Mo Y, Sun YY and Liu KY: Autophagy and inflammation in ischemic stroke. Neural Regen Res. 15:1388–1396. 2020. View Article : Google Scholar : PubMed/NCBI | |
Jayaraj RL, Azimullah S, Beiram R, Jalal FY and Rosenberg GA: Neuroinflammation: Friend and foe for ischemic stroke. J Neuroinflammation. 16:1422019. View Article : Google Scholar : PubMed/NCBI | |
Vats K, Sarmah D, Kaur H, Wanve M, Kalia K, Borah A, Dave KR, Yavagal DR and Bhattacharya P: Inflammasomes in stroke: A triggering role for acid-sensing ion channels. Ann N Y Acad Sci. 1431:14–24. 2018. View Article : Google Scholar | |
Forn-Cuni G, Meijer AH and Varela M: Zebrafish in inflammasome research. Cells. 8:9012019. View Article : Google Scholar : | |
Ma C, Liu S, Zhang S, Xu T, Yu X, Gao Y, Zhai C, Li C, Lei C, Fan S, et al: Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review). Int J Mol Med. 42:2979–2990. 2018. | |
Xu Q, Zhao B, Ye Y, Li Y, Zhang Y, Xiong X and Gu L: Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. J Neuroinflammation. 18:1232021. View Article : Google Scholar : PubMed/NCBI | |
Qian Y, Lyu Y, Jiang M, Tang B, Nie T and Lu S: Human urinary kallidinogenase or edaravone combined with butylphthalide in the treatment of acute ischemic stroke. Brain Behav. 9:e014382019. View Article : Google Scholar : PubMed/NCBI | |
Poh L, Kang SW, Baik SH, Ng GYQ, She DT, Balaganapathy P, Dheen ST, Magnus T, Gelderblom M, Sobey CG, et al: Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke. Brain Behav Immun. 75:34–47. 2019. View Article : Google Scholar | |
Cao Y, Zhang H, Lu X, Wang J, Zhang X, Sun S, Bao Z, Tian W, Ning S, Wang L and Cui L: Overexpression of MicroRNA-9a-5p Ameliorates NLRP1 inflammasome-mediated ischemic injury in rats following ischemic stroke. Neuroscience. 444:106–117. 2020. View Article : Google Scholar : PubMed/NCBI | |
Xu SY, Bian HJ, Shu S, Xia SN, Gu Y, Zhang MJ, Xu Y and Cao X: AIM2 deletion enhances blood-brain barrier integrity in experimental ischemic stroke. CNS Neurosci Ther. 27:1224–1237. 2021. View Article : Google Scholar : PubMed/NCBI | |
Yu JW and Lee MS: Mitochondria and the NLRP3 inflammasome: Physiological and pathological relevance. Arch Pharm Res. 39:1503–1518. 2016. View Article : Google Scholar : PubMed/NCBI | |
He Y, Hara H and Nunez G: Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 41:1012–1021. 2016. View Article : Google Scholar : PubMed/NCBI | |
Wang YL, Wu HR, Zhang SS, Xiao HL, Yu J, Ma YY, Zhang YD and Liu Q: Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation. Transl Psychiatry. 11:3532021. View Article : Google Scholar : PubMed/NCBI | |
Elliott EI and Sutterwala FS: Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev. 265:35–52. 2015. View Article : Google Scholar : PubMed/NCBI | |
Savyuk M, Krivonosov M, Mishchenko T, Gazaryan I, Ivanchenko M, Khristichenko A, Poloznikov A, Hushpulian D, Nikulin S, Tonevitsky E, et al: Neuroprotective Effect of HIF prolyl hydroxylase inhibition in an in vitro hypoxia model. Antioxidants (Basel). 9:6622020. View Article : Google Scholar | |
Huber W, Zanner R, Schneider G, Schmid R and Lahmer T: Assessment of regional perfusion and organ function: Less and non-invasive techniques. Front Med (Lausanne). 6:502019. View Article : Google Scholar | |
Wang W, Zhao F, Ma X, Perry G and Zhu X: Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances. Mol Neurodegener. 15:302020. View Article : Google Scholar : PubMed/NCBI | |
Li W, Kui L, Demetrios T, Gong X and Tang M: A Glimmer of hope: Maintain mitochondrial homeostasis to mitigate Alzheimer's disease. Aging Dis. 11:1260–1275. 2020. View Article : Google Scholar : | |
Ham PR and Raju R: Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol. 157:92–116. 2017. View Article : Google Scholar | |
Liu Y, Lin J, Wu X, Guo X, Sun H, Yu B, Shen J, Bai J, Chen Z, Yang H, et al: Aspirin-mediated attenuation of intervertebral disc degeneration by ameliorating reactive oxygen species in vivo and in vitro. Oxid Med Cell Longev. 2019:71898542019. View Article : Google Scholar | |
Anzell AR, Maizy R, Przyklenk K and Sanderson TH: Mitochondrial quality control and disease: Insights into ischemia-reperfusion injury. Mol Neurobiol. 55:2547–2564. 2018. View Article : Google Scholar | |
Babenko VA, Silachev DN, Popkov VA, Zorova LD, Pevzner IB, Plotnikov EY, Sukhikh GT and Zorov DB: Miro1 enhances mitochondria transfer from multipotent mesenchymal stem cells (MMSC) to neural cells and improves the efficacy of cell recovery. Molecules. 23:6872018. View Article : Google Scholar : | |
Mondal NK, Behera J, Kelly KE, George AK, Tyagi PK and Tyagi N: Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke. Neurochem Int. 122:120–138. 2019. View Article : Google Scholar : | |
Andrabi SS, Ali M, Tabassum H, Parveen S and Parvez S: Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 12:dmm0338602019. View Article : Google Scholar : | |
Chen N, Zhou Z, Li J, Li B, Feng J, He D, Luo Y, Zheng X, Luo J and Zhang J: 3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke. Drug Des Devel Ther. 12:4261–4271. 2018. View Article : Google Scholar : | |
Peng J, Wang H, Gong Z, Li X, He L, Shen Q, Pan J and Peng Y: Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity. Mol Immunol. 123:74–87. 2020. View Article : Google Scholar | |
Luan Y, Yang D, Zhang Z, Bie X, Zhao H, Wang Y, Liu Y, Yang S, Zhou B, Xu Y, et al: Association study between genetic variation in whole mitochondrial genome and ischemic stroke. J Mol Neurosci. 71:2152–2162. 2021. View Article : Google Scholar : PubMed/NCBI | |
Sarmah D, Datta A, Raut S, Sarkar A, Shah B, Bohra M, Singh U, Jagtap P, Baidya F, Kalia K, et al: The role of inflammasomes in atherosclerosis and stroke pathogenesis. Curr Pharm Des. 26:4234–4245. 2020. View Article : Google Scholar : PubMed/NCBI | |
Martynov MY and Gusev EI: Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke. J Exp Pharmacol. 7:17–28. 2015. View Article : Google Scholar : PubMed/NCBI | |
Bissen D, Foss F and Acker-Palmer A: AMPA receptors and their minions: Auxiliary proteins in AMPA receptor trafficking. Cell Mol Life Sci. 76:2133–2169. 2019. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Qin C, Huang J, Tang X, Liu C, Huang K, Xu J, Guo G, Tong A and Zhou L: The role of astrocytes in oxidative stress of central nervous system: A mixed blessing. Cell Prolif. 53:e127812020. View Article : Google Scholar : | |
Wen B, Xu K, Huang R, Jiang T, Wang J, Chen J, Chen J and He B: Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke. Mol Med Rep. 25:1652022. View Article : Google Scholar : PubMed/NCBI | |
Liu D, Gharavi R, Pitta M, Gleichmann M and Mattson MP: Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med. 11:28–42. 2009. View Article : Google Scholar : | |
Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T and Akira S: Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 14:454–460. 2013. View Article : Google Scholar : PubMed/NCBI | |
Li S, Wang T, Zhai L, Ge K, Zhao J, Cong W and Guo Y: Picroside II exerts a neuroprotective effect by inhibiting mPTP permeability and EndoG release after cerebral ischemia/reperfusion injury in rats. J Mol Neurosci. 64:144–155. 2018. View Article : Google Scholar | |
Zheng W, Talley WL, Holstein DM, Wewer J and Lechleiter JD: P2Y1R-initiated, IP3R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse. J Cereb Blood Flow Metab. 33:600–711. 2013. View Article : Google Scholar : PubMed/NCBI | |
Bonora M, Bononi A, De Marchi E, Giorgi C, Lebiedzinska M, Marchi S, Patergnani S, Rimessi A, Suski JM, Wojtala A, et al: Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle. 12:674–683. 2013. View Article : Google Scholar : PubMed/NCBI | |
Zhou H, Hu S, Jin Q, Shi C, Zhang Y, Zhu P, Ma Q, Tian F and Chen Y: Mff-Dependent mitochondrial fission contributes to the pathogenesis of cardiac microvasculature ischemia/reperfusion injury via induction of mROS-mediated cardiolipin oxidation and HK2/VDAC1 disassociation-involved mPTP opening. J Am Heart Assoc. 6:e0053282017. View Article : Google Scholar : PubMed/NCBI | |
Jin X, Zhang J, An T, Zhao H, Fu W, Li D, Liu S, Cao X and Liu B: A Genome-wide screen in saccharomyces cerevisiae reveals a critical role for oxidative phosphorylation in cellular tolerance to lithium hexafluorophosphate. Cells. 10:8882021. View Article : Google Scholar : | |
He J, Liu J, Huang Y, Zhuo Y, Chen W, Duan D, Tang X, Lu M and Hu Z: Olfactory mucosa mesenchymal stem cells alleviate cerebral ischemia/reperfusion injury via Golgi apparatus secretory pathway Ca2+-ATPase isoform1. Front Cell Dev Biol. 8:5865412020. View Article : Google Scholar | |
Chen M, Wang M, Yang Q, Wang M, Wang Z, Zhu Y, Zhang Y, Wang C, Jia Y, Li Y and Wen A: Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats. Int J Mol Med. 37:1501–1510. 2016. View Article : Google Scholar : | |
Wang C, Hao J, Liu X, Li C, Yuan X, Lee RJ, Bai T and Wang D: Isoforsythiaside attenuates Alzheimer's disease via regulating mitochondrial function through the PI3K/AKT pathway. Int J Mol Sci. 21:56872020. View Article : Google Scholar | |
Wang T, Wang F, Yu L and Li Z: Nobiletin alleviates cerebral ischemic-reperfusion injury via MAPK signaling pathway. Am J Transl Res. 11:5967–5977. 2019.PubMed/NCBI | |
Zhao Q, Zhang C, Wang X, Chen L, Ji H and Zhang Y: (S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death. Neurochem Int. 60:134–144. 2012. View Article : Google Scholar | |
Tan YQ, Zhang X, Zhang S, Zhu T, Garg M, Lobie PE and Pandey V: Mitochondria: The metabolic switch of cellular oncogenic transformation. Biochim Biophys Acta Rev Cancer. 1876:1885342021. View Article : Google Scholar : PubMed/NCBI | |
Jahani-Asl A, Cheung EC, Neuspiel M, MacLaurin JG, Fortin A, Park DS, McBride HM and Slack RS: Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. J Biol Chem. 282:23788–23798. 2007. View Article : Google Scholar : PubMed/NCBI | |
McGahan L, Hakim AM and Robertson GS: Hippocampal Myc and p53 expression following transient global ischemia. Brain Res Mol Brain Res. 56:133–145. 1998. View Article : Google Scholar : PubMed/NCBI | |
Li Y and Liu X: Novel insights into the role of mitochondrial fusion and fission in cardiomyocyte apoptosis induced by ischemia/reperfusion. J Cell Physiol. 233:5589–5597. 2018. View Article : Google Scholar : PubMed/NCBI | |
Grohm J, Kim SW, Mamrak U, Tobaben S, Cassidy-Stone A, Nunnari J, Plesnila N and Culmsee C: Inhibition of Drp1 provides neuroprotection in vitro and in vivo. Cell Death Differ. 19:1446–1458. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhao YX, Cui M, Chen SF, Dong Q and Liu XY: Amelioration of ischemic mitochondrial injury and Bax-dependent outer membrane permeabilization by Mdivi-1. CNS Neurosci Ther. 20:528–538. 2014. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Xiong S, Xie C, Markesbery WR and Lovell MA: Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J Neurochem. 93:953–962. 2005. View Article : Google Scholar : PubMed/NCBI | |
West AP and Shadel GS: Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol. 17:363–375. 2017. View Article : Google Scholar : PubMed/NCBI | |
Guo S, Geng X, Lee H and Ding Y: Phenothiazine inhibits neuroinflammation and inflammasome activation independent of hypothermia after ischemic stroke. Mol Neurobiol. 58:6136–6152. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lian L, Zhang Y, Liu L, Yang L, Cai Y, Zhang J and Xu S: Neuroinflammation in ischemic stroke: Focus on MicroRNA-mediated polarization of microglia. Front Mol Neurosci. 13:6124392020. View Article : Google Scholar | |
Shaheryar ZA, Khan MA, Adnan CS, Zaidi AA, Hanggi D and Muhammad S: Neuroinflammatory triangle presenting novel pharmacological targets for ischemic brain injury. Front Immunol. 12:7486632021. View Article : Google Scholar : PubMed/NCBI | |
Xue Y, Nie D, Wang LJ, Qiu HC, Ma L, Dong MX, Tu WJ and Zhao J: Microglial polarization: Novel therapeutic strategy against ischemic stroke. Aging Dis. 12:466–479. 2021. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Yu CC, Liu XY, Deng XN, Tian Q and Du YJ: Epigenetic modulation of microglia function and phenotypes in neurodegenerative diseases. Neural Plast. 2021:99126862021. View Article : Google Scholar : PubMed/NCBI | |
Ponsaerts L, Alders L, Schepers M, de Oliveira RMW, Prickaerts J, Vanmierlo T and Bronckaers A: Neuroinflammation in ischemic stroke: Inhibition of cAMP-Specific phosphodiesterases (PDEs) to the rescue. Biomedicines. 9:7032021. View Article : Google Scholar : | |
Guan X, Zhang Y, Gareev I, Beylerli O, Li X, Lu X, Lv L and Hai X: MiR-499a prevents astrocytes mediated inflammation in ischemic stroke by targeting PTEN. Noncoding RNA Res. 6:146–152. 2021. View Article : Google Scholar : PubMed/NCBI | |
Franke M, Bieber M, Kraft P, Weber A, Stoll G and Schuhmann MK: The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun. 92:223–233. 2021. View Article : Google Scholar | |
Gritsenko A, Green JP, Brough D and Lopez-Castejon G: Mechanisms of NLRP3 priming in inflammaging and age related diseases. Cytokine Growth Factor Rev. 55:15–25. 2020. View Article : Google Scholar : PubMed/NCBI | |
Xu S, Li X, Liu Y, Xia Y, Chang R and Zhang C: Inflammasome inhibitors: Promising therapeutic approaches against cancer. J Hematol Oncol. 12:642019. View Article : Google Scholar : PubMed/NCBI | |
Shim DW and Lee KH: Posttranslational regulation of the NLR family pyrin domain-containing 3 inflammasome. Front Immunol. 9:10542018. View Article : Google Scholar : | |
Han S, Lear TB, Jerome JA, Rajbhandari S, Snavely CA, Gulick DL, Gibson KF, Zou C, Chen BB and Mallampalli RK: Lipopolysaccharide primes the NALP3 inflammasome by inhibiting its ubiquitination and degradation mediated by the SCFFBXL2 E3 ligase. J Biol Chem. 290:18124–18133. 2015. View Article : Google Scholar : | |
Swanson KV, Deng M and Ting JP: The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol. 19:477–489. 2019. View Article : Google Scholar : PubMed/NCBI | |
Susjan P, Roskar S and Hafner-Bratkovic I: The mechanism of NLRP3 inflammasome initiation: Trimerization but not dimerization of the NLRP3 pyrin domain induces robust activation of IL-1beta. Biochem Biophys Res Commun. 483:823–828. 2017. View Article : Google Scholar | |
Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H and Egelman EH: Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 156:1193–1206. 2014. View Article : Google Scholar : PubMed/NCBI | |
Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, et al: Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. J Exp Med. 215:827–840. 2018. View Article : Google Scholar : | |
Dick MS, Sborgi L, Ruhl S, Hiller S and Broz P: ASC filament formation serves as a signal amplification mechanism for inflammasomes. Nat Commun. 7:119292016. View Article : Google Scholar : PubMed/NCBI | |
Lu L, Lu Q, Chen W, Li J, Li C and Zheng Z: Vitamin D3 protects against diabetic retinopathy by inhibiting high-glucose-induced activation of the ROS/TXNIP/NLRP3 inflammasome pathway. J Diabetes Res. 2018:81935232018. View Article : Google Scholar : | |
Ratajczak MZ, Bujko K, Cymer M, Thapa A, Adamiak M, Ratajczak J, Abdel-Latif AK and Kucia M: The Nlrp3 inflammasome as a 'rising star' in studies of normal and malignant hematopoiesis. Leukemia. 34:1512–1523. 2020. View Article : Google Scholar : PubMed/NCBI | |
Gao L, Dong Q, Song Z, Shen F, Shi J and Li Y: NLRP3 inflammasome: A promising target in ischemic stroke. Inflamm Res. 66:17–24. 2017. View Article : Google Scholar | |
Liu H, Wu X, Luo J, Zhao L, Li X, Guo H, Bai H, Cui W, Guo W, Feng D and Qu Y: Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3beta. Exp Neurol. 329:1133022020. View Article : Google Scholar | |
Zhao J, Piao X, Wu Y, Liang S, Han F, Liang Q, Shao S and Zhao D: Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling. Biomed Pharmacother. 127:1101512020. View Article : Google Scholar : PubMed/NCBI | |
Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y, Shi W, Li F, Xin T, Pang Q and Yi F: NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J Cereb Blood Flow Metab. 34:660–667. 2014. View Article : Google Scholar : PubMed/NCBI | |
Feng YS, Tan ZX, Wang MM, Xing Y, Dong F and Zhang F: Inhibition of NLRP3 inflammasome: A prospective target for the treatment of ischemic stroke. Front Cell Neurosci. 14:1552020. View Article : Google Scholar : PubMed/NCBI | |
Shi M, Chen J, Liu T, Dai W, Zhou Z, Chen L and Xie Y: Protective effects of remimazolam on cerebral ischemia/reperfusion injury in rats by inhibiting of NLRP3 inflammasome-dependent pyroptosis. Drug Des Devel Ther. 16:413–423. 2022. View Article : Google Scholar : PubMed/NCBI | |
Ye Y, Jin T, Zhang X, Zeng Z, Ye B, Wang J, Zhong Y, Xiong X and Gu L: Meisoindigo protects against focal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage polarization via TLR4/NF-κB signaling pathway. Front Cell Neurosci. 13:5532019. View Article : Google Scholar | |
He Z, Ning N, Zhou Q, Khoshnam SE and Farzaneh M: Mitochondria as a therapeutic target for ischemic stroke. Free Radic Biol Med. 146:45–58. 2020. View Article : Google Scholar | |
Chen Y, Zhou Z and Min W: Mitochondria, oxidative stress and innate immunity. Front Physiol. 9:14872018. View Article : Google Scholar : PubMed/NCBI | |
Meyers AK and Zhu X: The NLRP3 inflammasome: Metabolic regulation and contribution to inflammaging. Cells. 9:18082020. View Article : Google Scholar : | |
Bauernfeind F, Bartok E, Rieger A, Franchi L, Nunez G and Hornung V: Cutting edge: Reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol. 187:613–617. 2011. View Article : Google Scholar : PubMed/NCBI | |
Paik S, Kim JK, Silwal P, Sasakawa C and Jo EK: An update on the regulatory mechanisms of NLRP3 inflammasome activation. Cell Mol Immunol. 18:1141–1160. 2021. View Article : Google Scholar : PubMed/NCBI | |
Ren GM, Li J, Zhang XC, Wang Y, Xiao Y, Zhang XY, Liu X, Zhang W, Ma WB, Zhang J, et al: Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases. Sci Immunol. 6:eabe29332021. View Article : Google Scholar | |
Ren JD, Wu XB, Jiang R, Hao DP and Liu Y: Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species. Biochim Biophys Acta. 1863:50–55. 2016. View Article : Google Scholar | |
Wang Y, Shi P, Chen Q, Huang Z, Zou D, Zhang J, Gao X and Lin Z: Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol. 11:1069–1082. 2019. View Article : Google Scholar : PubMed/NCBI | |
Heid ME, Keyel PA, Kamga C, Shiva S, Watkins SC and Salter RD: Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 191:5230–5238. 2013. View Article : Google Scholar : PubMed/NCBI | |
Qiu Z, He Y, Ming H, Lei S, Leng Y and Xia ZY: Lipopolysaccharide (LPS) aggravates high glucose- and hypoxia/reoxygenation-induced injury through activating ROS-Dependent NLRP3 inflammasome-mediated pyroptosis in H9C2 cardiomyocytes. J Diabetes Res. 2019:81518362019. View Article : Google Scholar : PubMed/NCBI | |
Liu X, Zhang X, Ding Y, Zhou W, Tao L, Lu P, Wang Y and Hu R: Nuclear factor E2-Related Factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming. Antioxid Redox Signal. 26:28–43. 2017. View Article : Google Scholar : | |
Juliana C, Fernandes-Alnemri T, Kang S, Farias A, Qin F and Alnemri ES: Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem. 287:36617–36622. 2012. View Article : Google Scholar : PubMed/NCBI | |
Krysko DV, Agostinis P, Krysko O, Garg AD, Bachert C, Lambrecht BN and Vandenabeele P: Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. Trends Immunol. 32:157–164. 2011. View Article : Google Scholar : PubMed/NCBI | |
Arias-Cartin R, Grimaldi S, Arnoux P, Guigliarelli B and Magalon A: Cardiolipin binding in bacterial respiratory complexes: Structural and functional implications. Biochim Biophys Acta. 1817:1937–1949. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ji J, Baart S, Vikulina AS, Clark RS, Anthonymuthu TS, Tyurin VA, Du L, St Croix CM, Tyurina YY, Lewis J, et al: Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion. J Cereb Blood Flow Metab. 35:319–328. 2015. View Article : Google Scholar : | |
Liu J, Wang T, He K, Xu M and Gong JP: Cardiolipin inhibitor ameliorates the non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation. Eur Rev Med Pharmacol Sci. 23:8158–8167. 2019.PubMed/NCBI | |
Szeto HH, Liu S, Soong Y, Seshan SV, Cohen-Gould L, Manichev V, Feldman LC and Gustafsson T: Mitochondria protection after acute ischemia prevents prolonged upregulation of IL-1β and IL-18 and arrests CKD. J Am Soc Nephrol. 28:1437–1449. 2017. View Article : Google Scholar | |
Carinci M, Vezzani B, Patergnani S, Ludewig P, Lessmann K, Magnus T, Casetta I, Pugliatti M, Pinton P and Giorgi C: Different roles of mitochondria in cell death and inflammation: Focusing on mitochondrial quality control in ischemic stroke and reperfusion. Biomedicines. 9:1692021. View Article : Google Scholar : PubMed/NCBI | |
Yabal M, Calleja DJ, Simpson DS and Lawlor KE: Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation. J Leukoc Biol. 105:377–399. 2019. View Article : Google Scholar | |
Englander EW, Greeley GJ, Wang G, Perez-Polo JR and Lee HM: Hypoxia-induced mitochondrial and nuclear DNA damage in the rat brain. J Neurosci Res. 58:262–269. 1999. View Article : Google Scholar : PubMed/NCBI | |
Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, et al: Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 36:401–414. 2012. View Article : Google Scholar : PubMed/NCBI | |
Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, et al: Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 12:222–2230. 2011. View Article : Google Scholar | |
Lara PC, Macias-Verde D and Burgos-Burgos J: Age-induced NLRP3 inflammasome over-activation increases lethality of SARS-CoV-2 pneumonia in elderly patients. Aging Dis. 11:756–762. 2020. View Article : Google Scholar : | |
Fu L, Zhang DX, Zhang LM, Song YC, Liu FH, Li Y, Wang XP, Zheng WC, Wang XD, Gui CX, et al: Exogenous carbon monoxide protects against mitochondrial DNAinduced hippocampal pyroptosis in a model of hemorrhagic shock and resuscitation. Int J Mol Med. 45:1176–1186. 2020. | |
Simon R, Meller R, Yang T, Pearson A and Wilson G: Enhancing base excision repair of mitochondrial DNA to reduce ischemic injury following reperfusion. Transl Stroke Res. 10:664–671. 2019. View Article : Google Scholar : | |
Gomez-Suaga P, Bravo-San PJ, Gonzalez-Polo RA, Fuentes JM and Niso-Santano M: ER-mitochondria signaling in Parkinson's disease. Cell Death Dis. 9:3372018. View Article : Google Scholar : PubMed/NCBI | |
Tubbs E, Theurey P, Vial G, Bendridi N, Bravard A, Chauvin MA, Ji-Cao J, Zoulim F, Bartosch B, Ovize M, et al: Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance. Diabetes. 63:3279–3294. 2014. View Article : Google Scholar : PubMed/NCBI | |
Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, et al: Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci. 24:2143–2152. 2011. View Article : Google Scholar | |
Elliott EI, Miller AN, Banoth B, Iyer SS, Stotland A, Weiss JP, Gottlieb RA, Sutterwala FS and Cassel SL: Cutting Edge: Mitochondrial assembly of the NLRP3 inflammasome complex is initiated at priming. J Immunol. 200:3047–3052. 2018. View Article : Google Scholar : PubMed/NCBI | |
Hamilton C and Anand PK: Right place, right time: Localisation and assembly of the NLRP3 inflammasome. F1000Res. 8:F1000 Faculty Rev-676. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhou R, Yazdi AS, Menu P and Tschopp J: A role for mitochondria in NLRP3 inflammasome activation. Nature. 469:221–225. 2011. View Article : Google Scholar | |
Gu J, Zhang T, Guo J, Chen K, Li H and Wang J: PINK1 activation and translocation to mitochondria-associated membranes mediates mitophagy and protects against hepatic ischemia/reperfusion injury. Shock. 54:783–793. 2020. View Article : Google Scholar : PubMed/NCBI | |
Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, et al: Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke. Eur Heart J. 36:1590–1600. 2015. View Article : Google Scholar : PubMed/NCBI | |
Thoudam T, Jeon JH, Ha CM and Lee IK: Role of Mitochondria-Associated endoplasmic reticulum membrane in inflammation-mediated metabolic diseases. Mediators Inflamm. 2016:18514202016. View Article : Google Scholar | |
Fu MM and Holzbaur EL: Integrated regulation of motor-driven organelle transport by scaffolding proteins. Trends Cell Biol. 24:564–574. 2014. View Article : Google Scholar : PubMed/NCBI | |
Place DE and Kanneganti TD: Recent advances in inflammasome biology. Curr Opin Immunol. 50:32–38. 2018. View Article : Google Scholar : | |
Harkcom WT, Ghosh AK, Sung MS, Matov A, Brown KD, Giannakakou P and Jaffrey SR: NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents. Proc Natl Acad Sci USA. 111:E2443–E2452. 2014. View Article : Google Scholar : PubMed/NCBI | |
Nasoohi S, Ismael S and Ishrat T: Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication. Mol Neurobiol. 55:7900–7920. 2018. View Article : Google Scholar : PubMed/NCBI | |
Nagaraj K, Lapkina-Gendler L, Sarfstein R, Gurwitz D, Pasmanik-Chor M, Laron Z, Yakar S and Werner H: Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action. Proc Natl Acad Sci USA. 115:1045–1050. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhou R, Tardivel A, Thorens B, Choi I and Tschopp J: Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 11:136–140. 2010. View Article : Google Scholar | |
Fann DY, Lee SY, Manzanero S, Chunduri P, Sobey CG and Arumugam TV: Pathogenesis of acute stroke and the role of inflammasomes. Ageing Res Rev. 12:941–966. 2013. View Article : Google Scholar : PubMed/NCBI | |
Han Y, Xu X, Tang C, Gao P, Chen X, Xiong X, Yang M, Yang S, Zhu X, Yuan S, et al: Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis. Redox Biol. 16:32–46. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang BF and Yoshioka J: The Emerging role of thioredoxin-interacting protein in myocardial ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 22:219–229. 2017. View Article : Google Scholar : | |
Schafer MK, Pfeiffer A, Jaeckel M, Pouya A, Dolga AM and Methner A: Regulators of mitochondrial Ca(2+) homeostasis in cerebral ischemia. Cell Tissue Res. 357:395–405. 2014. View Article : Google Scholar | |
Missiroli S, Patergnani S, Caroccia N, Pedriali G, Perrone M, Previati M, Wieckowski MR and Giorgi C: Mitochondria-associated membranes (MAMs) and inflammation. Cell Death Dis. 9:3292018. View Article : Google Scholar : PubMed/NCBI | |
Lee GS, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL and Chae JJ: The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 492:123–127. 2012. View Article : Google Scholar : PubMed/NCBI | |
Wang C, Jia Q, Sun C and Jing C: Calcium sensing receptor contribute to early brain injury through the CaMKII/NLRP3 pathway after subarachnoid hemorrhage in mice. Biochem Biophys Res Commun. 530:651–657. 2020. View Article : Google Scholar : PubMed/NCBI | |
Triantafilou K, Hughes TR, Triantafilou M and Morgan BP: The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. J Cell Sci. 126:2903–2913. 2013.PubMed/NCBI | |
Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer AM and Horng T: Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci USA. 109:11282–11287. 2012. View Article : Google Scholar : PubMed/NCBI | |
Pan T, Zhu QJ, Xu LX, Ding X, Li JQ, Sun B, Hua J and Feng X: Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation. Neural Regen Res. 15:2154–2161. 2020. View Article : Google Scholar : PubMed/NCBI | |
Chen AQ, Fang Z, Chen XL, Yang S, Zhou YF, Mao L, Xia YP, Jin HJ, Li YN, You MF, et al: Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke. Cell Death Dis. 10:4872019. View Article : Google Scholar | |
Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS and Wang X: Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell. 54:133–146. 2014. View Article : Google Scholar : PubMed/NCBI | |
He S and Wang X: RIP kinases as modulators of inflammation and immunity. Nat Immunol. 19:912–922. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zeng F, Chen X, Cui W, Wen W, Lu F, Sun X, Ma D, Yuan Y, Li Z, Hou N, et al: RIPK1 Binds MCU to mediate induction of mitochondrial Ca2+ uptake and promotes colorectal oncogenesis. Cancer Res. 78:2876–2885. 2018. View Article : Google Scholar : PubMed/NCBI | |
Jiao Y, Wang J, Zhang H, Cao Y, Qu Y, Huang S, Kong X, Song C, Li J, Li Q, et al: Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke. J Cell Mol Med. 24:12585–12598. 2020. View Article : Google Scholar : PubMed/NCBI | |
Deng XX, Li SS and Sun FY: Necrostatin-1 prevents necroptosis in brains after ischemic stroke via inhibition of RIPK1-Mediated RIPK3/MLKL signaling. Aging Dis. 10:807–817. 2019. View Article : Google Scholar : PubMed/NCBI | |
Park S, Won JH, Hwang I, Hong S, Lee HK and Yu JW: Defective mitochondrial fission augments NLRP3 inflammasome activation. Sci Rep. 5:154892015. View Article : Google Scholar : PubMed/NCBI | |
Xie JH, Li YY and Jin J: The essential functions of mitochondrial dynamics in immune cells. Cell Mol Immunol. 17:712–721. 2020. View Article : Google Scholar : PubMed/NCBI | |
Ren L, Chen X, Chen X, Li J, Cheng B and Xia J: Mitochondrial dynamics: Fission and fusion in fate determination of mesenchymal stem cells. Front Cell Dev Biol. 8:5800702020. View Article : Google Scholar : PubMed/NCBI | |
Szabadkai G, Simoni AM, Chami M, Wieckowski MR, Youle RJ and Rizzuto R: Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. Mol Cell. 16:59–68. 2004. View Article : Google Scholar : PubMed/NCBI | |
Flippo KH, Gnanasekaran A, Perkins GA, Ajmal A, Merrill RA, Dickey AS, Taylor SS, McKnight GS, Chauhan AK, Usachev YM and Strack S: AKAP1 protects from cerebral ischemic stroke by inhibiting Drp1-dependent mitochondrial fission. J Neurosci. 38:8233–8242. 2018. View Article : Google Scholar : PubMed/NCBI | |
Guo M, Wang X, Zhao Y, Yang Q, Ding H, Dong Q, Chen X and Cui M: Ketogenic diet improves brain ischemic tolerance and inhibits NLRP3 inflammasome activation by preventing Drp1-Mediated mitochondrial fission and endoplasmic reticulum stress. Front Mol Neurosci. 11:862018. View Article : Google Scholar : | |
He J and Zhang X: miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke. Folia Neuropathol. 58:22–29. 2020. View Article : Google Scholar | |
Zhang X, Yan H, Yuan Y, Gao J, Shen Z, Cheng Y, Shen Y, Wang RR, Wang X, Hu WW, et al: Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy. 9:1321–1333. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Yu S, Li J, Li H, Jiang H, Xiao P, Pan Y, Zheng J, Yu L and Jiang J: Protective role of N-acetyl-l-tryptophan against hepatic ischemia-reperfusion injury via the RIP2/caspase-1/IL-1beta signaling pathway. Pharm Biol. 57:385–391. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Tian J, Qiao X, Su X, Mi Y, Zhang R and Li R: Intermedin protects against renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress. BMC Nephrol. 16:1692015. View Article : Google Scholar : PubMed/NCBI | |
He Q, Li Z, Meng C, Wu J, Zhao Y and Zhao J: Parkin-dependent mitophagy is required for the inhibition of ATF4 on NLRP3 inflammasome activation in cerebral ischemia-reperfusion injury in rats. Cells. 8:8972019. View Article : Google Scholar : | |
Yang J, Chen Y and Pang Y: Occurrence of mitochondrial autophagy and nlrp3 inflammatory bodies in cerebral ischemia-reperfusion injury and its correlation with neuroinflammatory response. Acta Medica Mediterranea. 37:1033–1037. 2021. | |
Su SH, Wu YF, Lin Q, Wang DP and Hai J: URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion. J Neuroinflammation. 16:2602019. View Article : Google Scholar : PubMed/NCBI | |
Fan Y, Zhu S, Wang J, Zhao Y and Wang X: Propofol protects against oxygen/glucose deprivationinduced cell injury via gap junction inhibition in astrocytes. Mol Med Rep. 22:2896–2904. 2020.PubMed/NCBI | |
Cai Y, Guo H, Fan Z, Zhang X, Wu D, Tang W, Gu T, Wang S, Yin A, Tao L, et al: Glycogenolysis is crucial for astrocytic glycogen accumulation and brain damage after reperfusion in ischemic stroke. iScience. 23:1011362020. View Article : Google Scholar : PubMed/NCBI | |
Gao L, Liu F, Hou PP, Manaenko A, Xiao ZP, Wang F, Xu TL and Hu Q: Neurons release injured mitochondria as 'Help-Me' signaling after ischemic stroke. Front Aging Neurosci. 14:7857612022. View Article : Google Scholar | |
Jiang D, Gao F, Zhang Y, Wong DS, Li Q, Tse HF, Xu G, Yu Z and Lian Q: Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage. Cell Death Dis. 7:e24672016. View Article : Google Scholar : PubMed/NCBI | |
Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA and Eide PK: Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients. Fluids Barriers CNS. 16:392019. View Article : Google Scholar : | |
Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, Shen Y, Wang X, Feng GS, Sun Y and Xu Q: Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 8:21682017. View Article : Google Scholar : | |
Aoki Y, Huang Z, Thomas SS, Bhide PG, Huang I, Moskowitz MA and Reeves SA: Increased susceptibility to ischemia-induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2. FASEB J. 14:1965–1973. 2000. View Article : Google Scholar : PubMed/NCBI | |
Zou X, Xie L, Wang W, Zhao G, Tian X and Chen M: FK866 alleviates cerebral pyroptosis and inflammation mediated by Drp1 in a rat cardiopulmonary resuscitation model. Int Immunopharmacol. 89:1070322020. View Article : Google Scholar : PubMed/NCBI | |
Dong J, Bobe G, Guan Y, Li G, Zuo R, Shu X, Wang Y, Sun X, Chen X and Li X: Mitochondrial membrane protein mitofusin 2 as a potential therapeutic target for treating free fatty acid-induced hepatic inflammation in dairy cows during early lactation. J Dairy Sci. 103:5561–5574. 2020. View Article : Google Scholar : PubMed/NCBI | |
Peng C, Rao W, Zhang L, Wang K, Hui H, Wang L, Su N, Luo P, Hao YL, Tu Y, et al: Mitofusin 2 ameliorates hypoxia-induced apoptosis via mitochondrial function and signaling pathways. Int J Biochem Cell Biol. 69:29–40. 2015. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Chen T, Ma X, Huang W, Huang Q, Liu K and Liang H: Progress on nuclear factor-E2 related factor 2 transcription factors in sepsis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 30:810–814. 2018.In Chinese. PubMed/NCBI | |
Zhao C, Gillette DD, Li X, Zhang Z and Wen H: Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation. J Biol Chem. 289:17020–17029. 2014. View Article : Google Scholar : PubMed/NCBI | |
Anandhan A, Nguyen N, Syal A, Dreher LA, Dodson M, Zhang DD and Madhavan L: NRF2 loss accentuates Parkinsonian pathology and behavioral dysfunction in human α-synuclein overexpressing mice. Aging Dis. 12:964–982. 2021. View Article : Google Scholar : PubMed/NCBI | |
Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S and Kong AN: Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol. 76:1485–1489. 2008. View Article : Google Scholar | |
Xu X, Zhang L, Ye X, Hao Q, Zhang T, Cui G and Yu M: Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion. Inflamm Res. 67:57–65. 2018. View Article : Google Scholar | |
Xu B, Zhang J, Strom J, Lee S and Chen QM: Myocardial ischemic reperfusion induces de novo Nrf2 protein translation. Biochim Biophys Acta. 1842:1638–1647. 2014. View Article : Google Scholar : PubMed/NCBI | |
Yu J, Wang WN, Matei N, Li X, Pang JW, Mo J, Chen SP, Tang JP, Yan M and Zhang JH: Ezetimibe attenuates oxidative stress and neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats. Oxid Med Cell Longev. 2020:47172582020. View Article : Google Scholar : PubMed/NCBI | |
Hou Y, Wang Y, He Q, Li L, Xie H, Zhao Y and Zhao J: Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury. Behav Brain Res. 336:32–39. 2018. View Article : Google Scholar | |
Zhang C, He M, Ni L, He K, Su K, Deng Y, Li Y and Xia H: The role of arachidonic acid metabolism in myocardial ischemia-reperfusion injury. Cell Biochem Biophys. 78:255–265. 2020. View Article : Google Scholar : PubMed/NCBI | |
Shi Y, Peng XH, Li X, Luo GP and Wu MF: Neuroprotective role of dexmedetomidine pretreatment in cerebral ischemia injury via ADRA2A-mediated phosphorylation of ERK1/2 in adult rats. Exp Ther Med. 16:5201–5209. 2018.PubMed/NCBI | |
Liu F, Lu J, Manaenko A, Tang J and Hu Q: Mitochondria in Ischemic Stroke: New Insight and Implications. Aging Dis. 9:924–937. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Li R, Wang X, Fu Q and Ma S: Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome. Neurosci Lett. 600:182–187. 2015. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Li J, Li S, Li Y, Wang X, Liu B, Fu Q and Ma S: Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol Appl Pharmacol. 286:53–63. 2015. View Article : Google Scholar : PubMed/NCBI | |
Cao G, Jiang N, Hu Y, Zhang Y, Wang G, Yin M, Ma X, Zhou K, Qi J, Yu B and Kou J: Ruscogenin attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Int J Mol Sci. 17:14182016. View Article : Google Scholar : | |
Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB and Fagan SC: Thioredoxin-interacting protein: A novel target for neuroprotection in experimental thromboembolic stroke in mice. Mol Neurobiol. 51:766–778. 2015. View Article : Google Scholar | |
Ismael S, Nasoohi S, Yoo A, Ahmed HA and Ishrat T: Tissue plasminogen activator promotes TXNIP-NLRP3 inflammasome activation after hyperglycemic stroke in mice. Mol Neurobiol. 57:2495–2508. 2020. View Article : Google Scholar : PubMed/NCBI | |
Liu T, Wang W, Liu M, Ma Y, Mu F, Feng X, Zhang Y, Guo C, Ding Y and Wen A: Z-Guggulsterone alleviated oxidative stress and inflammation through inhibiting the TXNIP/NLRP3 axis in ischemic stroke. Int Immunopharmacol. 89:1070942020. View Article : Google Scholar : PubMed/NCBI | |
Yang W, Chen X, Pan J, Ge H, Yin K, Wu Z, Li X, Sha D and Xu Y: Malibatol A protects against brain injury through reversing mitochondrial dysfunction in experimental stroke. Neurochem Int. 80:33–40. 2015. View Article : Google Scholar | |
Gao XJ, Xie GN, Liu L, Fu ZJ, Zhang ZW and Teng LZ: Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury. Exp Ther Med. 14:841–847. 2017. View Article : Google Scholar : PubMed/NCBI | |
Lu Y, Xiao G and Luo W: Minocycline suppresses NLRP3 inflammasome activation in experimental ischemic stroke. Neuroimmunomodulation. 23:230–238. 2016. View Article : Google Scholar : PubMed/NCBI | |
Qiu J, Wang M, Zhang J, Cai Q, Lu D, Li Y, Dong Y, Zhao T and Chen H: The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling. Int Immunopharmacol. 40:492–500. 2016. View Article : Google Scholar : PubMed/NCBI | |
Peng J, Deng X, Huang W, Yu JH, Wang JX, Wang JP, Yang SB, Liu X, Wang L, Zhang Y, et al: Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway. Mol Immunol. 91:185–194. 2017. View Article : Google Scholar : PubMed/NCBI | |
Qin YY, Li M, Feng X, Wang J, Cao L, Shen XK, Chen J, Sun M, Sheng R, Han F and Qin ZH: Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke. Free Radic Biol Med. 104:333–345. 2017. View Article : Google Scholar : PubMed/NCBI | |
Safakheil M and Safakheil H: The effect of exosomes derived from bone marrow stem cells in combination with rosuvastatin on functional recovery and neuroprotection in rats after ischemic stroke. J Mol Neurosci. 70:724–737. 2020. View Article : Google Scholar : PubMed/NCBI | |
Barakat W, Fahmy A, Askar M and El-Kannishy S: Effectiveness of arginase inhibitors against experimentally induced stroke. Naunyn Schmiedebergs Arch Pharmacol. 391:603–612. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Guan X, Gao CL, Ruan W, Zhao S, Kai G, Li F and Pang T: Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis. Pharmacol Res. 169:1056402021. View Article : Google Scholar | |
Hu J, Zeng C, Wei J, Duan F, Liu S, Zhao Y and Tan H: The combination of Panax ginseng and Angelica sinensis alleviates ischemia brain injury by suppressing NLRP3 inflammasome activation and microglial pyroptosis. Phytomedicine. 76:1532512020. View Article : Google Scholar : PubMed/NCBI | |
Yao Z, Liu N, Zhu X, Wang L, Zhao Y, Liu Q, Gao C and Li J: Subanesthetic isoflurane abates ROS-activated MAPK/NF-κB signaling to repress ischemia-induced microglia inflammation and brain injury. Aging (Albany NY). 12:26121–26139. 2020. View Article : Google Scholar | |
Lin KC, Chen KH, Wallace CG, Chen YL, Ko SF, Lee MS and Yip HK: Combined therapy with hyperbaric oxygen and melatonin effectively reduce brain infarct volume and preserve neurological function after acute ischemic infarct in rat. J Neuropathol Exp Neurol. 78:949–960. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yang M, Lv Y, Tian X, Lou J, An R, Zhang Q, Li M, Xu L and Dong Z: Neuroprotective effect of β-caryophyllene on cerebral ischemia-reperfusion injury via regulation of necroptotic neuronal death and inflammation: In vivo and in vitro. Front Neurosci. 11:5832017. View Article : Google Scholar | |
Zhong KL, Lu MY, Liu F, Mei Y, Zhang XJ, Zhang H, Zan J, Sun XO and Tan W: Isosteviol sodium protects neural cells against hypoxia-induced apoptosis through inhibiting MAPK and NF-κB pathways. J Stroke Cerebrovasc Dis. 28:175–184. 2019. View Article : Google Scholar | |
Turovskaya MV, Gaidin SG, Mal'Tseva VN, Zinchenko VP and Turovsky EA: Taxifolin protects neurons against ischemic injury in vitro via the activation of antioxidant systems and signal transduction pathways of GABAergic neurons. Mol Cell Neurosci. 96:10–24. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhao P, Chang RY, Liu N, Wang J, Zhou R, Qi X, Liu Y, Ma L, Niu Y, Sun T, et al: Neuroprotective effect of oxysophocarpine by modulation of MAPK pathway in rat hippocampal neurons subject to oxygen-glucose deprivation and reperfusion. Cell Mol Neurobiol. 38:529–540. 2018. View Article : Google Scholar | |
Wu D, Chen Y, Sun Y, Gao Q, Li H, Yang Z, Wang Y, Jiang X and Yu B: Target of MCC950 in Inhibition of NLRP3 inflammasome activation: A literature review. Inflammation. 43:17–23. 2020. View Article : Google Scholar | |
Coll RC, Hill JR, Day CJ, Zamoshnikova A, Boucher D, Massey NL, Chitty JL, Fraser JA, Jennings MP, Robertson AAB and Schroder K: MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nat Chem Biol. 15:556–559. 2019. View Article : Google Scholar : PubMed/NCBI | |
Jiao J, Zhao G, Wang Y, Ren P and Wu M: MCC950, a selective inhibitor of NLRP3 inflammasome, reduces the inflammatory response and improves neurological outcomes in mice model of spinal cord injury. Front Mol Biosci. 7:372020. View Article : Google Scholar : PubMed/NCBI | |
Joaquim LS, Danielski LG, Bonfante S, Biehl E, Mathias K, Denicol T, Bagio E, Lanzzarin EV, Machado RS, Bernades GC, et al: NLRP3 inflammasome activation increases brain oxidative stress after transient global cerebral ischemia in rats. Int J Neurosci. 1–14. 2021.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
Chen H, Guan B, Chen S, Yang D and Shen J: Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia. Free Radic Biol Med. 165:171–183. 2021. View Article : Google Scholar : PubMed/NCBI | |
Dwivedi DK and Jena GB: NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: Studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway. Naunyn Schmiedebergs Arch Pharmacol. 393:705–716. 2020. View Article : Google Scholar | |
Zhu S, Gao X, Huang K, Gu Y, Hu Y, Wu Y, Ji Z, Wang Q and Pan S: Glibenclamide enhances the therapeutic benefits of early hypothermia after severe stroke in rats. Aging Dis. 9:685–695. 2018. View Article : Google Scholar : PubMed/NCBI | |
Gueven N, Ravishankar P, Eri R and Rybalka E: Idebenone: When an antioxidant is not an antioxidant. Redox Biol. 38:1018122021. View Article : Google Scholar | |
Jiang W, Geng H, Lv X, Ma J, Liu F, Lin P and Yan C: Idebenone Protects against atherosclerosis in apolipoprotein E-Deficient mice via activation of the SIRT3-SOD2-mtROS pathway. Cardiovasc Drugs Ther. 35:1129–1145. 2021. View Article : Google Scholar | |
Akopova O, Kolchinskaya L, Nosar V, Mankovska I and Sagach V: Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale. BMC Mol Cell Biol. 21:312020. View Article : Google Scholar : PubMed/NCBI | |
Liu D, Lu C, Wan R, Auyeung WW and Mattson MP: Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release. J Cereb Blood Flow Metab. 22:431–443. 2002. View Article : Google Scholar : PubMed/NCBI | |
Lei X, Lei L, Zhang Z and Cheng Y: Diazoxide inhibits of ER stressmediated apoptosis during oxygenglucose deprivation in vitro and cerebral ischemiareperfusion in vivo. Mol Med Rep. 17:8039–8046. 2018.PubMed/NCBI | |
Mishra SR, Mahapatra KK, Behera BP, Patra S, Bhol CS, Panigrahi DP, Praharaj PP, Singh A, Patil S, Dhiman R and Bhutia SK: Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics. Int J Biochem Cell Biol. 136:1060132021. View Article : Google Scholar : PubMed/NCBI | |
Nógrádi B, Nyúl-Tóth Á, Kozma M, Molnár K, Patai R, Siklós L, Wilhelm I and Krizbai IA: Upregulation of nucleotide-binding oligomerization Domain-, LRR- and pyrin domain-containing protein 3 in motoneurons following peripheral nerve injury in mice. Front Pharmacol. 11:5841842020. View Article : Google Scholar : PubMed/NCBI | |
Gong Z, Pan J, Shen Q, Li M and Peng Y: Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury. J Neuroinflammation. 15:2422018. View Article : Google Scholar : PubMed/NCBI | |
Kondoh T, Uneyama H, Nishino H and Torii K: Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats. Life Sci. 72:583–590. 2002. View Article : Google Scholar : PubMed/NCBI | |
Kilic E, Caglayan B and Caglar BM: Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke. Turk J Med Sci. 50:1655–1664. 2020. View Article : Google Scholar : PubMed/NCBI | |
Fan W, He Y, Guan X, Gu W, Wu Z, Zhu X, Huang F and He H: Involvement of the nitric oxide in melatonin-mediated protection against injury. Life Sci. 200:142–147. 2018. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Jiang S, Dong Y, Fan C, Zhao L, Yang X, Li J, Di S, Yue L, Liang G, et al: Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice. J Pineal Res. 58:61–70. 2015. View Article : Google Scholar | |
Ramos E, Patino P, Reiter RJ, Gil-Martín E, Marco-Contelles J, Parada E, de Los Rios C, Romero A and Egea J: Ischemic brain injury: New insights on the protective role of melatonin. Free Radic Biol Med. 104:32–53. 2017. View Article : Google Scholar : PubMed/NCBI | |
Paredes SD, Rancan L, Kireev R, González A, Louzao P, González P, Rodríguez-Bobada C, García C, Vara E and Tresguerres JA: Melatonin counteracts at a transcriptional level the inflammatory and apoptotic response secondary to ischemic brain injury induced by middle cerebral artery blockade in aging rats. Biores Open Access. 4:407–416. 2015. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Figueroa BE, Stavrovskaya IG, Zhang Y, Sirianni AC, Zhu S, Day AL, Kristal BS and Friedlander RM: Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. Stroke. 40:1877–1885. 2009. View Article : Google Scholar : PubMed/NCBI | |
Gilani GS, Nimal RW, Mueller R and Mazza G: Effects of source of protein and supplementary extracted isoflavones and anthocyanins on longevity of Stroke-prone Spontaneously Hypertensive (SHRSP) rats. J Toxicol Sci. 34:335–341. 2009. View Article : Google Scholar : PubMed/NCBI | |
Song F, Zhu Y, Shi Z, Tian J, Deng X, Ren J, Andrews MC, Ni H, Ling W and Yang Y: Plant food anthocyanins inhibit platelet granule secretion in hypercholesterolaemia: Involving the signalling pathway of PI3K-Akt. Thromb Haemost. 112:981–991. 2014. View Article : Google Scholar : PubMed/NCBI | |
Feng R, Ni HM, Wang SY, Tourkova IL, Shurin MR, Harada H and Yin XM: Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. J Biol Chem. 282:13468–13476. 2007. View Article : Google Scholar : PubMed/NCBI | |
Dreiseitel A, Schreier P, Oehme A, Locher S, Rogler G, Piberger H, Hajak G and Sand PG: Inhibition of proteasome activity by anthocyanins and anthocyanidins. Biochem Biophys Res Commun. 372:57–61. 2008. View Article : Google Scholar : PubMed/NCBI | |
Cai Y, Li X, Pan Z, Zhu Y, Tuo J, Meng Q, Dai G, Yang G and Pan Y: Anthocyanin ameliorates hypoxia and ischemia induced inflammation and apoptosis by increasing autophagic flux in SH-SY5Y cells. Eur J Pharmacol. 883:1733602020. View Article : Google Scholar : PubMed/NCBI | |
Pan Z, Cui M, Dai G, Yuan T, Li Y, Ji T and Pan Y: Protective effect of anthocyanin on neurovascular unit in cerebral ischemia/reperfusion injury in rats. Front Neurosci. 12:9472018. View Article : Google Scholar | |
Liobikas J, Skemiene K, Trumbeckaite S and Borutaite V: Anthocyanins in cardioprotection: A path through mitochondria. Pharmacol Res. 113:808–815. 2016. View Article : Google Scholar : PubMed/NCBI | |
Min J, Yu SW, Baek SH, Nair KM, Bae ON, Bhatt A, Kassab M, Nair MG and Majid A: Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia. Neurosci Lett. 500:157–161. 2011. View Article : Google Scholar : PubMed/NCBI | |
Cui HX, Chen JH, Li JW, Cheng FR and Yuan K: Protection of anthocyanin from myrica rubra against cerebral ischemia-reperfusion injury via modulation of the TLR4/NF-κB and NLRP3 pathways. Moleculs. 23:17882018. View Article : Google Scholar | |
Gutierrez-Vargas JA, Munera A and Cardona-Gomez GP: CDK5 knockdown prevents hippocampal degeneration and cognitive dysfunction produced by cerebral ischemia. J Cereb Blood Flow Metab. 35:1937–1949. 2015. View Article : Google Scholar : PubMed/NCBI | |
Xue LX, Zhang T, Zhao YW, Geng Z, Chen JJ and Chen H: Efficacy and safety comparison of DL-3-n-butylphthalide and Cerebrolysin: Effects on neurological and behavioral outcomes in acute ischemic stroke. Exp Ther Med. 11:2015–2020. 2016. View Article : Google Scholar : PubMed/NCBI | |
Fagan SC, Waller JL, Nichols FT, Edwards DJ, Pettigrew LC, Clark WM, Hall CE, Switzer JA, Ergul A and Hess DC: Minocycline to improve neurologic outcome in stroke (MINOS): A dose-finding study. Stroke. 41:2283–2287. 2010. View Article : Google Scholar : PubMed/NCBI |