Open Access

Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)

  • Authors:
    • Xiaolu Zhang
    • Wenyun Zeng
    • Yue Zhang
    • Qun Yu
    • Miao Zeng
    • Jiali Gan
    • Wenlan Zhang
    • Xijuan Jiang
    • Huhu Li
  • View Affiliations

  • Published online on: April 7, 2022     https://doi.org/10.3892/ijmm.2022.5130
  • Article Number: 74
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Post‑ischemic neuroinflammation induced by the innate local immune response is a major pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of mortality and disability worldwide. NLR family pyrin domain containing (NLRP)3 inflammasome crucially mediates post‑ischemic inflammatory responses via its priming, activation and interleukin‑1β release during hypoxic‑ischemic brain damage. Mitochondrial dysfunctions are among the main hallmarks of several brain diseases, including ischemic stroke. In the present review, focus was addressed on the role of mitochondria in cerebral ischemic stroke while keeping NLRP3 inflammasome as a link. Under ischemia and hypoxia, mitochondria are capable of controlling NLRP3 inflammasome‑mediated neuroinflammation through mitochondrial released contents, mitochondrial localization and mitochondrial related proteins. Thus, inflammasome and mitochondria may be attractive targets to treat ischemic stroke as well as the several drugs that target the process of mitochondrial function to treat cerebral ischemic stroke. At present, certain drugs have already been studied in clinical trials.
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June-2022
Volume 49 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhang X, Zeng W, Zhang Y, Yu Q, Zeng M, Gan J, Zhang W, Jiang X and Li H: Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review). Int J Mol Med 49: 74, 2022
APA
Zhang, X., Zeng, W., Zhang, Y., Yu, Q., Zeng, M., Gan, J. ... Li, H. (2022). Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review). International Journal of Molecular Medicine, 49, 74. https://doi.org/10.3892/ijmm.2022.5130
MLA
Zhang, X., Zeng, W., Zhang, Y., Yu, Q., Zeng, M., Gan, J., Zhang, W., Jiang, X., Li, H."Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)". International Journal of Molecular Medicine 49.6 (2022): 74.
Chicago
Zhang, X., Zeng, W., Zhang, Y., Yu, Q., Zeng, M., Gan, J., Zhang, W., Jiang, X., Li, H."Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)". International Journal of Molecular Medicine 49, no. 6 (2022): 74. https://doi.org/10.3892/ijmm.2022.5130