Open Access

Insights regarding mitochondrial DNA copy number alterations in human cancer (Review)

  • Authors:
    • Siti Muslihah Abd Radzak
    • Siti Zulaikha Nashwa Mohd Khair
    • Farizan Ahmad
    • Azim Patar
    • Zamzuri Idris
    • Abdul Aziz Mohamed Yusoff
  • View Affiliations

  • Published online on: June 16, 2022     https://doi.org/10.3892/ijmm.2022.5160
  • Article Number: 104
  • Copyright: © Abd Radzak et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mitochondria are the critical organelles involved in various cellular functions. Mitochondrial biogenesis is activated by multiple cellular mechanisms which require a synchronous regulation between mitochondrial DNA (mtDNA) and nuclear DNA (nDNA). The mitochondrial DNA copy number (mtDNA‑CN) is a proxy indicator for mitochondrial activity, and its alteration reflects mitochondrial biogenesis and function. Despite the precise mechanisms that modulate the amount and composition of mtDNA, which have not been fully elucidated, mtDNA‑CN is known to influence numerous cellular pathways that are associated with cancer and as well as multiple other diseases. In addition, the utility of current technology in measuring mtDNA‑CN contributes to its extensive assessment of diverse traits and tumorigenesis. The present review provides an overview of mtDNA‑CN variations across human cancers and an extensive summary of the existing knowledge on the regulation and machinery of mtDNA‑CN. The current information on the advanced methods used for mtDNA‑CN assessment is also presented.
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August-2022
Volume 50 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Abd Radzak S, Mohd Khair SN, Ahmad F, Patar A, Idris Z and Mohamed Yusoff AA: Insights regarding mitochondrial DNA copy number alterations in human cancer (Review). Int J Mol Med 50: 104, 2022
APA
Abd Radzak, S., Mohd Khair, S.N., Ahmad, F., Patar, A., Idris, Z., & Mohamed Yusoff, A.A. (2022). Insights regarding mitochondrial DNA copy number alterations in human cancer (Review). International Journal of Molecular Medicine, 50, 104. https://doi.org/10.3892/ijmm.2022.5160
MLA
Abd Radzak, S., Mohd Khair, S. N., Ahmad, F., Patar, A., Idris, Z., Mohamed Yusoff, A. A."Insights regarding mitochondrial DNA copy number alterations in human cancer (Review)". International Journal of Molecular Medicine 50.2 (2022): 104.
Chicago
Abd Radzak, S., Mohd Khair, S. N., Ahmad, F., Patar, A., Idris, Z., Mohamed Yusoff, A. A."Insights regarding mitochondrial DNA copy number alterations in human cancer (Review)". International Journal of Molecular Medicine 50, no. 2 (2022): 104. https://doi.org/10.3892/ijmm.2022.5160