|
1
|
Sung H, Ferlay J, Siegel RL, Laversanne M,
Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020:
GLOBOCAN estimates of incidence and mortality worldwide for 36
cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Moon JJ, Lu A and Moon C: Role of genomic
instability in human carcinogenesis. Exp Biol Med (Maywood).
244:227–240. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Pikor L, Thu K, Vucic E and Lam W: The
detection and implication of genome instability in cancer. Cancer
Metastasis Rev. 32:341–352. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Yusoff AAM, Abdullah WSW, Khair SZNM and
Radzak SMA: A comprehensive overview of mitochondrial DNA 4977-bp
deletion in cancer studies. Oncol Rev. 13:4092019.PubMed/NCBI
|
|
5
|
Otto AM: Warburg effect(s)-a biographical
sketch of Otto Warburg and his impacts on tumor metabolism. Cancer
Metab. 4:52016. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Modica-Napolitano JS, Kulawiec M and Singh
K: Mitochondria and human cancer. Curr Mol Med. 7:121–131. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Chen EI: Mitochondrial dysfunction and
cancer metastasis. J Bioenerg Biomembr. 44:619–622. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Pedersen PL: Bioenergetics of cancer
cells-a brief orientation to this minireview series. J Bioenerg
Biomembr. 29:301–302. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Rempel A, Mathupala SP, Griffin CA,
Hawkins AL and Pedersen PL: Glucose catabolism in cancer cells:
Amplification of the gene encoding type II hexokinase. Cancer Res.
56:2468–2471. 1996.PubMed/NCBI
|
|
10
|
Wu M, Neilson A, Swift AL, Moran R,
Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J,
et al: Multiparameter metabolic analysis reveals a close link
between attenuated mitochondrial bioenergetic function and enhanced
glycolysis dependency in human tumor cells. Am J Physiol Cell
Physiol. 292:125–C136. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Radzak S, Khair Z, Ahmad F, Idris Z and
Yusoff A: Accumulation of mitochondrial DNA microsatellite
instability in Malaysian patients with primary central nervous
system tumors. Turk Neurosurg. 31:99–106. 2021.PubMed/NCBI
|
|
12
|
Campa D, Barrdahl M, Santoro A, Severi G,
Baglietto L, Omichessan H, Tumino R, Bueno-de-Mesquita HBA, Peeters
PH, Weiderpass E, et al: Mitochondrial DNA copy number variation,
leukocyte telomere length, and breast cancer risk in the European
prospective investigation into cancer and nutrition (EPIC) study.
Breast Cancer Res. 20:292018. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Dai JG, Zhang ZY, Liu QX and Min JX:
Mitochondrial genome microsatellite instability and copy number
alteration in lung carcinomas. Asian Pacific J Cancer Prev.
14:2393–2399. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kumar B, Bhat ZI, Bansal S, Saini S,
Naseem A, Wahabi K, Burman A, Kumar GT, Saluja SS and Rizvi MMA:
Association of mitochondrial copy number variation and T16189C
polymorphism with colorectal cancer in North Indian population.
Tumour Biol. 39:10104283177402962017. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zhao RZ, Jiang S, Zhang L and Yu ZB:
Mitochondrial electron transport chain, ROS generation and
uncoupling (Review). Int J Mol Med. 44:3–15. 2019.PubMed/NCBI
|
|
16
|
Zhu X, Mao Y, Huang T, Yan C, Yu F, Du J,
Dai J, Ma H and Jin G: High mitochondrial DNA copy number was
associated with an increased gastric cancer risk in a Chinese
population. Mol Carcinog. 56:2593–2600. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Gilkerson R, Bravo L, Garcia I, Gaytan N,
Herrera A, Maldonado A and Quintanilla B: The mitochondrial
nucleoid: Integrating mitochondrial DNA into cellular homeostasis.
Cold Spring Harb Perspect Biol. 5:a0110802013. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Facucho-Oliveira JM and St John JC: The
relationship between pluripotency and mitochondrial DNA
proliferation during early embryo development and embryonic stem
cell differentiation. Stem Cell Rev Rep. 5:140–158. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Montoya J, Christianson T, Levens D,
Rabinowitz M and Attardi G: Identification of initiation sites for
heavy-strand and light-strand transcription in human mitochondrial
DNA. Proc Natl Acad Sci USA. 79:7195–7199. 1982. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Clayton DA: Transcription and replication
of mitochondrial DNA. Hum Reprod. 15 (Suppl 2):S11–S17. 2000.
View Article : Google Scholar
|
|
21
|
Turnbull HE, Lax NZ, Diodato D, Ansorge O
and Turnbull DM: The mitochondrial brain: From mitochondrial genome
to neurodegeneration. Biochim Biophys Acta. 1802:111–121. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Chabi B, Mousson De Camaret B, Duborjal H,
Issartel JP and Stepien G: Quantification of mitochondrial DNA
deletion, depletion, and overreplication: Application to diagnosis.
Clin Chem. 49:1309–1317. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Castellani CA, Longchamps RJ, Sun J,
Guallar E and Arking DE: Thinking outside the nucleus:
Mitochondrial DNA copy number in health and disease. Mitochondrion.
53:214–223. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
D'Erchia AM, Atlante A, Gadaleta G, Pavesi
G, Chiara M, De Virgilio C, Manzari C, Mastropasqua F, Prazzoli GM,
Picardi E, et al: Tissue-specific mtDNA abundance from exome data
and its correlation with mitochondrial transcription, mass and
respiratory activity. Mitochondrion. 20:13–21. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Chen X, Prosser R, Simonetti S, Sadlock J,
Jagiello G and Schon EA: Rearranged mitochondrial genomes are
present in human oocytes. Am J Hum Genet. 57:239–247.
1995.PubMed/NCBI
|
|
26
|
Yusoff AA, Ahmad F, Idris Z, Jaafar H and
Abdullah JM: Understanding mitochondrial DNA in brain
tumorigenesis. Mol Considerations Evol Surg Manag Issues Treat
Patients with a Brain Tumor. 3–28. 2015.
|
|
27
|
Fontana GA and Gahlon HL: Mechanisms of
replication and repair in mitochondrial DNA deletion formation.
Nucleic Acids Res. 48:11244–11258. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Robberson DL, Kasamatsu H and Vinograd J:
Replication of mitochondrial DNA. Circular replicative
intermediates in mouse L cells. Proc Natl Acad Sci USA. 69:737–741.
1972. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Holt IJ, Lorimer HE and Jacobs HT: Coupled
leading-and lagging-strand synthesis of mammalian mitochondrial
DNA. Cell. 100:515–524. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Yasukawa T, Reyes A, Cluett TJ, Yang MY,
Bowmaker M, Jacobs HT and Holt IJ: Replication of vertebrate
mitochondrial DNA entails transient ribonucleotide incorporation
throughout the lagging strand. EMBO J. 25:5358–5371. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Clay Montier LL, Deng JJ and Bai Y: Number
matters: Control of mammalian mitochondrial DNA copy number. J
Genet Genomics. 36:125–131. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Falkenberg M: Mitochondrial DNA
replication in mammalian cells: Overview of the pathway. Essays
Biochem. 62:287–296. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Larsson NG, Wang J, Wilhelmsson H, Oldfors
A, Rustin P, Lewandoski M, Barsh GS and Clayton DA: Mitochondrial
transcription factor A is necessary for mtDNA maintenance and
embryogenesis in mice. Nat Genet. 18:231–236. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Kanki T, Ohgaki K, Gaspari M, Gustafsson
CM, Fukuoh A, Sasaki N, Hamasaki N and Kang D: Architectural role
of mitochondrial transcription factor A in maintenance of human
mitochondrial DNA. Mol Cell Biol. 24:9823–9834. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Ekstrand MI, Falkenberg M, Rantanen A,
Park CB, Gaspari M, Hultenby K, Rustin P, Gustafsson CM and Larsson
NG: Mitochondrial transcription factor A regulates mtDNA copy
number in mammals. Hum Mol Genet. 13:935–944. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Farge G, Mehmedovic M, Baclayon M, van den
Wildenberg SM, Roos WH, Gustafsson CM, Wuite GJ and Falkenberg M:
In vitro-reconstituted nucleoids can block mitochondrial DNA
replication and transcription. Cell Rep. 8:66–74. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Korhonen JA, Pham XH, Pellegrini M and
Falkenberg M: Reconstitution of a minimal mtDNA replisome in vitro.
EMBO J. 23:2423–2429. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Peter B and Falkenberg M: Twinkle and
other human mitochondrial DNA helicases: Structure, function and
disease. Genes (Basel). 11:4082020. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Korhonen JA, Gaspari M and Falkenberg M:
Twinkle has 5′ ->3′ DNA helicase activity and is specifically
stimulated by mitochondrial single-stranded DNA-binding protein. J
Biol Chem. 278:48627–48632. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Milenkovic D, Matic S, kühl I, Ruzzenente
B, Freyer C, Jemt E, Park CB, Falkenberg M and Larsson NG: Twinkle
is an essential mitochondrial helicase required for synthesis of
nascent D-loop strands and complete mtDNA replication. Hum Mol
Genet. 22:1983–1993. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Takamatsu C, Umeda S, Ohsato T, Ohno T,
Abe Y, Fukuoh A, Shinagawa H, Hamasaki N and Kang D: Regulation of
mitochondrial D-loops by transcription factor A and single-stranded
DNA-binding protein. EMBO Rep. 3:451–456. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Miralles Fusté J, Shi Y, Wanrooij S, Zhu
X, Jemt E, Persson Ö, Sabouri N, Gustafsson CM and Falkenberg M: In
vivo occupancy of mitochondrial single-stranded DNA binding protein
supports the strand displacement mode of DNA replication. PLoS
Genet. 10:e10048322014. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Datta A and Brosh RM Jr: New insights into
DNA helicases as druggable targets for cancer therapy. Front Mol
Biosci. 5:592018. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Ruhanen H, Borrie S, Szabadkai G,
Tyynismaa H, Jones AW, Kang D, Taanman JW and Yasukawa T:
Mitochondrial single-stranded DNA binding protein is required for
maintenance of mitochondrial DNA and 7S DNA but is not required for
mitochondrial nucleoid organisation. Biochim Biophys Acta.
1803:931–939. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Grzybowska-Szatkowska L and Slaska B:
Mitochondrial DNA and carcinogenesis (review). Mol Med Rep.
6:923–930. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Reddy TV, Govatati S, Deenadayal M,
Sisinthy S and Bhanoori M: Impact of mitochondrial DNA copy number
and displacement loop alterations on polycystic ovary syndrome risk
in south Indian women. Mitochondrion. 44:35–40. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Li HL, Slone J, Fei L and Huang T:
Mitochondrial DNA variants and common diseases: A mathematical
model for the diversity of age-related mtDNA mutations. Cells.
8:6082019. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Nicholls TJ and Minczuk M: In D-loop: 40
years of mitochondrial 7S DNA. Exp Gerontol. 56:175–181. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Lee HC, Li SH, Lin JC, Wu CC, Yeh DC and
Wei YH: Somatic mutations in the D-loop and decrease in the copy
number of mitochondrial DNA in human hepatocellular carcinoma.
Mutat Res. 547:71–78. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Yu M, Wan Y and Zou Q: Decreased copy
number of mitochondrial DNA in Ewing's sarcoma. Clin Chim Acta.
411:679–683. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Yu M, Zhou Y, Shi Y, Ning L, Yang Y, Wei X
and Zhang N: Reduced mitochondrial DNA copy number is correlated
with tumor progression and prognosis in Chinese breast cancer
patients. IUBMB Life. 59:450–457. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Bai R, Chang J, Yeh K, Lou MA, Lu JF, Tan
DJ, Liu H and Wong LJ: Mitochondrial DNA content varies with
pathological characteristics of breast cancer. J Oncol.
2011:4961892011. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Yusoff AAM, Radzak SMA and Khair SZNM:
Research highlights on contributions of mitochondrial DNA
microsatellite instability in solid cancers - an overview. Contemp
Oncol (Pozn). 26:8–26. 2022.PubMed/NCBI
|
|
54
|
Kazak L, Reyes A and Holt IJ: Minimizing
the damage : Repair pathways keep mitochondrial DNA intact. Nat Rev
Mol Cell Biol. 13:659–671. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Zhang D, Mott JL, Chang SW, Denniger G,
Feng Z and Zassenhaus HP: Construction of transgenic mice with
tissue-specific acceleration of mitochondrial DNA mutagenesis.
Genomics. 69:151–161. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Trifunovic A, Wredenberg A, Falkenberg M,
Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors
A, Wibom R, et al: Premature ageing in mice expressing defective
mitochondrial DNA polymerase. Nature. 429:417–423. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Spelbrink JN, Toivonen JM, Hakkaart GAJ,
Kurkela JM, Cooper HM, Lehtinen SK, Lecrenier N, Back JW, Speijer
D, Foury F and Jacobs HT: In vivo functional analysis of the human
mitochondrial DNA polymerase POLG expressed in cultured human
cells. J Biol Chem. 275:24818–24828. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Singh KK, Ayyasamy V, Owens KM, Koul MS
and Vujcic M: Mutations in mitochondrial DNA polymerase-gamma
promote breast tumorigenesis. J Hum Genet. 54:516–524. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Linkowska K, Jawien A, Marszałek A,
Skonieczna K and Grzybowski T: Searching for association of the CAG
repeat polymorphism in the mitochondrial DNA polymerase gamma gene
(POLG) with colorectal cancer. Acta Biochim Pol. 62:625–627. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Long X, Wang X, Chen Y, Guo X, Zhou F, Fan
Y, Ge N, Guo M, Zhang Z and Dong G: Polymorphisms in POLG were
associated with the prognosis and mtDNA content in hepatocellular
carcinoma patients. Bull Cancer. 104:500–507. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Spelbrink JN, Li FY, Tiranti V, Nikali K,
Yuan QP, Tariq M, Wanrooij S, Garrido N, Comi G, Morandi L, et al:
Human mitochondrial DNA deletions associated with mutations in the
gene encoding Twinkle, a phage T7 gene 4-like protein localized in
mitochondria. Nat Genet. 28:223–231. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Tyynismaa H, Sembongi H, Bokori-Brown M,
Granycome C, Ashley N, Poulton J, Jalanko A, Spelbrink JN, Holt IJ
and Suomalainen A: Twinkle helicase is essential for mtDNA
maintenance and regulates mtDNA copy number. Hum Mol Genet.
13:3219–3227. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Sanchez-Martinez A, Calleja M, Peralta S,
Matsushima Y, Hernandez-Sierra R, Whitworth AJ, Kaguni LS and
Garesse R: Modeling pathogenic mutations of human twinkle in
Drosophila suggests an apoptosis role in response to mitochondrial
defects. PLoS One. 7:e439542012. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Matsushima Y and Kaguni LS: Differential
phenotypes of active site and human autosomal dominant progressive
external ophthalmoplegia mutations in Drosophila mitochondrial DNA
helicase expressed in Schneider cells. J Biol Chem. 282:9436–9444.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Lin CS, Wang LS, Tsai CM and Wei YH: Low
copy number and low oxidative damage of mitochondrial DNA are
associated with tumor progression in lung cancer tissues after
neoadjuvant chemotherapy. Interact Cardiovasc Thorac Surg.
7:954–958. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Hu L, Yao X and Shen Y: Altered
mitochondrial DNA copy number contributes to human cancer risk:
Evidence from an updated meta-analysis. Sci Rep. 6:358592016.
View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Lee H, Lee JH, Kim DC, Hwang I, Kang YN,
Gwon GJ, Choi IJ and Kim S: Is mitochondrial DNA copy number
associated with clinical characteristics and prognosis in gastric
cancer? Asian Pacific J Cancer Prev. 16:87–90. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Han Y and Chen JZ: Oxidative stress
induces mitochondrial DNA damage and cytotoxicity through
independent mechanisms in human cancer cells. Biomed Res Int.
2013:8250652013. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Liu CS, Tsai CS, Kuo CL, Chen HW, Lii CK,
Ma YS and Wei YH: Oxidative stress-related alteration of the copy
number of mitochondrial DNA in human leukocytes. Free Radic Res.
37:1307–1317. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Al-Kafaji G and Golbahar J: High
glucose-induced oxidative stress increases the copy number of
mitochondrial DNA in human mesangial cells. Biomed Res Int.
2013:7549462013. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Guha M and Avadhani NG: Mitochondrial
retrograde signaling at the crossroads of tumor bioenergetics,
genetics and epigenetics. Mitochondrion. 13:577–591. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Corral M, Paris B, Baffet G, Tichonicky L,
Guguen-Guillouzo C, Kruh J and Defer N: Increased level of the
mitochondrial ND5 transcript in chemically induced rat hepatomas.
Exp Cell Res. 184:158–166. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Delsite RL, Rasmussen LJ, Rasmussen AK,
Kalen A, Goswami PC and Singh KK: Mitochondrial impairment is
accompanied by impaired oxidative DNA repair in the nucleus.
Mutagenesis. 18:497–503. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Suzuki S, Naito A, Asano T, Evans TT,
Reddy SAG and Higuchi M: Constitutive activation of AKT pathway
inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human
myelogenous leukemia ML-1a. Cancer Lett. 268:31–37. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Biswas G, Anandatheerthavarada HK, Zaidi M
and Avadhani NG: Mitochondria to nucleus stress signaling: A
distinctive mechanism of NFkappaB/Rel activation through
calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol.
161:507–519. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Lu T and Stark GR: Cytokine overexpression
and constitutive NFkappaB in cancer. Cell Cycle. 3:1114–1117. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Mei H, Sun S, Bai Y, Chen Y, Chai R and Li
H: Reduced mtDNA copy number increases the sensitivity of tumor
cells to chemotherapeutic drugs. Cell Death Dis. 6:e17102015.
View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Sun X, Zhan L, Chen Y, Wang G, He L, Wang
Q, Zhou F, Yang F, Wu J, Wu Y, et al: Increased mtDNA copy number
promotes cancer progression by enhancing mitochondrial oxidative
phosphorylation in microsatellite-stable colorectal cancer. Signal
Transduct Target Ther. 3:82018. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Moraes CT: What regulates mitochondrial
DNA copy number in animal cells? Trends Genet. 17:199–205. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Tang Y, Schon EA, Wilichowski E,
Vazquez-Memije ME, Davidson E and King MP: Rearrangements of human
mitochondrial DNA (mtDNA): New insights into the regulation of
mtDNA copy number and gene expression. Mol Biol Cell. 11:1471–1485.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Tang Y, Manfredi G, Hirano M and Schon EA:
Maintenance of human rearranged mitochondrial DNAs in long-term
cultured transmitochondrial cell lines. Mol Biol Cell.
11:2349–2358. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Kelly RD, Mahmud A, McKenzie M, Trounce IA
and St John JC: Mitochondrial DNA copy number is regulated in a
tissue specific manner by DNA methylation of the nuclear-encoded
DNA polymerase gamma A. Nucleic Acids Res. 40:10124–10138. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Lee W, Johnson J, Gough DJ, Donoghue J,
Cagnone GL, Vaghjiani V, Brown KA, Johns TG and St John JC:
Mitochondrial DNA copy number is regulated by DNA methylation and
demethylation of POLGA in stem and cancer cells and their
differentiated progeny. Cell Death Dis. 6:e16642015. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Dickinson A, Yeung KY, Donoghue J, Baker
MJ, Kelly RD, McKenzie M, Johns TG and St John JC: The regulation
of mitochondrial DNA copy number in glioblastoma cells. Cell Death
Differ. 20:1644–1653. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Sun X and St John JC: Modulation of
mitochondrial DNA copy number in a model of glioblastoma induces
changes to DNA methylation and gene expression of the nuclear
genome in tumours. Epigenetics Chromatin. 11:532018. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Tan AS, Baty JW, Dong LF, Bezawork-Geleta
A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B,
et al: Mitochondrial genome acquisition restores respiratory
function and tumorigenic potential of cancer cells without
mitochondrial DNA. Cell Metab. 21:81–94. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Berridge MV, Crasso C and Neuzil J:
Mitochondrial genome transfer to tumor cells breaks the rules and
establishes a new precedent in cancer biology. Mol Cell Oncol.
5:e10239292018. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Lee HC and Wei YH: Mitochondrial
biogenesis and mitochondrial DNA maintenance of mammalian cells
under oxidative stress. Int J Biochem Cell Biol. 37:822–834. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Yeung KY, Dickinson A, Donoghue JF,
Polekhina G, White SJ, Grammatopoulos DK, McKenzie M, Johns TG and
St John JC: The identification of mitochondrial DNA variants in
glioblastoma multiforme. Acta Neuropathol Commun. 2:12014.
View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon
CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, et al:
Comprehensive molecular characterization of mitochondrial genomes
in human cancers. Nat Genet. 52:342–352. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Jiang H, Zhao H, Xu H, Hu L, Wang W, Wei
Y, Wang Y, Peng X and Zhou F: Peripheral blood mitochondrial DNA
content, A10398G polymorphism, and risk of breast cancer in a Han
Chinese population. Cancer Sci. 105:639–645. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Shen J, Platek M, Mahasneh A, Ambrosone CB
and Zhao H: Mitochondrial copy number and risk of breast cancer: A
pilot study. Mitochondrion. 10:62–68. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Fazzini F, Schöpf B, Blatzer M, Coassin S,
Hicks AA, Kronenberg F and Fendt L: Plasmid-normalized
quantification of relative mitochondrial DNA copy number. Sci Rep.
8:153472018. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Castellani CA, Longchamps RJ, Sumpter JA,
Newcomb CE, Lane JA, Grove ML, Bressler J, Brody JA, Floyd JS,
Bartz TM, et al: Mitochondrial DNA copy number can influence
mortality and cardiovascular disease via methylation of nuclear DNA
CpGs. Genome Med. 12:842020. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Wang L, Lv H, Ji P, Zhu X, Yuan H, Jin G,
Dai J, Hu Z, Su Y and Ma H: Mitochondrial DNA copy number is
associated with risk of head and neck squamous cell carcinoma in
Chinese population. Cancer Med. 7:2776–2782. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Shen J, Wan J, Song R and Zhao H:
Peripheral blood mitochondrial DNA copy number, length heteroplasmy
and breast cancer risk: A replication study. Carcinogenesis.
36:1307–1313. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Xia P, An HX, Dang CX, Radpour R, Kohler
C, Fokas E, Engenhart-Cabillic R, Holzgreve W and Zhong XY:
Decreased mitochondrial DNA content in blood samples of patients
with stage I breast cancer. BMC Cancer. 9:4542009. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Jung SJ, Cho JH, Park WJ, Heo YR and Lee
JH: Telomere length is correlated with mitochondrial DNA copy
number in intestinal, but not diffuse, gastric cancer. Oncol Lett.
14:925–929. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
O'Hara R, Tedone E, Ludlow A, Huang E,
Arosio B, Mari D and Shay JW: Quantitative mitochondrial DNA copy
number determination using droplet digital PCR with single-cell
resolution. Genome Res. 29:1878–1888. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Memon AA, Zöller B, Hedelius A, Wang X,
Stenman E, Sundquist J and Sundquist K: Quantification of
mitochondrial DNA copy number in suspected cancer patients by a
well optimized ddPCR method. Biomol Detect Quantif. 13:32–39. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Filograna R, Mennuni M, Alsina D and
Larsson NG: Mitochondrial DNA copy number in human disease: The
more the better? FEBS Lett. 595:976–1002. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Longchamps RJ, Castellani CA, Yang SY,
Newcomb CE, Sumpter JA, Lane J, Grove ML, Guallar E, Pankratz N,
Taylor KD, et al: Evaluation of mitochondrial DNA copy number
estimation techniques. PLoS One. 15:e02281662020. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Zhou K, Mo Q, Guo S, Liu Y, Yin C, Ji X,
Guo X and Xing J: A novel next-generation sequencing-based approach
for concurrent detection of mitochondrial DNA copy number and
mutation. J Mol Diagn. 22:1408–1418. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Picard M: Blood mitochondrial DNA copy
number: What are we counting? Mitochondrion. 60:1–11. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Ware SA, Desai N, Lopez M, Leach D, Zhang
Y, Giordano L, Nouraie M, Picard M and Kaufman BA: An automated,
high-throughput methodology optimized for quantitative cell-free
mitochondrial and nuclear DNA isolation from plasma. J Biol Chem.
295:15677–15691. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Guo W, Jiang L, Bhasin S, Khan SM and
Swerdlow RH: DNA extraction procedures meaningfully influence
qPCR-based mtDNA copy number determination. Mitochondrion.
9:261–265. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Tseng LM, Yin PH, Chi CW, Hsu CY, Wu CW,
Lee LM, Wei YH and Lee HC: Mitochondrial DNA mutations and
mitochondrial DNA depletion in breast cancer. Genes Chromosom
Cancer. 45:629–638. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Fan AX, Radpour R, Haghighi MM, Kohler C,
Xia P, Hahn S, Holzgreve W and Zhong XY: Mitochondrial DNA content
in paired normal and cancerous breast tissue samples from patients
with breast cancer. J Cancer Res Clin Oncol. 135:983–989. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Nacheva E, Mokretar K, Soenmez A, Pittman
AM, Grace C, Valli R, Ejaz A, Vattathil S, Maserati E, Houlden H,
et al: DNA isolation protocol effects on nuclear DNA analysis by
microarrays, droplet digital PCR, and whole genome sequencing, and
on mitochondrial DNA copy number estimation. PLoS One.
12:e01804672017. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Hsu CW, Yin PH, Lee HC, Chi CW and Tseng
LM: Mitochondrial DNA content as a potential marker to predict
response to anthracycline in breast cancer patients. Breast J.
16:264–270. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Domínguez-de-la-Cruz E, Muñoz ML,
Pérez-Muñoz A, García-Hernández N, Moctezuma-Meza C and
Hinojosa-Cruz JC: Reduced mitochondrial DNA copy number is
associated with the haplogroup, and some clinical features of
breast cancer in Mexican patients. Gene. 761:1450472020. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Lemnrau A, Brook MN, Fletcher O, Coulson
P, Tomczyk K, Jones M, Ashworth A, Swerdlow A, Orr N and
Garcia-Closas M: Mitochondrial DNA copy number in peripheral blood
cells and risk of developing breast cancer. Cancer Res.
75:2844–2850. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Thyagarajan B, Wang R, Nelson H, Barcelo
H, Koh W and Yuan M: Mitochondrial DNA copy number is associated
with breast cancer risk. PLoS One. 8:e659682013. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Feng S, Xiong L, Ji Z, Cheng W and Yang H:
Correlation between increased copy number of mitochondrial DNA and
clinicopathological stage in colorectal cancer. Oncol Lett.
2:899–903. 2011.PubMed/NCBI
|
|
115
|
Chen T, He J, Shen L, Fang H, Nie H, Jin
T, Wei X, Xin Y, Jiang Y, Li H, et al: The mitochondrial DNA
4,977-bp deletion and its implication in copy number alteration in
colorectal cancer. BMC Med Genet. 12:82011. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Qu F, Liu X, Zhou F, Yang H, Bao G, He X
and Xing J: Association between mitochondrial DNA content in
leukocytes and colorectal cancer risk: A case-control analysis.
Cancer. 117:3148–3155. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Thyagarajan B, Wang R, Barcelo H, Koh WP
and Yuan JM: Mitochondrial copy number is associated with
colorectal cancer risk. Cancer Epidemiol Biomarkers Prev.
21:1574–1581. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Tong H, Zhang L, Gao J, Wen S, Zhou H and
Feng S: Methylation of mitochondrial DNA displacement loop region
regulates mitochondrial copy number in colorectal cancer. Mol Med
Rep. 16:5347–5353. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Yang K, Li X, Forman MR, Monahan PO,
Graham BH, Joshi A, Song M, Hang D, Ogino S, Giovannucci EL, et al:
Pre-diagnostic leukocyte mitochondrial DNA copy number and
colorectal cancer risk. Carcinogenesis. 40:1462–1468. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Mohideen AM, Dicks E, Parfrey P, Green R
and Savas S: Mitochondrial DNA polymorphisms, its copy number
change and outcome in colorectal cancer. BMC Res Notes. 8:2722015.
View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Cui HH, Huang P, Wang ZJ, Zhang Y, Zhang
Z, Xu W, Wang X, Han Y and Guo X: Association of decreased
mitochondrial DNA content with the progression of colorectal
cancer. BMC Cancer. 13:1102013. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Huang B, Gao YT, Shu XO, Wen W, Yang G, Li
G, Courtney R, Ji BT, Li HL, Purdue MP, et al: Association of
leukocyte mitochondrial DNA copy number with colorectal cancer
risk: Results from the Shanghai women's health study. Cancer
Epidemiol Biomarkers Prev. 23:2357–2365. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
van Osch FH, Voets AM, Schouten LJ,
Gottschalk RW, Simons CC, van Engeland M, Lentjes MH, van den
Brandt PA, Smeets HJ and Weijenberg MP: Mitochondrial DNA copy
number in colorectal cancer: Between tissue comparisons,
clinicopathological characteristics and survival. Carcinogenesis.
36:1502–1510. 2015.PubMed/NCBI
|
|
124
|
Marucci G, Maresca A, Caporali L, Farnedi
A, Betts CM, Morandi L, de Biase D, Cerasoli S, Foschini MP, Bonora
E, et al: Oncocytic glioblastoma: A glioblastoma showing oncocytic
changes and increased mitochondrial DNA copy number. Hum Pathol.
44:1867–1876. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Zhang J, Li D, Qu F, Chen Y, Li G, Jiang
H, Huang X, Yang H and Xing J: Association of leukocyte
mitochondrial DNA content with glioma risk: Evidence from a Chinese
case-control study. BMC Cancer. 14:6802014. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Shen J, Song R, Lu Z and Zhao H:
Mitochondrial DNA copy number in whole blood and glioma risk: A
case control study. Mol Carcinog. 55:2089–2094. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Chen Y, Zhang J, Huang X, Zhang J, Zhou X,
Hu J, Li G, He S and Xing J: High leukocyte mitochondrial DNA
content contributes to poor prognosis in glioma patients through
its immunosuppressive effect. Br J Cancer. 113:99–106. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Dardaud LM, Bris C, Desquiret-Dumas V,
Boisselier B, Tabouret E, Mokhtari K, Figarella-Branger D, Rousseau
A and Procaccio V: High mitochondrial DNA copy number is associated
with longer survival in young patients with glioblastoma. Neuro
Oncol. 21:1084–1085. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Zhang Y, Qu Y, Gao K, Yang Q, Shi B, Hou P
and Ji M: High copy number of mitochondrial DNA (mtDNA) predicts
good prognosis in glioma patients. Am J Cancer Res. 5:1207–16.
2015.PubMed/NCBI
|
|
130
|
Oliva CR, Nozell SE, Diers A, McClugage SG
III, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie
GY, Landar A and Griguer CE: Acquisition of temozolomide
chemoresistance in gliomas leads to remodeling of mitochondrial
electron transport chain. J Biol Chem. 285:39759–39767. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Shen H, Yu M, Tsoli M, Chang C, Joshi S,
Liu J, Ryall S, Chornenkyy Y, Siddaway R, Hawkins C and Ziegler DS:
Targeting reduced mitochondrial DNA quantity as a therapeutic
approach in pediatric high-grade gliomas. Neuro Oncol. 22:139–151.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Sravya P, Nimbalkar VP, Kanuri NN, Sugur
H, Verma BK, Kundu P, Rao S, Uday Krishna AS, Somanna S, Kondaiah
P, et al: Low mitochondrial DNA copy number is associated with poor
prognosis and treatment resistance in glioblastoma. Mitochondrion.
55:154–163. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Li F, Wang X, Han C and Lin J: Decreased
mtDNA copy number of gastric cancer: A new tumor marker? Chin J
Clin Oncol. 1:250–255. 2004. View Article : Google Scholar
|
|
134
|
Wu CW, Yin PH, Hung WY, Li AF, Li SH, Chi
CW, Wei YH and Lee HC: Mitochondria DNA mutations and mitochondrial
DNA depletion in gastric cancer. Genes Chromosom Cancer. 44:19–28.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Zhang G, Qu Y, Dang S, Yang Q, Shi B and
Hou P: Variable copy number of mitochondrial DNA (mtDNA) predicts
worse prognosis in advanced gastric cancer patients. Diagn Pathol.
8:1732013. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Liao LM, Baccarelli A, Shu XO, Gao YT, Ji
BT, Yang G, Li HL, Hoxha M, Dioni L, Rothman N, et al:
Mitochondrial DNA copy number and risk of gastric cancer: A report
from the Shanghai women's health study. Cancer Epidemiol Biomarkers
Prev. 20:1944–1949. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Wen SL, Zhang F and Feng S: Decreased copy
number of mitochondrial DNA: A potential diagnostic criterion for
gastric cancer. Oncol Lett. 6:1098–1102. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Mizumachi T, Muskhelishvili L, Naito A,
Furusawa J, Fan CY, Siegel ER, Kadlubar FF, Kumar U and Higuchi M:
Increased distributional variance of mitochondrial DNA content
associated with prostate cancer cells as compared with normal
prostate cells. Prostate. 68:408–417. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Zhou W, Zhu M, Gui M, Huang L, Long Z,
Wang L, Chen H, Yin Y, Jiang X, Dai Y, et al: Peripheral blood
mitochondrial DNA copy number is associated with prostate cancer
risk and tumor burden. PLoS One. 9:e1094702014. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Abhishek A, Singh V, Sinha RJ, Ansari NG,
Siddiqe MK, Verma M and Kumar M: To study the relationship between
cadmium, zinc and mtDNA copy number in North Indian patients
suffering from prostate cancer: A case control study. Afr J Urol.
23:126–132. 2017. View Article : Google Scholar
|
|
141
|
Moore A, Lan Q, Hofmann JN, Liu CS, Cheng
WL, Lin TT and Berndt SI: A prospective study of mitochondrial DNA
copy number and the risk of prostate cancer. Cancer Causes Control.
28:529–538. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Tu H, Gu J, Meng QH, Kim J, Davis JW, He
Y, Wagar EA, Thompson TC, Logothetis CJ and Wu X: Mitochondrial DNA
copy number in peripheral blood leukocytes and the aggressiveness
of localized prostate cancer. Oncotarget. 6:41988–41996. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Kalsbeek AM, Chan EK, Grogan J, Petersen
DC, Jaratlerdsiri W, Gupta R, Lyons RJ, Haynes AM, Horvath LG,
Kench JG, et al: Altered mitochondrial genome content signals worse
pathology and prognosis in prostate cancer. Prostate. 78:25–31.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Xu J, Chang WS, Tsai CW, Bau DT, Davis JW,
Thompson TC, Logothetis CJ and Gu J: Mitochondrial DNA copy number
in peripheral blood leukocytes is associated with biochemical
recurrence in prostate cancer patients in African Americans.
Carcinogenesis. 41:267–273. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Tan DJ, Chang J, Liu LL, Bai RK, Wang YF,
Yeh KT and Wong LJC: Significance of somatic mutations and content
alteration of mitochondrial DNA in esophageal cancer. BMC Cancer.
6:932006. View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Liu Z, Zhao Z and Zhao Q: Change in the
mitochondrial DNA copy number and its significance in esophageal
squamous cell carcinoma. Chin J Clin Oncol. 34:7–9. 2007.
|
|
147
|
Lin CS, Chang SC, Wang LS, Chou TY, Hsu
WH, Wu YC and Wei YH: The role of mitochondrial DNA alterations in
esophageal squamous cell carcinomas. J Thorac Cardiovasc Surg.
139:189–197.e4. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
148
|
Li H, Tian Z, Zhang Y, Yang Q, Shi B, Hou
P and Ji M: Increased copy number of mitochondrial DNA predicts
poor prognosis of esophageal squamous cell carcinoma. Oncol Lett.
15:1014–1020. 2018.PubMed/NCBI
|
|
149
|
Masuike Y, Tanaka K, Makino T, Yamasaki M,
Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Mori M and Doki Y:
Esophageal squamous cell carcinoma with low mitochondrial copy
number has mesenchymal and stem-like characteristics, and
contributes to poor prognosis. PLoS One. 13:e01931592018.
View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Xu E, Sun W, Gu J, Chow WH, Ajani JA and
Wu X: Association of mitochondrial DNA copy number in peripheral
blood leukocytes with risk of esophageal adenocarcinoma.
Carcinogenesis. 34:2521–2524. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
151
|
Kim MM, Clinger JD, Masayesva BG, Ha PK,
Zahurak ML, Westra WH and Califano JA: Mitochondrial DNA quantity
increases with histopathologic grade in premalignant and malignant
head and neck lesions. Clin Cancer Res. 10:8512–8515. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Jiang WW, Rosenbaum E, Mambo E, Zahurak M,
Masayesva B, Carvalho AL, Zhou S, Westra WH, Alberg AJ, Sidransky
D, et al: Decreased mitochondrial DNA content in posttreatment
salivary rinses from head and neck cancer patients. Cancer Ther
Clin. 12:1564–1569. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Cheau-Feng Lin F, Jeng YC, Huang TY, Chi
CS, Chou MC and Chin-Shaw Tsai S: Mitochondrial DNA copy number is
associated with diagnosis and prognosis of head and neck cancer.
Biomarkers. 19:269–274. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Kumar M, Srivastava S, Singh SA, Das AK,
Das GC, Dhar B, Ghosh SK and Mondal R: Cell-free mitochondrial DNA
copy number variation in head and neck squamous cell carcinoma: A
study of non-invasive biomarker from Northeast India. Tumor Biol.
Oct 26–2017.(Epub ahead of print). View Article : Google Scholar
|
|
155
|
Chen J, Zhang L, Yu X, Zhou H, Luo Y, Wang
W and Wang L: Clinical application of plasma mitochondrial DNA
content in patients with lung cancer. Oncol Lett. 16:7074–7081.
2018.PubMed/NCBI
|
|
156
|
Bonner MR, Shen M, Liu CS, DiVita M, He X
and Lan Q: Mitochondrial DNA content and lung cancer risk in Xuan
Wei, China. Lung Cancer. 63:331–334. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Hosgood HD III, Liu CS, Rothman N,
Weinstein SJ, Bonner MR, Shen M, Lim U, Virtamo J, Cheng WL,
Albanes D and Lan Q: Mitochondrial DNA copy number and lung cancer
risk in a prospective cohort study. Carcinogenesis. 31:847–849.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
158
|
Kim C, Bassig BA, Seow WJ, Hu W, Purdue
MP, Shu XO, Huang WY, Liu CS, Cheng WL, Lin TT, et al: Pooled
analysis of mitochondrial DNA copy number and lung cancer risk in
three prospective studies. Cancer Epidemiol Biomarkers Prev.
23:2977–2980. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
159
|
Meierhofer D, Mayr JA, Foetschl U, Berger
A, Fink K, Schmeller N, Hacker GW, Hauser-Kronberger C, Kofler B
and Sperl W: Decrease of mitochondrial DNA content and energy
metabolism in renal cell carcinoma. Carcinogenesis. 25:1005–1010.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
160
|
Xing J, Chen M, Wood CG, Lin J, Spitz MR,
Ma J, Amos CI, Shields PG, Benowitz NL, Gu J, et al: Mitochondrial
DNA content: Its genetic heritability and association with renal
cell carcinoma. J Natl Cancer Inst. 100:1104–1112. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Purdue MP, Hofmann JN, Colt JS, Hoxha M,
Ruterbusch JJ, Davis FG, Rothman N, Wacholder S, Schwartz KL,
Baccarelli A and Chow WH: A case-control study of peripheral blood
mitochondrial DNA copy number and risk of renal cell carcinoma.
PLoS One. 7:e431492012. View Article : Google Scholar : PubMed/NCBI
|
|
162
|
Lin CS, Lee HT, Lee MH, Pan SC, Ke CY,
Chiu AW and Wei YH: Role of mitochondrial DNA copy number
alteration in human renal cell carcinoma. Int J Mol Sci.
17:8142016. View Article : Google Scholar : PubMed/NCBI
|
|
163
|
Hofmann JN, Hosgood HD III, Liu CS, Chow
WH, Shuch B, Cheng WL, Lin TT, Moore LE, Lan Q, Rothman N and
Purdue MP: A nested case-control study of leukocyte mitochondrial
DNA copy number and renal cell carcinoma in the prostate, lung,
colorectal and ovarian cancer screening trial. Carcinogenesis.
35:1028–1031. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
164
|
Elsayed ET, Hashad MM and Elgohary IE:
Mitochondrial DNA copy number variation as a potential predictor of
renal cell carcinoma. Int J Biol Markers. 32:e313–e318. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
165
|
Wang Y, Liu VW, Xue WC, Tsang PC, Cheung
AN and Ngan HY: The increase of mitochondrial DNA content in
endometrial adenocarcinoma cells: A quantitative study using
laser-captured microdissected tissues. Gynecol Oncol. 98:104–110.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
166
|
Cormio A, Guerra F, Cormio G, Pesce V,
Fracasso F, Loizzi V, Resta L, Putignano G, Cantatore P, Selvaggi
LE and Gadaleta MN: Mitochondrial DNA content and mass increase in
progression from normal to hyperplastic to cancer endometrium. BMC
Res Notes. 5:2792012. View Article : Google Scholar : PubMed/NCBI
|
|
167
|
Sun Y, Zhang L, Ho SS, Wu X and Gu J:
Lower mitochondrial DNA copy number in peripheral blood leukocytes
increases the risk of endometrial cancer. Mol Carcinog.
55:1111–1117. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
168
|
Mondal R, Ghosh SK, Choudhury JH, Seram A,
Sinha K, Hussain M, Laskar RS, Rabha B, Dey P, Ganguli S, et al:
Mitochondrial DNA copy number and risk of oral cancer: A report
from Northeast India. PLoS One. 8:e577712013. View Article : Google Scholar : PubMed/NCBI
|
|
169
|
He Y, Gong Y, Gu J, Lee JJ, Lippman SM and
Wu X: Increased leukocyte mitochondrial DNA copy number is
associated with oral premalignant lesions: an epidemiology study.
Carcinogenesis. 35:1760–1764. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
170
|
Takeda D, Hasegawa T, Ueha T, Sakakibara
A, Kawamoto T, Minamikawa T, Sakai Y and Komori T: Decreased
mitochondrial copy numbers in oral squamous cell carcinoma. Head
Neck. 36:1170–1175. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
171
|
Lynch SM, Weinstein SJ, Virtamo J, Lan Q,
Liu CS, Cheng WL, Rothman N, Albanes D and Stolzenberg-Solomon RZ:
Mitochondrial DNA copy number and pancreatic cancer in the
alpha-tocopherol beta-carotene cancer prevention study. Cancer Prev
Res (Phila). 4:1912–1919. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
172
|
Tuchalska-Czuroń J, Lenart J, Augustyniak
J and Durlik M: Is mitochondrial DNA copy number a good prognostic
marker in resectable pancreatic cancer? Pancreatology. 19:73–79.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
173
|
Gentiluomo M, Katzke VA, Kaaks R,
Tjønneland A, Severi G, Perduca V, Boutron-Ruault MC, Weiderpass E,
Ferrari P, Johnson T, et al: Mitochondrial DNA copy-number
variation and pancreatic cancer risk in the prospective EPIC
cohort. Cancer Epidemiol Biomarkers Prev. 29:681–686. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
174
|
Wang Y, Liu VW, Xue WC, Cheung AN and Ngan
HY: Association of decreased mitochondrial DNA content with ovarian
cancer progression. Br J Cancer. 95:1087–1091. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
175
|
Keserű JS, Soltész B, Lukács J, Márton É,
Szilágyi-Bónizs M, Penyige A, Póka R and Nagy B: Detection of
cell-free, exosomal and whole blood mitochondrial DNA copy number
in plasma or whole blood of patients with serous epithelial ovarian
can. J Biotechnol. 298:76–81. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
176
|
Hyland PL, Pfeiffer RM, Rotunno M, Hofmann
JN, Liu CS, Cheng WL, Yuenger J, Lan Q, Tucker MA, Goldstein AM and
Yang XR: Constitutive mitochondrial DNA copy number in peripheral
blood of melanoma families with and without CDKN2A mutations. J
Carcinog Mutagen. 2014 (Suppl 4):S0062014.
|
|
177
|
Shen J, Gopalakrishnan V, Lee JE, Fang S
and Zhao H: Mitochondrial DNA copy number in peripheral blood and
melanoma risk. PLoS One. 10:e01316492015. View Article : Google Scholar : PubMed/NCBI
|
|
178
|
Dang S, Qu Y, Wei J, Shao Y, Yang Q, Ji M,
Shi B and Hou P: Low copy number of mitochondrial DNA (mtDNA)
predicts worse prognosis in early-stage laryngeal cancer patients.
Diagn Pathol. 9:282014. View Article : Google Scholar : PubMed/NCBI
|
|
179
|
Guo W, Yang D, Xu H, Zhang Y, Huang J,
Yang Z, Chen X and Huang Z: Mutations in the D-loop region and
increased copy number of mitochondrial DNA in human laryngeal
squamous cell carcinoma. Mol Biol Rep. 40:13–20. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
180
|
Hurtado-Roca Y, Ledesma M, Gonzalez-Lazaro
M, Moreno-Loshuertos R, Fernandez-Silva P, Enriquez JA and
Laclaustra M: Adjusting MtDNA quantification in whole blood for
peripheral blood platelet and leukocyte counts. PLoS One.
11:e01637702016. View Article : Google Scholar : PubMed/NCBI
|
|
181
|
Malik AN and Czajka A: Is mitochondrial
DNA content a potential biomarker of mitochondrial dysfunction?
Mitochondrion. 13:481–492. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
182
|
Anderson C, Fry RC, Hartwell H, Kleeberger
C, Sandler DP and Nichols HB: Measurement of mitochondrial DNA copy
number in dried blood spots: A pilot study. Mitochondrion.
56:35–39. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
183
|
Parr RL, Dakubo GD, Thayer RE, McKenney K
and Birch-Machin MA: Mitochondrial DNA as a potential tool for
early cancer detection. Hum Genomics. 2:252–257. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
184
|
Liu Y, Zhou K, Guo S, Wang Y, Ji X, Yuan
Q, Su L, Guo X, Gu X and Xing J: NGS-based accurate and efficient
detection of circulating cell-free mitochondrial DNA in cancer
patients. Mol Ther Nucleic Acids. 23:657–666. 2021. View Article : Google Scholar : PubMed/NCBI
|
