Role of microRNAs and long non‑coding RNAs in glucocorticoid signaling (Review)

Pierouli,Katerina; Papageorgiou,Louis; Mitsis,Thanasis; Papakonstantinou,Eleni; Diakou,Io; Leptidis,Stefanos; Sigala,Markezina; Dragoumani,Konstantina; Spandidos,Demetrios A.; Bacopoulou,Flora; Chrousos,George P.; Goulielmos,George Ν.; Eliopoulos,Elias; Vlachakis,Dimitrios

doi:10.3892/ijmm.2022.5203

Role of microRNAs and long non‑coding RNAs in glucocorticoid signaling (Review)

Authors:
- Katerina Pierouli
- Louis Papageorgiou
- Thanasis Mitsis
- Eleni Papakonstantinou
- Io Diakou
- Stefanos Leptidis
- Markezina Sigala
- Konstantina Dragoumani
- Demetrios A. Spandidos
- Flora Bacopoulou
- George P. Chrousos
- George Ν. Goulielmos
- Elias Eliopoulos
- Dimitrios Vlachakis
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Affiliations: Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, ‘Aghia Sophia’ Children's Hospital, 11527 Athens, University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, ‘Aghia Sophia’ Children's Hospital, 11527 Athens, Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece
Published online on: November 11, 2022 https://doi.org/10.3892/ijmm.2022.5203
Article Number: 147
Copyright: © Pierouli et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The synthesis and release of glucocorticoids in living organisms are related to their response to unfavorable stressful conditions in order to maintain homeostatic functions and survive. One such hormone in humans is cortisol, which is produced by the hypothalamic‑pituitary‑adrenal cortex axis and binds with the glucocorticoid receptor (GR) following its secretion. GR controls a number of distinct gene networks. Non‑coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non‑coding RNAs (lncRNAs), regulate the expression and function of GR, having a considerable impact on various biological processes and treatment approaches for numerous disorders. In the present review, the GR pathways and signaling as part of the stress response system are discussed. A detailed report on the role of miRNAs and lncRNAs in glucocorticoid signaling is also presented.

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