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Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway

  • Authors:
    • Xiaojuan Su
    • Junjie Ying
    • Dongqiong Xiao
    • Xia Qiu
    • Shiping Li
    • Fengyan Zhao
    • Jun Tang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 12
    |
    Published online on: December 14, 2022
       https://doi.org/10.3892/ijmm.2022.5215
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Abstract

Activin A (Act A) has been reported to promote oligodendrocyte progenitor cell (OPC) differentiation in vitro and improve neurological outcomes in adult mice. However, the roles and mechanisms of action of Act A in preterm brain injury are unknown. In the present study, P5 rats were subjected to hypoxia‑ischemia to establish a neonatal white matter injury (WMI) model and Act A was injected via the lateral ventricle. Pathological characteristics, OPC differentiation, myelination, and neurological performance were analyzed. Further, the involvement of the Noggin/BMP4/Id2 signaling pathway in the roles of Act A in WMI was explored. Act A attenuated pathological damage, promoted OPC differentiation, enhanced myelin sheath and myelinated axon formation, and improved neurological performance of WMI rats. Moreover, Act A enhanced noggin expression, which, in turn, inhibited the expression of bone morphogenetic protein 4 (BMP4) and inhibitor of DNA binding 2 (Id2). Furthermore, upregulation of Id2 completely abolished the rescue effects of Act A in WMI rats. In conclusion, the present findings suggested that Act A rescues preterm brain injury via targeting a novel Noggin/BMP4/Id2 signaling pathway.
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1 

Alexandrou G, Mårtensson G, Skiöld B, Blennow M, Adén U and Vollmer B: White matter microstructure is influenced by extremely preterm birth and neonatal respiratory factors. Acta Paediatr. 103:48–56. 2014. View Article : Google Scholar

2 

Liu XB, Shen Y, Plane JM and Deng W: Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury. Neurosci Bull. 29:229–238. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Gano D: White matter injury in premature newborns. Neonatal Netw. 35:73–77. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Suzuki N, Sekimoto K, Hayashi C, Mabuchi Y, Nakamura T and Akazawa C: Differentiation of oligodendrocyte precursor cells from Sox10-venus mice to oligodendrocytes and astrocytes. Sci Rep. 7:141332017. View Article : Google Scholar : PubMed/NCBI

5 

Anand C, Brandmaier AM, Arshad M, Lynn J, Stanley JA and Raz N: White-matter microstructural properties of the corpus callosum: Test-retest and repositioning effects in two parcellation schemes. Brain Struct Funct. 224:3373–3385. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Goebbels S, Wieser GL, Pieper A, Spitzer S, Weege B, Yan K, Edgar JM, Yagensky O, Wichert SP, Agarwal A, et al: A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci. 20:10–15. 2017. View Article : Google Scholar

7 

Wang X, Fischer G and Hyvönen M: Structure and activation of pro-activin A. Nat Commun. 7:120522016. View Article : Google Scholar : PubMed/NCBI

8 

Zheng J, Zhang T, Han S, Liu C, Liu M, Li S and Li J: Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination. Exp Neurol. 337:1135742021. View Article : Google Scholar

9 

Clancy B, Darlington RB and Finlay BL: Translating developmental time across mammalian species. Neuroscience. 105:7–17. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Huang L, Zhao F, Qu Y, Zhang L, Wang Y and Mu D: Animal models of hypoxic-ischemic encephalopathy: Optimal choices for the best outcomes. Rev Neurosci. 28:31–43. 2017. View Article : Google Scholar

11 

Huang Z, Liu J, Cheung PY and Chen C: Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxic-ischemic brain injury. Brain Res. 1301:100–109. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, et al: Enhancing oligodendrocyte myelination rescues synaptic loss and improves functional recovery after chronic hypoxia. Neuron. 99:689–701.e5. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, et al: Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell. 156:277–290. 2014. View Article : Google Scholar : PubMed/NCBI

14 

De Berdt P: Bottemanne P, Bianco J, Alhouayek M, Diogenes A, Lloyd A, Llyod A, Gerardo-Nava J, Brook GA, Miron V, et al Stem cells from human apical papilla decrease neuro-inflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion. Cell Mol Life Sci. 75:2843–2856. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Nishio S, Yunoki M, Chen ZF, Anzivino MJ and Lee KS: Ischemic tolerance in the rat neocortex following hypothermic preconditioning. J Neurosurg. 93:845–851. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Wang F, Shi Y, Lu L, Liu L, Cai Y, Zheng H, Liu X, Yan F, Zou C, Sun C, et al: Targeted delivery of GDNF through the blood-brain barrier by MRI-guided focused ultrasound. PLoS One. 7:e529252012. View Article : Google Scholar

17 

Simons M and Nave KA: Oligodendrocytes: Myelination and axonal support. Cold Spring Harb Perspect Biol. 8:a0204792015. View Article : Google Scholar : PubMed/NCBI

18 

Back SA: White matter injury in the preterm infant: Pathology and mechanisms. Acta Neuropathol. 134:331–349. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Y, Zhang J, Navrazhina K, Argaw AT, Zameer A, Gurfein BT, Brosnan CF and John GR: TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation. Glia. 58:964–974. 2010.PubMed/NCBI

20 

Derynck R and Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Chen XS, Zhang YH, Cai QY and Yao ZX: ID2: A negative transcription factor regulating oligodendroglia differentiation. J Neurosci Res. 90:925–932. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Gou X, Tang Y, Qu Y, Xiao D, Ying J and Mu D: Could the inhibitor of DNA binding 2 and 4 play a role in white matter injury? Rev Neurosci. 30:625–638. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Samanta J and Kessler JA: Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Development. 131:4131–4142. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Kim MS, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A and Lough J: Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS One. 10:e01186702015. View Article : Google Scholar : PubMed/NCBI

25 

Olsen OE, Wader KF, Hella H, Mylin AK, Turesson I, Nesthus I, Waage A, Sundan A and Holien T: Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B. Cell Commun Signal. 13:272015. View Article : Google Scholar : PubMed/NCBI

26 

Yang S, Yuan Q, Niu M, Hou J, Zhu Z, Sun M, Li Z and He Z: BMP4 promotes mouse iPS cell differentiation to male germ cells via Smad1/5, Gata4, Id1 and Id2. Reproduction. 153:211–220. 2017. View Article : Google Scholar

27 

Lepletier A, Hun ML, Hammett MV, Wong K, Naeem H, Hedger M, Loveland K and Chidgey AP: Interplay between follistatin, activin A, and BMP4 signaling regulates postnatal thymic epithelial progenitor cell differentiation during aging. Cell Rep. 27:3887–3901.e4. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Miyazono K and Miyazawa K: Id: A target of BMP signaling. Sci STKE. 2002:pe402002. View Article : Google Scholar : PubMed/NCBI

29 

Koyano S, Fukui A, Uchida S, Yamada K, Asashima M and Sakuragawa N: Synthesis and release of activin and noggin by cultured human amniotic epithelial cells. Dev Growth Differ. 44:103–112. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Bergestuen DS, Edvardsen T, Aakhus S, Ueland T, Oie E, Vatn M, Aukrust P and Thiis-Evensen E: Activin A in carcinoid heart disease: A possible role in diagnosis and pathogenesis. Neuroendocrinology. 92:168–177. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Volpe JJ: Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances. Lancet Neurol. 8:110–124. 2009. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Su X, Ying J, Xiao D, Qiu X, Li S, Zhao F and Tang J: Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway. Int J Mol Med 51: 12, 2023.
APA
Su, X., Ying, J., Xiao, D., Qiu, X., Li, S., Zhao, F., & Tang, J. (2023). Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway. International Journal of Molecular Medicine, 51, 12. https://doi.org/10.3892/ijmm.2022.5215
MLA
Su, X., Ying, J., Xiao, D., Qiu, X., Li, S., Zhao, F., Tang, J."Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway". International Journal of Molecular Medicine 51.2 (2023): 12.
Chicago
Su, X., Ying, J., Xiao, D., Qiu, X., Li, S., Zhao, F., Tang, J."Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway". International Journal of Molecular Medicine 51, no. 2 (2023): 12. https://doi.org/10.3892/ijmm.2022.5215
Copy and paste a formatted citation
x
Spandidos Publications style
Su X, Ying J, Xiao D, Qiu X, Li S, Zhao F and Tang J: Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway. Int J Mol Med 51: 12, 2023.
APA
Su, X., Ying, J., Xiao, D., Qiu, X., Li, S., Zhao, F., & Tang, J. (2023). Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway. International Journal of Molecular Medicine, 51, 12. https://doi.org/10.3892/ijmm.2022.5215
MLA
Su, X., Ying, J., Xiao, D., Qiu, X., Li, S., Zhao, F., Tang, J."Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway". International Journal of Molecular Medicine 51.2 (2023): 12.
Chicago
Su, X., Ying, J., Xiao, D., Qiu, X., Li, S., Zhao, F., Tang, J."Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway". International Journal of Molecular Medicine 51, no. 2 (2023): 12. https://doi.org/10.3892/ijmm.2022.5215
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