Open Access

Association of endometriosis with cardiovascular disease: Genetic aspects (Review)

  • Authors:
    • Vassilios M. Vazgiourakis
    • Maria I. Zervou
    • Louis Papageorgiou
    • Dimitrios Chaniotis
    • Demetrios A. Spandidos
    • Dimitrios Vlachakis
    • Elias Eliopoulos
    • George N. Goulielmos
  • View Affiliations

  • Published online on: February 15, 2023     https://doi.org/10.3892/ijmm.2023.5232
  • Article Number: 29
  • Copyright: © Vazgiourakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cardiovascular disease (CVD) comprises a broad spectrum of pathological conditions that affect the heart or blood vessels, including sequelae that arise from damaged vasculature in other organs of the body, such as the brain, kidneys or eyes. Atherosclerosis is a chronic inflammatory disease of the arterial intima and is the primary cause of coronary artery disease, peripheral vascular disease, heart attack, stroke and renal pathology. It represents a leading cause of mortality worldwide and the loss of human productivity that is marked by an altered immune response. Endometriosis is a heritable, heterogeneous, common gynecological condition influenced by multiple genetic, epigenetic and environmental factors, affecting up to 10% of the female population of childbearing age, causing pain and infertility; it is characterized by the ectopic growth of endometrial tissue outside the uterine cavity. Of note, epidemiological data obtained thus far have suggested a link between endometriosis and the risk of developing CVD. The similarities observed in specific molecular and cellular pathways of endometriosis and CVD may be partially explained by a shared genetic background. The present review presents and discusses the shared genetic factors which have been reported to be associated with the development of both disorders.
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March-2023
Volume 51 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Vazgiourakis VM, Zervou MI, Papageorgiou L, Chaniotis D, Spandidos DA, Vlachakis D, Eliopoulos E and Goulielmos GN: Association of endometriosis with cardiovascular disease: Genetic aspects (Review). Int J Mol Med 51: 29, 2023
APA
Vazgiourakis, V.M., Zervou, M.I., Papageorgiou, L., Chaniotis, D., Spandidos, D.A., Vlachakis, D. ... Goulielmos, G.N. (2023). Association of endometriosis with cardiovascular disease: Genetic aspects (Review). International Journal of Molecular Medicine, 51, 29. https://doi.org/10.3892/ijmm.2023.5232
MLA
Vazgiourakis, V. M., Zervou, M. I., Papageorgiou, L., Chaniotis, D., Spandidos, D. A., Vlachakis, D., Eliopoulos, E., Goulielmos, G. N."Association of endometriosis with cardiovascular disease: Genetic aspects (Review)". International Journal of Molecular Medicine 51.3 (2023): 29.
Chicago
Vazgiourakis, V. M., Zervou, M. I., Papageorgiou, L., Chaniotis, D., Spandidos, D. A., Vlachakis, D., Eliopoulos, E., Goulielmos, G. N."Association of endometriosis with cardiovascular disease: Genetic aspects (Review)". International Journal of Molecular Medicine 51, no. 3 (2023): 29. https://doi.org/10.3892/ijmm.2023.5232