|
1
|
Knezevic NN, Candido KD, Vlaeyen JWS, Van
Zundert J and Cohen SP: Low back pain. Lancet. 398:78–92. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Urits I, Burshtein A, Sharma M, Testa L,
Gold PA, Orhurhu V, Viswanath O, Jones MR, Sidransky MA, Spektor B
and Kaye AD: Low back pain, a comprehensive review:
Pathophysiology, diagnosis, and treatment. Curr Pain Headache Rep.
23:232019. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Lyu FJ, Cui H, Pan H, Mc Cheung K, Cao X,
Iatridis JC and Zheng Z: Painful intervertebral disc degeneration
and inflammation: From laboratory evidence to clinical
interventions. Bone Res. 9:72021. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Lawson LY and Harfe BD: Developmental
mechanisms of intervertebral disc and vertebral column formation.
Wiley Interdiscip Rev Dev Biol. 6:e2832017. View Article : Google Scholar
|
|
5
|
Chen HW, Zhang GZ, Liu MQ, Zhang LJ, Kang
JH, Wang ZH, Liu WZ, Lin AX and Kang XW: Natural products of
pharmacology and mechanisms in nucleus pulposus cells and
intervertebral disc degeneration. Evid Based Complement Alternat
Med. 2021:99636772021.PubMed/NCBI
|
|
6
|
Song D, Ge J, Wang Y, Yan Q, Wu C, Yu H,
Yang M, Yang H and Zou J: Tea polyphenol attenuates oxidative
stress-induced degeneration of intervertebral discs by regulating
the Keap1/Nrf2/ARE pathway. Oxid Med Cell Longev. 2021:66841472021.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wang D, Cai X, Xu F, Kang H, Li Y and Feng
R: Ganoderic acid A alleviates the degeneration of intervertebral
disc via suppressing the activation of TLR4/NLRP3 signaling
pathway. Bioengineered. 13:11684–11693. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Lyu FJ, Cheung KM, Zheng Z, Wang H, Sakai
D and Leung VY: IVD progenitor cells: A new horizon for
understanding disc homeostasis and repair. Nat Rev Rheumatol.
15:102–112. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Wang J, Huang Y, Huang L, Shi K, Wang J,
Zhu C, Li L, Zhang L, Feng G, Liu L and Song Y: Novel biomarkers of
intervertebral disc cells and evidence of stem cells in the
intervertebral disc. Osteoarthritis Cartilage. 29:389–401. 2021.
View Article : Google Scholar
|
|
10
|
Lambertini E, Penolazzi L, Pellielo G,
Pipino C, Pandolfi A, Fiorito S, Epifano F, Genovese S and Piva R:
Pro-osteogenic properties of Violina pumpkin (Cucurbita moschata)
leaf extracts: Data from in vitro human primary cell cultures.
Nutrients. 13:26332021. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Adaramoye OA, Achem J, Akintayo OO and
Fafunso MA: Hypolipidemic effect of Telfairia occidentalis (fluted
pumpkin) in rats fed a cholesterol-rich diet. J Med Food.
10:330–336. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Eseyin OA, Igboasoiyi AC, Mbagwu H, Umoh E
and Ekpe JF: Studies on the effects of an alcohol extract of the
leaves of Telfairia occidentalis on alloxan induced diabetic rats.
Global J Pure Appl Sci. 11:77–79. 2005.
|
|
13
|
Igbeneghu OA and Abdu AB: Multiple
antibiotic-resistant bacteria on fluted pumpkin leaves, a herb of
therapeutic value. J Health Popul Nutr. 32:176–182. 2014.PubMed/NCBI
|
|
14
|
Oboh G, Nwanna EE and Elusiyan CA:
Antioxidant and antimicrobial properties of Telfairia occidentalis
(Fluted pumpkin) leaf extracts. J Pharmacol Toxicol. 1:167–175.
2006. View Article : Google Scholar
|
|
15
|
P N O: Effect of aqueous extract of
Telfairia occidentalis leaf on the performance and haematological
indices of starter broilers. ISRN Vet Sci. 2012:7265152012.
|
|
16
|
Aderibigbe AO, Lawal BA and Oluwagbemi JO:
The antihyperglycamic effect of Telfaria occidentalis in mice. Afr
J Med Med Sci. 28:171–175. 1999.
|
|
17
|
van Breda SGJ and de Kok TMCM: Smart
combinations of bioactive compounds in fruits and vegetables may
guide new strategies for personalized prevention of chronic
diseases. Mol Nutr Food Res. 62:17005972018. View Article : Google Scholar
|
|
18
|
Cheng YH, Yang SH and Lin FH:
Thermosensitive chitosan-gelatin-glycerol phosphate hydrogel as a
controlled release system of ferulic acid for nucleus pulposus
regeneration. Biomaterials. 32:6953–6961. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Cheng YH, Yang SH, Yang KC, Chen MP and
Lin FH: The effects of ferulic acid on nucleus pulposus cells under
hydrogen peroxide-induced oxidative stress. Process Biochem.
46:1670–1677. 2011. View Article : Google Scholar
|
|
20
|
Sheng K, Li Y, Wang Z, Hang K and Ye Z:
p-Coumaric acid suppresses reactive oxygen species-induced
senescence in nucleus pulposus cells. Exp Ther Med. 23:1832022.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Chandra S, Khan S, Avula B, Lata H, Yang
MH, ElSohly MA and Khan IA: Assessment of total phenolic and
flavonoid content, antioxidant properties, and yield of
aeroponically and conventionally grown leafy vegetables and fruit
crops: A comparative study. Evid Based Complement Alternat Med.
2014:2538752014. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Re R, Pellegrini N, Proteggente A, Pannala
A, Yang M and Rice-Evans C: Antioxidant activity applying an
improved ABTS radical cation decolorization assay. Free Radic Biol
Med. 26:1231–1237. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Xu W, Liu L, Hu B, Sun Y, Ye H, Ma D and
Zeng X: TPC in the leaves of 116 sweet potato (Ipomoea batatas L.)
varieties and Pushu 53 leaf extracts. J Food Compos Anal.
23:599–604. 2010. View Article : Google Scholar
|
|
24
|
Penolazzi L, Lambertini E, Scussel
Bergamin L, Gandini C, Musio A, De Bonis P, Cavallo M and Piva R:
Reciprocal regulation of TRPS1 and miR-221 in intervertebral disc
cells. Cells. 8:11702019. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Nunes de Miranda SM, Wilhelm T, Huber M
and Zorn CN: Differential Lyn-dependence of the SHIP1-deficient
mast cell phenotype. Cell Commun Signal. 14:122016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lambertini E, Penolazzi L, Tavanti E,
Schincaglia GP, Zennaro M, Gambari R and Piva R: Human estrogen
receptor alpha gene is a target of Runx2 transcription factor in
osteoblasts. Exp Cell Res. 313:1548–1560. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Lisignoli G, Lambertini E, Manferdini C,
Gabusi E, Penolazzi L, Paolella F, Angelozzi M, Casagranda V and
Piva R: Collagen type XV and the 'osteogenic status'. J Cell Mol
Med. 21:2236–2244. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
29
|
Penolazzi L, Lambertini E, Bergamin LS,
Roncada T, De Bonis P, Cavallo M and Piva R: MicroRNA-221 silencing
attenuates the degenerated phenotype of intervertebral disc cells.
Aging (Albany NY). 10:2001–2015. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Ma K, Chen S, Li Z, Deng X, Huang D, Xiong
L and Shao Z: Mechanisms of endogenous repair failure during
intervertebral disc degeneration. Osteoarthritis Cartilage.
27:41–48. 2019. View Article : Google Scholar
|
|
31
|
Lefebvre V and Dvir-Ginzberg M: SOX9 and
the many facets of its regulation in the chondrocyte lineage.
Connect Tissue Res. 58:2–14. 2017. View Article : Google Scholar :
|
|
32
|
Alvarez-Garcia O, Matsuzaki T, Olmer M,
Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H and Lotz MK: FOXO
are required for intervertebral disk homeostasis during aging and
their deficiency promotes disk degeneration. Aging Cell.
17:e128002018. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Sivan SS, Hayes AJ, Wachtel E, Caterson B,
Merkher Y, Maroudas A, Brown S and Roberts S: Biochemical
composition and turnover of the extracellular matrix of the normal
and degenerate intervertebral disc. Eur Spine J. 23(Suppl 3):
S344–S353. 2014. View Article : Google Scholar
|
|
34
|
Liang H, Luo R, Li G, Zhang W, Song Y and
Yang C: The proteolysis of ECM in intervertebral disc degeneration.
Int J Mol Sci. 23:17152022. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Dimozi A, Mavrogonatou E, Sklirou A and
Kletsas D: Oxidative stress inhibits the proliferation, induces
premature senescence and promotes a catabolic phenotype in human
nucleus pulposus intervertebral disc cells. Eur Cell Mater.
30:89–102. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Wang X, Li H, Xu K, Zhu H, Peng Y, Liang
A, Li C, Huang D and Ye W: SIRT1 expression is refractory to
hypoxia and inflammatory cytokines in nucleus pulposus cells: Novel
regulation by HIF-1α and NF-κB signaling. Cell Biol Int.
40:716–726. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Song Y, Lu S, Geng W, Feng X, Luo R, Li G
and Yang C: Mitochondrial quality control in intervertebral disc
degeneration. Exp Mol Med. 53:1124–1133. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Clouet J, Fusellier M, Camus A, Le Visage
C and Guicheux J: Intervertebral disc regeneration: From cell
therapy to the development of novel bioinspired endogenous repair
strategies. Adv Drug Deliv Rev. 146:306–324. 2019. View Article : Google Scholar
|
|
39
|
Kaufmann T, Strasser A and Jost PJ: Fas
death receptor signalling: Roles of Bid and XIAP. Cell Death
Differ. 19:42–50. 2012. View Article : Google Scholar :
|
|
40
|
Brown R: The bcl-2 family of proteins. Br
Med Bull. 53:466–477. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Ciesielska S, Slezak-Prochazka I, Bil P
and Rzeszowska-Wolny J: Micro RNAs in regulation of cellular redox
homeostasis. Int J Mol Sci. 22:60222021. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Lolli A, Narcisi R, Lambertini E,
Penolazzi L, Angelozzi M, Kops N, Gasparini S, van Osch GJ and Piva
R: Silencing of anti-chondrogenic MicroRNA-221 in human mesenchymal
stem cells promotes cartilage repair in vivo. Stem Cells.
34:1801–1811. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Marques-Rocha JL, Samblas M, Milagro FI,
Bressan J, Martínez JA and Marti A: Noncoding RNAs, cytokines, and
inflammation-related diseases. FASEB J. 29:3595–3611. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Kang L, Zhang H, Jia C, Zhang R and Shen
C: Targeting oxidative stress and inflammation in intervertebral
disc degeneration: Therapeutic perspectives of phytochemicals.
Front Pharmacol. 13:9563552022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Roychoudhury S, Sinha B, Choudhury BP, Jha
NK, Palit P, Kundu S, Mandal SC, Kolesarova A, Yousef MI,
Ruokolainen J, et al: Scavenging properties of plant-derived
natural biomolecule para-coumaric acid in the prevention of
oxidative stress-induced diseases. Antioxidants (Basel).
10:12052021. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Ferreira PS, Victorelli FD, Fonseca-Santos
B and Chorilli M: A review of analytical methods for p-coumaric
acid in plant-based products, beverages, and biological matrices.
Crit Rev Anal Chem. 49:21–31. 2019. View Article : Google Scholar
|
|
47
|
Kamali A, Ziadlou R, Lang G, Pfannkuche J,
Cui S, Li Z, Richards RG, Alini M and Grad S: Small molecule-based
treatment approaches for intervertebral disc degeneration: Current
options and future directions. Theranostics. 11:27–47. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Saud B, Malla R and Shrestha K: A review
on the effect of plant extract on mesenchymal stem cell
proliferation and differentiation. Stem Cells Int.
2019:75134042019. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Hori YS, Kuno A, Hosoda R and Horio Y:
Regulation of FOXOs and p53 by SIRT1 modulators under oxidative
stress. PLoS One. 8:e738752013. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Zhu H, Zhang L, Itoh K, Yamamoto M, Ross
D, Trush MA, Zweier JL and Li Y: Nrf2 controls bone marrow stromal
cell susceptibility to oxidative and electrophilic stress. Free
Radic Biol Med. 41:132–143. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Dai X, Yan X, Wintergerst KA, Cai L,
Keller BB and Tan Y: Nrf2: Redox and metabolic regulator of stem
cell state and function. Trends Mol Med. 26:185–200. 2020.
View Article : Google Scholar
|
|
52
|
Kubo Y, Beckmann R, Fragoulis A, Conrads
C, Pavanram P, Nebelung S, Wolf M, Wruck CJ, Jahr H and Pufe T:
Nrf2/ARE signaling directly regulates SOX9 to potentially alter
age-dependent cartilage degeneration. Antioxidants (Basel).
11:2632022. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Zhao S, Huang Z, Jiang H, Xiu J, Zhang L,
Long Q, Yang Y, Yu L, Lu L and Gu H: Sirtuin 1 induces choroidal
neovascularization and triggers age-related macular degeneration by
promoting LCN2 through SOX9 deacetylation. Oxid Med Cell Longev.
2022:16714382022.PubMed/NCBI
|
|
54
|
de Crombrugghe B, Lefebvre V, Behringer
RR, Bi W, Murakami S and Huang W: Transcriptional mechanisms of
chondrocyte differentiation. Matrix Biol. 19:389–394. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Tan Z, Niu B, Tsang KY, Melhado IG, Ohba
S, He X, Huang Y, Wang C, McMahon AP, Jauch R, et al: Synergistic
co-regulation and competition by a SOX9-GLI-FOXA phasic
transcriptional network coordinate chondrocyte differentiation
transitions. PLoS Genet. 14:e10073462018. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Zhang CY, Hu XC, Zhang GZ, Liu MQ, Chen HW
and Kang XW: Role of Nrf2 and HO-1 in intervertebral disc
degeneration. Connect Tissue Res. 63:559–576. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Ganesh GV, Ganesan K, Xu B and Ramkumar
KM: Nrf2 driven macrophage responses in diverse pathophysiological
contexts: Disparate pieces from a shared molecular puzzle.
Biofactors. 48:795–812. 2022. View Article : Google Scholar
|
|
58
|
Singh P, Gupta A, Qayoom I, Singh S and
Kumar A: Orthobiologics with phytobioactive cues: A paradigm in
bone regeneration. Biomed Pharmacother. 130:1107542020. View Article : Google Scholar
|
|
59
|
Wagner H and Ulrich-Merzenich G: Synergy
research: Approaching a new generation of phytopharmaceuticals.
Phytomedicine. 16:97–110. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Caesar LK and Cech NB: Synergy and
antagonism in natural product extracts: When 1 + 1 does not equal
2. Nat Prod Rep. 36:869–888. 2019. View Article : Google Scholar : PubMed/NCBI
|
