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Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)

  • Authors:
    • Jiahao Li
    • Lei Xian
    • Zifeng Zhu
    • Yang Wang
    • Wenlei Zhang
    • Ruipeng Zheng
    • Wang Xue
    • Jiarui Li
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Therapy, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 88
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    Published online on: August 9, 2023
       https://doi.org/10.3892/ijmm.2023.5291
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Abstract

Ferroptosis is a novel form of regulated cellular necrosis that plays a critical role in promoting cancer progression and developing drug resistance. The main characteristic of ferroptosis is iron‑dependent lipid peroxidation caused by excess intracellular levels of reactive oxygen species. CUGBP ELAV‑like family number 2 (CELF2) is an RNA‑binding protein that is downregulated in various types of cancer and is associated with poor patient prognoses. CELF2 can directly bind mRNA to a variety of ferroptosis control factors; however, direct evidence of the regulatory role of CELF2 in ferroptosis is currently limited. The aim of the present review was to summarise the findings of previous studies on CELF2 and its role in regulating cellular redox homeostasis. The present review may provide insight into the possible mechanisms through which CELF2 affects ferroptosis and to provide recommendations for future studies.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Xian L, Zhu Z, Wang Y, Zhang W, Zheng R, Xue W and Li J: Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review). Int J Mol Med 52: 88, 2023.
APA
Li, J., Xian, L., Zhu, Z., Wang, Y., Zhang, W., Zheng, R. ... Li, J. (2023). Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review). International Journal of Molecular Medicine, 52, 88. https://doi.org/10.3892/ijmm.2023.5291
MLA
Li, J., Xian, L., Zhu, Z., Wang, Y., Zhang, W., Zheng, R., Xue, W., Li, J."Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)". International Journal of Molecular Medicine 52.4 (2023): 88.
Chicago
Li, J., Xian, L., Zhu, Z., Wang, Y., Zhang, W., Zheng, R., Xue, W., Li, J."Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)". International Journal of Molecular Medicine 52, no. 4 (2023): 88. https://doi.org/10.3892/ijmm.2023.5291
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Xian L, Zhu Z, Wang Y, Zhang W, Zheng R, Xue W and Li J: Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review). Int J Mol Med 52: 88, 2023.
APA
Li, J., Xian, L., Zhu, Z., Wang, Y., Zhang, W., Zheng, R. ... Li, J. (2023). Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review). International Journal of Molecular Medicine, 52, 88. https://doi.org/10.3892/ijmm.2023.5291
MLA
Li, J., Xian, L., Zhu, Z., Wang, Y., Zhang, W., Zheng, R., Xue, W., Li, J."Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)". International Journal of Molecular Medicine 52.4 (2023): 88.
Chicago
Li, J., Xian, L., Zhu, Z., Wang, Y., Zhang, W., Zheng, R., Xue, W., Li, J."Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)". International Journal of Molecular Medicine 52, no. 4 (2023): 88. https://doi.org/10.3892/ijmm.2023.5291
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