Open Access

Role of RIPK3‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases (Review)

  • Authors:
    • Sheng Chen
    • Senhong Guan
    • Zhaohan Yan
    • Fengshan Ouyang
    • Shuhuan Li
    • Lanyuan Liu
    • Jiankai Zhong
  • View Affiliations

  • Published online on: August 30, 2023     https://doi.org/10.3892/ijmm.2023.5301
  • Article Number: 98
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Necroptosis, which is distinct from apoptosis and necrosis, serves a crucial role in ontogeny and the maintenance of homeostasis. In the last decade, it has been demonstrated that the pathogenesis of cardiovascular diseases is also linked to necroptosis. Receptor interaction protein kinase (RIPK) 1, RIPK3 and mixed lineage kinase domain‑like protein serve vital roles in necroptosis. In addition to the aforementioned necroptosis‑related components, calcium/calmodulin‑dependent protein kinase II (CaMKII) has been identified as a novel substrate for RIPK3 that promotes the opening of the mitochondrial permeability transition pore (mPTP), and thus, mediates necroptosis of myocardial cells through the RIPK3‑CaMKII‑mPTP signaling pathway. The present review provides an overview of the current knowledge of the RIPK3‑CaMKII‑mPTP‑mediated necroptosis signaling pathway in cardiovascular diseases, focusing on the role of the RIPK3‑CaMKII‑mPTP signaling pathway in acute myocardial infarction, ischemia‑reperfusion injury, heart failure, abdominal aortic aneurysm, atherosclerosis, diabetic cardiomyopathy, hypertrophic cardiomyopathy, atrial fibrillation, and the cardiotoxicity associated with antitumor drugs and other chemicals. Finally, the present review discusses the research status of drugs targeting the RIPK3‑CaMKII‑mPTP signaling pathway.
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October-2023
Volume 52 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Chen S, Guan S, Yan Z, Ouyang F, Li S, Liu L and Zhong J: Role of RIPK3‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases (Review). Int J Mol Med 52: 98, 2023.
APA
Chen, S., Guan, S., Yan, Z., Ouyang, F., Li, S., Liu, L., & Zhong, J. (2023). Role of RIPK3‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases (Review). International Journal of Molecular Medicine, 52, 98. https://doi.org/10.3892/ijmm.2023.5301
MLA
Chen, S., Guan, S., Yan, Z., Ouyang, F., Li, S., Liu, L., Zhong, J."Role of RIPK3‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases (Review)". International Journal of Molecular Medicine 52.4 (2023): 98.
Chicago
Chen, S., Guan, S., Yan, Z., Ouyang, F., Li, S., Liu, L., Zhong, J."Role of RIPK3‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases (Review)". International Journal of Molecular Medicine 52, no. 4 (2023): 98. https://doi.org/10.3892/ijmm.2023.5301