Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November-2023 Volume 52 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2023 Volume 52 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Role of transcription factor FOXM1 in diabetes and its complications (Review)

  • Authors:
    • Baoqing Zhao
    • Mengxi Li
    • Yanting Su
    • Shigang Shan
    • Wenbin Qian
    • Dan Zhu
    • Xiufen Liu
    • Zhenwang Zhang
  • View Affiliations / Copyright

    Affiliations: Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437000, P.R. China, School of Nuclear Technology and Chemistry and Biology, Hubei University of Science and Technology, Xianning, Hubei 437000, P.R. China, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437000, P.R. China, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437000, P.R. China, Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 101
    |
    Published online on: September 5, 2023
       https://doi.org/10.3892/ijmm.2023.5304
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Diabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biological processes such as cell cycle, DNA damage repair, cell differentiation and epithelial‑mesenchymal transition. FOXM1 is involved in regulation of insulin secretion and insulin resistance, and FOXM1 affects insulin secretion by regulating expression of insulin‑related genes and signaling pathways; FOXM1 is involved in the inflammatory response in diabetes, and FOXM1 can regulate key genes associated with inflammatory response and immune cells, which in turn affects occurrence and development of the inflammatory response; finally, FOXM1 is involved in the regulation of diabetic complications such as cardiovascular disease, nephropathy and neuropathy. In summary, the transcription factor FOXM1 serves an important role in development of diabetes and its complications. Future studies should explore the mechanism of FOXM1 in diabetes and find new targets of FOXM1 as a potential treatment for diabetes and its complications.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE and Makaroff LE: IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015-2040. Diabetes Res Clin Pract. 128:40–50. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Tomic D, Shaw JE and Magliano DJ: The burden and risks of emerging complications of diabetes mellitus. Nat Rev Endocrinol. 18:525–539. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Huang HK, Liu PP, Lin SM, Hsu JY, Yeh JI, Lai EC, Peng CC, Munir KM, Loh CH and Tu YK: Diabetes-Related complications and mortality in patients with atrial fibrillation receiving different oral anticoagulants: A nationwide analysis. Ann Intern Med. 175:490–498. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Zhu S, Li J and Zhao X: Comparative risk of new-onset hyperkalemia for antihypertensive drugs in patients with diabetic nephropathy: A Bayesian network meta-analysis. Int J Clin Pract. 75:e139402021. View Article : Google Scholar

5 

Kong L, Zhao H, Fan J, Wang Q, Li J, Bai J and Mao J: Predictors of frailty among Chinese community-dwelling older adults with type 2 diabetes: A cross-sectional survey. BMJ Open. 11:e0415782021. View Article : Google Scholar : PubMed/NCBI

6 

Chen Y, Wu G and Xu M: The effect of L-thyroxine substitution on oxidative stress in early-stage diabetic nephropathy patients with subclinical hypothyroidism: A randomized double-blind and placebo-controlled study. Int Urol Nephrol. 50:97–103. 2018. View Article : Google Scholar

7 

Yao S, Fan LY and Lam EW: The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance. Semin Cancer Biol. 50:77–89. 2018. View Article : Google Scholar

8 

Zhang Z, Liu W, Bao X, Sun T, Wang J, Li M and Liu C: USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1. Am J Cancer Res. 12:3644–3661. 2022.PubMed/NCBI

9 

Sawaya AP, Stone RC, Brooks SR, Pastar I, Jozic I, Hasneen K, O'Neill K, Mehdizadeh S, Head CR, Strbo N, et al: Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing. Nat Commun. 11:46782020. View Article : Google Scholar : PubMed/NCBI

10 

Sawaya AP, Stone RC, Mehdizadeh S, Pastar I, Worrell S, Balukoff NC, Kaplan MJ, Tomic-Canic M and Morasso MI: FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers. EMBO Rep. 23:e545582022. View Article : Google Scholar : PubMed/NCBI

11 

Mondal A, Das S, Samanta J, Chakraborty S and Sengupta A: YAP1 induces hyperglycemic stress-mediated cardiac hypertrophy and fibrosis in an AKT-FOXM1 dependent signaling pathway. Arch Biochem Biophys. 722:1091982022. View Article : Google Scholar : PubMed/NCBI

12 

Cao J, Jiang X and Peng X: Forkhead box M1 inhibits endothelial cell apoptosis and cell-cycle arrest through ROS generation. Int J Clin Exp Pathol. 11:4899–4907. 2018.PubMed/NCBI

13 

Hamledari H, Sajjadi SF, Alikhah A, Boroumand MA and Behmanesh M: ASGR1 but not FOXM1 expression decreases in the peripheral blood mononuclear cells of diabetic atherosclerotic patients. J Diabetes Complications. 33:539–546. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Xu X, Zhang L, Hua F, Zhang C, Zhang C, Mi X, Qin N, Wang J, Zhu A, Qin Z and Zhou F: FOXM1-activated SIRT4 inhibits NF-κB signaling and NLRP3 inflammasome to alleviate kidney injury and podocyte pyroptosis in diabetic nephropathy. Exp Cell Res. 408:1128632021. View Article : Google Scholar

15 

Yang Y, Zhang B, Yang Y, Peng B and Ye R: FOXM1 accelerates wound healing in diabetic foot ulcer by inducing M2 macrophage polarization through a mechanism involving SEMA3C/NRP2/Hedgehog signaling. Diabetes Res Clin Pract. 184:1091212022. View Article : Google Scholar

16 

Gerst F, Kemter E, Lorza-Gil E, Kaiser G, Fritz AK, Nano R, Piemonti L, Gauder M, Dahl A, Nadalin S, et al: The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells. Diabetologia. 64:1358–1374. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Tabatabaei Dakhili SA, Perez DJ, Gopal K, Haque M, Ussher JR, Kashfi K and Velázquez-Martínez CA: SP1-independent inhibition of FOXM1 by modified thiazolidinediones. Eur J Med Chem. 209:1129022021. View Article : Google Scholar

18 

Shirakawa J and Terauchi Y: Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality. Endocr J. 67:1–8. 2020. View Article : Google Scholar

19 

Ma J, Xing B, Cao Y, He X, Bennett KE, Tong C, An C, Hojnacki T, Feng Z, Deng S, et al: Menin-regulated Pbk controls high fat diet-induced compensatory beta cell proliferation. EMBO Mol Med. 13:e135242021. View Article : Google Scholar : PubMed/NCBI

20 

Kohata M, Imai J, Izumi T, Yamamoto J, Kawana Y, Endo A, Sugawara H, Seike J, Kubo H, Komamura H, et al: Roles of FoxM1-driven basal β-cell proliferation in maintenance of β-cell mass and glucose tolerance during adulthood. J Diabetes Investig. 13:1666–1676. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Chen HY, Chen DT, Chiang YY, Lin SY and Lee CN: The correlation of forkhead box protein M1 (FOXM1) with gestational diabetes mellitus in maternal peripheral blood and neonatal umbilical cord blood. Taiwan J Obstet Gynecol. 61:652–656. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Detarya M, Thaenkaew S, Seubwai W, Indramanee S, Phoomak C, Saengboonmee C, Wongkham S and Wongkham C: High glucose upregulates FOXM1 expression via EGFR/STAT3 dependent activation to promote progression of cholangiocarcinoma. Life Sci. 271:1191142021. View Article : Google Scholar : PubMed/NCBI

23 

Peng G, Mosleh E, Yuhas A, Katada K, Cherry C and Golson ML: FOXM1 acts sexually dimorphically to regulate functional β-cell mass. bioRxiv. Jan 12–2023.Epub ahead of print.

24 

Zhong L, Zhao Z, Hu Q, Li Y, Zhao W, Li C, Xu Y, Rong R, Zhang J, Zhang Z, et al: Identification of maturity-onset diabetes of the young caused by mutation in FOXM1 via whole-exome sequencing in Northern China. Front Endocrinol (Lausanne). 11:–534362. 2021. View Article : Google Scholar

25 

Imai J: Regulation of compensatory β-cell proliferation by inter-organ networks from the liver to pancreatic β-cells. Endocr J. 65:677–684. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Imai J: Regulation of adaptive cell proliferation by vagal nerve signals for maintenance of whole-body homeostasis: Potential therapeutic target for insulin-deficient diabetes. Tohoku J Exp Med. 254:245–252. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Izumi T, Imai J, Yamamoto J, Kawana Y, Endo A, Sugawara H, Kohata M, Asai Y, Takahashi K, Kodama S, et al: Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation. Nat Commun. 9:53002018. View Article : Google Scholar : PubMed/NCBI

28 

Chen M, Zhao S, Guo WH, Zhu YP, Pan L, Xie ZW, Sun WL and Jiang JT: Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling. Ecotoxicol Environ Saf. 205:1111542020. View Article : Google Scholar : PubMed/NCBI

29 

Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN and Terauchi Y: Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway. Diabetologia. 63:577–587. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Sun X, Luo LH, Feng L and Li DS: Down-regulation of lncRNA MEG3 promotes endothelial differentiation of bone marrow derived mesenchymal stem cells in repairing erectile dysfunction. Life Sci. 208:246–252. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Peng W, Zhu T, Xiang G, Ding T, Zhao J, Xiong D, Zhong Y and Zhang Y: Identification of signalling downstream of the transcription factor forkhead box protein M1 that protects against endoplasmic reticulum stress in a diabetic foot ulcer model. Diabet Med. 40:e150512023. View Article : Google Scholar : PubMed/NCBI

32 

Zuppo DA, Missinato MA, Santana-Santos L, Li G, Benos PV and Tsang M: Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development. 150:dev2011632023. View Article : Google Scholar : PubMed/NCBI

33 

Zhang Z, Li M, Sun T, Zhang Z and Liu C: FOXM1: Functional roles of FOXM1 in Non-Malignant diseases. Biomolecules. 13:8572023. View Article : Google Scholar : PubMed/NCBI

34 

Filipsson K, Sundler F, Hannibal J and Ahren B: PACAP and PACAP receptors in insulin producing tissues: Localization and effects. Regul Pept. 74:167–175. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Ahren B: Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov. 8:369–385. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Zhang L, Jiang B, Zhu N, Tao M, Jun Y, Chen X, Wang Q and Luo C: Mitotic checkpoint kinase Mps1/TTK predicts prognosis of colon cancer patients and regulates tumor proliferation and differentiation via PKCα/ERK1/2 and PI3K/Akt pathway. Med Oncol. 37:52019. View Article : Google Scholar

37 

Zheng J, Bu X, Wei X, Ma X and Zhao P: The role of FoxM1 in immune cells. Clin Exp Med. Mar 13–2023.Epub ahead of print.

38 

Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, Costa RH and Gannon M: The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Mol Endocrinol. 20:1853–1866. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Mahmoodzadeh Sagheb M, Azarpira N, Mokhtary M, Hosseini SE and Yaghobi R: The effects of Leptin and Adiponectin on Pdx1, Foxm1, and PPARү Transcription in rat islets of langerhans. Hepat Mon. 13:e90552013.

40 

Liu MN, Zhang L, Dong XY, Liu M, Cheng G, Zhang XL, He F and Wang GQ: Effects of Akkermansia muciniphila on the proliferation, apoptosis and insulin secretion of rat islet cell tumor cells. Sichuan Da Xue Xue Bao Yi Xue Ban. 51:13–17. 2020.In Chinese. PubMed/NCBI

41 

Saavedra-García P, Nichols K, Mahmud Z, Fan LY and Lam EW: Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis. Mol Cell Endocrinol. 462(Pt B): 82–92. 2018. View Article : Google Scholar

42 

Yamamoto J, Imai J, Izumi T, Takahashi H, Kawana Y, Takahashi K, Kodama S, Kaneko K, Gao J, Uno K, et al: Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism. Nat Commun. 8:19302017. View Article : Google Scholar

43 

Imai J and Katagiri H: Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation. Int Immunol. 34:67–79. 2022. View Article : Google Scholar

44 

Shang R, Wang M, Dai B, Du J, Wang J, Liu Z, Qu S, Yang X, Liu J, Xia C, et al: Long noncoding RNA SLC2A1-AS1 regulates aerobic glycolysis and progression in hepatocellular carcinoma via inhibiting the STAT3/FOXM1/GLUT1 pathway. Mol Oncol. 14:1381–1396. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Yang Y, Cai Z, Pan Z, Liu F, Li D, Ji Y, Zhong J, Luo H, Hu S, Song L, et al: Rheb1 promotes glucose-stimulated insulin secretion in human and mouse β-cells by upregulating GLUT expression. Metabolism. 123:1548632021. View Article : Google Scholar

46 

Heo YJ, Choi SE, Jeon JY, Han SJ, Kim DJ, Kang Y, Lee KW and Kim HJ: Visfatin induces inflammation and insulin resistance via the NF-κB and STAT3 signaling pathways in hepatocytes. J Diabetes Res. 2019:40216232019. View Article : Google Scholar

47 

Alaaeldin R, Abdel-Rahman IAM, Hassan HA, Youssef N, Allam AE, Abdelwahab SF, Zhao QL and Fathy M: Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway. Molecules. 26:76292021. View Article : Google Scholar : PubMed/NCBI

48 

Gao W, Du X, Lei L, Wang H, Zhang M, Wang Z and Li X, Liu G and Li X: NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis. J Cell Mol Med. 22:3408–3422. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Shrestha S, Kumar Singh V, Kumar Sarkar S, Shanmugasundaram B, Jeevaratnam K and Chandra Koner B: Effect of sub-toxic exposure to Malathion on glucose uptake and insulin signaling in L6 myoblast derived myotubes. Drug Chem Toxicol. 43:663–670. 2020. View Article : Google Scholar

50 

Saltiel AR: Insulin signaling in health and disease. J Clin Invest. 131:e1422412021. View Article : Google Scholar : PubMed/NCBI

51 

Zarrouki B, Benterki I, Fontés G, Peyot ML, Seda O, Prentki M and Poitout V: Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1. Diabetes. 63:982–993. 2014. View Article : Google Scholar :

52 

Zhao C, Chen HY, Zhao F, Feng HJ and Su JP: Acylglycerol kinase promotes paclitaxel resistance in nasopharyngeal carcinoma cells by regulating FOXM1 via the JAK2/STAT3 pathway. Cytokine. 148:1555952021. View Article : Google Scholar : PubMed/NCBI

53 

Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, et al: Reciprocal regulation between forkhead box M1/NF-κB and methionine adenosyltransferase 1A drives liver cancer. Hepatology. 72:1682–1700. 2020. View Article : Google Scholar : PubMed/NCBI

54 

Bodis K and Roden M: Energy metabolism of white adipose tissue and insulin resistance in humans. Eur J Clin Invest. 48:e130172018. View Article : Google Scholar : PubMed/NCBI

55 

Zheng S, Chen N, Kang X, Hu Y and Shi S: Irisin alleviates FFA induced β-cell insulin resistance and inflammatory response through activating PI3K/AKT/FOXO1 signaling pathway. Endocrine. 75:740–751. 2022. View Article : Google Scholar

56 

Zhang Q, Kong X, Yuan H, Guan H, Li Y and Niu Y: Mangiferin improved palmitate-induced-insulin resistance by promoting free fatty acid metabolism in HepG2 and C2C12 cells via PPARα: Mangiferin improved insulin resistance. J Diabetes Res. 2019:20526752019. View Article : Google Scholar

57 

Choi HJ, Jhe YL, Kim J, Lim JY, Lee JE, Shin MK and Cheong JH: FoxM1-dependent and fatty acid oxidation-mediated ROS modulation is a cell-intrinsic drug resistance mechanism in cancer stem-like cells. Redox Biol. 36:1015892020. View Article : Google Scholar : PubMed/NCBI

58 

Longo M, Zatterale F, Naderi J, Parrillo L, Formisano P, Raciti GA, Beguinot F and Miele C: Adipose tissue dysfunction as determinant of obesity-associated metabolic complications. Int J Mol Sci. 20:23582019. View Article : Google Scholar : PubMed/NCBI

59 

Tian S, Lei I, Gao W, Liu L, Guo Y, Creech J, Herron TJ, Xian S, Ma PX, Eugene Chen Y, et al: HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction. EBioMedicine. 39:83–94. 2019. View Article : Google Scholar :

60 

Tang SCW and Yiu WH: Innate immunity in diabetic kidney disease. Nat Rev Nephrol. 16:206–222. 2020. View Article : Google Scholar : PubMed/NCBI

61 

Vaidya VS, Niewczas MA, Ficociello LH, Johnson AC, Collings FB, Warram JH, Krolewski AS and Bonventre JV: Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase. Kidney Int. 79:464–470. 2011. View Article : Google Scholar

62 

Alicic RZ, Johnson EJ and Tuttle KR: Inflammatory mechanisms as new biomarkers and therapeutic targets for diabetic kidney disease. Adv Chronic Kidney Dis. 25:181–191. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Nastase MV, Zeng-Brouwers J, Beckmann J, Tredup C, Christen U, Radeke HH, Wygrecka M and Schaefer L: Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biol. 68-69:293–317. 2018. View Article : Google Scholar

64 

Xie H, Miao N, Xu D, Zhou Z, Ni J, Yin F, Wang Y, Cheng Q, Chen P, Li J, et al: FoxM1 promotes Wnt/β-catenin pathway activation and renal fibrosis via transcriptionally regulating multi-Wnts expressions. J Cell Mol Med. 25:1958–1971. 2021. View Article : Google Scholar : PubMed/NCBI

65 

Zhu-Ge D, Yang YP and Jiang ZJ: Knockdown CRNDE alleviates LPS-induced inflammation injury via FOXM1 in WI-38 cells. Biomed Pharmacother. 103:1678–1687. 2018. View Article : Google Scholar : PubMed/NCBI

66 

Zhou M, Shi J, Lan S and Gong X: FOXM1 regulates the proliferation, apoptosis and inflammatory response of keratinocytes through the NF-κB signaling pathway. Hum Exp Toxicol. 40:1130–1140. 2021. View Article : Google Scholar : PubMed/NCBI

67 

Song S, Zhang R, Cao W, Fang G, Yu Y, Wan Y, Wang C, Li Y and Wang Q: Foxm1 is a critical driver of TGF-β-induced EndMT in endothelial cells through Smad2/3 and binds to the Snail promoter. J Cell Physiol. 234:9052–9064. 2019. View Article : Google Scholar

68 

Chen Y, Li Y, Xue J, Gong A, Yu G, Zhou A, Lin K, Zhang S, Zhang N, Gottardi CJ and Huang S: Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. EMBO J. 35:668–684. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Xie H, Gao YM, Zhang YC, Jia MW, Peng F, Meng QH and Wang YC: Low let-7d exosomes from pulmonary vascular endothelial cells drive lung pericyte fibrosis through the TGFβRI/FoxM1/Smad/β-catenin pathway. J Cell Mol Med. 24:13913–13926. 2020. View Article : Google Scholar : PubMed/NCBI

70 

Jalgaonkar MP, Parmar UM, Kulkarni YA and Oza MJ: SIRT1-FOXOs activity regulates diabetic complications. Pharmacol Res. 175:1060142022. View Article : Google Scholar

71 

Inoue Y, Moriwaki K, Ueda Y, Takeuchi T, Higuchi K and Asahi M: Elevated O-GlcNAcylation stabilizes FOXM1 by its reduced degradation through GSK-3β inactivation in a human gastric carcinoma cell line, MKN45 cells. Biochem Biophys Res Commun. 495:1681–1687. 2018. View Article : Google Scholar

72 

Behl T, Wadhwa M, Sehgal A, Singh S, Sharma N, Bhatia S, Al-Harrasi A, Aleya L and Bungau S: Mechanistic insights into the role of FOXO in diabetic retinopathy. Am J Transl Res. 14:3584–3602. 2022.PubMed/NCBI

73 

Sengupta A, Kalinichenko VV and Yutzey KE: FoxO1 and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell-cycle withdrawal and IGF1 gene regulation. Circ Res. 112:267–277. 2013. View Article : Google Scholar

74 

Ioannou K: Diabetic nephropathy: Is it always there? Assumptions, weaknesses and pitfalls in the diagnosis. Hormones (Athens). 16:351–361. 2017.

75 

Sanajou D, Ghorbani Haghjo A, Argani H and Aslani S: AGE-RAGE axis blockade in diabetic nephropathy: Current status and future directions. Eur J Pharmacol. 833:158–164. 2018. View Article : Google Scholar : PubMed/NCBI

76 

Tziomalos K and Athyros VG: Diabetic Nephropathy: New risk factors and improvements in diagnosis. Rev Diabet Stud. 12:110–118. 2015. View Article : Google Scholar : PubMed/NCBI

77 

Qi C, Mao X, Zhang Z and Wu H: Classification and differential diagnosis of diabetic nephropathy. J Diabetes Res. 2017:86371382017. View Article : Google Scholar : PubMed/NCBI

78 

Sinha S, Dwivedi N, Woodgett J, Tao S, Howard C, Fields TA, Jamadar A and Rao R: Glycogen synthase kinase-3β inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism. FASEB J. 34:13597–13608. 2020. View Article : Google Scholar : PubMed/NCBI

79 

Chang-Panesso M, Kadyrov FF, Lalli M, Wu H, Ikeda S, Kefaloyianni E, Abdelmageed MM, Herrlich A, Kobayashi A and Humphreys BD: FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury. J Clin Invest. 129:5501–5517. 2019. View Article : Google Scholar : PubMed/NCBI

80 

Wang Y, Zhou Q, Tang R, Huang Y and He T: FoxM1 inhibition ameliorates renal interstitial fibrosis by decreasing extracellular matrix and epithelial-mesenchymal transition. J Pharmacol Sci. 143:281–289. 2020. View Article : Google Scholar : PubMed/NCBI

81 

Yu W, Wang G, Li LX, Zhang H, Gui X, Zhou JX, Calvet JP and Li X: Transcription factor FoxM1 promotes cyst growth in PKD1 mutant ADPKD. Hum Mol Genet. 32:1114–1126. 2023. View Article : Google Scholar

82 

Halasi M and Gartel AL: Targeting FOXM1 in cancer. Biochem Pharmacol. 85:644–652. 2013. View Article : Google Scholar

83 

Liao GB, Li XZ, Zeng S, Liu C, Yang SM, Yang L, Hu CJ and Bai JY: Regulation of the master regulator FOXM1 in cancer. Cell Commun Signal. 16:572018. View Article : Google Scholar : PubMed/NCBI

84 

Zhu X, Yu M, Wang K, Zou W and Zhu L: FoxM1 affects adhesive, migratory, and invasive abilities of human retinoblastoma Y-79 cells by targeting matrix metalloproteinase 2. Acta Biochim Biophys Sin (Shanghai). 52:294–301. 2020. View Article : Google Scholar : PubMed/NCBI

85 

Zhu X, Xue L, Yao Y, Wang K, Tan C, Zhuang M, Zhou F and Zhu L: The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells. Acta Biochim Biophys Sin (Shanghai). 50:914–920. 2018. View Article : Google Scholar : PubMed/NCBI

86 

Wang RT, Miao RC, Zhang X, Yang GH, Mu YP, Zhang ZY, Qu K and Liu C: Fork head box M1 regulates vascular endothelial growth factor-A expression to promote the angiogenesis and tumor cell growth of gallbladder cancer. World J Gastroenterol. 27:692–707. 2021. View Article : Google Scholar : PubMed/NCBI

87 

Zhang Y, Cheng C, Wang S, Xu M, Zhang D and Zeng W: Knockdown of FOXM1 inhibits activation of keloid fibroblasts and extracellular matrix production via inhibition of TGF-β1/Smad pathway. Life Sci. 232:1166372019. View Article : Google Scholar

88 

Mencalha AL, Binato R, Ferreira GM, Du Rocher B and Abdelhay E: Forkhead box M1 (FoxM1) gene is a new STAT3 transcriptional factor target and is essential for proliferation, survival and DNA repair of K562 cell line. PLoS One. 7:e481602012. View Article : Google Scholar : PubMed/NCBI

89 

Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, et al: Regulation of pancreatic beta cell mass by neuronal signals from the liver. Science. 322:1250–1254. 2008. View Article : Google Scholar : PubMed/NCBI

90 

Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, Nadal-Ginard B and Anversa P: Myocardial cell death in human diabetes. Circ Res. 87:1123–1132. 2000. View Article : Google Scholar : PubMed/NCBI

91 

Dai Z, Zhu MM, Peng Y, Jin H, Machireddy N, Qian Z, Zhang X and Zhao YY: Endothelial and Smooth muscle cell interaction via FoxM1 Signaling mediates vascular remodeling and pulmonary hypertension. Am J Respir Crit Care Med. 198:788–802. 2018. View Article : Google Scholar : PubMed/NCBI

92 

Wang Y, Li Y, Feng J, Liu W, Li Y, Liu J, Yin Q, Lian H, Liu L and Nie Y: Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration. Theranostics. 10:9100–9112. 2020. View Article : Google Scholar : PubMed/NCBI

93 

Eltoft A, Arntzen KA, Wilsgaard T, Mathiesen EB and Johnsen SH: Interleukin-6 is an independent predictor of progressive atherosclerosis in the carotid artery: The Tromso Study. Atherosclerosis. 271:1–8. 2018. View Article : Google Scholar : PubMed/NCBI

94 

Li H, Horke S and Forstermann U: Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis. 237:208–219. 2014. View Article : Google Scholar : PubMed/NCBI

95 

Nahrendorf M and Swirski FK: Cholesterol, CCR2, and monocyte phenotypes in atherosclerosis. Eur Heart J. 38:1594–1596. 2017. View Article : Google Scholar : PubMed/NCBI

96 

Balli D, Ren X, Chou FS, Cross E, Zhang Y, Kalinichenko VV and Kalin TV: Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation. Oncogene. 31:3875–3888. 2012. View Article : Google Scholar :

97 

Lok GT, Chan DW, Liu VW, Hui WW, Leung TH, Yao KM and Ngan HY: Aberrant activation of ERK/FOXM1 signaling cascade triggers the cell migration/invasion in ovarian cancer cells. PLoS One. 6:e237902011. View Article : Google Scholar : PubMed/NCBI

98 

Xie Y, Cui D, Sui L, Xu Y, Zhang N, Ma Y, Li Y and Kong Y: Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion. Cell Tissue Res. 362:421–430. 2015. View Article : Google Scholar : PubMed/NCBI

99 

Brem H and Tomic-Canic M: Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 117:1219–1222. 2007. View Article : Google Scholar : PubMed/NCBI

100 

Armstrong DG, Swerdlow MA, Armstrong AA, Conte MS, Padula WV and Bus SA: Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer. J Foot Ankle Res. 13:162020. View Article : Google Scholar : PubMed/NCBI

101 

Soo BP, Rajbhandari S, Egun A, Ranasinghe U, Lahart IM and Pappachan JM: Survival at 10 years following lower extremity amputations in patients with diabetic foot disease. Endocrine. 69:100–106. 2020. View Article : Google Scholar : PubMed/NCBI

102 

Smirnov A, Panatta E, Lena A, Castiglia D, Di Daniele N, Melino G and Candi E: FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells. Aging (Albany NY). 8:1384–1397. 2016. View Article : Google Scholar : PubMed/NCBI

103 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y and Zychlinsky A: Neutrophil extracellular traps kill bacteria. Science. 303:1532–1535. 2004. View Article : Google Scholar : PubMed/NCBI

104 

Lood C, Blanco LP, Purmalek MM, Carmona-Rivera C, De Ravin SS, Smith CK, Malech HL, Ledbetter JA, Elkon KB and Kaplan MJ: Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med. 22:146–153. 2016. View Article : Google Scholar : PubMed/NCBI

105 

Carrasco K, Boufenzer A, Jolly L, Le Cordier H, Wang G, Heck AJ, Cerwenka A, Vinolo E, Nazabal A, Kriznik A, et al: TREM-1 multimerization is essential for its activation on monocytes and neutrophils. Cell Mol Immunol. 16:460–472. 2019. View Article : Google Scholar :

106 

Palmer WC and Patel T: Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma. J Hepatol. 57:69–76. 2012. View Article : Google Scholar : PubMed/NCBI

107 

de Beer JC and Liebenberg L: Does cancer risk increase with HbA1c, independent of diabetes? Br J Cancer. 110:2361–2368. 2014. View Article : Google Scholar : PubMed/NCBI

108 

Hosokawa T, Kurosaki M, Tsuchiya K, Matsuda S, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Nakata T, Nishimura T, et al: Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy. World J Gastroenterol. 19:249–257. 2013. View Article : Google Scholar : PubMed/NCBI

109 

Casagrande V, Mauriello A, Anemona L, Mavilio M, Iuliani G, De Angelis L, D'Onofrio M, Arisi I, Federici M and Menghini R: Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice. Acta Diabetol. 56:1265–1274. 2019. View Article : Google Scholar : PubMed/NCBI

110 

Andrei LG: Thiazole antibiotics siomycin a and thiostrepton inhibit the transcriptional activity of FOXM1. Front Oncol. 3:1502013.

111 

Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A and Kulkarni RN: Insulin signaling regulates the FoxM1/PLK1/CENP-A pathway to promote adaptive pancreatic β cell proliferation. Cell Metab. 25:868–882 e5. 2017. View Article : Google Scholar

112 

Ma Y, Wang X, Peng Y and Ding X: Forkhead box O1 promotes INS-1 cell apoptosis by reducing the expression of CD24. Mol Med Rep. 13:2991–2998. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao B, Li M, Su Y, Shan S, Qian W, Zhu D, Liu X and Zhang Z: Role of transcription factor FOXM1 in diabetes and its complications (Review). Int J Mol Med 52: 101, 2023.
APA
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D. ... Zhang, Z. (2023). Role of transcription factor FOXM1 in diabetes and its complications (Review). International Journal of Molecular Medicine, 52, 101. https://doi.org/10.3892/ijmm.2023.5304
MLA
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D., Liu, X., Zhang, Z."Role of transcription factor FOXM1 in diabetes and its complications (Review)". International Journal of Molecular Medicine 52.5 (2023): 101.
Chicago
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D., Liu, X., Zhang, Z."Role of transcription factor FOXM1 in diabetes and its complications (Review)". International Journal of Molecular Medicine 52, no. 5 (2023): 101. https://doi.org/10.3892/ijmm.2023.5304
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao B, Li M, Su Y, Shan S, Qian W, Zhu D, Liu X and Zhang Z: Role of transcription factor FOXM1 in diabetes and its complications (Review). Int J Mol Med 52: 101, 2023.
APA
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D. ... Zhang, Z. (2023). Role of transcription factor FOXM1 in diabetes and its complications (Review). International Journal of Molecular Medicine, 52, 101. https://doi.org/10.3892/ijmm.2023.5304
MLA
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D., Liu, X., Zhang, Z."Role of transcription factor FOXM1 in diabetes and its complications (Review)". International Journal of Molecular Medicine 52.5 (2023): 101.
Chicago
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D., Liu, X., Zhang, Z."Role of transcription factor FOXM1 in diabetes and its complications (Review)". International Journal of Molecular Medicine 52, no. 5 (2023): 101. https://doi.org/10.3892/ijmm.2023.5304
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team