Open Access

Role of transcription factor FOXM1 in diabetes and its complications (Review)

  • Authors:
    • Baoqing Zhao
    • Mengxi Li
    • Yanting Su
    • Shigang Shan
    • Wenbin Qian
    • Dan Zhu
    • Xiufen Liu
    • Zhenwang Zhang
  • View Affiliations

  • Published online on: September 5, 2023     https://doi.org/10.3892/ijmm.2023.5304
  • Article Number: 101
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetes mellitus is a chronic metabolic disease commonly associated with complications such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is increasing yearly. Transcription factor forkhead box M1 (FOXM1) serves an important role in development of diabetes and its complications. The present study aimed to review the association between FOXM1 with pathogenesis of diabetes and its complications. FOXM1 may be involved in development and progression of diabetes and its complications by regulating cell biological processes such as cell cycle, DNA damage repair, cell differentiation and epithelial‑mesenchymal transition. FOXM1 is involved in regulation of insulin secretion and insulin resistance, and FOXM1 affects insulin secretion by regulating expression of insulin‑related genes and signaling pathways; FOXM1 is involved in the inflammatory response in diabetes, and FOXM1 can regulate key genes associated with inflammatory response and immune cells, which in turn affects occurrence and development of the inflammatory response; finally, FOXM1 is involved in the regulation of diabetic complications such as cardiovascular disease, nephropathy and neuropathy. In summary, the transcription factor FOXM1 serves an important role in development of diabetes and its complications. Future studies should explore the mechanism of FOXM1 in diabetes and find new targets of FOXM1 as a potential treatment for diabetes and its complications.
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November-2023
Volume 52 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhao B, Li M, Su Y, Shan S, Qian W, Zhu D, Liu X and Zhang Z: Role of transcription factor FOXM1 in diabetes and its complications (Review). Int J Mol Med 52: 101, 2023
APA
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D. ... Zhang, Z. (2023). Role of transcription factor FOXM1 in diabetes and its complications (Review). International Journal of Molecular Medicine, 52, 101. https://doi.org/10.3892/ijmm.2023.5304
MLA
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D., Liu, X., Zhang, Z."Role of transcription factor FOXM1 in diabetes and its complications (Review)". International Journal of Molecular Medicine 52.5 (2023): 101.
Chicago
Zhao, B., Li, M., Su, Y., Shan, S., Qian, W., Zhu, D., Liu, X., Zhang, Z."Role of transcription factor FOXM1 in diabetes and its complications (Review)". International Journal of Molecular Medicine 52, no. 5 (2023): 101. https://doi.org/10.3892/ijmm.2023.5304