You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.
I agree
International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
![]() |
![]() |
![]() |
![]() |
![]() |
|
Wang X, Iyaswamy A, Xu D, Krishnamoorthi S, Sreenivasmurthy SG, Yang Y, Li Y, Chen C, Li M, Li HW and Wong MS: Real-time detection and visualization of amyloid-β aggregates induced by hydrogen peroxide in cell and mouse models of Alzheimer's disease. ACS Appl Mater Interfaces. 15:39–47. 2023. View Article : Google Scholar | |
|
Shih YH, Tu LH, Chang TY, Ganesan K, Chang WW, Chang PS, Fang YS, Lin YT, Jin LW and Chen YR: TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease. Nat Commun. 11:59502020. View Article : Google Scholar | |
|
Nasaruddin ML, Pan X, McGuinness B, Passmore P, Kehoe PG, Holscher C, Graham SF and Green BD: Evidence that parietal lobe fatty acids may be more profoundly affected in moderate Alzheimer's disease (AD) pathology than in severe AD pathology. Metabolites. 8:692018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen YG: Research progress in the pathogenesis of Alzheimer's disease. Chin Med J (Engl). 131:1618–1624. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, et al: Targeting neuroinflammation to treat Alzheimer's disease. CNS Drugs. 31:1057–1082. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Finneran DJ and Nash KR: Neuroinflammation and fractalkine signaling in Alzheimer's disease. J Neuroinflammation. 16:302019. View Article : Google Scholar : PubMed/NCBI | |
|
Souza LC, Filho CB, Goes AT, Fabbro LD, de Gomes MG, Savegnago L, Oliveira MS and Jesse CR: Neuroprotective effect of physical exercise in a mouse model of Alzheimer's disease induced by β-amyloid 2013. 1-40 peptide. Neurotox Res. 24:148–163. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ and Bowers WJ: Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. 2:232005. View Article : Google Scholar : PubMed/NCBI | |
|
Ma K, Mount HTJ and McLaurin J: Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice. Neurosci Lett. 492:5–10. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wu YY, Hsu JL, Wang HC, Wu SJ, Hong CJ and Cheng IHJ: Alterations of the neuroinflammatory markers IL-6 and TRAIL in Alzheimer's disease. Dement Geriatr Cogn Dis Extra. 5:424–434. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Takeda S, Sato N, Ikimura K, Nishino H, Rakugi H and Morishita R: Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model. Neurobiol Aging. 34:2064–2070. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Mann DM, Tucker CM and Yates PO: Alzheimer's disease: An olfactory connection? Mech Ageing Dev. 42:1–15. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Christen-Zaech S, Kraftsik R, Pillevuit O, Kiraly M, Martins R, Khalili K and Miklossy J: Early olfactory involvement in Alzheimer's disease. Can J Neurol Sci. 30:20–25. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, et al: Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model. Acta Neuropathol Commun. 8:672020. View Article : Google Scholar : PubMed/NCBI | |
|
Walker DG, Dalsing-Hernandez JE, Campbell NA and Lue LF: Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation. Exp Neurol. 215:5–19. 2009. View Article : Google Scholar : | |
|
Ham HJ, Lee YS, Yun J, Son DJ, Lee HP, Han SB and Hong JT: K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of chitinase-3-like 1 regulating ERK-dependent PTX3 pathway. J Neuroinflammation. 17:3502020. View Article : Google Scholar : PubMed/NCBI | |
|
Cullen NC, Malarstig AN, Stomrud E, Hansson O and Mattsson-Carlgren N: Accelerated inflammatory aging in Alzheimer's disease and its relation to amyloid, tau, and cognition. Sci Rep. 11:19652021. View Article : Google Scholar : PubMed/NCBI | |
|
Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, et al: A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation. Nat Commun. 9:20362018. View Article : Google Scholar : PubMed/NCBI | |
|
Erny D, Hrabě de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, et al: Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 18:965–977. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Sierra A, Beccari S, Diaz-Aparicio I, Encinas JM, Comeau S and Tremblay MÈ: Surveillance, phagocytosis, and inflammation: How never-resting microglia influence adult hippocampal neurogenesis. Neural Plast. 2014:6103432014. View Article : Google Scholar : PubMed/NCBI | |
|
Ben-Yehuda H, Matcovitch-Natan O, Kertser A, Spinrad A, Prinz M, Amit I and Schwartz M: Maternal Type-I interferon signaling adversely affects the microglia and the behavior of the offspring accompanied by increased sensitivity to stress. Mol Psychiatr. 25:1050–1067. 2020. View Article : Google Scholar | |
|
Town T, Nikolic V and Tan J: The microglial 'activation' continuum: From innate to adaptive responses. J Neuroinflammation. 2:242005. View Article : Google Scholar | |
|
Leng F and Edison P: Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here? Nat Rev Neurol. 17:157–172. 2021. View Article : Google Scholar | |
|
Song WM, Joshita S, Zhou Y, Ulland TK, Gilfillan S and Colonna M: Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism. J Exp Med. 215:745–760. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Tansey MG, McCoy MK and Frank-Cannon TC: Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol. 208:1–25. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Jankowsky JL and Patterson PH: Cytokine and growth factor involvement in long-term potentiation. Mol Cell Neurosci. 14:273–286. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Das S and Basu A: Inflammation: A new candidate in modulating adult neurogenesis. J Neurosci Res. 86:1199–1208. 2008. View Article : Google Scholar | |
|
Heneka MT, Carson MJ, El KJ, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, et al: Neuroinflammation in Alzheimer's disease. Lancet Neurol. 14:388–405. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Giridharan S and Srinivasan M: Mechanisms of NF-κB p65 and strategies for therapeutic manipulation. J Inflamm Res. 11:407–419. 2018. View Article : Google Scholar : | |
|
Noort AR, Tak PP and Tas SW: Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? Arthritis Res Ther. 17:152015. View Article : Google Scholar | |
|
Mattson MP and Meffert MK: Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ. 13:852–860. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Miyauchi T, Uchida Y, Kadono K, Hirao H, Kawasoe J, Watanabe T, Ueda S, Okajima H, Terajima H and Uemoto S: Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury. Proc Natl Acad Sci USA. 116:13533–13542. 2019. View Article : Google Scholar | |
|
Liu Y, Li D, Jiang Q, Zhang Q, Liu P, Wang L, Zong M, Zhang Q, Li H, An Y, et al: (3R, 7R)-7-Acetoxyl-9-Oxo-de-O-methyllasiodiplodin, a secondary metabolite of penicillium Sp., inhibits LPS-mediated inflammation in RAW 264.7 macrophages through blocking ERK/MAPKs and NF-κB signaling pathways. Inflammation. 42:1463–1473. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Christian F, Smith EL and Carmody RJ: The regulation of NF-κB subunits by phosphorylation. Cells. 5:122016. View Article : Google Scholar | |
|
Oeckinghaus A and Ghosh S: The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol. 1:a0000342009. View Article : Google Scholar | |
|
Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, et al: PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes. Sci Rep. 8:142902018. View Article : Google Scholar : PubMed/NCBI | |
|
Terai K, Matsuo A and McGeer PL: Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease. Brain Res. 735:159–168. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, et al: Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain. 131:651–664. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kolesnick R and Golde DW: The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell. 77:325–328. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Kitamura Y, Shimohama S, Ota T, Matsuoka Y, Nomura Y and Taniguchi T: Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains. Neurosci Lett. 237:17–20. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Chen CH, Zhou W, Liu S, Deng Y, Cai F, Tone M, Tone Y, Tong Y and Song W: Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. Int J Neuropsychopharmacol. 15:77–90. 2012. View Article : Google Scholar | |
|
Snow WM and Albensi BC: Neuronal gene targets of NF-κB and their dysregulation in Alzheimer's disease. Front Mol Neurosci. 9:1182016. View Article : Google Scholar | |
|
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, et al: Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nat Commun. 13:19692022. View Article : Google Scholar | |
|
López N, Tormo C, De Blas I, Llinares I and Alom J: Oxidative stress in Alzheimer's disease and mild cognitive impairment with high sensitivity and specificity. J Alzheimers Dis. 33:823–829. 2013. View Article : Google Scholar | |
|
Wang SW, Yang SG, Liu W, Zhang YX, Xu PX, Wang T, Ling TJ and Liu RT: Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease. Behav Brain Res. 296:109–117. 2016. View Article : Google Scholar | |
|
Sun HJ, Xue DD, Lu BZ, Li Y, Sheng LX, Zhu Z, Zhou YW, Zhang JX, Lin GJ, Lin SZ, et al: A novel synthetic steroid of 2β,3α,5α-trihydroxy-androst-6-one alleviates the loss of rat retinal ganglion cells caused by acute intraocular hypertension via inhibiting the inflammatory activation of microglia. Molecules. 24:2522019. View Article : Google Scholar | |
|
Belkhelfa M, Rafa H, Medjeber O, Arroul-Lammali A, Behairi N, Abada-Bendib M, Makrelouf M, Belarbi S, Masmoudi AN, Tazir M and Touil-Boukoffa C: IFN-γ and TNF-α are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients. J Interferon Cytokine Res. 34:839–847. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Sui Y, Stehno-Bittel L, Li S, Loganathan R, Dhillon NK, Pinson D, Nath A, Kolson D, Narayan O and Buch S: CXCL10-induced cell death in neurons: Role of calcium dysregulation. Eur J Neurosci. 23:957–964. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Xu PX, Wang SW, Yu XL, Su YJ, Wang T, Zhou WW, Zhang H, Wang YJ and Liu RT: Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 264:173–180. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Budzynska B, Faggio C, Kruk-Slomka M, Samec D, Nabavi SF, Sureda A, Devi KP and Nabavi SM: Rutin as neuroprotective agent: From bench to bedside. Curr Med Chem. 26:5152–5164. 2019. View Article : Google Scholar | |
|
Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL and Liu RT: Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease. J Neuroinflammation. 18:1312021. View Article : Google Scholar : PubMed/NCBI | |
|
Bernard CB, Krishanmurty HG, Chauret D, Durst T, Philogène BJ, Sánchez-Vindas P, Hasbun C, Poveda L, San Román L and Arnason JT: Insecticidal defenses of piperaceae from the neotropics. J Chem Ecol. 21:801–814. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Gu SM, Lee HP, Ham YW, Son DJ, Kim HY, Oh KW, Han SB, Yun J and Hong JT: Piperlongumine improves lipopolysaccharide-induced amyloidogenesis by suppressing NF-KappaB pathway. Neuromolecular Med. 20:312–327. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Son DJ, Lee JW, Lee YH, Song HS, Lee CK and Hong JT: Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol Ther. 115:246–270. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Gu SM, Park MH, Hwang CJ, Song HS, Lee US, Han SB, Oh KW, Ham YW, Song MJ, Son DJ and Hong JT: Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway. J Neuroinflammation. 12:1242015. View Article : Google Scholar : PubMed/NCBI | |
|
Lin CC, Hsu YF and Lin TC: Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am J Chin Med. 27:371–376. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Kim YE, Hwang CJ, Lee HP, Kim CS, Son DJ, Ham YW, Hellström M, Han SB, Kim HS, Park EK and Hong JT: Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB. Neuropharmacology. 117:21–32. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S and Jia J: Tenuifolin attenuates amyloid-β42-induced neuroinflammation in microglia through the NF-κB signaling pathway. J Alzheimers Dis. 76:195–205. 2020. View Article : Google Scholar | |
|
Hammad AS, Ravindran S, Khalil A and Munusamy S: Structure-activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro. Cell Stress Chaperones. 22:417–428. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Shahbazi S, Zakerali T, Frycz B and Kaur J: Impact of novel N-aryl substituted piperamide on NF-kappa B translocation as a potent anti-neuroinflammatory agent. Biomed Pharmacother. 127:1101992020. View Article : Google Scholar : PubMed/NCBI | |
|
Shahbazi S, Zakerali T, Frycz BA and Kaur J: The critical role of piperamide derivative D4 in the regulation of inflammatory response by the microglia and astrocytic glial cells. Biomed Pharmacother. 132:1108952020. View Article : Google Scholar : PubMed/NCBI | |
|
Hsu YL, Kuo PL, Chiang LC and Lin CC: Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines. Cancer Lett. 213:213–221. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Park WH, Kang S, Piao Y, Pak CJ, Oh MS, Kim J, Kang MS and Pak YK: Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB. J Ethnopharmacol. 174:37–44. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Leláková V, Béraud-Dufour S, Hošek J, Šmejkal K, Prachyawarakorn V, Pailee P, Widmann C, Václavík J, Coppola T, Mazella J, et al: Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia. J Ethnopharmacol. 263:1131472020. View Article : Google Scholar : PubMed/NCBI | |
|
Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, et al: Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature. 522:216–220. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yeo IJ, Yun J, Son DJ, Han SB and Hong JT: Antifungal drug miconazole ameliorated memory deficits in a mouse model of LPS-induced memory loss through targeting iNOS. Cell Death Dis. 11:6232020. View Article : Google Scholar : PubMed/NCBI | |
|
Solberg NO, Chamberlin R, Vigil JR, Deck LM, Heidrich JE, Brown DC, Brady CI, Vander Jagt TA, Garwood M, Bisoffi M, et al: Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain. J Alzheimers Dis. 40:191–212. 2014. View Article : Google Scholar | |
|
Lindsay A, Hickman D and Srinivasan M: A nuclear factor-kappa B inhibiting peptide suppresses innate immune receptors and gliosis in a transgenic mouse model of Alzheimer's disease. Biomed Pharmacother. 138:1114052021. View Article : Google Scholar : PubMed/NCBI | |
|
Choi JY, Yeo IJ, Kim KC, Choi WR, Jung JK, Han SB and Hong JT: K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression. J Neuroinflammation. 15:2242018. View Article : Google Scholar | |
|
Lian W, Jia H, Xu L, Zhou W, Kang D, Liu A and Du G: Multi-protection of DL0410 in ameliorating cognitive defects in D-galactose induced aging mice. Front Aging Neurosci. 9:4092017. View Article : Google Scholar : PubMed/NCBI | |
|
Heynekamp JJ, Weber WM, Hunsaker LA, Gonzales AM, Orlando RA, Deck LM and Jagt DL: Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. J Med Chem. 49:7182–7189. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Ayroldi E and Riccardi C: Glucocorticoid-induced leucine zipper (GILZ): A new important mediator of glucocorticoid action. FASEB J. 23:3649–3658. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Cannarile L, Zollo O, D'Adamio F, Ayroldi E, Marchetti C, Tabilio A, Bruscoli S and Riccardi C: Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene. Cell Death Differ. 8:201–203. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Bonneh-Barkay D, Wang G, Starkey A, Hamilton RL and Wiley CA: In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. J Neuroinflammation. 7:342010. View Article : Google Scholar : PubMed/NCBI | |
|
Muszyński P, Groblewska M, Kulczyńska-Przybik A, Kułakowska A and Mroczko B: YKL-40 as a potential biomarker and a possible target in therapeutic strategies of Alzheimer's disease. Curr Neuropharmacol. 15:906–917. 2017. View Article : Google Scholar | |
|
Di Rosa M and Malaguarnera L: Chitinase 3 like-1: An emerging molecule involved in diabetes and diabetic complications. Pathobiology. 83:228–242. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Billod JM, Lacetera A, Guzmán-Caldentey J and Martín-Santamaría S: Computational approaches to Toll-like receptor 4 modulation. Molecules. 21:9942016. View Article : Google Scholar : PubMed/NCBI | |
|
Mertowski S, Grywalska E, Gosik K, Smarz-Widelska I, Hymos A, Dworacki G, Niedźwiedzka-Rystwej P, Drop B, Roliński J and Załuska W: TLR2 expression on select lymphocyte subsets as a new marker in glomerulonephritis. J Clin Med. 9:5412020. View Article : Google Scholar : PubMed/NCBI | |
|
Elmaidomy AH, Alhadrami HA, Amin E, Aly HF, Othman AM, Rateb ME, Hetta MH, Abdelmohsen UR and M Hassan H: Anti-inflammatory and antioxidant activities of terpene- and polyphenol-rich premna odorata leaves on alcohol-inflamed female wistar albino rat liver. Molecules. 25:31162020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhong X, Liu M, Yao W, Du K, He M, Jin X, Jiao L, Ma G, Wei B and Wei M: Epigallocatechin-3-gallate attenuates microglial inflammation and neurotoxicity by suppressing the activation of canonical and noncanonical inflammasome via TLR4/NF-κB pathway. Mol Nutr Food Res. 63:e18012302019. View Article : Google Scholar | |
|
Zhou X, Yuan L, Zhao X, Hou C, Ma W, Yu H and Xiao R: Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB. Nutrition. 30:90–95. 2014. View Article : Google Scholar | |
|
Chen R, Wang Z, Zhi Z, Tian J, Zhao Y and Sun J: Targeting the TLR4/NF-κB pathway in β-amyloid-stimulated microglial cells: A possible mechanism that oxysophoridine exerts anti-oxidative and anti-inflammatory effects in an in vitro model of Alzheimer's disease. Brain Res Bull. 175:150–157. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Onishi S, Meguro S, Pervin M, Kitazawa H, Yoto A, Ishino M, Shimba Y, Mochizuki Y, Miura S, Tokimitsu I and Unno K: Green tea extracts attenuate brain dysfunction in high-fat-diet-fed SAMP8 mice. Nutrients. 11:8212019. View Article : Google Scholar : PubMed/NCBI | |
|
Balázs A, Faisal Z, Csepregi R, Kőszegi T, Kriszt B, Szabó I and Poór M: In Vitro evaluation of the individual and combined cytotoxic and estrogenic effects of zearalenone, its reduced metabolites, alternariol, and genistein. Int J Mol Sci. 22:62812021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang R, Deng X, Gao Q, Wu X, Han L, Gao X, Zhao S, Chen W, Zhou R, Li Z and Bai C: Sophora alopecuroides L.: An ethnopharmacological, phytochemical, and pharmacological review. J Ethnopharmacol. 248:1121722020. View Article : Google Scholar | |
|
Rui C, Yuxiang L, Ning J, Ningtian M, Qingluan Z, Yinju H, Ru Z, Lin M, Tao S and Jianqiang Y: Anti-apoptotic and neuroprotective effects of oxysophoridine on cerebral ischemia both in vivo and in vitro. Planta Med. 79:916–923. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Wang Y, Jia S, Dong Q, Chen Y, Lu S and Hou L: Effect of lipid-bound apolipoprotein A-I cysteine mutant on ATF3 in RAW264.7 cells. Biosci Rep. 37:BSR201603982017. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng KW, Zhao MB, Ma ZZ, Jiang Y and Tu PF: Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol. 14:558–569. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Mo Y, Sun YY and Liu KY: Autophagy and inflammation in ischemic stroke. Neural Regen Res. 15:1388–1396. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Capiralla H, Vingtdeux V, Zhao H, Sankowski R, Al-Abed Y, Davies P and Marambaud P: Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade. J Neurochem. 120:461–472. 2012. View Article : Google Scholar | |
|
Xu Y, Huang X, Huangfu B, Hu Y, Xu J, Gao R, Huang K and He X: Sulforaphane ameliorates nonalcoholic fatty liver disease induced by high-fat and high-fructose diet via LPS/TLR4 in the gut-liver axis. Nutrients. 15:7432023. View Article : Google Scholar : PubMed/NCBI | |
|
Song J, Feng L, Zhong R, Xia Z, Zhang L, Cui L, Yan H, Jia X and Zhang Z: Icariside II inhibits the EMT of NSCLC cells in inflammatory microenvironment via down-regulation of Akt/NF-κB signaling pathway. Mol Carcinogen. 56:36–48. 2017. View Article : Google Scholar | |
|
Lee KS, Lee HJ, Ahn KS and Kim SH, Nam D, Kim DK, Choi DY, Ahn KS, Lu J and Kim SH: Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. Cancer Lett. 280:93–100. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou J, Deng Y, Li F, Yin C, Shi J and Gong Q: Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats. Biomed Pharmacother. 111:315–324. 2019. View Article : Google Scholar | |
|
Zhou D, Zhou W, Song JK, Feng ZY, Yang RY, Wu S, Wang L, Liu AL and Du GH: DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway. Acta Pharmacol Sin. 37:1401–1412. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yang RY, Zhao G, Wang DM, Pang XC, Wang SB, Fang JS, Li C, Liu AL, Wu S and Du GH: DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice. Pharmacol Biochem Behav. 139:15–26. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang B, Lian W, Zhao J, Wang Z, Liu A and Du G: DL0410 Alleviates memory impairment in D-galactose-induced aging rats by suppressing neuroinflammation via the TLR4/MyD88/NF-κB pathway. Oxid Med Cell Longev. 2021:65211462021. | |
|
Mao J, Huang S, Liu S, Feng XL, Yu M, Liu J, Sun YE, Chen G, Yu Y, Zhao J and Pei G: A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation. Aging Cell. 14:784–796. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Geng Y, Li C, Liu J, Xing G, Zhou L, Dong M, Li X and Niu Y: Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. Biol Pharm Bull. 33:836–843. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Zhong J, Qiu X, Yu Q, Chen H and Yan C: A novel polysaccharide from Acorus tatarinowii protects against LPS-induced neuroinflammation and neurotoxicity by inhibiting TLR4-mediated MyD88/NF-κB and PI3K/Akt signaling pathways. Int J Biol Macromol. 163:464–475. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu M, Guo H, Li Z, Zhang C, Zhang X, Cui Q and Tian J: Molecular level insight into the benefit of myricetin and dihydromyricetin uptake in patients with Alzheimer's diseases. Front Aging Neurosci. 12:6016032020. View Article : Google Scholar : PubMed/NCBI | |
|
Jing N and Li X: Dihydromyricetin attenuates inflammation through TLR4/NF-kappaB pathway. Open Med (Wars). 14:719–725. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Gu RX, Gu H, Xie ZY, Wang JF, Arias HR, Wei DQ and Chou KC: Possible drug candidates for Alzheimer's disease deduced from studying their binding interactions with alpha7 nicotinic acetylcholine receptor. Med Chem. 5:250–262. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Shi S, Liang D, Chen Y, Xie Y, Wang Y, Wang L, Wang Z and Qiao Z: Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2 expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease. Eur J Immunol. 46:665–676. 2016. View Article : Google Scholar | |
|
Zheng P, Huang C, Leng D, Sun B and Zhang XD: Transcriptome analysis of peripheral whole blood identifies crucial lncRNAs implicated in childhood asthma. Bmc Med Genomics. 13:1362020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhong X, Feng L, Xu WH, Wu X, Ding YD, Zhou Y, Lei CQ and Shu HB: The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding. Cell Mol Immunol. 17:741–752. 2020. View Article : Google Scholar : | |
|
Wang Z, Xia Q, Liu X, Liu W, Huang W, Mei X, Luo J, Shan M, Lin R, Zou D and Ma Z: Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: A review. J Ethnopharmacol. 210:318–339. 2018. View Article : Google Scholar | |
|
Kong F, Jiang X, Wang R, Zhai S, Zhang Y and Wang D: Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-κB signaling in Alzheimer's disease. J Neuroinflammation. 17:3052020. View Article : Google Scholar | |
|
Lu TC, Wu YH, Chen WY and Hung YC: Targeting oxidative stress and endothelial dysfunction using tanshinone IIA for the treatment of tissue inflammation and fibrosis. Oxid Med Cell Longev. 2022:28117892022. View Article : Google Scholar : PubMed/NCBI | |
|
Lu BL, Li J, Zhou J, Li WW and Wu HF: Tanshinone IIA decreases the levels of inflammation induced by Aβ1-42 in brain tissues of Alzheimer's disease model rats. Neuroreport. 27:883–893. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang P, Li C, Xiang Z and Jiao B: Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. Mol Med Rep. 10:689–694. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Maione F, Piccolo M, De Vita S, Chini MG, Cristiano C, De Caro C, Lippiello P, Miniaci MC, Santamaria R, Irace C, et al: Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer's disease. Pharmacol Res. 129:482–490. 2018. View Article : Google Scholar | |
|
Ding B, Lin C, Liu Q, He Y, Ruganzu JB, Jin H, Peng X, Ji S, Ma Y and Yang W: Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro. J Neuroinflammation. 17:3022020. View Article : Google Scholar | |
|
Xing L, Tan ZR, Cheng JL, Huang WH, Zhang W, Deng W, Yuan CS and Zhou HH: Bioavailability and pharmacokinetic comparison of tanshinones between two formulations of Salvia miltiorrhiza in healthy volunteers. Sci Rep. 7:47092017. View Article : Google Scholar : PubMed/NCBI | |
|
Hu X, Zhang J, Deng L, Hu H, Hu J and Zheng G: Galactose-modified PH-sensitive niosomes for controlled release and hepatocellular carcinoma target delivery of tanshinone IIA. AAPS PharmSciTech. 22:962021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Kang X, Du L, Zhang L, Huang Y, Wang J, Wang S, Chang Y, Liu Y and Zhao Y: Tanshinone IIA loaded chitosan nanoparticles decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of disease. Free Radical Bio Med. 193:81–94. 2022. View Article : Google Scholar | |
|
Thundyil J, Pavlovski D, Sobey CG and Arumugam TV: Adiponectin receptor signalling in the brain. Brit J Pharmacol. 165:313–327. 2012. View Article : Google Scholar | |
|
Ng RC, Cheng OY, Jian M, Kwan JS, Ho PW, Cheng KK, Yeung PK, Zhou LL, Hoo RL, Chung SK, et al: Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice. Mol Neurodegener. 11:712016. View Article : Google Scholar : PubMed/NCBI | |
|
Boza-Serrano A, Yang Y, Paulus A and Deierborg T: Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer's disease mouse model 5xFAD. Sci Rep. 8:15502018. View Article : Google Scholar : PubMed/NCBI | |
|
Jian M, Kwan JSC, Bunting M, Ng RCL and Chan KH: Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway. J Neuroinflammation. 16:1102019. View Article : Google Scholar | |
|
Chen X, Su J, Wang R, Hao R, Fu C, Chen J, Li J and Wang X: Structural optimization of cannabidiol as multifunctional cosmetic raw materials. Antioxidants (Basel). 12:3142023. View Article : Google Scholar : PubMed/NCBI | |
|
Malakoti F, Targhazeh N, Abadifard E, Zarezadeh R, Samemaleki S, Asemi Z, Younesi S, Mohammadnejad R, Hadi Hossini S, Karimian A, et al: DNA repair and damage pathways in mesothelioma development and therapy. Cancer Cell Int. 22:1762022. View Article : Google Scholar : PubMed/NCBI | |
|
Schiffmann SN and Vanderhaeghen JJ: Distribution of cells containing mRNA encoding cholecystokinin in the rat central nervous system. J Comp Neurol. 304:219–233. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Hensley K, Floyd RA, Zheng NY, Nael R, Robinson KA, Nguyen X, Pye QN, Stewart CA, Geddes J, Markesbery WR, et al: p38 kinase is activated in the Alzheimer's disease brain. J Neurochem. 72:2053–2058. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H and Smith MA: Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem. 76:435–441. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Jin Y, Yan EZ, Fan Y, Zong ZH, Qi ZM and Li Z: Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus. Acta Pharmacol Sin. 26:943–951. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
McDonald DR, Bamberger ME, Combs CK and Landreth GE: beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. J Neurosci. 18:4451–4460. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Koistinaho M and Koistinaho J: Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia. 40:175–183. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SH, Smith CJ and Van Eldik LJ: Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Neurobiol Aging. 25:431–439. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD and Li QX: 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, a selective and potent dual inhibitor of soluble epoxide hydrolase and p38 kinase intervenes in Alzheimer's signaling in human nerve cells. ACS Chem Neurosci. 10:4018–4030. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chang D, Li H, Qian C and Wang Y: DiOHF protects against doxorubicin-induced cardiotoxicity through ERK1 signaling pathway. Front Pharmacol. 10:10812019. View Article : Google Scholar : PubMed/NCBI | |
|
Lee HC, Yu HP, Liao CC, Chou AH and Liu FC: Escin protects against acetaminophen-induced liver injury in mice via attenuating inflammatory response and inhibiting ERK signaling pathway. Am J Transl Res. 11:5170–5182. 2019.PubMed/NCBI | |
|
Sclip A, Tozzi A, Abaza A, Cardinetti D, Colombo I, Calabresi P, Salmona M, Welker E and Borsello T: c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo. Cell Death Dis. 5:e10192014. View Article : Google Scholar : PubMed/NCBI | |
|
Jeong YH, Li W, Go Y and Oh YC: Atractylodis rhizoma alba attenuates neuroinflammation in BV2 microglia upon LPS stimulation by inducing HO-1 activity and inhibiting NF-κB and MAPK. Int J Mol Sci. 20:40152019. View Article : Google Scholar | |
|
Dang TK, Hong SM, Dao VT, Tran PTT, Tran HT, Do GH, Hai TN, Nguyet Pham HT and Kim SY: Anti-neuroinflammatory effects of alkaloid-enriched extract from Huperzia serrata on lipopolysaccharide-stimulated BV-2 microglial cells. Pharm Biol. 61:135–143. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Sun A, Liu M, Nguyen XV and Bing G: P38 MAP kinase is activated at early stages in Alzheimer's disease brain. Exp Neurol. 183:394–405. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Schnöder L, Hao W, Qin Y, Liu S, Tomic I, Liu X, Fassbender K and Liu Y: Deficiency of neuronal p38α MAPK attenuates amyloid pathology in Alzheimer disease mouse and cell models through facilitating lysosomal degradation of BACE1. J Biol Chem. 291:2067–2079. 2016. View Article : Google Scholar | |
|
Wu H, Hu B, Zhou X, Zhou C, Meng J, Yang Y, Zhao X, Shi Z and Yan S: Artemether attenuates LPS-induced inflammatory bone loss by inhibiting osteoclastogenesis and bone resorption via suppression of MAPK signaling pathway. Cell Death Dis. 9:4982018. View Article : Google Scholar : PubMed/NCBI | |
|
Xing B, Bachstetter AD and Van Eldik LJ: Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα. Mol Neurodegener. 6:842011. View Article : Google Scholar | |
|
Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, Chico LW, Van Eldik LJ and Watterson DM: A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J Neuroinflammation. 4:212007. View Article : Google Scholar : PubMed/NCBI | |
|
Maphis N, Jiang S, Xu G, Kokiko-Cochran ON, Roy SM, Van Eldik LJ, Watterson DM, Lamb BT and Bhaskar K: Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology. Alzheimers Res Ther. 8:542016. View Article : Google Scholar | |
|
Haddad JJ: VX-745. Vertex pharmaceuticals. Curr Opin Investig Drugs. 2:1070–1076. 2001. | |
|
Alam JJ: Selective brain-targeted antagonism of p38 MAPKα reduces hippocampal IL-1β levels and improves morris water maze performance in aged rats. J Alzheimers Dis. 48:219–227. 2015. View Article : Google Scholar | |
|
Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A and Gaestel M: Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol. 26:2399–2407. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE, Seymour ZM, Guillot F, Gaestel M and Richardson JC: MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J Biol Chem. 281:23658–23667. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Brugnano JL, Chan BK, Seal BL and Panitch A: Cell-penetrating peptides can confer biological function: regulation of inflammatory cytokines in human monocytes by MK2 inhibitor peptides. J Control Release. 155:128–133. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang J, Wang Z, Liang X, Nie Y, Chang X, Xue H, Li S and Min C: Intranasal MMI-0100 attenuates Aβ1-42 - and LPS-induced neuroinflammation and memory impairments via the MK2 signaling pathway. Front Immunol. 10:27072019. View Article : Google Scholar | |
|
Mittal D, Ali A, Md S, Baboota S, Sahni JK and Ali J: Insights into direct nose to brain delivery: current status and future perspective. Drug Deliv. 21:75–86. 2014. View Article : Google Scholar | |
|
Mistry A, Stolnik S and Illum L: Nose-to-brain delivery: Investigation of the transport of nanoparticles with different surface characteristics and sizes in excised porcine olfactory epithelium. Mol Pharm. 12:2755–2766. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zakaria ZA, Patahuddin H, Mohamad AS, Israf DA and Sulaiman MR: In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum. J Ethnopharmacol. 128:42–48. 2010. View Article : Google Scholar | |
|
Chan EWL, Yeo ETY, Wong KWL, See ML, Wong KY and Gan SY: Piper sarmentosum Roxb. Root extracts confer neuroprotection by attenuating beta amyloid-induced pro-inflammatory cytokines released from microglial cells. Curr Alzheimer Res. 16:251–260. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X, Zhao X and Tang S: Inhibitory effects of EGb761 on the expression of matrix metalloproteinases (MMPs) and cartilage matrix destruction. Cell Stress Chaperon. 20:781–786. 2015. View Article : Google Scholar | |
|
Meng M, Ai D, Sun L, Xu X and Cao X: EGb 761 inhibits Aβ1-42-induced neuroinflammatory response by suppressing P38 MAPK signaling pathway in BV-2 microglial cells. Neuroreport. 30:434–440. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Marchand G, Wambang N, Pellegrini S, Molinaro C, Martoriati A, Bousquet T, Markey A, Lescuyer-Rousseau A, Bodart JF, Cailliau K, et al: Effects of ferrocenyl 4-(Imino)-1,4-dihydro-quinolines on xenopus laevis prophase I-arrested oocytes: Survival and hormonal-induced M-phase entry. Int J Mol Sci. 21:30492020. View Article : Google Scholar | |
|
Chiu YJ, Hsieh YH, Lin TH, Lee GC, Hsieh-Li HM, Sun YC, Chen CM, Chang KH and Lee-Chen GJ: Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease. Neurochem Int. 125:175–186. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Czarnecka K, Girek M, Maciejewska K, Skibiński R, Jończyk J, Bajda M, Kabziński J, Sołowiej P, Majsterek I and Szymański P: New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer's disease. J Enzym Inhib Med Chem. 33:158–170. 2017. View Article : Google Scholar | |
|
Olajide OA, Bhatia HS, de Oliveira AC, Wright CW and Fiebich BL: Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine. Evid Based Complement Alternat Med. 2013:4597232013. View Article : Google Scholar : PubMed/NCBI | |
|
Castro-Torres RD, Busquets O, Parcerisas A, Verdaguer E, Olloquequi J, Ettcheto M, Beas-Zarate C, Folch J, Camins A and Auladell C: Involvement of JNK1 in neuronal polarization during brain development. Cells. 9:18972020. View Article : Google Scholar : PubMed/NCBI | |
|
Ma Z, Zang T, Birnbaum SG, Wang Z, Johnson JE, Zhang CL and Parada LF: TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response. Nat Commun. 8:16682017. View Article : Google Scholar : PubMed/NCBI | |
|
Guo YJ, Pan WW, Liu SB, Shen ZF, Xu Y and Hu LL: ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med. 19:1997–2007. 2020.PubMed/NCBI | |
|
Paquet C, Nicoll JA, Love S, Mouton-Liger F, Holmes C, Hugon J and Boche D: Downregulated apoptosis and autophagy after anti-Aβ immunotherapy in Alzheimer's disease. Brain Pathol. 28:603–610. 2018. View Article : Google Scholar | |
|
Yuan Y, Chen J, Ge X, Deng J, Xu X, Zhao Y and Wang H: Activation of ERK-Drp1 signaling promotes hypoxia-induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity. Febs Open Bio. 11:2740–2755. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Ho WC, Hsu CC, Huang HJ, Wang HT and Lin AMY: Anti-inflammatory effect of AZD6244 on acrolein-induced neuroinflammation. Mol Neurobiol. 57:88–95. 2020. View Article : Google Scholar | |
|
Qiu Z, Lu P, Wang K, Zhao X, Li Q, Wen J, Zhang H, Li R, Wei H, Lv Y, et al: Dexmedetomidine inhibits neuroinflammation by altering microglial M1/M2 polarization through MAPK/ERK pathway. Neurochem Res. 45:345–353. 2020. View Article : Google Scholar | |
|
Goldfarb G, Doan Ba Tri and Duran A: Human placenta for chronic leg ulcers. Lancet. 2:401980. View Article : Google Scholar : PubMed/NCBI | |
|
Lee KW, Ji HM, Kim DW, Choi SM, Kim S and Yang EJ: Effects of Hominis placenta on LPS-induced cell toxicity in BV2 microglial cells. J Ethnopharmacol. 147:286–292. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Filocamo A, Bisignano C, Ferlazzo N, Cirmi S, Mandalari G and Navarra M: In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pylori. BMC Complement Altern Med. 15:2562015. View Article : Google Scholar : PubMed/NCBI | |
|
Currò M, Risitano R, Ferlazzo N, Cirmi S, Gangemi C, Caccamo D, Ientile R and Navarra M: Citrus bergamia juice extract attenuates β-amyloid-induced pro-inflammatory activation of THP-1 cells through MAPK and AP-1 pathways. Sci Rep. 6:208092016. View Article : Google Scholar | |
|
Eglitis MA and Mezey E: Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci USA. 94:4080–4085. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Hickey WF and Kimura H: Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science. 239:290–292. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Tao M, Zheng D, Liang X, Wu D, Hu K, Jin J and He Q: Tripterygium glycoside suppresses epithelial-to-mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway. Mol Med Rep. 24:5922021. View Article : Google Scholar : | |
|
Tang L, Xiang Q, Xiang J, Zhang Y and Li J: Tripterygium glycoside ameliorates neuroinflammation in a mouse model of Aβ25-35-induced Alzheimer's disease by inhibiting the phosphorylation of IκBα and p38. Bioengineered. 12:8540–8554. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Cao X, Jin Y, Zhang H, Yu L, Bao X, Li F and Xu Y: The antiinflammatory effects of 4-[(5-Bromo-3-chloro-2-hydroxybenzyl) amino]-2-hydroxybenzoic acid in lipopolysaccharide-activated primary microglial cells. Inflammation. 41:530–540. 2018. View Article : Google Scholar | |
|
Kim ME, Jung I, Na JY, Lee Y, Lee J and Lee JS and Lee JS: Pseudane-VII regulates LPS-induced neuroinflammation in brain microglia cells through the inhibition of iNOS expression. Molecules. 23:31962018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao H, Wang SL, Qian L, Jin JL, Li H, Xu Y and Zhu XL: Diammonium glycyrrhizinate attenuates Aβ(1-42)-induced neuroinflammation and regulates MAPK and NF-κB pathways in vitro and in vivo. CNS Neurosci Ther. 19:117–124. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ramana KV and Srivastava SK: Aldose reductase: A novel therapeutic target for inflammatory pathologies. Int J Biochem Cell Biol. 42:17–20. 2010. View Article : Google Scholar | |
|
Song XM, Yu Q, Dong X, Yang HO, Zeng KW, Li J and Tu PF: Aldose reductase inhibitors attenuate β-amyloid-induced TNF-α production in microlgia via ROS-PKC-mediated NF-κB and MAPK pathways. Int Immunopharmacol. 50:30–37. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Meza CA, La Favor JD, Kim DH and Hickner RC: Endothelial dysfunction: Is there a hyperglycemia-induced imbalance of NOX and NOS? Int J Mol Sci. 20:37752019. View Article : Google Scholar : PubMed/NCBI | |
|
Lee J, Narayan VP, Hong EY, Whang WK and Park T: Artemisia iwayomogi extract attenuates high-fat diet-induced hypertriglyceridemia in mice: Potential involvement of the adiponectin-AMPK pathway and very low density lipoprotein assembly in the liver. Int J Mol Sci. 18:17622017. View Article : Google Scholar : PubMed/NCBI | |
|
Ju IG, Huh E, Kim N, Lee S, Choi JG, Hong J and Oh MS: Artemisiae iwayomogii herba inhibits lipopolysaccharide-induced neuroinflammation by regulating NF-κB and MAPK signaling pathways. Phytomedicine. 84:1535012021. View Article : Google Scholar | |
|
Hilliard A, Mendonca P and Soliman KFA: Involvement of NFkB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS. J Neuroimmunol. 345:5772692020. View Article : Google Scholar | |
|
Cheung WM, Hui WS, Chu PW, Chiu SW and Ip NY: Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett. 486:291–296. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Geng X, Zhong D, Su L and Yang B: Preventive and therapeutic effect of ganoderma (Lingzhi) on renal diseases and clinical applications. Adv Exp Med Biol. 1182:243–262. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen LG, Jan YS, Tsai PW, Norimoto H, Michihara S, Murayama C and Wang CC: Anti-inflammatory and antinociceptive constituents of atractylodes japonica koidzumi. J Agric Food Chem. 64:2254–2262. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Tang JJ, Wang MR, Dong S, Huang LF, He QR and Gao JM: 1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways. Eur J Med Chem. 224:1137132021. View Article : Google Scholar | |
|
Choi MS, Jung UJ, Kim HJ, Do GM, Jeon SM, Kim MJ and Lee MK: Du-zhong (Eucommia ulmoides Oliver) leaf extract mediates hypolipidemic action in hamsters fed a high-fat diet. Am J Chin Med. 36:81–93. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
He X, Wang J, Li M, Hao D, Yang Y, Zhang C, He R and Tao R: Eucommia ulmoides Oliv.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol. 151:78–92. 2014. View Article : Google Scholar | |
|
Han R, Yuan T, Yang Z, Zhang Q, Wang WW, Lin LB, Zhu MQ and Gao JM: Ulmoidol, an unusual nortriterpenoid from Eucommia ulmoides Oliv. Leaves prevents neuroinflammation by targeting the PU.1 transcriptional signaling pathway. Bioorg Chem. 116:1053452021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang C, Hu L, Liu D, Huang J and Lin W: Circumdatin D exerts neuroprotective effects by attenuating LPS-induced pro-inflammatory responses and downregulating acetylcholinesterase activity in vitro and in vivo. Front Pharmacol. 11:7602020. View Article : Google Scholar : PubMed/NCBI | |
|
Gong P, Deng F, Zhang W, Ji J, Liu J, Sun Y and Hu J: Tectorigenin attenuates the MPP+-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition. Exp Ther Med. 14:4431–4437. 2017.PubMed/NCBI | |
|
Oh KB, Kang H and Matsuoka H: Detection of antifungal activity in Belamcanda chinensis by a single-cell bioassay method and isolation of its active compound, tectorigenin. Biosci Biotechnol Biochem. 65:939–942. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Lim HS, Kim YJ, Kim BY, Park G and Jeong SJ: The Anti-neuroinflammatory activity of tectorigenin pretreatment via downregulated NF-κB and ERK/JNK pathways in BV-2 microglial and microglia inactivation in mice with lipopolysaccharide. Front Pharmacol. 9:4622018. View Article : Google Scholar | |
|
Wang BR, Shi JQ, Ge NN, Ou Z, Tian YY, Jiang T, Zhou JS, Xu J and Zhang YD: PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer's disease. J Neuroinflammation. 15:1322018. View Article : Google Scholar : PubMed/NCBI | |
|
Shao BZ, Xu ZQ, Han BZ, Su DF and Liu C: NLRP3 inflammasome and its inhibitors: A review. Front Pharmacol. 6:2622015. View Article : Google Scholar : PubMed/NCBI | |
|
Feng YS, Tan ZX, Wu LY, Dong F and Zhang F: The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease. Ageing Res Rev. 64:1011922020. View Article : Google Scholar : PubMed/NCBI | |
|
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, et al: NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 493:674–678. 2013. View Article : Google Scholar | |
|
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ and Golenbock DT: The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 9:857–865. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lonnemann N, Hosseini S, Marchetti C, Skouras DB, Stefanoni D, D'Alessandro A, Dinarello CA and Korte M: The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 117:32145–32154. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, et al: OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc Natl Acad Sci USA. 115:E1530–E1539. 2018. View Article : Google Scholar | |
|
Klück V, Jansen TLTA, Janssen M, Comarniceanu A, Efdé M, Tengesdal IW, Schraa K, Cleophas MCP, Scribner CL, Skouras DB, et al: Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: An open-label, dose-adaptive, proof-of-concept, phase 2a trial. Lancet Rheumatol. 2:e270–e280. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ and Lynch MA: Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain Behav Immun. 61:306–316. 2017. View Article : Google Scholar | |
|
Fekete C, Vastagh C, Dénes Á, Hrabovszky E, Nyiri G, Kalló I, Liposits Z and Sárvári M: Chronic amyloid β oligomer infusion evokes sustained inflammation and microglial changes in the rat hippocampus via NLRP3. Neuroscience. 405:35–46. 2019. View Article : Google Scholar | |
|
Kuwar R, Rolfe A, Di L, Blevins H, Xu Y, Sun X, Bloom GS, Zhang S and Sun D: A novel inhibitor targeting NLRP3 inflammasome reduces neuropathology and improves cognitive function in Alzheimer's disease transgenic mice. J Alzheimers Dis. 82:1769–1783. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Zhao Y, Zhang J, Gao Y, Li S, Chang C, Yu D and Yang G: Ginkgolide B inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization in Aβ1-42 -induced microglia cells. Neurosci Lett. 764:1362062021. View Article : Google Scholar | |
|
Gu JH, Ge JB, Li M, Wu F, Zhang W and Qin ZH: Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury. Eur J Pharm Sci. 47:652–660. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kaur N, Dhiman M, Perez-Polo JR and Mantha AK: Ginkgolide B revamps neuroprotective role of apurinic/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against Aβ25-35-induced neurotoxicity in human neuroblastoma cells. J Neurosci Res. 93:938–947. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HR, Peng JH, Cheng XB, Shi BZ, Zhang MY and Xu RX: Paeoniflorin atttenuates amyloidogenesis and the inflammatory responses in a transgenic mouse model of Alzheimer's disease. Neurochem Res. 40:1583–1592. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Liu HQ, Zhang WY, Luo XT, Ye Y and Zhu XZ: Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor. Brit J Pharmacol. 148:314–325. 2006. View Article : Google Scholar | |
|
Liu DZ, Xie KQ, Ji XQ, Ye Y, Jiang CL and Zhu XZ: Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists. Br J Pharmacol. 146:604–611. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
English BK, Ihle JN, Myracle A and Yi T: Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages. J Exp Med. 178:1017–1022. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Kong X, Liao Y, Zhou L, Zhang Y, Cheng J, Yuan Z and Wang S: Hematopoietic cell kinase (HCK) is essential for NLRP3 inflammasome activation and lipopolysaccharide-induced inflammatory response in vivo. Front Pharmacol. 11:5810112020. View Article : Google Scholar : PubMed/NCBI | |
|
Cui W, Sun C, Ma Y, Wang S, Wang X and Zhang Y: Inhibition of TLR4 induces M2 microglial polarization and provides neuroprotection via the NLRP3 inflammasome in Alzheimer's disease. Front Neurosci. 14:4442020. View Article : Google Scholar : PubMed/NCBI | |
|
Hua F, Tang H, Wang J, Prunty MC, Hua X, Sayeed I and Stein DG: TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice. J Cereb Blood Flow Metab. 35:536–542. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Dai Y, Li Q, Chen C, Chen H, Song Y, Hua F and Zhang Z: Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia. Neurosci Lett. 736:1352792020. View Article : Google Scholar : PubMed/NCBI | |
|
Poulose SM, Thangthaeng N, Miller MG and Shukitt-Hale B: Effects of pterostilbene and resveratrol on brain and behavior. Neurochem Int. 89:227–233. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li Q, Chen L, Liu X, Li X, Cao Y, Bai Y and Qi F: Pterostilbene inhibits amyloid-β-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway. J Cell Biochem. 119:7053–7062. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wang SY, Liu Y, Li XM, Algradi AM, Jiang H, Sun YP, Guan W, Pan J, Kuang HX and Yang BY: Discovery of active ingredients targeted TREM2 by SPR biosensor-UPLC/MS recognition system, and investigating the mechanism of anti-neuroinflammatory activity on the lignin-amides from Datura metel seeds. Molecules. 26:59462021. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Yang X, Lei Q, Li Z, Hu J, Wen X, Wang H and Liu Z: PEG-PEI/siROCK2 protects against Aβ42-induced neurotoxicity in primary neuron cells for Alzheimer disease. Cell Mol Neurobiol. 35:841–848. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Zhang H, Peng A, Cai X, Wang Y, Tang K, Wu X, Liang Y, Wang L and Li Z: PEG-PEI/siROCK2 inhibits Aβ42-induced microglial inflammation via NLRP3/caspase 1 pathway. Neuroreport. 33:26–32. 2022. View Article : Google Scholar | |
|
Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Ćiković T, et al: The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity. Cell Rep. 21:3846–3859. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Han C, Hu Q, Yu A, Jiao Q and Yang Y: Mafenide derivatives inhibit neuroinflammation in Alzheimer's disease by regulating pyroptosis. J Cell Mol Med. 25:10534–10542. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang CZ, Du GJ, Zhen Z, Calway T and Yuan CS: Significant dose differences in donepezil purchased from the United States and Canada. Ann Intern Med. 155:279–280. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Birks JS and Harvey RJ: Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev. 6:CD0011902018.PubMed/NCBI | |
|
Wang H, Zong Y, Han Y, Zhao J, Liu H and Liu Y: Compared of efficacy and safety of high-dose donepezil vs standard-dose donepezil among elderly patients with Alzheimer's disease: A systematic review and meta-analysis. Expert Opin Drug Saf. 21:407–415. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Kim J, Lee HJ, Park SK, Park JH, Jeong HR, Lee S, Lee H, Seol E and Hoe HS: Donepezil regulates LPS and Aβ-stimulated neuroinflammation through MAPK/NLRP3 inflammasome/STAT3 signaling. Int J Mol Sci. 22:106372021. View Article : Google Scholar | |
|
Kim HG, Moon M, Choi JG, Park G, Kim AJ, Hur J, Lee KT and Oh MS: Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo. Neurotoxicology. 40:23–32. 2014. View Article : Google Scholar | |
|
Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L and Chen Q: Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy. 12:689–702. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Devi TS, Somayajulu M, Kowluru RA and Singh LP: TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: Implications for diabetic retinopathy. Cell Death Dis. 8:e27772017. View Article : Google Scholar | |
|
Gao Y, Li J, Li J, Hu C and Zhang L, Yan J, Li L and Zhang L: Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway. Biochem Pharmacol. 177:1139972020. View Article : Google Scholar : PubMed/NCBI | |
|
Li F, Zhang T, He Y, Gu W, Yang X, Zhao R and Yu J: Inflammation inhibition and gut microbiota regulation by TSG to combat atherosclerosis in ApoE−/− mice. J Ethnopharmacol. 247:1122322020. View Article : Google Scholar | |
|
Mu Y, Xu Z, Zhou X, Zhang H, Yang Q, Zhang Y, Xie Y, Kang J, Li F and Wang S: 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-gluc oside attenuates ischemia/reperfusion-induced brain injury in rats by promoting angiogenesis. Planta Med. 83:676–683. 2017. | |
|
Zhou W, Yang Y, Mei C, Dong P, Mu S, Wu H, Zhou Y, Zheng Y, Guo F and Yang JQ: Inhibition of rho-kinase downregulates Th17 cells and ameliorates hepatic fibrosis by schistosoma japonicum infection. Cells. 8:12622019. View Article : Google Scholar : PubMed/NCBI | |
|
Kimura T, Horikoshi Y, Kuriyagawa C and Niiyama Y: Rho/ROCK pathway and noncoding RNAs: Implications in ischemic stroke and spinal cord injury. Int J Mol Sci. 22:115732021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou Y, Su Y, Li B, Liu F, Ryder JW, Wu X, Gonzalez-DeWhitt PA, Gelfanova V, Hale JE, May PC, et al: Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Science. 302:1215–1217. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Scheiblich H and Bicker G: Regulation of microglial phagocytosis by RhoA/ROCK-inhibiting drugs. Cell Mol Neurobiol. 37:461–473. 2017. View Article : Google Scholar | |
|
Alokam R, Singhal S, Srivathsav GS, Garigipati S, Puppala S, Sriram D and Perumal Y: Design of dual inhibitors of ROCK-I and NOX2 as potential leads for the treatment of neuroinflammation associated with various neurological diseases including autism spectrum disorder. Mol Biosyst. 11:607–617. 2015. View Article : Google Scholar | |
|
Moon MY, Kim HJ, Li Y, Kim JG, Jeon YJ, Won HY, Kim JS, Kwon HY, Choi IG, Ro E, et al: Involvement of small GTPase RhoA in the regulation of superoxide production in BV2 cells in response to fibrillar Aβ peptides. Cell Signal. 25:1861–1869. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Ye P, Wang D, Liu Y, Cao L, Wang Y, Xu Y and Zhu C: Involvement of RhoA/ROCK signaling in Aβ-induced chemotaxis, cytotoxicity and inflammatory response of microglial BV2 cells. Cell Mol Neurobiol. 39:637–650. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
van der Meer DLM, Degenhardt T, Väisänen S, de Groot PJ, Heinäniemi M, de Vries SC, Müller M, Carlberg C and Kersten S: Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis. Nucleic Acids Res. 38:2839–2850. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Xia P, Pan Y, Zhang F, Wang N, Wang E, Guo Q and Ye Z: Pioglitazone confers neuroprotection against ischemia-induced pyroptosis due to its inhibitory effects on HMGB-1/RAGE and Rac1/ROS pathway by activating PPAR-ɤ. Cell Physiol Biochem. 45:2351–2368. 2018. View Article : Google Scholar | |
|
Janani C and Ranjitha Kumari BD: PPAR gamma gene-a review. Diabetes Metab Syndr. 9:46–50. 2015. View Article : Google Scholar | |
|
Stark JM, Coquet JM and Tibbitt CA: The role of PPAR-γ in allergic disease. Curr Allergy Asthma Rep. 21:452021. View Article : Google Scholar | |
|
Kumar AP, P P, Kumar BRP, Jeyarani V, Dhanabal SP and Justin A: Glitazones, PPAR-γ and neuroprotection. Mini Rev Med Chem. 21:1457–1464. 2021. View Article : Google Scholar | |
|
Furth N, Pateras IS, Rotkopf R, Vlachou V, Rivkin I, Schmitt I, Bakaev D, Gershoni A, Ainbinder E, Leshkowitz D, et al: LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state. Life Sci Alliance. 1:e2018001712018. View Article : Google Scholar : PubMed/NCBI | |
|
Villapol S: Roles of peroxisome proliferator-activated receptor gamma on brain and peripheral inflammation. Cell Mol Neurobiol. 38:121–132. 2018. View Article : Google Scholar | |
|
Moosecker S, Gomes P, Dioli C, Yu S, Sotiropoulos I and Almeida OFX: Activated PPARγ abrogates misprocessing of amyloid precursor protein, tau missorting and synaptotoxicity. Front Cell Neurosci. 13:2392019. View Article : Google Scholar | |
|
de la Monte SM and Wands JR: Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease. J Alzheimers Dis. 9:167–181. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Watson GS, Cholerton BA, Reger MA, Baker LD, Plymate SR, Asthana S, Fishel MA, Kulstad JJ, Green PS, Cook DG, et al: Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study. Am J Geriatr Psychiatry. 13:950–958. 2005.PubMed/NCBI | |
|
Risner ME, Saunders AM, Altman JF, Ormandy GC, Craft S, Foley IM, Zvartau-Hind ME, Hosford DA and Roses AD; Rosiglitazone in Alzheimer's Disease Study Group: Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J. 6:246–254. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Mandrekar-Colucci S, Karlo JC and Landreth GE: Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci. 32:10117–10128. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Moreno S, Farioli-Vecchioli S and Cerù MP: Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience. 123:131–145. 2004. View Article : Google Scholar | |
|
Liu ZJ, Liu W, Liu L, Xiao C, Wang Y and Jiao JS: Curcumin protects neuron against cerebral ischemia-induced inflammation through improving PPAR-gamma function. Evid Based Complement Alternat Med. 2013:4709752013.PubMed/NCBI | |
|
Song GJ, Nam Y, Jo M, Jung M, Koo JY, Cho W, Koh M, Park SB and Suk K: A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype. Neuropharmacology. 109:159–169. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Qi Y, Zhang Q and Zhu H: Huang-Lian Jie-Du decoction: A review on phytochemical, pharmacological and pharmacokinetic investigations. Chin Med. 14:572019. View Article : Google Scholar : PubMed/NCBI | |
|
Wong LR, Tan EA, Lim MEJ, Shen W, Lian XL, Wang Y, Chen L and Ho PCL: Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells-in vitro models simulating Alzheimer's disease pathology. Life Sci. 282:1198242012. View Article : Google Scholar | |
|
Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J and Eckert GP: Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med. 18:347–363. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
El-Din SS, Abd ES, Rashed L, Fayez S, Aboulhoda BE, Heikal OA, Galal AF and Nour ZA: Possible role of rice bran extract in microglial modulation through PPAR-gamma receptors in alzheimer's disease mice model. Metab Brain Dis. 36:1903–1915. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
De Felice FG and Ferreira ST: Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes. 63:2262–2272. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Bouriche H, Meziti H, Senator A and Arnhold J: Anti-inflammatory, free radical-scavenging, and metal-chelating activities of Malva parviflora. Pharm Biol. 49:942–946. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Medrano-Jiménez E, Jiménez-Ferrer Carrillo I, Pedraza-Escalona M, Ramírez-Serrano CE, Álvarez-Arellano L, Cortés-Mendoza J, Herrera-Ruiz M, Jiménez-Ferrer E, Zamilpa A, Tortoriello J, et al: Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism. J Neuroinflammation. 16:1432019. View Article : Google Scholar | |
|
Villapol S, Yaszemski AK, Logan TT, Sanchez-Lemus E, Saavedra JM and Symes AJ: Candesartan, an angiotensin II AT1-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology. 37:2817–2829. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Shindo T, Takasaki K, Uchida K, Onimura R, Kubota K, Uchida N, Irie K, Katsurabayashi S, Mishima K, Nishimura R, et al: Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors. Biol Pharm Bull. 35:2141–2147. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Li NC, Lee A, Whitmer RA, Kivipelto M, Lawler E, Kazis LE and Wolozin B: Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis. BMJ. 340:b54652010. View Article : Google Scholar : PubMed/NCBI | |
|
Wang ZF, Li J, Ma C, Huang C and Li ZQ: Telmisartan ameliorates Aβ oligomer-induced inflammation via PPARγ/PTEN pathway in BV2 microglial cells. Biochem Pharmacol. 171:1136742020. View Article : Google Scholar | |
|
He Z, Li X, Han S, Ren B, Hu X, Li N, Du X, Ni J, Yang X and Liu Q: Bis(ethylmaltolato)oxidovanadium (IV) attenuates amyloid-beta-mediated neuroinflammation by inhibiting NF-κB signaling pathway via a PPARγ-dependent mechanism. Metallomics. 13:mfab0362021. View Article : Google Scholar | |
|
Yang Z, Liu B, Yang LE and Zhang C: Platycodigenin as potential drug candidate for Alzheimer's disease via modulating microglial polarization and neurite regeneration. Molecules. 24:32072019. View Article : Google Scholar : PubMed/NCBI | |
|
Pan D, Xu Y, Zhang L, Su Q, Chen M, Li B, Xiao Q, Gao Q, Peng X, Jiang B, et al: Gene expression profile in peripheral blood mononuclear cells of postpartum depression patients. Sci Rep. 8:101392018. View Article : Google Scholar : PubMed/NCBI | |
|
Ahn S, Jang DM, Park SC, An S, Shin J, Han BW and Noh M: Cyclin-dependent kinase 5 inhibitor butyrolactone I elicits a partial agonist activity of peroxisome proliferator-activated receptor γ. Biomolecules. 10:2752020. View Article : Google Scholar | |
|
Wang J, Zhu G, Sun C, Xiong K, Yao T, Su Y and Fang H: TAK-242 ameliorates DSS-induced colitis by regulating the gut microbiota and the JAK2/STAT3 signaling pathway. Microb Cell Fact. 19:1582020. View Article : Google Scholar : PubMed/NCBI | |
|
Kulesza DW, Ramji K, Maleszewska M, Mieczkowski J, Dabrowski M, Chouaib S and Kaminska B: Search for novel STAT3-dependent genes reveals SERPINA3 as a new STAT3 target that regulates invasion of human melanoma cells. Lab Invest. 99:1607–1621. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lee DY, Hwang CJ, Choi JY, Park MH, Song MJ, Oh KW, Han SB, Park WK, Cho HY, Cho SY, et al: KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer's disease models. Oncotarget. 8:68654–68667. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang ZH, Yu LJ, Hui XC, Wu ZZ, Yin KL, Yang H and Xu Y: Hydroxy-safflor yellow A attenuates Aβ1-42-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway. Brain Res. 1563:72–80. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng ZV, Chen J, Lyu H, Lam S, Lu G, Chan WY and Wong GKC: Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage. Stroke Vasc Neurol. 7:62–70. 2022. View Article : Google Scholar : | |
|
Wan J, Fu AK, Ip FC, Ng HK, Hugon J, Page G, Wang JH, Lai KO, Wu Z and Ip NY: Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer's disease. J Neurosci. 30:6873–6881. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Carret-Rebillat AS, Pace C, Gourmaud S, Ravasi L, Montagne-Stora S, Longueville S, Tible M, Sudol E, Chang RC, Paquet C, et al: Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation. Sci Rep. 5:84892015. View Article : Google Scholar | |
|
Jin P, Kim JA, Choi DY, Lee YJ, Jung HS and Hong JT: Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer's disease mice model. J Neuroinflammation. 10:22013. View Article : Google Scholar : PubMed/NCBI | |
|
Choi JY, Hwang CJ, Lee DY, Gu SM, Lee HP, Choi DY, Oh KW, Han SB and Hong JT: (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol ameliorates LPS-mediated memory impairment by inhibition of STAT3 pathway. Neuromolecular Med. 19:555–570. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Hussein G, Sankawa U, Goto H, Matsumoto K and Watanabe H: Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod. 69:443–449. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Han JH, Lee YS, Im JH, Ham YW, Lee HP, Han SB and Hong JT: Astaxanthin ameliorates lipopolysaccharide-induced neuroinflammation, oxidative stress and memory dysfunction through inactivation of the signal transducer and activator of transcription 3 pathway. Mar Drugs. 17:1232019. View Article : Google Scholar : PubMed/NCBI | |
|
Safar MM, Shahin NN, Mohamed AF and Abdelkader NF: Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats. Chem Biol Interact. 328:1091442020. View Article : Google Scholar : PubMed/NCBI | |
|
Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T, Wang L, Figueroa H, Herman M, et al: Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron. 57:680–690. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Millot P, San C, Bennana E, Porte B, Vignal N, Hugon J, Paquet C, Hosten B and Mouton-Liger F: STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation. Immunol Lett. 228:129–134. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Long QH, Wu YG, He LL, Ding L, Tan AH, Shi HY and Wang P: Suan-Zao-Ren decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice. Chin Med. 16:142021. View Article : Google Scholar | |
|
Jia T, Xing Z, Wang And H and Li G: Protective effect of dexmedetomidine on intestinal mucosal barrier function in rats after cardiopulmonary bypass. Exp Biol Med (Maywood). 247:498–508. 2022. View Article : Google Scholar | |
|
Wang LC, Liao LX, Zhao MB, Dong X, Zeng KW and Tu PF: Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 15:674–679. 2017.PubMed/NCBI | |
|
Porro C, Cianciulli A, Trotta T, Lofrumento DD and Panaro MA: Curcumin regulates anti-inflammatory responses by JAK/STAT/SOCS signaling pathway in BV-2 microglial cells. Biology (Basel). 8:512019.PubMed/NCBI | |
|
Amalraj A, Pius A and Gopi S and Gopi S: Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives-a review. J Tradit Complement Med. 7:205–233. 2016. View Article : Google Scholar | |
|
He G and Karin M: NF-κB and STAT3-key players in liver inflammation and cancer. Cell Res. 21:159–168. 2011. View Article : Google Scholar | |
|
Sim DY, Lee HJ, Jung JH, Im E, Hwang J, Kim DS and Kim SH: Suppression of STAT3 phosphorylation and RelA/p65 acetylation mediated by MicroRNA134 plays a pivotal role in the apoptotic effect of lambertianic acid. Int J Mol Sci. 20:29932019. View Article : Google Scholar : PubMed/NCBI | |
|
Song SY, Jung YY, Hwang CJ, Lee HP, Sok CH, Kim JH, Lee SM, Seo HO, Hyun BK, Choi DY, et al: Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-κB activation in cultured astrocytes and microglial BV-2 cells. J Neuroinflammation. 11:1182014. View Article : Google Scholar | |
|
Kim J, Park JH, Park SK and Hoe HS: Sorafenib modulates the LPS- and Aβ-induced neuroinflammatory response in cells, wild-type mice, and 5xFAD mice. Front Immunol. 12:6843442021. View Article : Google Scholar | |
|
Hei YY, Xin M, Zhang H, Xie XX, Mao S and Zhang SQ: Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors. Bioorg Med Chem Lett. 26:4408–4413. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
You JS, Li CY, Chen W, Wu XL, Huang LJ, Li RK, Gao F, Zhang MY, Liu HL and Qu WL: A network pharmacology-based study on Alzheimer disease prevention and treatment of Qiong Yu Gao. BioData Min. 13:22020. View Article : Google Scholar : PubMed/NCBI | |
|
Yang S, Chen Z, Cao M, Li R, Wang Z and Zhang M: Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation. Mol Med Rep. 15:2588–2594. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Wang H, Bei J, Zhao J, Jiang G and Liu X: The protective role of miR-132 targeting HMGA2 through the PI3K/AKT pathway in mice with Alzheimer's disease. Am J Transl Res. 13:4632–4643. 2021.PubMed/NCBI | |
|
Hwang SY, Jung JS, Lim SJ, Kim JY, Kim TH, Cho KH and Han IO: LY294002 inhibits interferon-gamma-stimulated inducible nitric oxide synthase expression in BV2 microglial cells. Biochem Biophys Res Commun. 318:691–697. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
He Y, Zhou A and Jiang W: Toll-like receptor 4-mediated signaling participates in apoptosis of hippocampal neurons. Neural Regen Res. 8:2744–2753. 2013. | |
|
Zu HB, Liu XY and Yao K: DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ25-35 treated BV-2 cells. Life Sci. 260:1184702020. View Article : Google Scholar | |
|
Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H and Hiltunen M: Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis. J Biol Chem. 284:34433–34443. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Yang W, Liu Y, Xu QQ, Xian YF and Lin ZX: Sulforaphene ameliorates neuroinflammation and hyperphosphorylated tau protein via regulating the PI3K/Akt/GSK-3 β pathway in experimental models of Alzheimer's disease. Oxid Med Cell Longev. 2020:47541952020. View Article : Google Scholar | |
|
Ivanovics G and Horvath S: Raphanin, an antibacterial principle of the radish (Raphanus sativus). Nature. 160:2971947. View Article : Google Scholar : PubMed/NCBI | |
|
Lonze BE and Ginty DD: Function and regulation of CREB family transcription factors in the nervous system. Neuron. 35:605–623. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Ahn SH, Suh JS, Jang YK, Kim HS, Choi GH, Kim E and Kim TJ: Rhynchosia volubilis promotes cell survival via cAMP-PKA/ERK-CREB pathway. Pharmaceuticals (Basel). 15:732022. View Article : Google Scholar : PubMed/NCBI | |
|
Hu YJ, Sun Q, Zhang WH, Huo YJ, Xu CJ and Liu JF: Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation. Acta Pharmacol Sin. 40:460–467. 2019. View Article : Google Scholar : | |
|
Viola H, Furman M, Izquierdo LA, Alonso M, Barros DM, de Souza MM, Izquierdo I and Medina JH: Phosphorylated cAMP response element-binding protein as a molecular marker of memory processing in rat hippocampus: effect of novelty. J Neurosci. 20:RC1122000. View Article : Google Scholar : PubMed/NCBI | |
|
Dineley KT, Westerman M, Bui D, Bell K, Ashe KH and Sweatt JD: Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci. 21:4125–4133. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Yamamoto-Sasaki M, Ozawa H, Saito T, Rösler M and Riederer P: Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type. Brain Res. 824:300–303. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Mizuno M, Yamada K, Maekawa N, Saito K, Seishima M and Nabeshima T: CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. Behav Brain Res. 133:135–141. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Sharma VK and Singh TG: CREB: A multifaceted target for Alzheimer's disease. Curr Alzheimer Res. 17:1280–1293. 2020. View Article : Google Scholar | |
|
Li C, Chen T, Zhou H, Feng Y, Hoi MPM, Ma D, Zhao C, Zheng Y and Lee SMY: BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB. Front Pharmacol. 9:6142018. View Article : Google Scholar | |
|
Ghosh M, Xu Y and Pearse DD: Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines. J Neuroinflammation. 13:92016. View Article : Google Scholar : PubMed/NCBI | |
|
Tripathi MK, Kartawy M and Amal H: The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders. Redox Biol. 34:1015672020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang J, Guo J, Zhao X, Chen Z, Wang G, Liu A, Wang Q, Zhou W, Xu Y and Wang C: Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice. Behav Brain Res. 250:230–237. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zeitlin R, Patel S, Burgess S, Arendash GW and Echeverria V: Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice. Brain Res. 1417:127–136. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Bitner RS, Markosyan S, Nikkel AL and Brioni JD: In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease. Neuropharmacology. 60:460–466. 2011. View Article : Google Scholar | |
|
Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, et al: GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 321:1032–1045. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Liu B, Sun F, Xu Y, Luan H, Yang M, Wang C, Zhang T, Zhou Z and Yan H: Histamine H3R antagonist counteracts the impaired hippocampal neurogenesis in lipopolysaccharide-induced neuroinflammation. Int Immunopharmacol. 110:1090452022. View Article : Google Scholar : PubMed/NCBI | |
|
Hiraga N, Adachi N, Liu K, Nagaro T and Arai T: Suppression of inflammatory cell recruitment by histamine receptor stimulation in ischemic rat brains. Eur J Pharmacol. 557:236–244. 2007. View Article : Google Scholar | |
|
Amin FU, Shah SA, Badshah H, Khan M and Kim MO: Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1-42-induced oxidative stress. J Nanobiotechnology. 15:122017. View Article : Google Scholar | |
|
von Otter M, Landgren S, Nilsson S, Zetterberg M, Celojevic D, Bergström P, Minthon L, Bogdanovic N, Andreasen N, Gustafson DR, et al: Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract. Mech Ageing Dev. 131:105–110. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL and Koistinaho J: Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. Mol Cell Neurosci. 39:302–313. 2008. View Article : Google Scholar | |
|
Li XX, Zheng X, Liu Z, Xu Q, Tang H, Feng J, Yang S, Vong CT, Gao H and Wang Y: Cryptotanshinone from Salvia miltiorrhiza Bunge (Danshen) inhibited inflammatory responses via TLR4/MyD88 signaling pathway. Chin Med. 15:202020. View Article : Google Scholar : PubMed/NCBI | |
|
Fragoulis A, Siegl S, Fendt M, Jansen S, Soppa U, Brandenburg LO, Pufe T, Weis J and Wruck CJ: Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. Redox Biol. 12:843–853. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Bilia AR, Scalise L, Bergonzi MC and Vincieri FF: Analysis of kavalactones from Piper methysticum (kava-kava). J Chromatogr B Analyt Technol Biomed Life Sci. 812:203–214. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Mattioli R, Francioso A, d'Erme M, Trovato M, Mancini P, Piacentini L, Casale AM, Wessjohann L, Gazzino R, Costantino P and Mosca L: Anti-inflammatory activity of a polyphenolic extract from Arabidopsis thaliana in in vitro and in vivo models of Alzheimer's disease. Int J Mol Sci. 20:7082019. View Article : Google Scholar : PubMed/NCBI | |
|
Rateb ME, Houssen WE, Schumacher M, Harrison WT, Diederich M, Ebel R and Jaspars M: Bioactive diterpene derivatives from the marine sponge Spongionella sp. J Nat Prod. 72:1471–1476. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Alvariño R, Alonso E, Abbasov ME, Chaheine CM, Conner ML, Romo D, Alfonso A and Botana LM: Gracilin A derivatives target early events in Alzheimer's disease: In vitro effects on neuroinflammation and oxidative stress. ACS Chem Neurosci. 10:4102–4111. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X and Asghar M: Protein disulfide isomerase regulates renal AT1 receptor function and blood pressure in rats. Am J Physiol Renal Physiol. 313:F461–F466. 2017. View Article : Google Scholar : | |
|
Itoh K, Mimura J and Yamamoto M: Discovery of the negative regulator of Nrf2, Keap1: A historical overview. Antioxid Redox Signal. 13:1665–1678. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wu H, Zhao G, Jiang K, Li C, Qiu C and Deng G: Engeletin alleviates lipopolysaccharide-induced endometritis in mice by inhibiting TLR4-mediated NF-κB activation. J Agric Food Chem. 64:6171–6178. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Huang Z, Ji H, Shi J, Zhu X and Zhi Z: Engeletin attenuates Aβ1-42-induced oxidative stress and neuroinflammation by Keap1/Nrf2 pathway. Inflammation. 43:1759–1771. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Barone E, Di Domenico F, Sultana R, Coccia R, Mancuso C, Perluigi M and Butterfield DA: Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment. Free Radic Biol Med. 52:2292–2301. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zou Y, Hong B, Fan L, Zhou L, Liu Y, Wu Q, Zhang X and Dong M: Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: Involvement of the GSK-3β/Nrf2 signaling pathway. Free Radic Res. 47:55–63. 2013. View Article : Google Scholar | |
|
Eom HW, Park SY, Kim YH, Seong SJ, Jin ML, Ryu EY, Kim MJ and Lee SJ: Bambusae caulis in taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. Int J Mol Med. 30:1512–1520. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Yin W, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y and Pi R: L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation. Eur J Pharmacol. 806:1–9. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan TW, Tian YX, Wang Q, Wu ZX, Zhang WP, Lu YB and Wu M: Cangrelor alleviates pulmonary fibrosis by inhibiting GPR17-mediated inflammation in mice. Int Immunopharmacol. 62:261–269. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Jin S, Wang X, Xiang X, Wu Y, Hu J, Li Y, Lin DY, Tan Y and Wu X: Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ1-42 through Nrf2/HO-1 and NF-κB signaling pathway in mice. Int Immunopharmacol. 101:1083352021. View Article : Google Scholar | |
|
Gao X, He D, Liu D, Hu G, Zhang Y, Meng T, Su Y, Zhou A, Huang B, Du J and Fu S: Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-kappaB signaling axis. Immunobiology. 225:1519652020. View Article : Google Scholar | |
|
Just PA, Charawi S, Denis RGP, Savall M, Traore M, Foretz M, Bastu S, Magassa S, Senni N, Sohier P, et al: Lkb1 suppresses amino acid-driven gluconeogenesis in the liver. Nat Commun. 11:61272020. View Article : Google Scholar : PubMed/NCBI | |
|
Marinangeli C, Didier S, Ahmed T, Caillerez R, Domise M, Laloux C, Bégard S, Carrier S, Colin M, Marchetti P, et al: AMP-activated protein kinase is essential for the maintenance of energy levels during synaptic activation. iScience. 9:1–13. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Vingtdeux V, Davies P, Dickson DW and Marambaud P: AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol. 121:337–349. 2011. View Article : Google Scholar : | |
|
Shah SA, Yoon GH, Chung SS, Abid MN, Kim TH, Lee HY and Kim MO: Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer's disease neuropathological deficits. Mol Psychiatry. 22:407–416. 2017. View Article : Google Scholar : | |
|
Vingtdeux V, Chandakkar P, Zhao H, d'Abramo C, Davies P and Marambaud P: Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation. FASEB J. 25:219–231. 2011. View Article : Google Scholar : | |
|
Domise M, Didier S, Marinangeli C, Zhao H, Chandakkar P, Buée L, Viollet B, Davies P, Marambaud P and Vingtdeux V: AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo. Sci Rep. 6:267582016. View Article : Google Scholar : PubMed/NCBI | |
|
Li C, Zhang C, Zhou H, Feng Y, Tang F, Hoi M, He C, Ma D, Zhao C and Lee S: Inhibitory effects of betulinic acid on LPS-induced neuroinflammation involve M2 microglial polarization via CaMKKβ-Dependent AMPK activation. Front Mol Neurosci. 11:982018. View Article : Google Scholar | |
|
Voss U and Ekblad E: Lipopolysaccharide-induced loss of cultured rat myenteric neurons-role of AMP-activated protein kinase. PLoS One. 9:e1140442014. View Article : Google Scholar | |
|
Zhou Z, Zhang L, Liu Y, Huang C, Xia W, Zhou H, Zhou Z and Zhou X: Luteolin protects chondrocytes from H O oxidative injury and attenuates osteoarthritis progression by 2 2-induced activating AMPK-Nrf2 signaling. Oxid Med Cell Longev. 2022:56357972022. View Article : Google Scholar | |
|
Zhou F, Wang M, Ju J, Wang Y, Liu Z, Zhao X, Yan Y, Yan S, Luo X and Fang Y: Schizandrin A protects against cerebral ischemia-reperfusion injury by suppressing inflammation and oxidative stress and regulating the AMPK/Nrf2 pathway regulation. Am J Transl Res. 11:199–209. 2019.PubMed/NCBI | |
|
Park SY, Choi MH, Park G and Choi YW: Petasites japonicus bakkenolide B inhibits lipopolysaccharide-induced pro-inflammatory cytokines via AMPK/Nrf2 induction in microglia. Int J Mol Med. 41:1683–1692. 2018. | |
|
Lee KP, Kang S, Park SJ, Choi YW, Lee YG and Im DS: Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves. J Ethnopharmacol. 148:890–894. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Wen PY, Li WW and Zhou J: Upregulation effects of tanshinone IIA on the expressions of NeuN, Nissl body, and IκB and downregulation effects on the expressions of GFAP and NF-κB in the brain tissues of rat models of Alzheimer's disease. Neuroreport. 26:758–766. 2015. View Article : Google Scholar : PubMed/NCBI |