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Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review)

  • Authors:
    • Yifeng Zhang
    • Hang Yang
    • Shuai Hou
    • Yulei Xia
    • Yan-Qiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology II, The Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261041, P.R. China, Department of Emergency, The Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261041, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 30
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    Published online on: January 29, 2024
       https://doi.org/10.3892/ijmm.2024.5354
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Abstract

Stroke, a debilitating cerebrovascular ailment, poses significant threats to human life and health. The intricate interplay between the gut‑brain‑microbiota axis (GBMA) and cerebral ischemia‑reperfusion has increasingly become a focal point of scientific exploration, emerging as a pivotal research avenue in stroke pathophysiology. In the present review, the authors delved into the nexus between the GBMA and neuroinflammation observed post‑stroke. The analysis underscored the pivotal roles of histone deacetylase 3 and neutrophil extracellular traps subsequent to stroke incidents. The influence of gut microbial compositions and their metabolites, notably short‑chain fatty acids and trimethylamine N‑oxide, on neuroinflammatory processes, was further elucidated. The involvement of immune cells, especially regulatory T‑cells, and the intricate signaling cascades including cyclic GMP‑AMP synthase/stimulator of interferon genes/Toll‑like receptor, further emphasized the complex regulatory mechanisms of GBMA in cerebral ischemia/reperfusion injury (CI/RI). Collectively, the present review offered a comprehensive perspective on the metabolic, immune and inflammatory modulations orchestrated by GBMA, augmenting the understanding of its role in neuroinflammation following CI/RI.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Yang H, Hou S, Xia Y and Wang Y: Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review). Int J Mol Med 53: 30, 2024.
APA
Zhang, Y., Yang, H., Hou, S., Xia, Y., & Wang, Y. (2024). Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review). International Journal of Molecular Medicine, 53, 30. https://doi.org/10.3892/ijmm.2024.5354
MLA
Zhang, Y., Yang, H., Hou, S., Xia, Y., Wang, Y."Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review)". International Journal of Molecular Medicine 53.3 (2024): 30.
Chicago
Zhang, Y., Yang, H., Hou, S., Xia, Y., Wang, Y."Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review)". International Journal of Molecular Medicine 53, no. 3 (2024): 30. https://doi.org/10.3892/ijmm.2024.5354
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Yang H, Hou S, Xia Y and Wang Y: Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review). Int J Mol Med 53: 30, 2024.
APA
Zhang, Y., Yang, H., Hou, S., Xia, Y., & Wang, Y. (2024). Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review). International Journal of Molecular Medicine, 53, 30. https://doi.org/10.3892/ijmm.2024.5354
MLA
Zhang, Y., Yang, H., Hou, S., Xia, Y., Wang, Y."Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review)". International Journal of Molecular Medicine 53.3 (2024): 30.
Chicago
Zhang, Y., Yang, H., Hou, S., Xia, Y., Wang, Y."Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review)". International Journal of Molecular Medicine 53, no. 3 (2024): 30. https://doi.org/10.3892/ijmm.2024.5354
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