Open Access

Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway

  • Authors:
    • Qingling Liu
    • Liqin Jiang
    • Yun Zhao
    • Fang Su
    • Junfeng Li
    • Xinxin Tian
    • Wenhong Liu
    • Xiawei Jiang
    • Ye Xu
    • Fangfang Tao
  • View Affiliations

  • Published online on: May 21, 2024     https://doi.org/10.3892/ijmm.2024.5384
  • Article Number: 60
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ovarian cancer (OC) is one of the most common gynecological malignancies. Currently, chemoradiotherapy is the primary clinical treatment approach for OC; however, it has severe side effects and a high rate of recurrence. Thus, there is an urgent need to develop innovative therapeutic options. Paeoniflorigenone (PFG) is a monoterpene compound isolated from the traditional Chinese medicine Paeoniae Radix Rubra. PFG can inhibit the proliferation of tumor cells; however, its anticancer activity against OC has yet to be elucidated. Mucin 1 (MUC1) is highly expressed in various malignant tumors, and is associated with tumor proliferation, metastasis and epithelial‑mesenchymal transition (EMT). In addition, MUC1 affects numerous signaling pathways in tumor cells. In order to develop a possible treatment approach for metastatic OC, the antitumor activity of PFG in OC cells was investigated using Cell Counting Kit‑8 assay, Edu assay, flow cytometry, Transwell assay and western blot analysis. In addition, it was assessed how PFG affects MUC1 expression and function. The experiments revealed that PFG significantly inhibited OC cell proliferation, migration, invasion and EMT. PFG also induced S‑phase cell cycle arrest in OC cells. Furthermore, PFG inhibited MUC1 promoter activity, which led to a decrease in MUC1 protein expression. By contrast, MUC1 promoted OC progression, including cell proliferation, cell cycle progression and cell migration. Stable knockdown of MUC1 in OC cells improved the ability of PFG to block the Wnt/β‑catenin pathway, and to limit tumor cell invasion and migration, whereas MUC1 overexpression partially counteracted the antitumor effects of PFG. In conclusion, the present study demonstrated that PFG may inhibit the MUC1/Wnt/β‑catenin pathway to induce anti‑metastatic, anti‑invasive and anti‑EMT effects on OC. Notably, MUC1 may be a direct target of PFG. Thus, PFG holds promise as a specific antitumor agent for the treatment of OC.

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July-2024
Volume 54 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Q, Jiang L, Zhao Y, Su F, Li J, Tian X, Liu W, Jiang X, Xu Y, Tao F, Tao F, et al: Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway. Int J Mol Med 54: 60, 2024
APA
Liu, Q., Jiang, L., Zhao, Y., Su, F., Li, J., Tian, X. ... Tao, F. (2024). Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway. International Journal of Molecular Medicine, 54, 60. https://doi.org/10.3892/ijmm.2024.5384
MLA
Liu, Q., Jiang, L., Zhao, Y., Su, F., Li, J., Tian, X., Liu, W., Jiang, X., Xu, Y., Tao, F."Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway". International Journal of Molecular Medicine 54.1 (2024): 60.
Chicago
Liu, Q., Jiang, L., Zhao, Y., Su, F., Li, J., Tian, X., Liu, W., Jiang, X., Xu, Y., Tao, F."Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/β‑catenin pathway". International Journal of Molecular Medicine 54, no. 1 (2024): 60. https://doi.org/10.3892/ijmm.2024.5384