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Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review)

  • Authors:
    • Ming-Wei Liu
    • Shao-Xin Duan
    • Xue-Yan Zhao
    • Qiong-Fen Wang
    • Shan-Lan Yang
    • Ni Ma
    • Xuan Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan 671000, P.R. China, Department of Trauma, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan 671000, P.R. China, Department of Endocrinology, First Affiliated Hospital of Dali University, Dali, Yunnan 671000, P.R. China, Department of Gastroenterology, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan 671000, P.R. China, Department of Oncology, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan 671000, P.R. China, Department of Pharmacy, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan 671000, P.R. China, Department of Rehabilitation, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan 671000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 94
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    Published online on: April 17, 2025
       https://doi.org/10.3892/ijmm.2025.5535
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Abstract

Sepsis‑induced organ dysfunction syndrome (ODS) arises from a dysregulated response to infection, leading to multiple life‑threatening organ dysfunctions, and is a common complication in critically ill patients. Sepsis results in varying degrees of injury to the brain, lungs, kidneys and liver, culminating in immune dysfunction and multiple ODS (MODS). Current evidence indicates a direct correlation between the severity of organ injury and the prognosis of septic patients. Understanding the mechanisms of MODS in sepsis and developing effective management strategies are vital research areas. The protective effects of dexmedetomidine (DEX) on sepsis are well established, demonstrating its capacity to mitigate injuries to the brain, lungs, kidneys, liver and immune system. The present study reviews recent research progress on the role and mechanisms of action of DEX in the treatment of sepsis.
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Copy and paste a formatted citation
Spandidos Publications style
Liu M, Duan S, Zhao X, Wang Q, Yang S, Ma N and Li X: Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review). Int J Mol Med 55: 94, 2025.
APA
Liu, M., Duan, S., Zhao, X., Wang, Q., Yang, S., Ma, N., & Li, X. (2025). Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review). International Journal of Molecular Medicine, 55, 94. https://doi.org/10.3892/ijmm.2025.5535
MLA
Liu, M., Duan, S., Zhao, X., Wang, Q., Yang, S., Ma, N., Li, X."Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review)". International Journal of Molecular Medicine 55.6 (2025): 94.
Chicago
Liu, M., Duan, S., Zhao, X., Wang, Q., Yang, S., Ma, N., Li, X."Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review)". International Journal of Molecular Medicine 55, no. 6 (2025): 94. https://doi.org/10.3892/ijmm.2025.5535
Copy and paste a formatted citation
x
Spandidos Publications style
Liu M, Duan S, Zhao X, Wang Q, Yang S, Ma N and Li X: Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review). Int J Mol Med 55: 94, 2025.
APA
Liu, M., Duan, S., Zhao, X., Wang, Q., Yang, S., Ma, N., & Li, X. (2025). Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review). International Journal of Molecular Medicine, 55, 94. https://doi.org/10.3892/ijmm.2025.5535
MLA
Liu, M., Duan, S., Zhao, X., Wang, Q., Yang, S., Ma, N., Li, X."Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review)". International Journal of Molecular Medicine 55.6 (2025): 94.
Chicago
Liu, M., Duan, S., Zhao, X., Wang, Q., Yang, S., Ma, N., Li, X."Research status and advances in dexmedetomidine for sepsis‑induced multiple organ dysfunction syndrome (Review)". International Journal of Molecular Medicine 55, no. 6 (2025): 94. https://doi.org/10.3892/ijmm.2025.5535
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