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Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review)

  • Authors:
    • Mingcheng Peng
    • Jun Gong
    • Taixue An
    • Hongbing Cheng
    • Liangji Chen
    • Mengyang Cai
    • Jinhua Lan
    • Yueting Tang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Thoracic Surgery, Xiantao First People's Hospital, Xiantao, Hubei 433099, P.R. China, Department of Clinical Laboratory, Xiantao First People's Hospital, Xiantao, Hubei 433099, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 106
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    Published online on: May 9, 2025
       https://doi.org/10.3892/ijmm.2025.5547
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Abstract

The diagnosis of malignant and benign pulmonary nodules has always been a prominent research topic. Accurately distinguishing between these types of lesions, particularly small or ground glass nodules, is crucial for the early detection and proactive treatment of lung cancer, ultimately leading to improved patient survival. Although various imaging methods and tissue biopsies have advanced the diagnostic efficacy of pulmonary nodules, each approach possesses inherent limitations. In recent years, there has been a growing interest in liquid biopsy as a non‑invasive and easily obtainable alternative. Furthermore, in‑depth investigations into the mechanisms underlying tumor initiation and progression have contributed to the development of circulating biomarkers for monitoring treatment response and efficacy in lung cancer. This review provides a comprehensive overview of the current landscape of pulmonary nodule diagnosis while highlighting the latest advancements in liquid biopsy techniques, such as extracellular vesicles, tumor‑educated platelets, non‑coding RNA, circulating tumor DNA and circulating antibodies.
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Copy and paste a formatted citation
Spandidos Publications style
Peng M, Gong J, An T, Cheng H, Chen L, Cai M, Lan J and Tang Y: Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review). Int J Mol Med 56: 106, 2025.
APA
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M. ... Tang, Y. (2025). Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review). International Journal of Molecular Medicine, 56, 106. https://doi.org/10.3892/ijmm.2025.5547
MLA
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M., Lan, J., Tang, Y."Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review)". International Journal of Molecular Medicine 56.1 (2025): 106.
Chicago
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M., Lan, J., Tang, Y."Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review)". International Journal of Molecular Medicine 56, no. 1 (2025): 106. https://doi.org/10.3892/ijmm.2025.5547
Copy and paste a formatted citation
x
Spandidos Publications style
Peng M, Gong J, An T, Cheng H, Chen L, Cai M, Lan J and Tang Y: Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review). Int J Mol Med 56: 106, 2025.
APA
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M. ... Tang, Y. (2025). Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review). International Journal of Molecular Medicine, 56, 106. https://doi.org/10.3892/ijmm.2025.5547
MLA
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M., Lan, J., Tang, Y."Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review)". International Journal of Molecular Medicine 56.1 (2025): 106.
Chicago
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M., Lan, J., Tang, Y."Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review)". International Journal of Molecular Medicine 56, no. 1 (2025): 106. https://doi.org/10.3892/ijmm.2025.5547
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