Open Access

Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review)

  • Authors:
    • Mingcheng Peng
    • Jun Gong
    • Taixue An
    • Hongbing Cheng
    • Liangji Chen
    • Mengyang Cai
    • Jinhua Lan
    • Yueting Tang
  • View Affiliations

  • Published online on: May 9, 2025     https://doi.org/10.3892/ijmm.2025.5547
  • Article Number: 106
  • Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The diagnosis of malignant and benign pulmonary nodules has always been a prominent research topic. Accurately distinguishing between these types of lesions, particularly small or ground glass nodules, is crucial for the early detection and proactive treatment of lung cancer, ultimately leading to improved patient survival. Although various imaging methods and tissue biopsies have advanced the diagnostic efficacy of pulmonary nodules, each approach possesses inherent limitations. In recent years, there has been a growing interest in liquid biopsy as a non‑invasive and easily obtainable alternative. Furthermore, in‑depth investigations into the mechanisms underlying tumor initiation and progression have contributed to the development of circulating biomarkers for monitoring treatment response and efficacy in lung cancer. This review provides a comprehensive overview of the current landscape of pulmonary nodule diagnosis while highlighting the latest advancements in liquid biopsy techniques, such as extracellular vesicles, tumor‑educated platelets, non‑coding RNA, circulating tumor DNA and circulating antibodies.
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July-2025
Volume 56 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Peng M, Gong J, An T, Cheng H, Chen L, Cai M, Lan J and Tang Y: Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review). Int J Mol Med 56: 106, 2025.
APA
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M. ... Tang, Y. (2025). Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review). International Journal of Molecular Medicine, 56, 106. https://doi.org/10.3892/ijmm.2025.5547
MLA
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M., Lan, J., Tang, Y."Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review)". International Journal of Molecular Medicine 56.1 (2025): 106.
Chicago
Peng, M., Gong, J., An, T., Cheng, H., Chen, L., Cai, M., Lan, J., Tang, Y."Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review)". International Journal of Molecular Medicine 56, no. 1 (2025): 106. https://doi.org/10.3892/ijmm.2025.5547