Open Access

Multifaceted regulatory mechanisms of the EGR family in tumours and prospects for therapeutic applications (Review)

  • Authors:
    • Rongqi Guo
    • Rui Wang
    • Weisong Zhang
    • Yangyang Li
    • Yihao Wang
    • Hao Wang
    • Xia Li
    • Jianxiang Song
  • View Affiliations

  • Published online on: May 27, 2025     https://doi.org/10.3892/ijmm.2025.5554
  • Article Number: 113
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The early growth response (EGR) family comprises four zinc finger transcription factors: EGR1, EGR2, EGR3 and EGR4. These transcription factors belong to the Cys2‑His2‑type zinc finger protein family and are essential in cell differentiation, proliferation, apoptosis and stress response. Initially, EGR1 was recognised for its essential regulatory role in tumourigenesis. Recent studies have identified similarities between other members of the EGR family and EGR1 in tumour regulation and the multifaceted regulatory mechanism employed by the EGR family to affect tumours. Therefore, the present review describes the dual roles of the EGR family in tumours and their regulatory mechanisms in immunity, metabolism and differentiation. Additionally, the present review offers a new perspective on relevant tumour therapeutic studies based on current EGR targeting.
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July-2025
Volume 56 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Guo R, Wang R, Zhang W, Li Y, Wang Y, Wang H, Li X and Song J: Multifaceted regulatory mechanisms of the EGR family in tumours and prospects for therapeutic applications (Review). Int J Mol Med 56: 113, 2025.
APA
Guo, R., Wang, R., Zhang, W., Li, Y., Wang, Y., Wang, H. ... Song, J. (2025). Multifaceted regulatory mechanisms of the EGR family in tumours and prospects for therapeutic applications (Review). International Journal of Molecular Medicine, 56, 113. https://doi.org/10.3892/ijmm.2025.5554
MLA
Guo, R., Wang, R., Zhang, W., Li, Y., Wang, Y., Wang, H., Li, X., Song, J."Multifaceted regulatory mechanisms of the EGR family in tumours and prospects for therapeutic applications (Review)". International Journal of Molecular Medicine 56.1 (2025): 113.
Chicago
Guo, R., Wang, R., Zhang, W., Li, Y., Wang, Y., Wang, H., Li, X., Song, J."Multifaceted regulatory mechanisms of the EGR family in tumours and prospects for therapeutic applications (Review)". International Journal of Molecular Medicine 56, no. 1 (2025): 113. https://doi.org/10.3892/ijmm.2025.5554