Open Access

Research status and future perspectives of IL‑27 in the treatment of stroke (Review)

  • Authors:
    • Weiqin Liu
    • Zhenyou Zou
    • Wenyang Li
    • Guang Yang
    • Jie Zhang
    • Zhenyu Zhang
    • Hua Yao
  • View Affiliations

  • Published online on: May 30, 2025     https://doi.org/10.3892/ijmm.2025.5557
  • Article Number: 116
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Stroke is a life‑threatening cerebrovascular disorder categorized into two major subtypes: Ischemic and hemorrhagic. Characterized by high morbidity and mortality rates, its clinical management remains challenging due to limited therapeutic options. Interleukin (IL)‑27, a pleiotropic cytokine with demonstrated neuroprotective potential, has emerged as a promising candidate for stroke intervention. IL‑27 exerts immunomodulatory effects within the central nervous system, including suppression of proinflammatory T‑cell proliferation and induction of regulatory T‑cell differentiation. These mechanisms collectively attenuate neuroinflammation, mitigate neuronal apoptosis and prevent neurodegenerative processes. The efficacy of IL‑27 in reducing cerebral damage in both ischemic and hemorrhagic stroke models has been validated, although clinical translation remains to be achieved. The present review summarizes: i) The epidemiology of stroke; ii) the immunoregulatory functions of IL‑27 and its neuroprotective mechanisms across stroke subtypes; iii) innovative brain‑targeted delivery approaches; iv) IL‑27 clinical applicability with supporting evidence; and v) possible risks and solutions in clinical applications. By collating the current knowledge, the present study provides a translational framework for advancing IL‑27‑based therapies in stroke management.
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August-2025
Volume 56 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Liu W, Zou Z, Li W, Yang G, Zhang J, Zhang Z and Yao H: Research status and future perspectives of IL‑27 in the treatment of stroke (Review). Int J Mol Med 56: 116, 2025.
APA
Liu, W., Zou, Z., Li, W., Yang, G., Zhang, J., Zhang, Z., & Yao, H. (2025). Research status and future perspectives of IL‑27 in the treatment of stroke (Review). International Journal of Molecular Medicine, 56, 116. https://doi.org/10.3892/ijmm.2025.5557
MLA
Liu, W., Zou, Z., Li, W., Yang, G., Zhang, J., Zhang, Z., Yao, H."Research status and future perspectives of IL‑27 in the treatment of stroke (Review)". International Journal of Molecular Medicine 56.2 (2025): 116.
Chicago
Liu, W., Zou, Z., Li, W., Yang, G., Zhang, J., Zhang, Z., Yao, H."Research status and future perspectives of IL‑27 in the treatment of stroke (Review)". International Journal of Molecular Medicine 56, no. 2 (2025): 116. https://doi.org/10.3892/ijmm.2025.5557