Open Access

Role and mechanisms of cuproptosis in the pathogenesis of Wilson's disease (Review)

  • Authors:
    • Hong Chen
    • Xie Wang
    • Jin Xing
    • Yue Pu
    • Hao Ye
    • Ying Ma
    • Juan Zhang
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  • Published online on: May 30, 2025     https://doi.org/10.3892/ijmm.2025.5558
  • Article Number: 117
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Copper, an indispensable trace element in living organisms, plays a pivotal role in human physiological processes. Wilson's disease (WD), an inherited disorder of copper metabolism, is caused by mutations in the ATP7B gene. This genetic malfunction disrupts the dynamics of copper transport and metabolism, thereby impairing ceruloplasmin synthesis and copper excretion. The resultant accumulation of copper in various tissues and organs precipitates a cascade of cellular demise and functional impairment. Notably, cuproptosis, a recently discovered copper‑dependent regulated cell death mechanism, distinctly deviates from conventional cell death paradigms. This novel mode of cell death involves the interaction of copper with lipoacylated proteins within the tricarboxylic acid cycle, leading to proteinotoxic stress and culminating in cell death. In the realm of pathophysiology, cuproptosis has emerged as a pivotal player in a spectrum of diseases, with WD standing as a paradigm closely intertwined with the dysregulation of copper metabolism. This study aimed to encapsulate the pivotal molecular underpinnings of cuproptosis and delve into its crucial involvement in the etiopathogenesis of WD. By elucidating these mechanisms, the present analysis contributes significantly to the nuanced understanding of the pathological underpinnings of WD, thereby providing fresh insights and evidence that may direct innovative therapeutic strategies for this condition.
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August-2025
Volume 56 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Chen H, Wang X, Xing J, Pu Y, Ye H, Ma Y and Zhang J: Role and mechanisms of cuproptosis in the pathogenesis of Wilson's disease (Review). Int J Mol Med 56: 117, 2025.
APA
Chen, H., Wang, X., Xing, J., Pu, Y., Ye, H., Ma, Y., & Zhang, J. (2025). Role and mechanisms of cuproptosis in the pathogenesis of Wilson's disease (Review). International Journal of Molecular Medicine, 56, 117. https://doi.org/10.3892/ijmm.2025.5558
MLA
Chen, H., Wang, X., Xing, J., Pu, Y., Ye, H., Ma, Y., Zhang, J."Role and mechanisms of cuproptosis in the pathogenesis of Wilson's disease (Review)". International Journal of Molecular Medicine 56.2 (2025): 117.
Chicago
Chen, H., Wang, X., Xing, J., Pu, Y., Ye, H., Ma, Y., Zhang, J."Role and mechanisms of cuproptosis in the pathogenesis of Wilson's disease (Review)". International Journal of Molecular Medicine 56, no. 2 (2025): 117. https://doi.org/10.3892/ijmm.2025.5558