Open Access

Molecular mechanisms and intervention approaches of heart failure (Review)

  • Authors:
    • Shuang Guo
    • Yingqing Hu
    • Li Ling
    • Zhuangzhuang Yang
    • Luxuan Wan
    • Xiaosong Yang
    • Min Lei
    • Xiying Guo
    • Zhanhong Ren
  • View Affiliations

  • Published online on: June 13, 2025     https://doi.org/10.3892/ijmm.2025.5566
  • Article Number: 125
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Heart failure is a major health issue that threatens life and health. Previous studies have shown that heart failure is the terminal stage of arrhythmia, dilated cardiomyopathy, hypertension, hypertrophic cardiomyopathy and myocardial infarction. The pathological mechanisms through which cardiovascular diseases result in heart failure include myocardial fibrosis and hypertrophy, myocardial cell death, mitochondrial dysfunction, vascular remodeling and calcium dysregulation. However, the detailed molecular mechanisms of heart failure remain elusive because of its complexity, hindering the development of intervention approaches for heart failure. The present study reviewed recent research progress on heart failure and provided references and strategies for the prevention and treatment of heart failure.
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August-2025
Volume 56 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Guo S, Hu Y, Ling L, Yang Z, Wan L, Yang X, Lei M, Guo X and Ren Z: Molecular mechanisms and intervention approaches of heart failure (Review). Int J Mol Med 56: 125, 2025.
APA
Guo, S., Hu, Y., Ling, L., Yang, Z., Wan, L., Yang, X. ... Ren, Z. (2025). Molecular mechanisms and intervention approaches of heart failure (Review). International Journal of Molecular Medicine, 56, 125. https://doi.org/10.3892/ijmm.2025.5566
MLA
Guo, S., Hu, Y., Ling, L., Yang, Z., Wan, L., Yang, X., Lei, M., Guo, X., Ren, Z."Molecular mechanisms and intervention approaches of heart failure (Review)". International Journal of Molecular Medicine 56.2 (2025): 125.
Chicago
Guo, S., Hu, Y., Ling, L., Yang, Z., Wan, L., Yang, X., Lei, M., Guo, X., Ren, Z."Molecular mechanisms and intervention approaches of heart failure (Review)". International Journal of Molecular Medicine 56, no. 2 (2025): 125. https://doi.org/10.3892/ijmm.2025.5566