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![Exposure to ionizing radiation
induces NETs. (A) BMDNs were exposed to 5, 10 and 15 Gy radiation.
NETs were assessed via flow cytometry 24 h after irradiation. (B)
The frequencies of NET positive neutrophils are shown. Groups were
compared using a one-way ANOVA and Tukey's multiple comparison
test. (C) Representative images of BMDNs that were exposed to 10 Gy
radiation. NET formation was assessed by fluorescence microscopy
using SYTOX Green 24 h after irradiation. White arrows indicate the
NET structures. Scale bar, 200 μm (Bright field and SYTOX
Green); scale bar, 100 μm [SYTOX Green (enlarged)]. (D)
Wild-type adult mice were exposed to 10 Gy TBI. Bone marrow cells
were isolated 24 h after TBI and NETs were assessed using flow
cytometry. (E) The frequencies of NET positive neutrophils. Groups
were compared using an unpaired two-tailed Student's t-test. Data
are expressed as the mean ± SEM (n=6/group). *P<0.05,
**P<0.01 and ****P<0.0001. ns, not
significant; cont, control; NET, neutrophil extracellular traps;
BMDNs, bone marrow-derived neutrophils; TBI, total body
irradiation.](/article_images/ijmm/56/4/ijmm-56-04-05598-g00.jpg)
