|
1
|
Luengo-Fernandez R, Walli-Attaei M, Gray
A, Torbica A, Maggioni AP, Huculeci R, Bairami F, Aboyans V, Timmis
AD, Vardas P and Leal J: Economic burden of cardiovascular diseases
in the European Union: A population-based cost study. Eur Heart J.
44:4752–4767. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Weintraub WS: High costs of cardiovascular
disease in the European Union. Eur Heart J. 44:4768–4770. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Goldsborough E III, Osuji N and Blaha MJ:
Assessment of cardiovascular disease risk: A 2022 update.
Endocrinol Metab Clin North Am. 51:483–509. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Raleigh V and Colombo F: Cardiovascular
disease should be a priority for health systems globally. BMJ.
382:e0765762023. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Falk E: Pathogenesis of atherosclerosis. J
Am Coll Cardiol. 47(Suppl 8): C7–C12. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Fan J and Watanabe T: Atherosclerosis:
Known and unknown. Pathol Int. 72:151–160. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Libby P: The changing landscape of
atherosclerosis. Nature. 592:524–533. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Rocha VZ and Libby P: Obesity,
inflammation, and atherosclerosis. Nat Rev Cardiol. 6:399–409.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Shoaran M and Maffia P: Tackling
inflammation in atherosclerosis. Nat Rev Cardiol. 21:4422024.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Bäck M, Yurdagul A Jr, Tabas I, Öörni K
and Kovanen PT: Inflammation and its resolution in atherosclerosis:
Mediators and therapeutic opportunities. Nat Rev Cardiol.
16:389–406. 2019.PubMed/NCBI
|
|
11
|
Kong P, Cui ZY, Huang XF, Zhang DD, Guo RJ
and Han M: Inflammation and atherosclerosis: Signaling pathways and
therapeutic intervention. Signal Transduct Target Ther. 7:1312022.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Wolf D and Ley K: Immunity and
inflammation in atherosclerosis. Circ Res. 124:315–327. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Saigusa R, Winkels H and Ley K: T cell
subsets and functions in atherosclerosis. Nat Rev Cardiol.
17:387–401. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Srikakulapu P and McNamara CA: B cells and
atherosclerosis. Am J Physiol Heart Circ Physiol. 312:H1060–H1067.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Taghavie-Moghadam PL, Butcher MJ and
Galkina EV: The dynamic lives of macrophage and dendritic cell
subsets in atherosclerosis. Ann N Y Acad Sci. 1319:19–37. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Tedgui A and Mallat Z: Cytokines in
atherosclerosis: Pathogenic and regulatory pathways. Physiol Rev.
86:515–581. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Kzhyshkowska J, Shen J and Larionova I:
Targeting of TAMs: Can we be more clever than cancer cells? Cell
Mol Immunol. 21:1376–1409. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Sun P, Ma L and Lu Z: Lactylation: Linking
the Warburg effect to DNA damage repair. Cell Metab. 36:1637–1639.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhang D, Tang Z, Huang H, Zhou G, Cui C,
Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, et al: Metabolic
regulation of gene expression by histone lactylation. Nature.
574:575–580. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Li F, Si W, Xia L, Yin D, Wei T, Tao M,
Cui X, Yang J, Hong T and Wei R: Positive feedback regulation
between glycolysis and histone lactylation drives oncogenesis in
pancreatic ductal adenocarcinoma. Mol Cancer. 23:902024. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Yang Z, Zheng Y and Gao Q: Lysine
lactylation in the regulation of tumor biology. Trends Endocrinol
Metab. 35:720–731. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Li H, Sun L, Gao P and Hu H: Lactylation
in cancer: Current understanding and challenges. Cancer Cell.
42:1803–1807. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Li X, Yang Y, Zhang B, Lin X, Fu X, An Y,
Zou Y, Wang JX, Wang Z and Yu T: Lactate metabolism in human health
and disease. Signal Transduct Target Ther. 7:3052022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Zhu W, Guo S, Sun J, Zhao Y and Liu C:
Lactate and lactylation in cardiovascular diseases: Current
progress and future perspectives. Metabolism. 158:1559572024.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Roy P, Orecchioni M and Ley K: How the
immune system shapes atherosclerosis: Roles of innate and adaptive
immunity. Nat Rev Immunol. 22:251–265. 2022. View Article : Google Scholar
|
|
26
|
Ouyang J, Wang H and Huang J: The role of
lactate in cardiovascular diseases. Cell Commun Signal. 21:3172023.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Li X, Cai P, Tang X, Wu Y, Zhang Y and
Rong X: Lactylation modification in cardiometabolic disorders:
Function and mechanism. Metabolites. 14:2172024. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Rabinowitz JD and Enerbäck S: Lactate: The
ugly duckling of energy metabolism. Nat Metab. 2:566–571. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Bonen A: Lactate transporters (MCT
proteins) in heart and skeletal muscles. Med Sci Sports Exerc.
32:778–789. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Singh M, Afonso J, Sharma D, Gupta R and
Kumar V, Rani R, Baltazar F and Kumar V: Targeting monocarboxylate
transporters (MCTs) in cancer: How close are we to the clinics?
Semin Cancer Biol. 90:1–14. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Certo M, Llibre A, Lee W and Mauro C:
Understanding lactate sensing and signalling. Trends Endocrinol
Metab. 33:722–735. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Apostolova P and Pearce EL: Lactic acid
and lactate: Revisiting the physiological roles in the tumor
microenvironment. Trends Immunol. 43:969–977. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Goenka A, Khan F, Verma B, Sinha P, Dmello
CC, Jogalekar MP, Gangadaran P and Ahn BC: Tumor microenvironment
signaling and therapeutics in cancer progression. Cancer Commun
(Lond). 43:525–561. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Liao M, Yao D, Wu L, Luo C, Wang Z, Zhang
J and Liu B: Targeting the Warburg effect: A revisited perspective
from molecular mechanisms to traditional and innovative therapeutic
strategies in cancer. Acta Pharm Sin B. 14:953–1008. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Wang Y and Patti GJ: The Warburg effect: A
signature of mitochondrial overload. Trends Cell Biol.
33:1014–1020. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Magistretti PJ and Allaman I: Lactate in
the brain: From metabolic end-product to signalling molecule. Nat
Rev Neurosci. 19:235–249. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Zhang W, Wang G, Xu ZG, Tu H, Hu F, Dai J,
Chang Y, Chen Y, Lu Y, Zeng H, et al: Lactate is a natural
suppressor of RLR signaling by targeting MAVS. Cell.
178:176–189.e15. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Brown TP and Ganapathy V: Lactate/GPR81
signaling and proton motive force in cancer: Role in angiogenesis,
immune escape, nutrition, and Warburg phenomenon. Pharmacol Ther.
206:1074512020. View Article : Google Scholar
|
|
39
|
Li H, Liu C, Li R, Zhou L, Ran Y, Yang Q,
Huang H, Lu H, Song H, Yang B, et al: AARS1 and AARS2 sense
L-lactate to regulate cGAS as global lysine lactyltransferases.
Nature. 634:1229–1237. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Lee WD, Weilandt DR, Liang L, MacArthur
MR, Jaiswal N, Ong O, Mann CG, Chu Q, Hunter CJ, Ryseck RP, et al:
Lactate homeostasis is maintained through regulation of glycolysis
and lipolysis. Cell Metab. 37:758–771.e8. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Feron O: Pyruvate into lactate and back:
from the Warburg effect to symbiotic energy fuel exchange in cancer
cells. Radiother Oncol. 92:329–333. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Wang K, Zhang Y and Chen ZN: Metabolic
interaction: Tumor-derived lactate inhibiting CD8+ T
cell cytotoxicity in a novel route. Signal Transduct Target Ther.
8:522023. View Article : Google Scholar
|
|
43
|
Fischer K, Hoffmann P, Voelkl S,
Meidenbauer N, Ammer J, Edinger M, Gottfried E, Schwarz S, Rothe G,
Hoves S, et al: Inhibitory effect of tumor cell-derived lactic acid
on human T cells. Blood. 109:3812–3819. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Feng Q, Liu Z, Yu X, Huang T, Chen J, Wang
J, Wilhelm J, Li S, Song J, Li W, et al: Lactate increases stemness
of CD8+ T cells to augment anti-tumor immunity. Nat
Commun. 13:49812022. View Article : Google Scholar
|
|
45
|
Mohazzab-H KM, Kaminski PM and Wolin MS:
Lactate and PO2 modulate superoxide anion production in bovine
cardiac myocytes: Potential role of NADH oxidase. Circulation.
96:614–620. 1997. View Article : Google Scholar
|
|
46
|
Gaspar JA, Doss MX, Hengstler JG, Cadenas
C, Hescheler J and Sachinidis A: Unique metabolic features of stem
cells, cardiomyocytes, and their progenitors. Circ Res.
114:1346–1360. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Chen X, Wu H, Liu Y, Liu L, Houser SR and
Wang WE: Metabolic reprogramming: A byproduct or a driver of
cardiomyocyte proliferation? Circulation. 149:1598–1610. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Chung S, Arrell DK, Faustino RS, Terzic A
and Dzeja PP: Glycolytic network restructuring integral to the
energetics of embryonic stem cell cardiac differentiation. J Mol
Cell Cardiol. 48:725–734. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Dziegala M, Kobak KA, Kasztura M, Bania J,
Josiak K, Banasiak W, Ponikowski P and Jankowska EA: Iron depletion
affects genes encoding mitochondrial electron transport chain and
genes of non-oxidative metabolism, pyruvate kinase and lactate
dehydrogenase, in primary human cardiac myocytes cultured upon
mechanical stretch. Cells. 7:1752018. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Li X, Zhao L, Chen Z, Lin Y, Yu P and Mao
L: Continuous electrochemical monitoring of extracellular lactate
production from neonatal rat cardiomyocytes following myocardial
hypoxia. Anal Chem. 84:5285–5291. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Hammond GL, Nadal-Ginard B, Talner NS and
Markert CL: Myocardial LDH isozyme distribution in the ischemic and
hypoxic heart. Circulation. 53:637–643. 1976. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Pan RY, He L, Zhang J, Liu X, Liao Y, Gao
J, Liao Y, Yan Y, Li Q, Zhou X, et al: Positive feedback regulation
of microglial glucose metabolism by histone H4 lysine 12
lactylation in Alzheimer's disease. Cell Metab. 34:634–648.e6.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Liu M, Yu W, Fang Y, Zhou H, Liang Y,
Huang C, Liu H and Zhao G: Pyruvate and lactate based hydrogel film
inhibits UV radiation-induced skin inflammation and oxidative
stress. Int J Pharm. 634:1226972023. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Huang YF, Wang G, Ding L, Bai ZR, Leng Y,
Tian JW, Zhang JZ, Li YQ, Ahmad, Qin YH, et al: Lactate-upregulated
NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes
to ROS-induced osteoarthritis chondrocyte damage. Redox Biol.
67:1028672023. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Groussard C, Morel I, Chevanne M, Monnier
M, Cillard J and Delamarche A: Free radical scavenging and
antioxidant effects of lactate ion: An in vitro study. J Appl
Physiol (1985). 89:169–175. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Shantha GPS, Wasserman B, Astor BC, Coresh
J, Brancati F, Sharrett AR and Young JH: Association of blood
lactate with carotid atherosclerosis: The atherosclerosis risk in
communities (ARIC) carotid MRI study. Atherosclerosis. 228:249–255.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Perrotta P, Van der Veken B, Van Der Veken
P, Pintelon I, Roosens L, Adriaenssens E, Timmerman V, Guns PJ, De
Meyer GRY and Martinet W: Partial Inhibition of glycolysis reduces
atherogenesis independent of intraplaque neovascularization in
mice. Arterioscler Thromb Vasc Biol. 40:1168–1181. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Sneck M, Kovanen PT and Oörni K: Decrease
in pH strongly enhances binding of native, proteolyzed, lipolyzed,
and oxidized low density lipoprotein particles to human aortic
proteoglycans. J Biol Chem. 280:37449–37454. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Li L, Wang M, Ma Q, Ye J and Sun G: Role
of glycolysis in the development of atherosclerosis. Am J Physiol
Cell Physiol. 323:C617–C629. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Li X, Chen M, Chen X, He X, Li X, Wei H,
Tan Y, Min J, Azam T, Xue M, et al: TRAP1 drives smooth muscle cell
senescence and promotes atherosclerosis via HDAC3-primed histone H4
lysine 12 lactylation. Eur Heart J. 45:4219–4235. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Zhou LJ, Lin WZ, Meng XQ, Zhu H, Liu T, Du
LJ, Bai XB, Chen BY, Liu Y, Xu Y, et al: Periodontitis exacerbates
atherosclerosis through Fusobacterium nucleatum-promoted hepatic
glycolysis and lipogenesis. Cardiovasc Res. 119:1706–1717. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Nilsson J and Hansson GK: Vaccination
strategies and immune modulation of atherosclerosis. Circ Res.
126:1281–1296. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Xue S, Su Z and Liu D: Immunometabolism
and immune response regulate macrophage function in
atherosclerosis. Ageing Res Rev. 90:1019932023. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Kim KW, Ivanov S and Williams JW: Monocyte
recruitment, specification, and function in atherosclerosis. Cells.
10:152020. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Wang B, Tang X, Yao L, Wang Y, Chen Z, Li
M, Wu N, Wu D, Dai X, Jiang H and Ai D: Disruption of USP9X in
macrophages promotes foam cell formation and atherosclerosis. J
Clin Invest. 132:e1542172022. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Tabas I and Bornfeldt KE: Macrophage
phenotype and function in different stages of atherosclerosis. Circ
Res. 118:653–667. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang
F, Feng J, Yang D, Qin Z and Yan X: Macrophagic CD146 promotes foam
cell formation and retention during atherosclerosis. Cell Res.
27:352–372. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Kim K, Shim D, Lee JS, Zaitsev K, Williams
JW, Kim KW, Jang MY, Seok Jang H, Yun TJ, Lee SH, et al:
Transcriptome analysis reveals nonfoamy rather than foamy plaque
macrophages are proinflammatory in atherosclerotic murine models.
Circ Res. 123:1127–1142. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Spann NJ, Garmire LX, McDonald JG, Myers
DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D,
et al: Regulated accumulation of desmosterol integrates macrophage
lipid metabolism and inflammatory responses. Cell. 151:138–152.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Kojima Y, Weissman IL and Leeper NJ: The
role of efferocytosis in atherosclerosis. Circulation. 135:476–489.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Wanschel A, Seibert T, Hewing B,
Ramkhelawon B, Ray TD, van Gils JM, Rayner KJ, Feig JE, O'Brien ER,
Fisher EA, et al: Neuroimmune guidance cue Semaphorin 3E is
expressed in atherosclerotic plaques and regulates macrophage
retention. Arterioscler Thromb Vasc Biol. 33:886–893. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
van Gils JM, Derby MC, Fernandes LR,
Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL,
Alvarez-Leite JI, et al: The neuroimmune guidance cue netrin-1
promotes atherosclerosis by inhibiting the emigration of
macrophages from plaques. Nat Immunol. 13:136–143. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Trogan E, Feig JE, Dogan S, Rothblat GH,
Angeli V, Tacke F, Randolph GJ and Fisher EA: Gene expression
changes in foam cells and the role of chemokine receptor CCR7
during atherosclerosis regression in ApoE-deficient mice. Proc Natl
Acad Sci USA. 103:3781–3786. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Feig JE, Parathath S, Rong JX, Mick SL,
Vengrenyuk Y, Grauer L, Young SG and Fisher EA: Reversal of
hyperlipidemia with a genetic switch favorably affects the content
and inflammatory state of macrophages in atherosclerotic plaques.
Circulation. 123:989–998. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Colin S, Chinetti-Gbaguidi G and Staels B:
Macrophage phenotypes in atherosclerosis. Immunol Rev. 262:153–166.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Zernecke A, Winkels H, Cochain C, Williams
JW, Wolf D, Soehnlein O, Robbins CS, Monaco C, Park I, McNamara CA,
et al: Meta-analysis of leukocyte diversity in atherosclerotic
mouse aortas. Circ Res. 127:402–426. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Williams JW, Zaitsev K, Kim KW, Ivanov S,
Saunders BT, Schrank PR, Kim K, Elvington A, Kim SH, Tucker CG, et
al: Limited proliferation capacity of aortic intima resident
macrophages requires monocyte recruitment for atherosclerotic
plaque progression. Nat Immunol. 21:1194–1204. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Ait-Oufella H, Taleb S, Mallat Z and
Tedgui A: Recent advances on the role of cytokines in
atherosclerosis. Arterioscler Thromb Vasc Biol. 31:969–979. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Ley K, Laudanna C, Cybulsky MI and
Nourshargh S: Getting to the site of inflammation: The leukocyte
adhesion cascade updated. Nat Rev Immunol. 7:678–689. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Ait-Oufella H, Sage AP, Mallat Z and
Tedgui A: Adaptive (T and B cells) immunity and control by
dendritic cells in atherosclerosis. Circ Res. 114:1640–1660. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Chen J, Xiang X, Nie L, Guo X, Zhang F,
Wen C, Xia Y and Mao L: The emerging role of Th1 cells in
atherosclerosis and its implications for therapy. Front Immunol.
13:10796682023. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Kuan R, Agrawal DK and Thankam FG: Treg
cells in atherosclerosis. Mol Biol Rep. 48:4897–4910. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Shao Y, Yang WY, Saaoud F, Drummer C IV,
Sun Y, Xu K, Lu Y, Shan H, Shevach EM, Jiang X, et al: IL-35
promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via
maintaining CCR5-amplified Treg-suppressive mechanisms. JCI
Insight. 6:e1525112021. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Klingenberg R, Gerdes N, Badeau RM,
Gisterå A, Strodthoff D, Ketelhuth DFJ, Lundberg AM, Rudling M,
Nilsson SK, Olivecrona G, et al: Depletion of FOXP3+ regulatory T
cells promotes hypercholesterolemia and atherosclerosis. J Clin
Invest. 123:1323–1334. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Sharma M, Schlegel MP, Afonso MS, Brown
EJ, Rahman K, Weinstock A, Sansbury BE, Corr EM, van Solingen C,
Koelwyn GJ, et al: Regulatory T cells license macrophage
pro-resolving functions during atherosclerosis regression. Circ
Res. 127:335–353. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Fernández-Gallego N, Castillo-González R,
Méndez-Barbero N, López-Sanz C, Obeso D, Villaseñor A, Escribese
MM, López-Melgar B, Salamanca J, Benedicto-Buendía A, et al: The
impact of type 2 immunity and allergic diseases in atherosclerosis.
Allergy. 77:3249–3266. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Vinson A, Curran JE, Johnson MP, Dyer TD,
Moses EK, Blangero J, Cox LA, Rogers J, Havill LM, Vandeberg JL and
Mahaney MC: Genetical genomics of Th1 and Th2 immune response in a
baboon model of atherosclerosis risk factors. Atherosclerosis.
217:387–394. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Weinstock A, Rahman K, Yaacov O, Nishi H,
Menon P, Nikain CA, Garabedian ML, Pena S, Akbar N, Sansbury BE, et
al: Wnt signaling enhances macrophage responses to IL-4 and
promotes resolution of atherosclerosis. Elife. 10:e679322021.
View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Engelbertsen D, Andersson L, Ljungcrantz
I, Wigren M, Hedblad B, Nilsson J and Björkbacka H: T-helper 2
immunity is associated with reduced risk of myocardial infarction
and stroke. Arterioscler Thromb Vasc Biol. 33:637–644. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Knutsson A, Björkbacka H, Dunér P,
Engström G, Binder CJ, Nilsson AH and Nilsson J: Associations of
interleukin-5 with plaque development and cardiovascular events.
JACC Basic Transl Sci. 4:891–902. 2019. View Article : Google Scholar
|
|
91
|
Cardilo-Reis L, Gruber S, Schreier SM,
Drechsler M, Papac-Milicevic N, Weber C, Wagner O, Stangl H,
Soehnlein O and Binder CJ: Interleukin-13 protects from
atherosclerosis and modulates plaque composition by skewing the
macrophage phenotype. EMBO Mol Med. 4:1072–1086. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Gao Q, Jiang Y, Ma T, Zhu F, Gao F, Zhang
P, Guo C, Wang Q, Wang X, Ma C, et al: A critical function of Th17
proinflammatory cells in the development of atherosclerotic plaque
in mice. J Immunol. 185:5820–5827. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Gisterå A, Robertson AK, Andersson J,
Ketelhuth DFJ, Ovchinnikova O, Nilsson SK, Lundberg AM, Li MO,
Flavell RA and Hansson GK: Transforming growth factor-β signaling
in T cells promotes stabilization of atherosclerotic plaques
through an interleukin-17-dependent pathway. Sci Transl Med.
5:196ra1002013. View Article : Google Scholar
|
|
94
|
Lu H and Daugherty A: Regulatory B cells,
interleukin-10, and atherosclerosis. Curr Opin Lipidol. 26:470–471.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Bu T, Li Z, Hou Y, Sun W, Zhang R, Zhao L,
Wei M, Yang G and Yuan L: Exosome-mediated delivery of
inflammation-responsive Il-10 mRNA for controlled atherosclerosis
treatment. Theranostics. 11:9988–10000. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Guo S, Mao X and Liu J: Multi-faceted
roles of C1q/TNF-related proteins family in atherosclerosis. Front
Immunol. 14:12534332023. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Fanola CL, Morrow DA, Cannon CP, Jarolim
P, Lukas MA, Bode C, Hochman JS, Goodrich EL, Braunwald E and
O'Donoghue ML: Interleukin-6 and the risk of adverse outcomes in
patients after an acute coronary syndrome: Observations from the
SOLID-TIMI 52 (stabilization of plaque using
darapladib-thrombolysis in myocardial infarction 52) trial. J Am
Heart Assoc. 6:e0056372017. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Schieffer B, Schieffer E, Hilfiker-Kleiner
D, Hilfiker A, Kovanen PT, Kaartinen M, Nussberger J, Harringer W
and Drexler H: Expression of angiotensin II and interleukin 6 in
human coronary atherosclerotic plaques: Potential implications for
inflammation and plaque instability. Circulation. 101:1372–1378.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Rosenfeld SM, Perry HM, Gonen A, Prohaska
TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM,
Tsimikas S, et al: B-1b cells secrete atheroprotective IgM and
attenuate atherosclerosis. Circ Res. 117:e28–e39. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Ravandi A, Boekholdt SM, Mallat Z, Talmud
PJ, Kastelein JJP, Wareham NJ, Miller ER, Benessiano J, Tedgui A,
Witztum JL, et al: Relationship of IgG and IgM autoantibodies and
immune complexes to oxidized LDL with markers of oxidation and
inflammation and cardiovascular events: Results from the
EPIC-norfolk study. J Lipid Res. 52:1829–1836. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Lappalainen J, Lindstedt KA, Oksjoki R and
Kovanen PT: OxLDL-IgG immune complexes induce expression and
secretion of proatherogenic cytokines by cultured human mast cells.
Atherosclerosis. 214:357–363. 2011. View Article : Google Scholar
|
|
102
|
Tew JG, El Shikh ME, El Sayed RM and
Schenkein HA: Dendritic cells, antibodies reactive with oxLDL, and
inflammation. J Dent Res. 91:8–16. 2012. View Article : Google Scholar :
|
|
103
|
Yang H, Chen J, Liu S, Xue Y, Li Z, Wang
T, Jiao L, An Q, Liu B, Wang J and Zhao H: Exosomes from
IgE-stimulated mast cells aggravate asthma-mediated atherosclerosis
through circRNA CDR1as-mediated endothelial cell dysfunction in
mice. Arterioscler Thromb Vasc Biol. 44:e99–e115. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Zhang X, Li J, Luo S, Wang M, Huang Q,
Deng Z, de Febbo C, Daoui A, Liew PX, Sukhova GK, et al: IgE
contributes to atherosclerosis and obesity by affecting macrophage
polarization, macrophage protein network, and foam cell formation.
Arterioscler Thromb Vasc Biol. 40:597–610. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Silvestre-Roig C, Braster Q, Ortega-Gomez
A and Soehnlein O: Neutrophils as regulators of cardiovascular
inflammation. Nat Rev Cardiol. 17:327–340. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Franck G: Role of mechanical stress and
neutrophils in the pathogenesis of plaque erosion. Atherosclerosis.
318:60–69. 2021. View Article : Google Scholar
|
|
107
|
Ionita MG, van den Borne P, Catanzariti
LM, Moll FL, de Vries JPPM, Pasterkamp G, Vink A and de Kleijn DPV:
High neutrophil numbers in human carotid atherosclerotic plaques
are associated with characteristics of rupture-prone lesions.
Arterioscler Thromb Vasc Biol. 30:1842–1848. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Palano MT, Cucchiara M, Gallazzi M, Riccio
F, Mortara L, Gensini GF, Spinetti G, Ambrosio G and Bruno A: When
a friend becomes your enemy: Natural killer cells in
atherosclerosis and atherosclerosis-associated risk factors. Front
Immunol. 12:7981552021. View Article : Google Scholar
|
|
109
|
Kovanen PT and Bot I: Mast cells in
atherosclerotic cardiovascular disease-activators and actions. Eur
J Pharmacol. 816:37–46. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Spinas E, Kritas SK, Saggini A, Mobili A,
Caraffa A, Antinolfi P, Pantalone A, Tei M, Speziali A, Saggini R
and Conti P: Role of mast cells in atherosclerosis: A classical
inflammatory disease. Int J Immunopathol Pharmacol. 27:517–521.
2014. View Article : Google Scholar
|
|
111
|
Lin A, Miano JM, Fisher EA and Misra A:
Chronic inflammation and vascular cell plasticity in
atherosclerosis. Nat Cardiovasc Res. 3:1408–1423. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Moriya J: Critical roles of inflammation
in atherosclerosis. J Cardiol. 73:22–27. 2019. View Article : Google Scholar
|
|
113
|
Song B, Bie Y, Feng H, Xie B, Liu M and
Zhao F: Inflammatory factors driving atherosclerotic plaque
progression new insights. J Transl Int Med. 10:36–47. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Jing F, Zhang J, Zhang H and Li T:
Unlocking the multifaceted molecular functions and diverse disease
implications of lactylation. Biol Rev Camb Philos Soc. 100:172–189.
2025. View Article : Google Scholar
|
|
115
|
Zhang D, Gao J, Zhu Z, Mao Q, Xu Z, Singh
PK, Rimayi CC, Moreno-Yruela C, Xu S, Li G, et al: Lysine
L-lactylation is the dominant lactylation isomer induced by
glycolysis. Nat Chem Biol. 21:91–99. 2025. View Article : Google Scholar
|
|
116
|
Hu XT, Wu XF, Xu JY and Xu X:
Lactate-mediated lactylation in human health and diseases: Progress
and remaining challenges. J Adv Res. S2090-1232(24)00529-02024.Epub
ahead of print. PubMed/NCBI
|
|
117
|
Zhang N, Zhang Y, Xu J, Wang P, Wu B, Lu
S, Lu X, You S, Huang X, Li M, et al: α-myosin heavy chain
lactylation maintains sarcomeric structure and function and
alleviates the development of heart failure. Cell Res. 33:679–698.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Zhu R, Ye X, Lu X, Xiao L, Yuan M, Zhao H,
Guo D, Meng Y, Han H, Luo S, et al: ACSS2 acts as a lactyl-CoA
synthetase and couples KAT2A to function as a lactyltransferase for
histone lactylation and tumor immune evasion. Cell Metab.
37:361–376.e7. 2025. View Article : Google Scholar
|
|
119
|
Chen H, Li Y, Li H, Chen X, Fu H, Mao D,
Chen W, Lan L, Wang C, Hu K, et al: NBS1 lactylation is required
for efficient DNA repair and chemotherapy resistance. Nature.
631:663–669. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Jia M, Yue X, Sun W, Zhou Q, Chang C, Gong
W, Feng J, Li X, Zhan R, Mo K, et al: ULK1-mediated metabolic
reprogramming regulates Vps34 lipid kinase activity by its
lactylation. Sci Adv. 9:eadg49932023. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Xie B, Zhang M, Li J, Cui J, Zhang P, Liu
F, Wu Y, Deng W, Ma J, Li X, et al: KAT8-catalyzed lactylation
promotes eEF1A2-mediated protein synthesis and colorectal
carcinogenesis. Proc Natl Acad Sci USA. 121:e23141281212024.
View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Zou Y, Cao M, Tao L, Wu S, Zhou H, Zhang
Y, Chen Y, Ge Y, Ju Z and Luo S: Lactate triggers KAT8-mediated
LTBP1 lactylation at lysine 752 to promote skin rejuvenation by
inducing collagen synthesis in fibroblasts. Int J Biol Macromol.
277:1344822024. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Moreno-Yruela C, Zhang D, Wei W, Bæk M,
Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, et al:
Class I histone deacetylases (HDAC1-3) are histone lysine
delactylases. Sci Adv. 8:eabi66962022. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Jin J, Bai L, Wang D, Ding W, Cao Z, Yan
P, Li Y, Xi L, Wang Y, Zheng X, et al: SIRT3-dependent
delactylation of cyclin E2 prevents hepatocellular carcinoma
growth. EMBO Rep. 24:e560522023. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Fan Z, Liu Z, Zhang N, Wei W, Cheng K, Sun
H and Hao Q: Identification of SIRT3 as an eraser of H4K16la.
iScience. 26:1077572023. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Li XM, Yang Y, Jiang FQ, Hu G, Wan S, Yan
WY, He XS, Xiao F, Yang XM, Guo X, et al: Histone lactylation
inhibits RARγ expression in macrophages to promote colorectal
tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling.
Cell Rep. 43:1136882024. View Article : Google Scholar
|
|
127
|
Dai J, Huang YJ, He X, Zhao M, Wang X, Liu
ZS, Xue W, Cai H, Zhan XY, Huang SY, et al: Acetylation blocks cGAS
activity and inhibits self-DNA-induced autoimmunity. Cell.
176:1447–1460.e14. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Wang T, Ye Z, Li Z, Jing DS, Fan GX, Liu
MQ, Zhuo QF, Ji SR, Yu XJ, Xu XW and Qin Y: Lactate-induced protein
lactylation: A bridge between epigenetics and metabolic
reprogramming in cancer. Cell Prolif. 56:e134782023. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Tian Q and Zhou LQ: Lactate activates
germline and cleavage embryo genes in mouse embryonic stem cells.
Cells. 11:5482022. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Li L, Chen K, Wang T, Wu Y, Xing G, Chen
M, Hao Z, Zhang C, Zhang J, Ma B, et al: Glis1 facilitates
induction of pluripotency via an epigenome-metabolome-epigenome
signalling cascade. Nat Metab. 2:882–892. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Yang W, Wang P, Cao P, Wang S, Yang Y, Su
H and Nashun B: Hypoxic in vitro culture reduces histone
lactylation and impairs pre-implantation embryonic development in
mice. Epigenetics Chromatin. 14:572021. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Yang D, Zheng H, Lu W, Tian X, Sun Y and
Peng H: Histone lactylation is involved in mouse oocyte maturation
and embryo development. Int J Mol Sci. 25:48212024. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Merkuri F, Rothstein M and Simoes-Costa M:
Histone lactylation couples cellular metabolism with developmental
gene regulatory networks. Nat Commun. 15:902024. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Hagihara H, Shoji H, Otabi H, Toyoda A,
Katoh K, Namihira M and Miyakawa T: Protein lactylation induced by
neural excitation. Cell Rep. 37:1098202021. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Ma W, Jia K, Cheng H, Xu H, Li Z, Zhang H,
Xie H, Sun H, Yi L, Chen Z, et al: Orphan nuclear receptor NR4A3
promotes vascular calcification via histone lactylation. Circ Res.
134:1427–1447. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Wu J, Hu M, Jiang H, Ma J, Xie C, Zhang Z,
Zhou X, Zhao J, Tao Z, Meng Y, et al: Endothelial cell-derived
lactate triggers bone mesenchymal stem cell histone lactylation to
attenuate osteoporosis. Adv Sci (Weinh). 10:e23013002023.
View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Li Q, Zhang F, Wang H, Tong Y, Fu Y, Wu K,
Li J, Wang C, Wang Z, Jia Y, et al: NEDD4 lactylation promotes APAP
induced liver injury through caspase11 dependent non-canonical
pyroptosis. Int J Biol Sci. 20:1413–1435. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
138
|
You X, Xie Y, Tan Q, Zhou C, Gu P, Zhang
Y, Yang S, Yin H, Shang B, Yao Y, et al: Glycolytic reprogramming
governs crystalline silica-induced pyroptosis and inflammation
through promoting lactylation modification. Ecotoxicol Environ Saf.
283:1169522024. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Sun W, Jia M, Feng Y and Cheng X: Lactate
is a bridge linking glycolysis and autophagy through lactylation.
Autophagy. 19:3240–3241. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Zhao W, Wang Y, Liu J, Yang Q, Zhang S, Hu
X, Shi Z, Zhang Z, Tian J, Chu D and An L: Progesterone activates
the histone lactylation-Hif1α-glycolysis feedback loop to promote
decidualization. Endocrinology. 165:bqad1692023. View Article : Google Scholar
|
|
141
|
Chen Y, Wu J, Zhai L, Zhang T, Yin H, Gao
H, Zhao F, Wang Z, Yang X, Jin M, et al: Metabolic regulation of
homologous recombination repair by MRE11 lactylation. Cell.
187:294–311.e21. 2024. View Article : Google Scholar
|
|
142
|
Sun L, Zhang Y, Yang B, Sun S, Zhang P,
Luo Z, Feng T, Cui Z, Zhu T, Li Y, et al: Lactylation of METTL16
promotes cuproptosis via m6A-modification on FDX1 mRNA
in gastric cancer. Nat Commun. 14:65232023. View Article : Google Scholar
|
|
143
|
Dai W, Wu G, Liu K, Chen Q, Tao J, Liu H
and Shen M: Lactate promotes myogenesis via activating H3K9
lactylation-dependent up-regulation of Neu2 expression. J Cachexia
Sarcopenia Muscle. 14:2851–2865. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei
Y, Zhou K, Lin Y, Yu H, Zhang H, et al: Hypoxia induces
mitochondrial protein lactylation to limit oxidative
phosphorylation. Cell Res. 34:13–30. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Wu J, Lv Y, Hao P, Zhang Z, Zheng Y, Chen
E and Fan Y: Immunological profile of lactylation-related genes in
Crohn's disease: A comprehensive analysis based on bulk and
single-cell RNA sequencing data. J Transl Med. 22:3002024.
View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Zhang Y, Gao Y, Wang Y, Jiang Y, Xiang Y,
Wang X, Wang Z, Ding Y, Chen H, Rui B, et al: RBM25 is required to
restrain inflammation via ACLY RNA splicing-dependent metabolism
rewiring. Cell Mol Immunol. 21:1231–1250. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Sun Z, Gao Z, Xiang M, Feng Y, Wang J, Xu
J, Wang Y and Liang J: Comprehensive analysis of lactate-related
gene profiles and immune characteristics in lupus nephritis. Front
Immunol. 15:13290092024. View Article : Google Scholar : PubMed/NCBI
|
|
148
|
Rho H, Terry AR, Chronis C and Hay N:
Hexokinase 2-mediated gene expression via histone lactylation is
required for hepatic stellate cell activation and liver fibrosis.
Cell Metab. 35:1406–1423.e8. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
149
|
Wang Y, Li H, Jiang S, Fu D, Lu X, Lu M,
Li Y, Luo D, Wu K, Xu Y, et al: The glycolytic enzyme PFKFB3 drives
kidney fibrosis through promoting histone lactylation-mediated
NF-κB family activation. Kidney Int. 106:226–240. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Wei L, Yang X, Wang J, Wang Z, Wang Q,
Ding Y and Yu A: H3K18 lactylation of senescent microglia
potentiates brain aging and Alzheimer's disease through the NFκB
signaling pathway. J Neuroinflammation. 20:2082023. View Article : Google Scholar
|
|
151
|
Huang Y, Wang C, Zhou T, Xie F, Liu Z, Xu
H, Liu M, Wang S, Li L, Chi Q, et al: Lumican promotes calcific
aortic valve disease through H3 histone lactylation. Eur Heart J.
45:3871–3885. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Maschari D, Saxena G, Law TD, Walsh E,
Campbell MC and Consitt LA: Lactate-induced lactylation in skeletal
muscle is associated with insulin resistance in humans. Front
Physiol. 13:9513902022. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Gao R, Li Y, Xu Z, Zhang F, Xu J, Hu Y,
Yin J, Yang K, Sun L, Wang Q, et al: Mitochondrial pyruvate carrier
1 regulates fatty acid synthase lactylation and mediates treatment
of nonalcoholic fatty liver disease. Hepatology. 78:1800–1815.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Si WY, Yang CL, Wei SL, Du T, Li LK, Dong
J, Zhou Y, Li H, Zhang P, Liu QJ, et al: Therapeutic potential of
microglial SMEK1 in regulating H3K9 lactylation in cerebral
ischemia-reperfusion. Commun Biol. 7:17012024. View Article : Google Scholar : PubMed/NCBI
|
|
155
|
Liao Z, Chen B, Yang T, Zhang W and Mei Z:
Lactylation modification in cardio-cerebral diseases: A
state-of-the-art review. Ageing Res Rev. 104:1026312025. View Article : Google Scholar
|
|
156
|
Li W, Zhou J, Gu Y, Chen Y, Huang Y, Yang
J, Zhu X, Zhao K, Yan Q, Zhao Z, et al: Lactylation of RNA
m6A demethylase ALKBH5 promotes innate immune response
to DNA herpesviruses and mpox virus. Proc Natl Acad Sci USA.
121:e24091321212024. View Article : Google Scholar
|
|
157
|
Yan Q, Zhou J, Gu Y, Huang W, Ruan M,
Zhang H, Wang T, Wei P, Chen G, Li W and Lu C: Lactylation of NAT10
promotes N4-acetylcytidine modification on
tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV
reactivation. Cell Death Differ. 31:1362–1374. 2024. View Article : Google Scholar :
|
|
158
|
Wang Z, Mao Y, Wang Z, Li S, Hong Z, Zhou
R, Xu S, Xiong Y and Zhang Y: Histone lactylation-mediated
overexpression of RASD2 promotes endometriosis progression via
upregulating the SUMOylation of CTPS1. Am J Physiol Cell Physiol.
328:C500–C513. 2025. View Article : Google Scholar
|
|
159
|
Ye L, Jiang Y and Zhang M: Crosstalk
between glucose metabolism, lactate production and immune response
modulation. Cytokine Growth Factor Rev. 68:81–92. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
160
|
Kes MMG, Van den Bossche J, Griffioen AW
and Huijbers EJM: Oncometabolites lactate and succinate drive
pro-angiogenic macrophage response in tumors. Biochim Biophys Acta
Rev Cancer. 1874:1884272020. View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Zhou HC, Xin-Yan Yan, Yu WW, Liang XQ, Du
XY, Liu ZC, Long JP, Zhao GH and Liu HB: Lactic acid in macrophage
polarization: The significant role in inflammation and cancer. Int
Rev Immunol. 41:4–18. 2022. View Article : Google Scholar
|
|
162
|
Cai X, Ng CP, Jones O, Fung TS, Ryu KW, Li
D and Thompson CB: Lactate activates the mitochondrial electron
transport chain independently of its metabolism. Mol Cell.
83:3904–3920.e7. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
163
|
Adam C, Paolini L, Gueguen N, Mabilleau G,
Preisser L, Blanchard S, Pignon P, Manero F, Le Mao M, Morel A, et
al: Acetoacetate protects macrophages from lactic acidosis-induced
mitochondrial dysfunction by metabolic reprograming. Nat Commun.
12:71152021. View Article : Google Scholar : PubMed/NCBI
|
|
164
|
Noe JT, Rendon BE, Geller AE, Conroy LR,
Morrissey SM, Young LEA, Bruntz RC, Kim EJ, Wise-Mitchell A,
Barbosa de Souza Rizzo M, et al: Lactate supports a
metabolic-epigenetic link in macrophage polarization. Sci Adv.
7:eabi86022021. View Article : Google Scholar : PubMed/NCBI
|
|
165
|
Ajam-Hosseini M, Heydari R, Rasouli M,
Akhoondi F, Asadi Hanjani N, Bekeschus S and Doroudian M: Lactic
acid in macrophage polarization: A factor in carcinogenesis and a
promising target for cancer therapy. Biochem Pharmacol.
222:1160982024. View Article : Google Scholar : PubMed/NCBI
|
|
166
|
Yang K, Xu J, Fan M, Tu F, Wang X, Ha T,
Williams DL and Li C: Lactate suppresses macrophage
pro-inflammatory response to LPS stimulation by inhibition of YAP
and NF-κB activation via GPR81-mediated signaling. Front Immunol.
11:5879132020. View Article : Google Scholar
|
|
167
|
Wang J, Yang P, Yu T, Gao M, Liu D, Zhang
J, Lu C, Chen X, Zhang X and Liu Y: Lactylation of PKM2 suppresses
inflammatory metabolic adaptation in pro-inflammatory macrophages.
Int J Biol Sci. 18:6210–6225. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
168
|
Dichtl S, Lindenthal L, Zeitler L, Behnke
K, Schlösser D, Strobl B, Scheller J, El Kasmi KC and Murray PJ:
Lactate and IL6 define separable paths of inflammatory metabolic
adaptation. Sci Adv. 7:eabg35052021. View Article : Google Scholar : PubMed/NCBI
|
|
169
|
Irizarry-Caro RA, McDaniel MM, Overcast
GR, Jain VG, Troutman TD and Pasare C: TLR signaling adapter BCAP
regulates inflammatory to reparatory macrophage transition by
promoting histone lactylation. Proc Natl Acad Sci USA.
117:30628–30638. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
170
|
Zhang Y, Jiang H, Dong M, Min J, He X, Tan
Y, Liu F, Chen M, Chen X, Yin Q, et al: Macrophage MCT4 inhibition
activates reparative genes and protects from atherosclerosis by
histone H3 lysine 18 lactylation. Cell Rep. 43:1141802024.
View Article : Google Scholar : PubMed/NCBI
|
|
171
|
Hoque R, Farooq A, Ghani A, Gorelick F and
Mehal WZ: Lactate reduces liver and pancreatic injury in Toll-like
receptor- and inflammasome-mediated inflammation via GPR81-mediated
suppression of innate immunity. Gastroenterology. 146:1763–1774.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
172
|
Fang Y, Li Z, Yang L, Li W, Wang Y, Kong
Z, Miao J, Chen Y, Bian Y and Zeng L: Emerging roles of lactate in
acute and chronic inflammation. Cell Commun Signal. 22:2762024.
View Article : Google Scholar : PubMed/NCBI
|
|
173
|
Pucino V, Certo M, Bulusu V, Cucchi D,
Goldmann K, Pontarini E, Haas R, Smith J, Headland SE, Blighe K, et
al: Lactate buildup at the site of chronic inflammation promotes
disease by inducing CD4+ T cell metabolic rewiring. Cell
Metab. 30:1055–1074.e8. 2019. View Article : Google Scholar
|
|
174
|
Subudhi I, Konieczny P, Prystupa A,
Castillo RL, Sze-Tu E, Xing Y, Rosenblum D, Reznikov I, Sidhu I,
Loomis C, et al: Metabolic coordination between skin epithelium and
type 17 immunity sustains chronic skin inflammation. Immunity.
57:1665–1680.e7. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
175
|
Ma S, Ming Y, Wu J and Cui G: Cellular
metabolism regulates the differentiation and function of T-cell
subsets. Cell Mol Immunol. 21:419–435. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
176
|
Zhang YT, Xing ML, Fang HH, Li WD, Wu L
and Chen ZP: Effects of lactate on metabolism and differentiation
of CD4+T cells. Mol Immunol. 154:96–107. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
177
|
Cao J, Liao S, Zeng F, Liao Q, Luo G and
Zhou Y: Effects of altered glycolysis levels on CD8+ T
cell activation and function. Cell Death Dis. 14:4072023.
View Article : Google Scholar
|
|
178
|
Almeida L, Dhillon-LaBrooy A, Carriche G,
Berod L and Sparwasser T: CD4+ T-cell differentiation
and function: Unifying glycolysis, fatty acid oxidation, polyamines
NAD mitochondria. J Allergy Clin Immunol. 148:16–32. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
179
|
Haas R, Smith J, Rocher-Ros V, Nadkarni S,
Montero-Melendez T, D'Acquisto F, Bland EJ, Bombardieri M, Pitzalis
C, Perretti M, et al: Lactate regulates metabolic and
pro-inflammatory circuits in control of T cell migration and
effector functions. PLoS Biol. 13:e10022022015. View Article : Google Scholar : PubMed/NCBI
|
|
180
|
Bechara R, McGeachy MJ and Gaffen SL: The
metabolism-modulating activity of IL-17 signaling in health and
disease. J Exp Med. 218:e202021912021. View Article : Google Scholar : PubMed/NCBI
|
|
181
|
Chang CH, Curtis JD, Maggi LB Jr, Faubert
B, Villarino AV, O'Sullivan D, Huang SCC, van der Windt GJW, Blagih
J, Qiu J, et al: Posttranscriptional control of T cell effector
function by aerobic glycolysis. Cell. 153:1239–1251. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
182
|
Yin Y, Choi SC, Xu Z, Zeumer L, Kanda N,
Croker BP and Morel L: Glucose oxidation is critical for CD4+ T
cell activation in a mouse model of systemic lupus erythematosus. J
Immunol. 196:80–90. 2016. View Article : Google Scholar
|
|
183
|
Watson MJ, Vignali PDA, Mullett SJ,
Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV,
Rittenhouse NL, DePeaux K, Whetstone RD, et al: Metabolic support
of tumour-infiltrating regulatory T cells by lactic acid. Nature.
591:645–651. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
184
|
Tay C, Tanaka A and Sakaguchi S:
Tumor-infiltrating regulatory T cells as targets of cancer
immunotherapy. Cancer Cell. 41:450–465. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
185
|
Fan W, Wang X, Zeng S, Li N, Wang G, Li R,
He S, Li W, Huang J, Li X, et al: Global lactylome reveals
lactylation-dependent mechanisms underlying TH17
differentiation in experimental autoimmune uveitis. Sci Adv.
9:eadh46552023. View Article : Google Scholar
|
|
186
|
Gu J, Zhou J, Chen Q, Xu X, Gao J, Li X,
Shao Q, Zhou B, Zhou H, Wei S, et al: Tumor metabolite lactate
promotes tumorigenesis by modulating MOESIN lactylation and
enhancing TGF-beta signaling in regulatory T cells. Cell Rep.
39:1109862022. View Article : Google Scholar
|
|
187
|
Sharma R, Smolkin RM, Chowdhury P,
Fernandez KC, Kim Y, Cols M, Alread W, Yen WF, Hu W, Wang ZM, et
al: Distinct metabolic requirements regulate B cell activation and
germinal center responses. Nat Immunol. 24:1358–1369. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
188
|
Martinis E, Tonon S, Colamatteo A, La Cava
A, Matarese G and Pucillo CEM: B cell immunometabolism in health
and disease. Nat Immunol. 26:366–377. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
189
|
Lee SC, Marzec M, Liu X, Wehrli S,
Kantekure K, Ragunath PN, Nelson DS, Delikatny EJ, Glickson JD and
Wasik MA: Decreased lactate concentration and glycolytic enzyme
expression reflect inhibition of mTOR signal transduction pathway
in B-cell lymphoma. NMR Biomed. 26:106–114. 2013. View Article : Google Scholar
|
|
190
|
Yao Y, Zhu J, Qin S, Zhou Z, Zeng Q, Long
R, Mao Z, Dong X, Zhao R, Zhang R, et al: Resveratrol induces
autophagy impeding BAFF-stimulated B-cell proliferation and
survival by inhibiting the Akt/mTOR pathway. Biochem Pharmacol.
202:1151392022. View Article : Google Scholar : PubMed/NCBI
|
|
191
|
Lee P, Chandel NS and Simon MC: Cellular
adaptation to hypoxia through hypoxia inducible factors and beyond.
Nat Rev Mol Cell Biol. 21:268–283. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
192
|
Meng X, Asadi-Asadabad S, Cao S, Song R,
Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, et al:
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell
differentiation and intestinal inflammation. Cell Mol Immunol.
22:54–67. 2025. View Article : Google Scholar
|
|
193
|
Lee DC, Sohn HA, Park ZY, Oh S, Kang YK,
Lee K, Kang M, Jang YJ, Yang SJ, Hong YK, et al: A lactate-induced
response to hypoxia. Cell. 161:595–609. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
194
|
Liu T, Zhang L, Joo D and Sun SC: NF-κB
signaling in inflammation. Sig Transduct Target Ther. 2:170232017.
View Article : Google Scholar
|
|
195
|
Ma N, Wang L, Meng M, Wang Y, Huo R, Chang
G and Shen X: D-sodium lactate promotes the activation of NF-κB
signaling pathway induced by lipopolysaccharide via histone
lactylation in bovine mammary epithelial cells. Microb Pathog.
199:1071982025. View Article : Google Scholar
|
|
196
|
Chi W, Kang N, Sheng L, Liu S, Tao L, Cao
X, Liu Y, Zhu C, Zhang Y, Wu B, et al: MCT1-governed pyruvate
metabolism is essential for antibody class-switch recombination
through H3K27 acetylation. Nat Commun. 15:1632024. View Article : Google Scholar : PubMed/NCBI
|
