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Pyroptosis in gastric mucosal injury‑related diseases (Review)

  • Authors:
    • Bei Ji
    • Zhiyuan Ma
    • Shuhui Liu
    • Shun Yao
    • Kenichi Mizuno
    • Shuji Terai
    • Biguang Tuo
    • Taolang Li
    • Xuemei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 9502181, Japan, Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China
    Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 165
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    Published online on: August 6, 2025
       https://doi.org/10.3892/ijmm.2025.5606
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Abstract

Gastric mucosal epithelial cells, immune cells and signaling molecules constitute the innate and adaptive immune systems of the gastric mucosa, working together to maintain its integrity. Once the balance is disrupted, gastric mucosal diseases may occur. Pyroptosis, as a unique inflammatory programmed cell death mechanism, participates in the dynamic balance between innate and adaptive immunity by identifying and responding to damage factors, and participating in the maturation and release process of inflammatory factors. Pyroptosis is involved in the association of gastric mucosal resistance with microbial invasion and endogenous damage. By releasing inflammatory factors, the immune environment of the gastric mucosa is reshaped, thereby affecting repair mechanisms and the specific direction of cell differentiation. The present review summarizes the important role of pyroptosis in focal and diffuse gastric mucosal injury. The review aims to provide a novel theoretical basis for the optimization of prevention strategies and treatment plans for current gastric mucosal diseases, and proposes a new option for the scientific management of these diseases.
View Figures

Figure 1

Role of pyroptosis in gastric mucosal
injury-related diseases, including both focal injuries (such as
stress-induced gastric mucosal injury and gastric ulcers) and
diffuse injuries, which can be initiated by AIG, and include SPEM,
GC and gastric MALT lymphoma. AIG, autoimmune gastritis; SPEM,
spasmolytic polypeptide-expressing metaplasia; GC, gastric cancer;
MALT lymphoma, mucosa-associated lymphoid tissue lymphoma.
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Copy and paste a formatted citation
Spandidos Publications style
Ji B, Ma Z, Liu S, Yao S, Mizuno K, Terai S, Tuo B, Li T and Liu X: Pyroptosis in gastric mucosal injury‑related diseases (Review). Int J Mol Med 56: 165, 2025.
APA
Ji, B., Ma, Z., Liu, S., Yao, S., Mizuno, K., Terai, S. ... Liu, X. (2025). Pyroptosis in gastric mucosal injury‑related diseases (Review). International Journal of Molecular Medicine, 56, 165. https://doi.org/10.3892/ijmm.2025.5606
MLA
Ji, B., Ma, Z., Liu, S., Yao, S., Mizuno, K., Terai, S., Tuo, B., Li, T., Liu, X."Pyroptosis in gastric mucosal injury‑related diseases (Review)". International Journal of Molecular Medicine 56.4 (2025): 165.
Chicago
Ji, B., Ma, Z., Liu, S., Yao, S., Mizuno, K., Terai, S., Tuo, B., Li, T., Liu, X."Pyroptosis in gastric mucosal injury‑related diseases (Review)". International Journal of Molecular Medicine 56, no. 4 (2025): 165. https://doi.org/10.3892/ijmm.2025.5606
Copy and paste a formatted citation
x
Spandidos Publications style
Ji B, Ma Z, Liu S, Yao S, Mizuno K, Terai S, Tuo B, Li T and Liu X: Pyroptosis in gastric mucosal injury‑related diseases (Review). Int J Mol Med 56: 165, 2025.
APA
Ji, B., Ma, Z., Liu, S., Yao, S., Mizuno, K., Terai, S. ... Liu, X. (2025). Pyroptosis in gastric mucosal injury‑related diseases (Review). International Journal of Molecular Medicine, 56, 165. https://doi.org/10.3892/ijmm.2025.5606
MLA
Ji, B., Ma, Z., Liu, S., Yao, S., Mizuno, K., Terai, S., Tuo, B., Li, T., Liu, X."Pyroptosis in gastric mucosal injury‑related diseases (Review)". International Journal of Molecular Medicine 56.4 (2025): 165.
Chicago
Ji, B., Ma, Z., Liu, S., Yao, S., Mizuno, K., Terai, S., Tuo, B., Li, T., Liu, X."Pyroptosis in gastric mucosal injury‑related diseases (Review)". International Journal of Molecular Medicine 56, no. 4 (2025): 165. https://doi.org/10.3892/ijmm.2025.5606
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