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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
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|
Cicinelli MV, Buchan JC, Nicholson M, Varadaraj V and Khanna RC: Cataracts. Lancet. 401:377–389. 2023. View Article : Google Scholar | |
|
Shiels A and Hejtmancik JF: Mutations and mechanisms in congenital and age-related cataracts. Exp Eye Res. 156:95–102. 2017. View Article : Google Scholar : | |
|
Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M and Epstein S: Age-related cataract. Lancet. 365:599–609. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Abdelkader H, Alany RG and Pierscionek B: Age-related cataract and drug therapy: Opportunities and challenges for topical antioxidant delivery to the lens. J Pharm Pharmacol. 67:537–550. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Meacock WR, Spalton DJ, Boyce J and Marshall J: The effect of posterior capsule opacification on visual function. Invest Ophthalmol Vis Sci. 44:4665–4669. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Yang C, An Q, Zhou H and Ge H: Research progress on the impact of cataract surgery on corneal endothelial cells. Adv Ophthalmol Pract Res. 4:194–201. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Beebe DC, Holekamp NM and Shui YB: Oxidative damage and the prevention of age-related cataracts. Ophthalmic Res. 44:155–165. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kulbay M, Wu KY, Nirwal GK, Bélanger P and Tran SD: Oxidative stress and cataract formation: Evaluating the efficacy of antioxidant therapies. Biomolecules. 14:10552024. View Article : Google Scholar : PubMed/NCBI | |
|
Lou MF: Redox regulation in the lens. Prog Retin Eye Res. 22:657–682. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Rahman K: Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2:219–236. 2007.PubMed/NCBI | |
|
Berthoud VM and Beyer EC: Oxidative stress, lens gap junctions, and cataracts. Antioxid Redox Signal. 11:339–353. 2009. View Article : Google Scholar : | |
|
Petrash JM: Aging and age-related diseases of the ocular lens and vitreous body. Invest Ophthalmol Vis Sci. 54:ORSF54–ORSF59. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Babizhayev MA and Costa EB: Lipid peroxide and reactive oxygen species generating systems of the crystalline lens. Biochim Biophys Acta. 1225:326–337. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Dische Z and Zil H: Studies on the oxidation of cysteine to cystine in lens proteins during cataract formation. Am J Ophthalmol. 34:104–113. 1951. View Article : Google Scholar : PubMed/NCBI | |
|
Kleiman NJ and Spector A: DNA single strand breaks in human lens epithelial cells from patients with cataract. Curr Eye Res. 12:423–431. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Kruk J, Kubasik-Kladna K and Aboul-Enein HY: The role oxidative stress in the pathogenesis of eye diseases: Current status and a dual role of physical activity. Mini Rev Med Chem. 16:241–257. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kubota M, Shui YB, Liu M, Bai F, Huang AJ, Ma N, Beebe DC and Siegfried CJ: Mitochondrial oxygen metabolism in primary human lens epithelial cells: Association with age, diabetes and glaucoma. Free Radic Biol Med. 97:513–519. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Brennan LA, McGreal RS and Kantorow M: Oxidative stress defense and repair systems of the ocular lens. Front Biosci (Elite Ed). 4:141–155. 2012. View Article : Google Scholar | |
|
Cekić S, Zlatanović G, Cvetković T and Petrović B: Oxidative stress in cataractogenesis. Bosn J Basic Med Sci. 10:265–269. 2010. View Article : Google Scholar | |
|
Li G, Song H, Chen L, Yang W, Nan K and Lu P: TUG1 promotes lens epithelial cell apoptosis by regulating miR-421/caspase-3 axis in age-related cataract. Exp Cell Res. 356:20–27. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Li WC, Kuszak JR, Dunn K, Wang RR, Ma W, Wang GM, Spector A, Leib M, Cotliar AM, Weiss M, et al: Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. J Cell Biol. 130:169–181. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, Xu H, Shu X and Song CX: Mapping epigenetic modifications by sequencing technologies. Cell Death Differ. 32:56–65. 2025. View Article : Google Scholar : | |
|
Chen Y, Hong T, Wang S, Mo J, Tian T and Zhou X: Epigenetic modification of nucleic acids: From basic studies to medical applications. Chem Soc Rev. 46:2844–2872. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Mazzio EA and Soliman KF: Basic concepts of epigenetics: Impact of environmental signals on gene expression. Epigenetics. 7:119–130. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Dawson MA and Kouzarides T: Cancer epigenetics: From mechanism to therapy. Cell. 150:12–27. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Peixoto P, Cartron PF, Serandour AA and Hervouet E: From 1957 to nowadays: A brief history of epigenetics. Int J Mol Sci. 21:75712020. View Article : Google Scholar : PubMed/NCBI | |
|
Gangisetty O, Cabrera MA and Murugan S: Impact of epigenetics in aging and age related neurodegenerative diseases. Front Biosci (Landmark Ed). 23:1445–1464. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Nikolac Perkovic M, Videtic Paska A, Konjevod M, Kouter K, Svob Strac D, Nedic Erjavec G and Pivac N: Epigenetics of Alzheimer's disease. Biomolecules. 11:1952021. View Article : Google Scholar : PubMed/NCBI | |
|
Suárez R, Chapela SP, Álvarez-Córdova L, Bautista-Valarezo E, Sarmiento-Andrade Y, Verde L, Frias-Toral E and Sarno G: Epigenetics in obesity and diabetes mellitus: New insights. Nutrients. 15:8112023. View Article : Google Scholar : PubMed/NCBI | |
|
Sun L, Zhang H and Gao P: Metabolic reprogramming and epigenetic modifications on the path to cancer. Protein Cell. 13:877–919. 2022. View Article : Google Scholar : | |
|
Okugawa Y, Grady WM and Goel A: Epigenetic alterations in colorectal cancer: Emerging biomarkers. Gastroenterology. 149:1204–1225.e12. 2015. View Article : Google Scholar | |
|
Trnkova L, Buocikova V, Mego M, Cumova A, Burikova M, Bohac M, Miklikova S, Cihova M and Smolkova B: Epigenetic deregulation in breast cancer microenvironment: Implications for tumor progression and therapeutic strategies. Biomed Pharmacother. 174:1165592024. View Article : Google Scholar : PubMed/NCBI | |
|
Henikoff S and Greally JM: Epigenetics, cellular memory and gene regulation. Curr Biol. 26:R644–R648. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Meng H, Cao Y, Qin J, Song X, Zhang Q, Shi Y and Cao L: DNA methylation, its mediators and genome integrity. Int J Biol Sci. 11:604–617. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Z, Zhang W, Qu J and Liu GH: Emerging epigenetic insights into aging mechanisms and interventions. Trends Pharmacol Sci. 45:157–172. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Desmettre TJ: Epigenetics in age-related macular degeneration (AMD). J Fr Ophtalmol. 41:e407–e415. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Kapuganti RS and Alone DP: Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma. Mol Aspects Med. 94:1012142023. View Article : Google Scholar : PubMed/NCBI | |
|
Kowluru RA, Kowluru A, Mishra M and Kumar B: Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy. Prog Retin Eye Res. 48:40–61. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y and Guan H: The role of DNA methylation in lens development and cataract formation. Cell Mol Neurobiol. 37:979–984. 2017. View Article : Google Scholar | |
|
Ling C and Rönn T: Epigenetics in human obesity and type 2 diabetes. Cell Metab. 29:1028–1044. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Li P, Yu H, Zhang G, Kang L, Qin B, Cao Y, Luo J, Chen X, Wang Y, Qin M, et al: Identification and characterization of N6-methyladenosine CircRNAs and methyltransferases in the lens epithelium cells from age-related cataract. Invest Ophthalmol Vis Sci. 61:132020. View Article : Google Scholar : PubMed/NCBI | |
|
Wei YL and Sun H: Identification of hsa-mir-34a, hsa-mir-124, and hsa-mir-204 as signatures for cataract. J Cell Physiol. 234:10709–10717. 2019. View Article : Google Scholar | |
|
Zhu X, Zhang G, Kang L and Guan H: Epigenetic regulation of Werner syndrome gene in age-related cataract. J Ophthalmol. 2015:5796952015. View Article : Google Scholar : PubMed/NCBI | |
|
Crick F: Central dogma of molecular biology. Nature. 227:561–563. 1970. View Article : Google Scholar : PubMed/NCBI | |
|
Crick FH: On protein synthesis. Symp Soc Exp Biol. 12:138–163. 1958.PubMed/NCBI | |
|
Kim SS and Lee SJV: Non-coding RNAs in caenorhabditis elegans aging. Mol Cells. 42:379–385. 2019.PubMed/NCBI | |
|
Yao ZT, Yang YM, Sun MM, He Y, Liao L, Chen KS and Li B: New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer. Cancer Commun (Lond). 42:117–140. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Dykes IM and Emanueli C: Transcriptional and post-transcriptional gene regulation by long non-coding RNA. Genomics Proteomics Bioinformatics. 15:177–186. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Smillie CL, Sirey T and Ponting CP: Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk. Crit Rev Biochem Mol Biol. 53:231–245. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Luo S, He F, Luo J, Dou S, Wang Y, Guo A and Lu J: Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response. Nucleic Acids Res. 46:5250–5268. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HK, Xu J, Chu K, Park H, Jang H, Li P, Valdmanis PN, Zhang QC and Kay MA: A tRNA-derived small RNA regulates ribosomal protein S28 protein levels after translation initiation in humans and mice. Cell Rep. 29:3816–3824.e4. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ardekani AM and Naeini MM: The role of MicroRNAs in human diseases. Avicenna J Med Biotechnol. 2:161–179. 2010.PubMed/NCBI | |
|
Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, Suciu N, Cretoiu SM and Voinea SC: miRNAs as biomarkers in disease: Latest findings regarding their role in diagnosis and prognosis. Cells. 9:2762020. View Article : Google Scholar : PubMed/NCBI | |
|
Wawrzyniak O, Zarębska Ż, Rolle K and Gotz-Więckowska A: Circular and long non-coding RNAs and their role in ophthalmologic diseases. Acta Biochim Pol. 65:497–508. 2018.PubMed/NCBI | |
|
Chen S, Zhang C, Shen L, Hu J, Chen X and Yu Y: Noncoding RNAs in cataract formation: Star molecules emerge in an endless stream. Pharmacol Res. 184:1064172022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang C, Hu J and Yu Y: CircRNA is a rising star in researches of ocular diseases. Front Cell Dev Biol. 8:8502020. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng JL, Sun J, Zhang H and Zhang Y: Role of microRNA and lncRNA in lens development and cataract formation. Zhonghua Yan Ke Za Zhi. 54:390–395. 2018.In Chinese. PubMed/NCBI | |
|
Michlewski G and Cáceres JF: Post-transcriptional control of miRNA biogenesis. RNA. 25:1–16. 2019. View Article : Google Scholar : | |
|
Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Broughton JP, Lovci MT, Huang JL, Yeo GW and Pasquinelli AE: Pairing beyond the seed supports MicroRNA targeting specificity. Mol Cell. 64:320–333. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
O'Brien J, Hayder H, Zayed Y and Peng C: Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne). 9:4022018. View Article : Google Scholar : PubMed/NCBI | |
|
Majid S, Dar AA, Saini S, Yamamura S, Hirata H, Tanaka Y, Deng G and Dahiya R: MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer. Cancer. 116:5637–5649. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Place RF, Li LC, Pookot D, Noonan EJ and Dahiya R: MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci USA. 105:1608–1613. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Vasudevan S: Posttranscriptional upregulation by microRNAs. Wiley Interdiscip Rev RNA. 3:311–330. 2012. View Article : Google Scholar | |
|
Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R and Rajewsky N: Widespread changes in protein synthesis induced by microRNAs. Nature. 455:58–63. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kang L, Luo J, Li P, Zhang G, Wei M, Ji M and Guan H: miR-125a-3p regulates apoptosis by suppressing TMBIM4 in lens epithelial cells. Int Ophthalmol. 43:1261–1274. 2023. View Article : Google Scholar | |
|
Cao Y, Li P, Zhang G, Kang L, Zhou T, Wu J, Wang Y, Wang Y, Chen X and Guan H: MicroRNA Let-7c-5p-mediated regulation of ERCC6 disrupts autophagic flux in age-related cataract via the binding to VCP. Curr Eye Res. 46:1353–1362. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Li ZN, Ge MX and Yuan ZF: MicroRNA-182-5p protects human lens epithelial cells against oxidative stress-induced apoptosis by inhibiting NOX4 and p38 MAPK signalling. BMC Ophthalmol. 20:2332020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang C, Chen M, Zhou N and Qi Y: Metformin prevents H2O2-induced senescence in human lens epithelial B3 cells. Med Sci Monit Basic Res. 26:e9233912020. | |
|
Zou X, Kang L, Yang M, Wu J and Guan H: MicroRNA binding mediated Functional sequence variant in 3'-UTR of DNA repair gene XPC in age-related cataract. Sci Rep. 8:151982018. View Article : Google Scholar : PubMed/NCBI | |
|
Wu C, Lin H, Wang Q, Chen W, Luo H, Chen W and Zhang H: Discrepant expression of microRNAs in transparent and cataractous human lenses. Invest Ophthalmol Vis Sci. 53:3906–3912. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kim YJ, Lee WJ, Ko BW, Lim HW, Yeon Y, Ahn SJ and Lee BR: Investigation of MicroRNA expression in anterior lens capsules of senile cataract patients and MicroRNA differences according to the cataract type. Transl Vis Sci Technol. 10:142021. View Article : Google Scholar | |
|
Peng CH, Liu JH, Woung LC, Lin TJ, Chiou SH, Tseng PC, Du WY, Cheng CK, Hu CC, Chien KH and Chen SJ: MicroRNAs and cataracts: Correlation among let-7 expression, age and the severity of lens opacity. Br J Ophthalmol. 96:747–751. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D and Wu SY: The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol. 111:831–836. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Chien KH, Chen SJ, Liu JH, Chang HM, Woung LC, Liang CM, Chen JT, Lin TJ, Chiou SH and Peng CH: Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts. Eye (Lond). 27:883–888. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Xu C, Xu J, Zhang W, Zheng F and Lou X: Expression of miR-210-3p in the aqueous humor of patients with age-related cataracts and its effect on human lens epithelial cell injury induced by hydrogen peroxide. Arq Bras Oftalmol. 87:e202202742023. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Liu S, Zhang F, Jiang P, Wu X and Liang Y: Expression of the microRNAs hsa-miR-15a and hsa-miR-16-1 in lens epithelial cells of patients with age-related cataract. Int J Clin Exp Med. 8:2405–2410. 2015.PubMed/NCBI | |
|
Zhou W, Xu J, Wang C, Shi D and Yan Q: miR-23b-3p regulates apoptosis and autophagy via suppressing SIRT1 in lens epithelial cells. J Cell Biochem. 120:19635–19646. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lu B, Christensen IT, Ma LW, Wang XL, Jiang LF, Wang CX, Feng L, Zhang JS and Yan QC: miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts. Int J Ophthalmol. 11:201–207. 2018.PubMed/NCBI | |
|
Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R, Patil K, Tuttle J, Cleghorn W and Leone G: Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem. 280:18211–18220. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Shen ZG, Liu XZ, Chen CX and Lu JM: Knockdown of E2F3 inhibits proliferation, migration, and invasion and increases apoptosis in glioma cells. Oncol Res. 25:1555–1566. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Q, Liang D, Yang T, Leone G and Overbeek PA: Distinct capacities of individual E2Fs to induce cell cycle re-entry in postmitotic lens fiber cells of transgenic mice. Dev Neurosci. 26:435–445. 2004. View Article : Google Scholar | |
|
Chong JL, Tsai SY, Sharma N, Opavsky R, Price R, Wu L, Fernandez SA and Leone G: E2f3a and E2f3b contribute to the control of cell proliferation and mouse development. Mol Cell Biol. 29:414–424. 2009. View Article : Google Scholar : | |
|
Wenzel PL, Chong JL, Sáenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, et al: Cell proliferation in the absence of E2F1-3. Dev Biol. 351:35–45. 2011. View Article : Google Scholar | |
|
Yan Q, Liu JP and Li DWC: Apoptosis in lens development and pathology. Differentiation. 74:195–211. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Xiang W, Lin H, Wang Q and Chen W, Liu Z, Chen H, Zhang H and Chen W: miR-34a suppresses proliferation and induces apoptosis of human lens epithelial cells by targeting E2F3. Mol Med Rep. 14:5049–5056. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Li Q, Pan H and Liu Q: MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts. Biosci Rep. 39:BSR201917732019. View Article : Google Scholar : PubMed/NCBI | |
|
Gong W, Li J, Wang Y, Meng J and Zheng G: miR-221 promotes lens epithelial cells apoptosis through interacting with SIRT1 and E2F3. Chem Biol Interact. 306:39–46. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Gao W, Zhou X and Lin R: miR-378a-5p and miR-630 induce lens epithelial cell apoptosis in cataract via suppression of E2F3. Braz J Med Biol Res. 53:e96082020. View Article : Google Scholar : PubMed/NCBI | |
|
Fan F, Zhuang J, Zhou P, Liu X and Luo Y: MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2. Oncotarget. 8:110209–110220. 2017. View Article : Google Scholar | |
|
Feng L, Wei Y, Sun Y, Zhou L, Bi S, Chen W and Xiang W: MIR34A modulates lens epithelial cell apoptosis and cataract development via the HK1/caspase 3 signaling pathway. Aging (Albany NY). 15:6331–6345. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Li H and Liu Y: microRNA-378a regulates the reactive oxygen species (ROS)/phosphatidylinositol 3-kinases (PI3K)/AKT signaling pathway in human lens epithelial cells and cataract. Med Sci Monit. 25:4314–4321. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang F, Meng W and Tong B: Down-regulation of MicroRNA-133b suppresses apoptosis of lens epithelial cell by up-regulating BCL2L2 in age-related cataracts. Med Sci Monit. 22:4139–4145. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Qin Y, Zhao J, Min X, Wang M, Luo W, Wu D, Yan Q, Li J, Wu X and Zhang J: MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract. Biochim Biophys Acta. 1842:2439–2447. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Gao M, Huang Y, Wang L, Huang M, Liu F, Liao S, Yu S, Lu Z, Han S, Hu X, et al: HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Cell Death Dis. 8:e30822017. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Fan DB, Zhao YT, Li Y, Kong DQ, Cai FF and Zheng GY: Two novel mutations identified in ADCC families impair crystallin protein distribution and induce apoptosis in human lens epithelial cells. Sci Rep. 7:178482017. View Article : Google Scholar : PubMed/NCBI | |
|
Peng J, Zheng TT, Liang Y, Duan LF, Zhang YD, Wang LJ, He GM and Xiao HT: p-Coumaric acid protects human lens epithelial cells against oxidative stress-induced apoptosis by MAPK signaling. Oxid Med Cell Longev. 2018:85490522018. View Article : Google Scholar : PubMed/NCBI | |
|
Youle RJ and Strasser A: The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 9:47–59. 2008. View Article : Google Scholar | |
|
Zhang DJ, Du FF, Jing XY, Wang L, Liu D and Yang XQ: Sequence and expression regulation of the BCL2L2 gene in pigs. Gene. 851:1469922023. View Article : Google Scholar | |
|
İçme G, Yilmaz A, Dinç E, Görür A, Fidanci ŞB and Tamer L: Assessment of miR-182, miR-183, miR-184, and miR-221 expressions in primary pterygium and comparison with the normal conjunctiva. Eye Contact Lens. 45:208–211. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Bailey JC, Helwa I, Dismuke WM, Cai J, Drewry M, Brilliant MH, Budenz DL, Christen WG, Chasman DI, et al: A common variant in MIR182 is associated with primary open-angle glaucoma in the NEIGHBORHOOD consortium. Invest Ophthalmol Vis Sci. 57:4528–4535. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Szemraj M, Oszajca K, Szemraj J and Jurowski P: MicroRNA expression analysis in serum of patients with congenital hemochromatosis and age-related macular degeneration (AMD). Med Sci Monit. 23:4050–4060. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ren H, Tao H, Gao Q, Shen W, Niu Z, Zhang J, Mao H, Du A and Li W: MiR-326 antagomir delays the progression of age-related cataract by upregulating FGF1-mediated expression of betaB2-crystallin. Biochem Biophys Res Commun. 505:505–510. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Fang R, Li HL, Lv NX, Yue PL, Jia YX, Liu ZC, Zhou HG and Song XD: Inhibition of miR-29a-3p alleviates apoptosis of lens epithelial cells via upregulation of CAND1. Curr Eye Res. 49:391–400. 2024. View Article : Google Scholar | |
|
Wang F and Ren Y: Nanofluorescence probe in detection of miR-187 and its correlation with oxidative stress response in cataracts. Altern Ther Health Med. 29:73–79. 2023. | |
|
Vymetalkova V, Pardini B, Rosa F, Jiraskova K, Di Gaetano C, Bendova P, Levy M, Veskrnova V, Buchler T, Vodickova L, et al: Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients. Carcinogenesis. 38:28–39. 2017. View Article : Google Scholar | |
|
Liu XC, Liu XF, Hu ZD and Li ZH: Polymorphisms of DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln), and the risk of age-related cataract: A meta-analysis. Curr Eye Res. 40:676–682. 2015. View Article : Google Scholar | |
|
Wang Y, Li F, Zhang G, Kang L and Guan H: Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation. Clin Epigenetics. 8:622016. View Article : Google Scholar : PubMed/NCBI | |
|
Kang L, Zou X, Zhang G, Xiang J, Wang Y, Yang M, Chen X, Wu J and Guan H: A variant in a microRNA binding site in NEIL2 3'UTR confers susceptibility to age-related cataracts. FASEB J. 33:10469–10476. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Y, Li X and Zhu S: rs78378222 polymorphism in the 3'-untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells. Mol Med Rep. 14:2305–2310. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Luo J, Li P, Kang L, Ji M, Zhou T, Qin B, Zhang J and Guan H: Exosomal microRNA-222-3p increases UVB sensitivity of lens epithelium cells by suppressing MGMT. Int Ophthalmol. 43:1611–1628. 2023. View Article : Google Scholar | |
|
Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W and Geuze HJ: Exosome: From internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci. 113:3365–3374. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Meldolesi J: Exosomes and ectosomes in intercellular communication. Curr Biol. 28:R435–R444. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Perez-Hernandez J, Olivares D, Forner MJ, Ortega A, Solaz E, Martinez F, Chaves FJ, Redon J and Cortes R: Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension. J Transl Med. 16:2282018. View Article : Google Scholar : PubMed/NCBI | |
|
Creemers EE, Tijsen AJ and Pinto YM: Circulating microRNAs: Novel biomarkers and extracellular communicators in cardiovascular disease? Circ Res. 110:483–495. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Turchinovich A, Samatov TR, Tonevitsky AG and Burwinkel B: Circulating miRNAs: Cell-cell communication function? Front Genet. 4:1192013. View Article : Google Scholar : PubMed/NCBI | |
|
Fan Q, Yang L, Zhang X, Peng X, Wei S, Su D, Zhai Z, Hua X and Li H: The emerging role of exosome-derived non-coding RNAs in cancer biology. Cancer Lett. 414:107–115. 2018. View Article : Google Scholar | |
|
Machida T, Tomofuji T, Ekuni D, Maruyama T, Yoneda T, Kawabata Y, Mizuno H, Miyai H, Kunitomo M and Morita M: MicroRNAs in salivary exosome as potential biomarkers of aging. Int J Mol Sci. 16:21294–21309. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zamani P, Fereydouni N, Butler AE, Navashenaq JG and Sahebkar A: The therapeutic and diagnostic role of exosomes in cardiovascular diseases. Trends Cardiovasc Med. 29:313–323. 2019. View Article : Google Scholar | |
|
Li J, Wang J and Chen Z: Emerging role of exosomes in cancer therapy: Progress and challenges. Mol Cancer. 24:132025. View Article : Google Scholar : PubMed/NCBI | |
|
Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Moreno JA, Hamza E, Guerrero-Hue M, Rayego-Mateos S, García-Caballero C, Vallejo-Mudarra M, Metzinger L and Metzinger-Le Meuth V: Non-coding RNAs in kidney diseases: The long and short of them. Int J Mol Sci. 22:60772021. View Article : Google Scholar : PubMed/NCBI | |
|
Goodall GJ and Wickramasinghe VO: RNA in cancer. Nat Rev Cancer. 21:22–36. 2021. View Article : Google Scholar | |
|
Javed Z, Khan K, Sadia H, Raza S, Salehi B, Sharifi-Rad J and Cho WC: LncRNA & Wnt signaling in colorectal cancer. Cancer Cell Int. 20:3262020. View Article : Google Scholar | |
|
Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A and Bozzoni I: A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 147:358–369. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Gong C and Maquat LE: lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature. 470:284–288. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Hong Y, Wu J, Sun Y, Zhang S, Lu Y and Ji Y: ceRNA network construction and identification of hub genes as novel therapeutic targets for age-related cataracts using bioinformatics. PeerJ. 11:e150542023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou T, Yang M, Zhang G, Kang L, Yang L and Guan H: Long non-coding RNA nuclear paraspeckle assembly transcript 1 protects human lens epithelial cells against H2O2 stimuli through the nuclear factor kappa b/p65 and p38/mitogen-activated protein kinase axis. Ann Transl Med. 8:16532020. View Article : Google Scholar | |
|
Zhou T, Zhang J, Qin B, Xu H, Zhang S and Guan H: Long non-coding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR-4728-5p/OGG1 axis. Int J Mol Med. 46:1838–1848. 2020.PubMed/NCBI | |
|
Zhang N, Zhang C, Wang X and Qi Y: High-throughput sequencing reveals novel lincRNA in age-related cataract. Int J Mol Med. 40:1829–1839. 2017.PubMed/NCBI | |
|
Li H, Gao L, Du J, Ma T, Ye Z and Li Z: Differentially expressed gene profiles and associated ceRNA network in ATG7-deficient lens epithelial cells under oxidative stress. Front Genet. 13:10889432022. View Article : Google Scholar : PubMed/NCBI | |
|
Jin X, Jin H, Shi Y, Guo Y and Zhang H: Long non-coding RNA KCNQ1OT1 promotes cataractogenesis via miR-214 and activation of the caspase-1 pathway. Cell Physiol Biochem. 42:295–305. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang M and Cheng K: Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis. Exp Eye Res. 206:1085432021. View Article : Google Scholar : PubMed/NCBI | |
|
Xu Y, Zheng Y, Shen P and Zhou L: Role of long noncoding RNA KCNQ1 overlapping transcript 1/microRNA-124-3p/BCL-2-like 11 axis in hydrogen peroxide (H2O2)-stimulated human lens epithelial cells. Bioengineered. 13:5035–5045. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Shen Q and Zhou T: Knockdown of lncRNA TUG1 protects lens epithelial cells from oxidative stress-induced injury by regulating miR-196a-5p expression in age-related cataracts. Exp Ther Med. 22:12862021. View Article : Google Scholar : PubMed/NCBI | |
|
Sun M, Li K, Li X, Wang H, Li L and Zheng G: lncRNA TUG1 regulates Smac/DIABLO expression by competitively inhibiting miR-29b and modulates the apoptosis of lens epithelial cells in age-related cataracts. Chin Med J (Engl). 136:2340–2350. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Guo X, Li C, Wang Y, Jiang C and Yang L: Long non-coding RNA nuclear paraspeckle assembly transcript 1 downregulation protects lens epithelial cells from oxidative stress-induced apoptosis by regulating the microRNA-124-3p/death-associated protein kinase 1 axis in age-related cataract. Int Ophthalmol. 43:3413–3424. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Tu Y, Xie L, Chen L, Yuan Y, Qin B, Wang K, Zhu Q, Ji N, Zhu M and Guan H: Long non-coding RNA MEG3 promotes cataractogenesis by upregulating TP53INP1 expression in age-related cataract. Exp Eye Res. 199:1081852020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Zheng C, Zhao J, Xu X and Yao J: LncRNA MEG3 regulates ferroptosis of lens epithelial cells via PTBP1/GPX4 axis to participate in age-related cataract. J Cell Physiol. 239:e313302024. View Article : Google Scholar : PubMed/NCBI | |
|
Jing R, Ma B, Qi T, Hu C, Liao C, Wen C, Shao Y and Pei C: Long noncoding RNA OIP5-AS1 promotes cell apoptosis and cataract formation by blocking POLG expression under oxidative stress. Invest Ophthalmol Vis Sci. 61:32020. View Article : Google Scholar : PubMed/NCBI | |
|
Xiang J, Chen Q, Kang L, Zhang G, Wang Y, Qin B, Wu J, Zhou T, Han Y and Guan H: LncRNA PLCD3-OT1 functions as a CeRNA to prevent age-related cataract by sponging miR-224-5p and regulating PLCD3 expression. Invest Ophthalmol Vis Sci. 60:4670–4680. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Cheng T, Xu M, Qin B, Wu J, Tu Y, Kang L, Wang Y and Guan H: lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis. J Cell Mol Med. 23:6131–6139. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Alkan AH and Akgül B: Endogenous miRNA sponges. Methods Mol Biol. 2257:91–104. 2022. View Article : Google Scholar | |
|
Alshahrani SH, Al-Hadeithi ZSM, Almalki SG, Malviya J, Hjazi A, Mustafa YF, Alawady AHR, Alsaalamy AH, Joshi SK and Alkhafaji AT: LncRNA-miRNA interaction is involved in colorectal cancer pathogenesis by modulating diverse signaling pathways. Pathol Res Pract. 251:1548982023. View Article : Google Scholar : PubMed/NCBI | |
|
Karagkouni D, Karavangeli A, Paraskevopoulou MD and Hatzigeorgiou AG: Characterizing miRNA-lncRNA Interplay. Methods Mol Biol. 2372:243–262. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Cai S, Jia Y, Qi C, Sun J, Zhang H, Wang F, Cao Y and Li X: Decoding noncoding RNAs: Role of MicroRNAs and long noncoding RNAs in ocular neovascularization. Theranostics. 7:3155–3167. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Magistri M, Faghihi MA, St Laurent G III and Wahlestedt C: Regulation of chromatin structure by long noncoding RNAs: Focus on natural antisense transcripts. Trends Genet. 28:389–396. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Xue Y, Ma G, Zhang Z, Hua Q, Chu H, Tong N, Yuan L, Qin C, Yin C, Zhang Z and Wang M: A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer. Oncotarget. 6:484–493. 2015. View Article : Google Scholar : | |
|
Zhang CL, Zhu KP and Ma XL: Antisense lncRNA FOXC2-AS1 promotes doxorubicin resistance in osteosarcoma by increasing the expression of FOXC2. Cancer Lett. 396:66–75. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
He A, He S, Li X and Zhou L: ZFAS1: A novel vital oncogenic lncRNA in multiple human cancers. Cell Prolif. 52:e125132019. View Article : Google Scholar | |
|
Zong X, Nakagawa S, Freier SM, Fei J, Ha T, Prasanth SG and Prasanth KV: Natural antisense RNA promotes 3' end processing and maturation of MALAT1 lncRNA. Nucleic Acids Res. 44:2898–2908. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Tu Y, Li L, Qin B, Wu J, Cheng T, Kang L and Guan H: Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract. Mol Vis. 25:734–744. 2019.PubMed/NCBI | |
|
Zhu M, Dong Q, Bing J, Songbuerbatu, Zheng L, Dorjee T, Liu Q, Zhou Y and Gao F: Combined lncRNA and mRNA expression profiles identified the lncRNA-miRNA-mRNA modules regulating the cold stress response in Ammopiptanthus nanus. Int J Mol Sci. 24:65022023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Liu C, Shan K, Zhang S, Lu Y, Yan B and Luo Y: Long non-coding RNA H19 regulates human lens epithelial cells function. Cell Physiol Biochem. 50:246–260. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Harland R and Misher L: Stability of RNA in developing Xenopus embryos and identification of a destabilizing sequence in TFIIIA messenger RNA. Development. 102:837–852. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang XO, Dong R, Zhang Y, Zhang JL, Luo Z, Zhang J, Chen LL and Yang L: Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Genome Res. 26:1277–1287. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar : | |
|
Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB and Kjems J: The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 20:675–691. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Panda AC: Circular RNAs Act as miRNA sponges. Adv Exp Med Biol. 1087:67–79. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Tong KL, Tan KE, Lim YY, Tien XY and Wong PF: CircRNA-miRNA interactions in atherogenesis. Mol Cell Biochem. 477:2703–2733. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA and Goodall GJ: The RNA binding protein quaking regulates formation of circRNAs. Cell. 160:1125–1134. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N and Kadener S: circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 56:55–66. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, et al: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 22:256–264. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, et al: Translation of CircRNAs. Mol Cell. 66:9–21.e7. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, et al: Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res. 27:626–641. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Liu T, Wang X and He A: Circles reshaping the RNA world: From waste to treasure. Mol Cancer. 16:582017. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu JN, Shan K, Xiang J, Gu JY, Zhou RM, Zhang XL, Zhang CR and Xu JJ: Comprehensive analysis of circRNA-associated-ceRNA networks in human corneal endothelial dysfunction. Cornea. 41:1545–1552. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Qu B, Wang J, Li Y, Wu X and Zhang M: Hsa_circ_0023826 protects against glaucoma by regulating miR-188-3p/MDM4 axis. Acta Biochim Pol. 70:253–260. 2023.PubMed/NCBI | |
|
Tian H, Zhao L, Li H, Huang Y and Wang Y: Circular RNA in retina: A potential biomarker and therapeutic target. Ophthalmic Res. 66:516–528. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Li D, Che X, Gao N and Li J: CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1. Exp Eye Res. 241:1098172024. View Article : Google Scholar | |
|
Wang Y, Zhang G, Li P, Kang L, Qin B, Cao Y, Luo J, Chen X, Qin M and Guan H: Profiling and integrated analysis of the ERCC6-regulated circRNA-miRNA-mRNA network in lens epithelial cells. Curr Eye Res. 46:1341–1352. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Xu X, Gao R, Li S, Jiang K, Sun X and Zhang J: Circular RNA circZNF292 regulates H2 O2-induced injury in human lens epithelial HLE-B3 cells depending on the regulation of the miR-222-3p/E2F3 axis. Cell Biol Int. 45:1757–1767. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Mao W and Zhang Z: The Hsa_circ_0105558/miR-182-5p/ATF6 cascade affects H2O2-triggered oxidative damage and apoptosis of human lens epithelial cells. Biochem Genet. 63:1241–1257. 2025. View Article : Google Scholar | |
|
Li R, Zhu H, Li Q, Tang J, Jin Y and Cui H: METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1. PeerJ. 11:e148632023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Zhang J, Zhang G, Zhou T, Zou X, Guan H and Wang Y: CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract. Aging (Albany NY). 13:5383–5402. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Cui G, Wang L and Huang W: Circular RNA HIPK3 regulates human lens epithelial cell dysfunction by targeting the miR-221-3p/PI3K/AKT pathway in age-related cataract. Exp Eye Res. 198:1081282020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Liu B, Zhou M, Fan F, Yu M, Gao C, Lu Y and Luo Y: Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis. Biochem Biophys Res Commun. 503:2277–2285. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S, Wang M, Jian R, Li H, Liu G, Zhou C, Xiong Y and Wang W: Circ_HIPK3 Inhibits H2O2-induced lens epithelial cell injury in age-related cataract depending on the regulation of miR-495-3p/HDAC4 pathway. Biochem Genet. 61:565–577. 2023. View Article : Google Scholar | |
|
Liu T, Zhao L, Yan D and Wang N: Circ_0060,144 inhibits the occurrence and development of age-related cataract via the miR-23b-3p/HIPK3 axis. Exp Eye Res. 222:1091792022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou C, Huang X, Li X and Xiong Y: Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5'-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner. Bioengineered. 12:8953–8964. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Fang R, Li JH, Li HL, Yue PL, Ding XF, Jia YX, Liu ZC, Zhou HG, Yang C and Song XD: CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression. Exp Eye Res. 235:1096402023. View Article : Google Scholar : PubMed/NCBI | |
|
Li R, Jiang J, Shi H, Qian H, Zhang X and Xu W: CircRNA: A rising star in gastric cancer. Cell Mol Life Sci. 77:1661–1680. 2020. View Article : Google Scholar | |
|
Cui F, Sun Z, Zhang X and Liu C: CircMAP3K4 suppresses H2O2-induced human lens epithelial cell injury by miR-630/ERCC6 axis in age-related cataract. Curr Eye Res. 49:487–495. 2024. View Article : Google Scholar | |
|
Sun L, Li F, Bai S and Bi C: CircRNA HLCS regulates lens epithelial cell apoptosis via miR-338-3p/BPNT1 axis. Int Ophthalmol. 44:1422024. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Q, Liu H, Ma B and Wang C: Circular RNA Circ_0122396 regulates human lens epithelial cell progression by regulating miR-23a-3p and MMP16 in age-related cataract. Curr Eye Res. 49:1161–1170. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Liu B, Cao J, Wang X, Guo C, Liu Y and Wang T: Deciphering the tRNA-derived small RNAs: Origin, development, and future. Cell Death Dis. 13:242021. View Article : Google Scholar : PubMed/NCBI | |
|
Xie Y, Yao L, Yu X, Ruan Y, Li Z and Guo J: Action mechanisms and research methods of tRNA-derived small RNAs. Signal Transduct Target Ther. 5:1092020. View Article : Google Scholar : PubMed/NCBI | |
|
Pan J, Liu Z, Shen B, Xu J, Dai G, Xu W, Wang J, Li L and Cheng L: tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells. J Orthop Surg Res. 18:4132023. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng T, Hua Y, Sun C, Zhang Y, Yang F, Yang M, Yang Y, Li J, Huang X, Wu H, et al: Relationship between tRNA-derived fragments and human cancers. Int J Cancer. 147:3007–3018. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L, Liu J and Hou Y: Classification, function, and advances in tsRNA in non-neoplastic diseases. Cell Death Dis. 14:7482023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Luo Z, Yuan L, Lin X, Tang Y, Yin L, Liang P and Jiang B: tRNA-derived small RNAs: Novel insights into the pathogenesis and treatment of cardiovascular diseases. J Cardiovasc Transl Res. 16:300–309. 2023. View Article : Google Scholar | |
|
Zhang X, Trebak F, Souza LAC, Shi J, Zhou T, Kehoe PG, Chen Q and Feng Earley Y: Small RNA modifications in Alzheimer's disease. Neurobiol Dis. 145:1050582020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou M, He X, Zhang J, Mei C, Zhong B and Ou C: tRNA-derived small RNAs in human cancers: Roles, mechanisms, and clinical application. Mol Cancer. 23:762024. View Article : Google Scholar : PubMed/NCBI | |
|
Han X, Cai L, Lu Y, Li D and Yang J: Identification of tRNA-derived fragments and their potential roles in diabetic cataract rats. Epigenomics. 12:1405–1418. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ma Y, Zhang Y, Zhang HY, Zhao Y, Li XM, Jiang YF, Yao MD, Jiang Q and Yan B: Dual anti-angiogenic and anti-inflammatory action of tRNA-Cys-5-0007 in ocular vascular disease. J Transl Med. 22:5622024. View Article : Google Scholar : PubMed/NCBI | |
|
Peng Y, Zou J, Wang JH, Zeng H, Tan W, Yoshida S, Zhang L, Li Y and Zhou Y: Small RNA sequencing reveals transfer RNA-derived small RNA expression profiles in retinal neovascularization. Int J Med Sci. 17:1713–1722. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang G, Kang L, Li P, Ran Q, Chen X, Ji M and Guan H: Genome-wide repertoire of transfer RNA-derived fragments in a mouse model of age-related cataract. Curr Eye Res. 47:1397–1404. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Anastasiadou E, Jacob LS and Slack FJ: Non-coding RNA networks in cancer. Nat Rev Cancer. 18:5–18. 2018. View Article : Google Scholar | |
|
Ma Y, Liu Y, Shu B, Yang J, Lv L, Zhou L, Wang L and Shi Z: CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract. Cell Cycle. 22:303–315. 2023. View Article : Google Scholar | |
|
Xu J, Shao T, Ding N, Li Y and Li X: miRNA-miRNA crosstalk: From genomics to phenomics. Brief Bioinform. 18:1002–1011. 2017. | |
|
Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M and Rajewsky N: Combinatorial microRNA target predictions. Nat Genet. 37:495–500. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Shao T, Wang G, Chen H, Xie Y, Jin X, Bai J, Xu J, Li X, Huang J, Jin Y and Li Y: Survey of miRNA-miRNA cooperative regulation principles across cancer types. Brief Bioinform. 20:1621–1638. 2019. View Article : Google Scholar | |
|
Chiu HS, Somvanshi S, Patel E, Chen TW, Singh VP, Zorman B, Patil SL, Pan Y, Chatterjee SS; Cancer Genome Atlas Research Network; et al: Pan-cancer analysis of lncRNA regulation supports their targeting of cancer genes in each tumor context. Cell Rep. 23:297–312.e12. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang K, Chen L, Qu L and Yan H: A comprehensive investigation of identifying miRNA biomarkers and their potential role in age-related cataract by meta-analysis and bioinformatics analysis. Graefes Arch Clin Exp Ophthalmol. 263:1307–1325. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Michalak EM, Burr ML, Bannister AJ and Dawson MA: The roles of DNA, RNA and histone methylation in ageing and cancer. Nat Rev Mol Cell Biol. 20:573–589. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Dossin F, Pinheiro I, Żylicz JJ, Roensch J, Collombet S, Le Saux A, Chelmicki T, Attia M, Kapoor V, Zhan Y, et al: SPEN integrates transcriptional and epigenetic control of X-inactivation. Nature. 578:455–460. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Grigoryan A, Pospiech J, Krämer S, Lipka D, Liehr T, Geiger H, Kimura H, Mulaw MA and Florian MC: Attrition of X chromosome inactivation in aged hematopoietic stem cells. Stem Cell Reports. 16:708–716. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Kulis M, Queirós AC, Beekman R and Martín-Subero JI: Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer. Biochim Biophys Acta. 1829:1161–1174. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Nishiyama A and Nakanishi M: Navigating the DNA methylation landscape of cancer. Trends Genet. 37:1012–1027. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
May MS and Hattaman S: Deoxyribonucleic acid-cytosine methylation by host- and plasmid-controlled enzymes. J Bacteriol. 122:129–138. 1975. View Article : Google Scholar : PubMed/NCBI | |
|
Kohli RM and Zhang Y: TET enzymes, TDG and the dynamics of DNA demethylation. Nature. 502:472–479. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Harris AJ and Goldman AD: The complex phylogenetic relationships of a 4mC/6mA DNA methyltransferase in prokaryotes. Mol Phylogenet Evol. 149:1068372020. View Article : Google Scholar : PubMed/NCBI | |
|
Thomas B, Matson S, Chopra V, Sun L, Sharma S, Hersch S, Rosas HD, Scherzer C, Ferrante R and Matson W: A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease. Anal Biochem. 436:112–120. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Hashimoto H, Pais JE, Zhang X, Saleh L, Fu ZQ, Dai N, Corrêa IR Jr, Zheng Y and Cheng X: Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA. Nature. 506:391–395. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Angeloni A and Bogdanovic O: Enhancer DNA methylation: Implications for gene regulation. Essays Biochem. 63:707–715. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng Y and Chen T: DNA methylation reprogramming during mammalian development. Genes (Basel). 10:2572019. View Article : Google Scholar : PubMed/NCBI | |
|
Zong FF, Jia DD, Huang GK, Pan M, Hu H, Song SY, Xiao L, Wang RW and Liang L: New perspectives on DNA methylation modifications in ocular diseases. Int J Ophthalmol. 18:340–350. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Chen X and Lu C: The interplay between DNA and histone methylation: Molecular mechanisms and disease implications. EMBO Rep. 22:e518032021. View Article : Google Scholar : PubMed/NCBI | |
|
Bird A: DNA methylation patterns and epigenetic memory. Genes Dev. 16:6–21. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Boyes J and Bird A: DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell. 64:1123–1134. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Cvekl A and Mitton KP: Epigenetic regulatory mechanisms in vertebrate eye development and disease. Heredity (Edinb). 105:135–151. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Gao Y, Yan Y and Huang T: Human age-related cataracts: epigenetic suppression of the nuclear factor erythroid 2-related factor 2-mediated antioxidant system. Mol Med Rep. 11:1442–1447. 2015. View Article : Google Scholar | |
|
Jin B and Robertson KD: DNA methyltransferases, DNA damage repair, and cancer. Adv Exp Med Biol. 754:3–29. 2013. View Article : Google Scholar | |
|
Kim DJ: The role of the DNA methyltransferase family and the therapeutic potential of DNMT inhibitors in tumor treatment. Curr Oncol. 32:882025. View Article : Google Scholar : PubMed/NCBI | |
|
Asada M, Hayashi H and Takagi N: Possible involvement of DNA methylation and protective effect of zebularine on neuronal cell death after glutamate excitotoxity. Biol Pharm Bull. 45:770–779. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Liu S, Hu C, Luo Y and Yao K: Genome-wide DNA methylation profiles may reveal new possible epigenetic pathogenesis of sporadic congenital cataract. Epigenomics. 12:771–788. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Song J, VanBuskirk JA and Merbs SL: Regulation of opsin gene expression by DNA methylation and histone acetylation. Int J Mol Sci. 23:14082022. View Article : Google Scholar : PubMed/NCBI | |
|
Johnson WM, Finnegan LK, Hauser MA and Stamer WD: lncRNAs, DNA methylation, and the pathobiology of exfoliation glaucoma. J Glaucoma. 27:202–209. 2018. View Article : Google Scholar | |
|
Zhou P, Luo Y, Liu X, Fan L and Lu Y: Down-regulation and CpG island hypermethylation of CRYAA in age-related nuclear cataract. FASEB J. 26:4897–4902. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Baird PN and Wei L: Age-related macular degeneration and DNA methylation. Epigenomics. 5:239–241. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Chai P, Jia R, Li Y, Zhou C, Gu X, Yang L, Shi H, Tian H, Lin H, Yu J, et al: Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma. Prog Retin Eye Res. 89:1010302022. View Article : Google Scholar | |
|
Wolff SP: Cataract and UV radiation. Doc Ophthalmol. 88:201–204. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Xie J, Xu J, Deng L, Cao G, Huang S, Zeng C, Liu C, Zhu S, He G, et al: Long-term exposure to ambient PM2.5 and age-related cataracts among chinese middle-aged and older adults: Evidence from two national cohort studies. Environ Sci Technol. 57:11792–11802. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Zhou J, Wu J, Zhang G, Kang L, Ben J, Wang Y, Qin B and Guan H: Aberrant epigenetic alterations of glutathione-S-transferase P1 in age-related nuclear cataract. Curr Eye Res. 42:402–410. 2017. View Article : Google Scholar | |
|
Liu X, Zhou P, Fan F, Li D, Wu J, Lu Y and Luo Y: CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells. BMC Ophthalmol. 16:1412016. View Article : Google Scholar : PubMed/NCBI | |
|
Jin SL, Zhang Y, Chen ZH, Qian DW, Qine YJ, Yongjie Q, He SK and Guo HK: Epigenetic changes of the Klotho gene in age-related cataracts. Eur Rev Med Pharmacol Sci. 19:2544–2553. 2015.PubMed/NCBI | |
|
Wang Y, Zhang G, Kang L and Guan H: Expression profiling of DNA methylation and transcriptional repression associated genes in lens epithelium cells of age-related cataract. Cell Mol Neurobiol. 37:537–543. 2017. View Article : Google Scholar | |
|
Chen X, Su D, Sun Z, Fu Y, Hu Y, Zhang Y, Zhang X, Wei Q, Zhu W, Ma X and Hu S: Preliminary study on whole genome methylation and transcriptomics in age-related cataracts. Gene. 898:1480962024. View Article : Google Scholar | |
|
Wang L, Li P and Guo X: Screening of methylation genes in age-related cataract. Int J Ophthalmol. 11:1102–1107. 2018.PubMed/NCBI | |
|
Pendergrass W, Penn P, Possin D and Wolf N: Accumulation of DNA, nuclear and mitochondrial debris, and ROS at sites of age-related cortical cataract in mice. Invest Ophthalmol Vis Sci. 46:4661–4670. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Zhang L, Zhang L, Bai J, Ge H and Liu P: Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens. Mol Vis. 16:1754–1763. 2010.PubMed/NCBI | |
|
Li B, Zhou J, Zhang G, Wang Y, Kang L, Wu J, Chen J and Guan H: Relationship between the altered expression and epigenetics of GSTM3 and age-related cataract. Invest Ophthalmol Vis Sci. 57:4721–4732. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Rushmore TH, Morton MR and Pickett CB: The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem. 266:11632–11639. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Ling X, Zhu L, Yan Y, Qian H, Kang Z, Ye W, Xie Z and Xue C: Ferulic acid protects human lens epithelial cells against UVA-induced oxidative damage by downregulating the DNA demethylation of the keap1 promoter. J Biochem Mol Toxicol. 38:e700312024. View Article : Google Scholar : PubMed/NCBI | |
|
Palsamy P, Bidasee KR and Shinohara T: Selenite cataracts: Activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection. Biochim Biophys Acta. 1842:1794–1805. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rabbani PS, Soares MA, Hameedi SG, Qian H, Kang Z, Ye W, Xie Z and Xue C: Dysregulation of Nrf2/Keap1 redox pathway in diabetes affects multipotency of stromal cells. Diabetes. 68:141–155. 2019. View Article : Google Scholar : | |
|
Raghunath A, Sundarraj K, Nagarajan R, Arfuso F, Bian J, Kumar AP, Sethi G and Perumal E: Antioxidant response elements: Discovery, classes, regulation and potential applications. Redox Biol. 17:297–314. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Wang T, Liu P, Yang F, Wang X, Zheng W and Sun W: Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. Food Funct. 12:3898–3918. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Osama A, Zhang J, Yao J, Yao X and Fang J: Nrf2: A dark horse in Alzheimer's disease treatment. Ageing Res Rev. 64:1012062020. View Article : Google Scholar : PubMed/NCBI | |
|
Palsamy P, Bidasee KR and Shinohara T: Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells. Exp Eye Res. 121:26–34. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Palsamy P, Bidasee KR, Ayaki M, Augusteyn RC, Chan JY and Shinohara T: Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts. Free Radic Biol Med. 72:134–148. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zduńska K, Dana A, Kolodziejczak A and Rotsztejn H: Antioxidant properties of ferulic acid and its possible application. Skin Pharmacol Physiol. 31:332–336. 2018. View Article : Google Scholar | |
|
Rampelotto CR, Pereira VG, da Silva Silveira L, Rossato A, Machado AK, Sagrillo MR, Gündel A, Burger ME, Schaffazick SR and de Bona da Silva C: Ferulic acid-loaded nanocapsules: Evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells. Toxicol In Vitro. 78:1052592022. View Article : Google Scholar | |
|
Mathew S and Abraham TE: Ferulic acid: an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications. Crit Rev Biotechnol. 24:59–83. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Yang SP, Yang XZ and Cao GP: Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells. Mol Med Rep. 12:1145–1150. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Giblin FJ: Glutathione: A vital lens antioxidant. J Ocul Pharmacol Ther. 16:121–135. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Sheehan D, Meade G, Foley VM and Dowd CA: Structure, function and evolution of glutathione transferases: Implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J. 360:1–16. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Whalen R and Boyer TD: Human glutathione S-transferases. Semin Liver Dis. 18:345–358. 1998. View Article : Google Scholar | |
|
Hayes JD and Pulford DJ: The glutathione S-transferase super-gene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 30:445–600. 1995. View Article : Google Scholar | |
|
Choi YJ, Yeo HJ, Shin MJ, Youn GS, Park JH, Yeo EJ, Kwon HJ, Lee LR, Kim NY, Kwon SY, et al: Tat-GSTpi inhibits dopaminergic cells against MPP+-induced cellular damage via the reduction of oxidative stress and MAPK activation. Biomedicines. 11:8362023. View Article : Google Scholar | |
|
Laborde E: Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death. Cell Death Differ. 17:1373–1380. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Hayes JD and McLellan LI: Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res. 31:273–300. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Babizhayev MA: Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma. BBA Clin. 6:49–68. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Sorte K, Sune P, Bhake A, Shivkumar VB, Gangane N and Basak A: Quantitative assessment of DNA damage directly in lens epithelial cells from senile cataract patients. Mol Vis. 17:1–6. 2011.PubMed/NCBI | |
|
Xu B, Kang L, Zhang G, Wu J, Zhu R, Yang M and Guan H: The changes of 8-OHdG, hOGG1, APE1 and Pol β in lenses of patients with age-related cataract. Curr Eye Res. 40:378–385. 2015. View Article : Google Scholar | |
|
Chatterjee N and Walker GC: Mechanisms of DNA damage, repair, and mutagenesis. Environ Mol Mutagen. 58:235–263. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Maugeri-Saccà M, Bartucci M and De Maria R: DNA damage repair pathways in cancer stem cells. Mol Cancer Ther. 11:1627–1636. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kong M, Liu L, Chen X, Driscoll KI, Mao P, Böhm S, Kad NM, Watkins SC, Bernstein KA, Wyrick JJ, et al: Single-molecule imaging reveals that Rad4 employs a dynamic DNA damage recognition process. Mol Cell. 64:376–387. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Licht CL, Stevnsner T and Bohr VA: Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet. 73:1217–1239. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Fleming AM and Burrows CJ: 8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis. DNA Repair (Amst). 56:75–83. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Dinçer Y, Akkaya Ç, Mutlu T, Yavuzer S, Erkol G, Bozluolcay M and Guven M: DNA repair gene OGG1 polymorphism and its relation with oxidative DNA damage in patients with Alzheimer's disease. Neurosci Lett. 709:1343622019. View Article : Google Scholar : PubMed/NCBI | |
|
Synowiec E, Blasiak J, Zaras M, Szaflik J and Szaflik JP: Association between polymorphisms of the DNA base excision repair genes MUTYH and hOGG1 and age-related macular degeneration. Exp Eye Res. 98:58–66. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wu X, Lai W, Lin H and Liu Y: Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis. PLoS One. 12:e01720922017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Li F, Zhang G, Kang L, Qin B and Guan H: Altered DNA methylation and expression profiles of 8-oxoguanine DNA glycosylase 1 in lens tissue from age-related cataract patients. Curr Eye Res. 40:815–821. 2015. View Article : Google Scholar | |
|
Yan H, McCane J, Toczylowski T and Chen C: Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair. J Cell Biol. 171:217–227. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Tranah GJ, Bugni J, Giovannucci E, Ma J, Fuchs C, Hines L, Samson L and Hunter DJ: O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the nurses' health study and physicians' health study (United States). Cancer Causes Control. 17:721–731. 2006.PubMed/NCBI | |
|
Li F, Wang Y, Zhang G, Zhou J, Yang L and Guan H: Expression and methylation of DNA repair genes in lens epithelium cells of age-related cataract. Mutat Res. 766-767:31–36. 2014. View Article : Google Scholar | |
|
Andley UP: Effects of alpha-crystallin on lens cell function and cataract pathology. Curr Mol Med. 9:887–892. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Horwitz J: Alpha-crystallin can function as a molecular chaperone. Proc Natl Acad Sci USA. 89:10449–10453. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Thampi P, Hassan A, Smith JB and Abraham EC: Enhanced C-terminal truncation of alphaA- and alphaB-crystallins in diabetic lenses. Invest Ophthalmol Vis Sci. 43:3265–3272. 2002.PubMed/NCBI | |
|
Horwitz J: Alpha-crystallin. Exp Eye Res. 76:145–153. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Christopher KL, Pedler MG, Shieh B, Ammar DA, Petrash JM and Mueller NH: Alpha-crystallin-mediated protection of lens cells against heat and oxidative stress-induced cell death. Biochim Biophys Acta. 1843:309–315. 2014. View Article : Google Scholar : | |
|
Wang Z, Sun Y, Zhang Y, Zhang Y, Zhang R, Li C, Liu X, Pan F, Qiao D, Shi X, et al: Identification of seven variants in the col4a1 gene that alter RNA splicing by minigene assay. Clin Genet. 106:336–341. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Zhu D, Yang Y, He Y, Sun J, Li YM, Wang ZJ and Li P: DNA hypermethylation of COL4A1 in ultraviolet-B-induced age-related cataract models in vitro and in vivo. Int J Ophthalmol. 17:1791–1799. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Fujisawa T and Filippakopoulos P: Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Nat Rev Mol Cell Biol. 18:246–262. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Bhaumik SR, Smith E and Shilatifard A: Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol. 14:1008–1016. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Fu J, Rack JGM, Li C, Voorneveld J, Filippov DV, Ahel I, Luo ZQ and Das C: Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain. Nat Commun. 15:24522024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu D, Zhang Y and Wang S: Histone citrullination: A new target for tumors. Mol Cancer. 20:902021. View Article : Google Scholar : PubMed/NCBI | |
|
Rong X, Qiu X, Jiang Y, Li D, Xu J, Zhang Y and Lu Y: Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. Sci Rep. 6:347042016. View Article : Google Scholar : PubMed/NCBI | |
|
Kouzarides T: Chromatin modifications and their function. Cell. 128:693–705. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
de Lera AR and Ganesan A: Epigenetic polypharmacology: From combination therapy to multitargeted drugs. Clin Epigenetics. 8:1052016. View Article : Google Scholar : PubMed/NCBI | |
|
Scarano N, Brullo C, Musumeci F, Millo E, Bruzzone S, Schenone S and Cichero E: Recent advances in the discovery of SIRT1/2 inhibitors via computational methods: A perspective. Pharmaceuticals (Basel). 17:6012024. View Article : Google Scholar : PubMed/NCBI | |
|
Li G, Jiang H, Chang M, Xie H and Hu L: HDAC6 α-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases. J Neurol Sci. 304:1–8. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Mimura T, Kaji Y, Noma H, Funatsu H and Okamoto S: The role of SIRT1 in ocular aging. Exp Eye Res. 116:17–26. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ağaoğlu NB, Varol N, Yıldız SH, Karaosmanoğlu C, Duman R, Özdemir Erdoğan M and Solak M: Relationship between SIRT1 gene expression level and disease in age-related cataract cases. Turk J Med Sci. 49:1068–1072. 2019. View Article : Google Scholar | |
|
Zheng T and Lu Y: Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. Curr Eye Res. 36:449–455. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zentner GE and Henikoff S: Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol. 20:259–266. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Bannister AJ and Kouzarides T: Regulation of chromatin by histone modifications. Cell Res. 21:381–395. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Black JC, Van Rechem C and Whetstine JR: Histone lysine methylation dynamics: Establishment, regulation, and biological impact. Mol Cell. 48:491–507. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Cheng X: Structural and functional coordination of DNA and histone methylation. Cold Spring Harb Perspect Biol. 6:a0187472014. View Article : Google Scholar : PubMed/NCBI | |
|
Bachman KE, Rountree MR and Baylin SB: Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem. 276:32282–32287. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Shi H, Chai P, Jia R and Fan X: Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation. Mol Cancer. 19:782020. View Article : Google Scholar : PubMed/NCBI | |
|
Tang J, Zhou C, Ye F, Zuo S, Zhou M, Lu L, Chai P and Fan X: RNA methylation homeostasis in ocular diseases: All eyes on Me. Prog Retin Eye Res. 105:1013352025. View Article : Google Scholar : PubMed/NCBI | |
|
Jia G, Fu Y and He C: Reversible RNA adenosine methylation in biological regulation. Trends Genet. 29:108–115. 2013. View Article : Google Scholar : | |
|
Kumari R, Ranjan P, Suleiman ZG, Goswami SK, Li J, Prasad R and Verma SK: mRNA modifications in cardiovascular biology and disease: With a focus on m6A modification. Cardiovasc Res. 118:1680–1692. 2022. View Article : Google Scholar : | |
|
Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, et al: Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 485:201–206. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE and Jaffrey SR: Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 149:1635–1646. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zaccara S, Ries RJ and Jaffrey SR: Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol. 20:608–624. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, Wang Y, Wang JN, Cao QC, Sun RX, Zhu HJ, Zhang YR, Ji JD and Liu QH: m6A modification of circSPECC1 suppresses RPE oxidative damage and maintains retinal homeostasis. Cell Rep. 41:1116712022. View Article : Google Scholar | |
|
Sheng Z, Pan Y, Shao L and Bao Y: METTL3 mediates CPB1 expression by regulating transcription factor BACH2 to promote apoptosis and oxidative stress of lens epithelial cells. J Bioenerg Biomembr. 57:161–171. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Wang T, Kong S, Tao M and Ju S: The potential role of RNA N6-methyladenosine in cancer progression. Mol Cancer. 19:882020. View Article : Google Scholar : PubMed/NCBI | |
|
Kang L, Bao S, Li P, Zhang G, Zhu X, Ji M and Guan H: METTL14-mediated depression of NEIL1 aggravates oxidative damage and mitochondrial dysfunction of lens epithelial cells through regulating KEAP1/NRF2 pathways. Cell Signal. 127:1116232025. View Article : Google Scholar : PubMed/NCBI | |
|
Ye HF, Zhang X, Zhao ZN, Zheng C, Fei P, Xu Y, Lyu J, Chen JL, Guo XX, Zhu H and Zhao PQ: Characterization of N6-methyladenosine long non-coding RNAs in sporadic congenital cataract and age-related cataract. Int J Ophthalmol. 17:1973–1986. 2024. View Article : Google Scholar : | |
|
Wang Y, Li P, Wang C, Bao S, Wang S, Zhang G, Zou X, Wu J, Guan Y, Ji M and Guan H: Lens epithelium cell ferroptosis mediated by m6A-lncRNA and GPX4 expression in lens tissue of age-related cataract. BMC Ophthalmol. 23:5142023. View Article : Google Scholar | |
|
Luo G, Xu W, Chen X, Wang S, Wang J, Dong F, Hu DN, Reinach PS and Yan D: NSUN2-mediated RNA m5C modification modulates uveal melanoma cell proliferation and migration. Epigenetics. 17:922–933. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Y, Kong L, Pei Z, Li F, Li C, Sun X, Shi B and Ge J: m7G methyltransferase METTL1 promotes post-ischemic angiogenesis via promoting VEGFA mRNA translation. Front Cell Dev Biol. 9:6420802021. View Article : Google Scholar | |
|
Wu C, Liu Z, Ma L, Pei C, Qin L, Gao N, Li J and Yin Y: MiRNAs regulate oxidative stress related genes via binding to the 3' UTR and TATA-box regions: A new hypothesis for cataract pathogenesis. BMC Ophthalmol. 17:1422017. View Article : Google Scholar : PubMed/NCBI | |
|
Gu X, Sun J, Li S, Wu X and Li L: Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: Potential epigenetic mechanisms in gene transcription in Aβ production. Neurobiol Aging. 34:1069–1079. 2013. View Article : Google Scholar | |
|
Niu Y, DesMarais TL, Tong Z, Yao Y and Costa M: Oxidative stress alters global histone modification and DNA methylation. Free Radic Biol Med. 82:22–28. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li Q, Li X, Tang H, Jiang B, Dou Y, Gorospe M and Wang W: NSUN2-mediated m5C methylation and METTL3/METTL14-mediated m6A methylation cooperatively enhance p21 translation. J Cell Biochem. 118:2587–2598. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Q and Ni X: ROS-mediated DNA methylation pattern alterations in carcinogenesis. Curr Drug Targets. 16:13–19. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chouliaras L, Mastroeni D, Delvaux E, Grover A, Kenis G, Hof PR, Steinbusch HW, Coleman PD, Rutten BP and van den Hove DL: Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol Aging. 34:2091–2099. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, et al: The 5-hydroxymethylcytosine landscape of prostate cancer. Cancer Res. 82:3888–3902. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Vatapalli R, Rossi AP, Chan HM and Zhang J: Cancer epigenetic therapy: Recent advances, challenges, and emerging opportunities. Epigenomics. 17:59–74. 2025. View Article : Google Scholar : | |
|
Gomez S, Tabernacki T, Kobyra J, Roberts P and Chiappinelli KB: Combining epigenetic and immune therapy to overcome cancer resistance. Semin Cancer Biol. 65:99–113. 2020. View Article : Google Scholar : | |
|
Zhang P and Zhang M: Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma. Clin Epigenetics. 12:1692020. View Article : Google Scholar : PubMed/NCBI | |
|
Raj K and Mufti GJ: Azacytidine (Vidaza(R)) in the treatment of myelodysplastic syndromes. Ther Clin Risk Manag. 2:377–388. 2006. View Article : Google Scholar | |
|
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, et al: TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes. N Engl J Med. 375:2023–2036. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Duvic M and Vu J: Vorinostat in cutaneous T-cell lymphoma. Drugs Today (Barc). 43:585–599. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
McDermott J and Jimeno A: Belinostat for the treatment of peripheral T-cell lymphomas. Drugs Today (Barc). 50:337–345. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Smolewski P and Robak T: The discovery and development of romidepsin for the treatment of T-cell lymphoma. Expert Opin Drug Discov. 12:859–873. 2017.PubMed/NCBI | |
|
Kim YH, Bagot M, Pinter-Brown L, Rook AH, Porcu P, Horwitz SM, Whittaker S, Tokura Y, Vermeer M, Zinzani PL, et al: Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): An international, open-label, randomised, controlled phase 3 trial. Lancet Oncol. 19:1192–1204. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Geissler K, Koristek Z, Del Castillo TB, Novák J, Rodríguez-Macías G, Metzelder SK, Illes A, Mayer J, Arnan M, Keating MM, et al: Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study. Br J Haematol. 205:1734–1745. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Fu S, Hu W, Iyer R, Kavanagh JJ, Coleman RL, Levenback CF, Sood AK, Wolf JK, Gershenson DM, Markman M, et al: Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer. Cancer. 117:1661–1669. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Mathew OP, Ranganna K and Milton SG: Involvement of the antioxidant effect and anti-inflammatory response in butyrate-inhibited vascular smooth muscle cell proliferation. Pharmaceuticals (Basel). 7:1008–1027. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ziemka-Nalecz M and Zalewska T: Neuroprotective effects of histone deacetylase inhibitors in brain ischemia. Acta Neurobiol Exp (Wars). 74:383–395. 2014. View Article : Google Scholar | |
|
Qiu X, Rong X, Yang J and Lu Y: Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure. BMC Ophthalmol. 19:422019. View Article : Google Scholar : PubMed/NCBI | |
|
Hong DS, Kang YK, Borad M, Sachdev J, Ejadi S, Lim HY, Brenner AJ, Park K, Lee JL, Kim TY, et al: Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours. Br J Cancer. 122:1630–1637. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ottosen S, Parsley TB, Yang L, Zeh K, van Doorn LJ, van der Veer E, Raney AK, Hodges MR and Patick AK: In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122. Antimicrob Agents Chemother. 59:599–608. 2015. View Article : Google Scholar : | |
|
Vermeire S, Sands BE, Tilg H, Tulassay Z, Kempinski R, Danese S, Bunganič I, Nitcheu J, Santo J, Scherrer D, et al: ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase 2b, double-blind, randomised, placebo-controlled induction trial and 48 week, open-label extension. Lancet Gastroenterol Hepatol. 7:1024–1035. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Winkle M, El-Daly SM, Fabbri M and Calin GA: Noncoding RNA therapeutics-challenges and potential solutions. Nat Rev Drug Discov. 20:629–651. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Qiu H, Zhang F and Ding S: Advances in single-cell multi-omics and application in cardiovascular research. Front Cell Dev Biol. 10:8838612022. View Article : Google Scholar : PubMed/NCBI | |
|
Armand EJ, Li J, Xie F, Luo C and Mukamel EA: Single-cell sequencing of brain cell transcriptomes and epigenomes. Neuron. 109:11–26. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Nam AS, Chaligne R and Landau DA: Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics. Nat Rev Genet. 22:3–18. 2021. View Article : Google Scholar : | |
|
Liu X, Zhang L, Li X, Chen L, Lu L, Yang Y, Wu Y, Zheng L, Tang J, Wang F, et al: Single-cell multi-omics profiling uncovers the immune heterogeneity in HIV-infected immunological non-responders. EBioMedicine. 115:1056672025. View Article : Google Scholar : PubMed/NCBI | |
|
Tangeman JA, Rebull SM, Grajales-Esquivel E, Bendezu-Sayas S, Robinson ML, Lachke SA and Del Rio-Tsonis K: Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology. Development. 151:dev2022492024. View Article : Google Scholar : PubMed/NCBI | |
|
Vickovic S, Eraslan G, Salmén F, Klughammer J, Stenbeck L, Schapiro D, Äijö T, Bonneau R, Bergenstråhle L, Navarro JF, et al: High-definition spatial transcriptomics for in situ tissue profiling. Nat Methods. 16:987–990. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Robles-Remacho A, Sanchez-Martin RM and Diaz-Mochon JJ: Spatial transcriptomics: emerging technologies in tissue gene expression profiling. Anal Chem. 95:15450–15460. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Cilento MA, Sweeney CJ and Butler LM: Spatial transcriptomics in cancer research and potential clinical impact: A narrative review. J Cancer Res Clin Oncol. 150:2962024. View Article : Google Scholar : PubMed/NCBI | |
|
Duan R, Fu Q, Sun Y and Li Q: Epigenetic clock: A promising biomarker and practical tool in aging. Ageing Res Rev. 81:1017432022. View Article : Google Scholar : PubMed/NCBI | |
|
Horvath S, Lu AT, Haghani A, Zoller JA, Li CZ, Lim AR, Brooke RT, Raj K, Serres-Armero A, Dreger DL, et al: DNA methylation clocks for dogs and humans. Proc Natl Acad Sci USA. 119:e21208871192022. View Article : Google Scholar : PubMed/NCBI | |
|
Margiotti K, Monaco F, Fabiani M, Mesoraca A and Giorlandino C: Epigenetic clocks: In aging-related and complex diseases. Cytogenet Genome Res. 163:247–256. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Yuan XL, Zhou X, Xu J, Zhang X and Duan X: Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes. Clin Epigenetics. 16:1062024. View Article : Google Scholar : PubMed/NCBI |