|
1
|
Kwiatkowski S, Kiersztan A and Drozak J:
Biosynthesis of carnosine and related dipeptides in vertebrates.
Curr Protein Pept Sci. 19:771–789. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Maugeri S, Sibbitts J, Privitera A,
Cardaci V, Di Pietro L, Leggio L, Iraci N, Lunte SM and Caruso G:
The anti-cancer activity of the naturally occurring dipeptide
carnosine: Potential for breast cancer. Cells. 12:25922023.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Hayes JD, Dinkova-Kostova AT and Tew KD:
Oxidative stress in cancer. Cancer Cell. 38:167–197. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Deng J, Zhong YF, Wu YP, Luo Z, Sun YM,
Wang GE, Kurihara H, Li YF and He RR: Carnosine attenuates
cyclophosphamide-induced bone marrow suppression by reducing
oxidative DNA damage. Redox Biol. 14:1–6. 2018. View Article : Google Scholar
|
|
5
|
Babizhayev MA, Seguin MC, Gueyne J,
Evstigneeva RP, Ageyeva EA and Zheltukhina GA: L-carnosine
(beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act
as natural antioxidants with hydroxyl-radical-scavenging and
lipid-peroxidase activities. Biochem J. 304:509–516. 1994.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Posa DK, Miller J, Hoetker D, Ramage MI,
Gao H, Zhao J, Doelling B, Bhatnagar A, Wigmore SJ, Skipworth RJE
and Baba SP: Skeletal muscle analysis of cancer patients reveals a
potential role for carnosine in muscle wasting. J Cachexia
Sarcopenia Muscle. 14:1802–1814. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Zhao J, Posa DK, Kumar V, Hoetker D, Kumar
A, Ganesan S, Riggs DW, Bhatnagar A, Wempe MF and Baba SP:
Carnosine protects cardiac myocytes against lipid peroxidation
products. Amino Acids. 51:123–138. 2019. View Article : Google Scholar :
|
|
8
|
Freund MA, Chen B and Decker EA: The
inhibition of advanced glycation end products by carnosine and
other natural dipeptides to reduce diabetic and age-related
complications. Compr Rev Food Sci Food Saf. 17:1367–1378. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Moulahoum H, Sanli S, Timur S and
Zihnioglu F: Potential effect of carnosine encapsulated niosomes in
bovine serum albumin modifications. Int J Biol Macromol.
137:583–591. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Boldyrev AA, Aldini G and Derave W:
Physiology and pathophysiology of carnosine. Physiol Rev.
93:1803–1845. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Bell SM, Hariharan R, Laud P, Majid A and
Courten B: Carnosine supplementation improves delayed recall: A
systematic review and meta-analysis. Alzheimer's Dement.
19:e0710042023. View Article : Google Scholar
|
|
12
|
Caruso G, Benatti C, Musso N, Fresta CG,
Fidilio A, Spampinato G, Brunello N, Bucolo C, Drago F, Lunte SM,
et al: Carnosine protects macrophages against the toxicity of
Aβ1-42 oligomers by decreasing oxidative stress. Biomedicines.
9:4772021. View Article : Google Scholar
|
|
13
|
Caruso G, Godos J, Castellano S, Micek A,
Murabito P, Galvano F, Ferri R, Grosso G and Caraci F: The
therapeutic potential of carnosine/anserine supplementation against
cognitive decline: A systematic review with meta-analysis.
Biomedicines. 9:2532021. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Cardaci V, Di Pietro L, Zupan MC, Sibbitts
J, Privitera A, Lunte SM, Caraci F, Hartley MD and Caruso G:
Characterizing oxidative stress induced by Aβ oligomers and the
protective role of carnosine in primary mixed glia cultures. Free
Radic Biol Med. 229:213–224. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Corona C, Frazzini V, Silvestri E,
Lattanzio R, La Sorda R, Piantelli M, Canzoniero LMT, Ciavardelli
D, Rizzarelli E and Sensi SL: P2-452: Effects of dietary
supplementation of carnosine on mitochondrial dysfuncti2on, amyloid
pathology, and cognitive deficits in 3xTg-AD mice. PLoS One.
6:e179712011. View Article : Google Scholar
|
|
16
|
Costa R, Speretta E, Saraiva MJ, Crowther
DC and Cardoso I: P2-453: Testing the therapeutic potential of
doxycycline in a drosophila melanogaster model of Alzheimer's
disease. Alzheimer's Dement. 7:S4582011. View Article : Google Scholar
|
|
17
|
Keykhaee M, Rahimifard M, Najafi A, Baeeri
M, Abdollahi M, Mottaghitalab F, Farokhi M and Khoobi M:
Alginate/gum arabic-based biomimetic hydrogel enriched with
immobilized nerve growth factor and carnosine improves diabetic
wound regeneration. Carbohydr Polym. 321:1211792023. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Wu J, Lv D, Lin W, Mao Y, Xia Y, Feng L,
Zhao T, Mao X, Shu F and Guo H: Chronic exposure to liquid crystal
monomer EBCN at environmentally relevant concentrations induces
testicular dysfunction via the gut-testis axis. J Hazard Mater.
486:1370332025. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Yu T, Xu X, Liu Y, Wang X, Wu S, Qiu Z,
Liu X, Pan X, Gu C, Wang S, et al: Multi-omics signatures reveal
genomic and functional heterogeneity of Cutibacterium acnes in
normal and diseased skin. Cell Host Microbe. 32:1129–1146.e8. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Lei S, Zhang Z, Wang J, Yu X, Jiang J,
Wang Y, Fu S, Shi J, Tang G and Wang S: Carnosine-copper
chelator-modified small-diameter vascular grafts for the promotion
of anticoagulation and endothelial regeneration. Chem Eng J.
493:1524682024. View Article : Google Scholar
|
|
21
|
Calabrese V, Scuto M, Salinaro AT,
Dionisio G, Modafferi S, Ontario ML, Greco V, Sciuto S, Schmitt CP,
Calabrese EJ and Peters V: Hydrogen sulfide and carnosine:
Modulation of oxidative stress and inflammation in kidney and brain
axis. Antioxidants (Basel). 9:13032020. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Huang J, Wang T, Yu D, Fang X, Fan H and
Liu Q, Yi G, Yi X and Liu Q: l-Homocarnosine attenuates
inflammation in cerebral ischemia-reperfusion injury through
inhibition of nod-like receptor protein 3 inflammasome. Int J Biol
Macromol. 118:357–364. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Lee YT, Hsu CC, Lin MH, Liu KS and Yin MC:
Histidine and carnosine delay diabetic deterioration in mice and
protect human low density lipoprotein against oxidation and
glycation. Eur J Pharmacol. 513:145–150. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Tsai SJ, Kuo WW, Liu WH and Yin MC:
Antioxidative and anti-inflammatory protection from carnosine in
the striatum of MPTP-treated mice. J Agric Food Chem.
58:11510–11516. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Swietach P, Jäättelä M, Pillon-Thomas S
and Boedtkjer E: Carnosine facilitates lysosomal release of
inhibitors of T cell surveillance. Cell Metab. 36:461–462. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
No authors listed. Carnosine helps cancer
cells to evade immune surveillance by regulating intracellular pH.
Nat Immunol. 25:399–400. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Garofalo M, Iovine B, Kuryk L, Capasso C,
Hirvinen M, Vitale A, Bevilacqua MA and Cerullo V: 622. Oncolytic
adenoviruses loaded with active drugs as a novel drug delivery
system for cancer therapy. Mol Ther. 23(Suppl 1): S2472015.
View Article : Google Scholar
|
|
28
|
Caruso G, Caraci F and Jolivet RB: Pivotal
role of carnosine in the modulation of brain cells activity:
Multimodal mechanism of action and therapeutic potential in
neurodegenerative disorders. Prog Neurobiol. 175:35–53. 2019.
View Article : Google Scholar
|
|
29
|
Russo S, Privitera A, Greco G, Di Pietro
L, Cardaci V, Carota G, Sarpietro MG and Caruso G: Development and
in vitro characterization of new carnosine-loaded liposomal
formulations. J Liposome Res. 35:117–124. 2025. View Article : Google Scholar
|
|
30
|
Bonaccorso A, Privitera A, Grasso M,
Salamone S, Carbone C, Pignatello R, Musumeci T, Caraci F and
Caruso G: The therapeutic potential of novel carnosine
formulations: Perspectives for drug development. Pharmaceuticals
(Basel). 16:7782023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Jain S, Kim ES, Kim D, Burrows D, De
Felice M, Kim M, Baek SH, Ali A, Redgrave J, Doeppner TR, et al:
Comparative cerebroprotective potential of d- and l-carnosine
following ischemic stroke in mice. Int J Mol Sci. 21:30532020.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kim ES, Kim D, Nyberg S, Poma A, Cecchin
D, Jain SA, Kim KA, Shin YJ, Kim EH, Kim M, et al: LRP-1
functionalized polymersomes enhance the efficacy of carnosine in
experimental stroke. Sci Rep. 10:6992020. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Ma H, Zhao J, Meng H, Hu D, Zhou Y, Zhang
X, Wang C, Li J, Yuan J and Wei Y: Carnosine-modified fullerene as
a highly enhanced ROS scavenger for mitigating acute oxidative
stress. ACS Appl Mater Interfaces. 12:16104–16113. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Dash UC, Bhol NK, Swain SK, Samal RR,
Nayak PK, Raina V, Panda SK, Kerry RG, Duttaroy AK and Jena AB:
Oxidative stress and inflammation in the pathogenesis of
neurological disorders: Mechanisms and implications. Acta Pharm Sin
B. 15:15–34. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Kunsch C and Medford RM: Oxidative stress
as a regulator of gene expression in the vasculature. Circ Res.
85:753–766. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Sack MN, Fyhrquist FY, Saijonmaa OJ,
Fuster V and Kovacic JC: Basic biology of oxidative stress and the
cardiovascular system: Part 1 of a 3-part series. J Am Coll
Cardiol. 70:196–211. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Yan Z and Spaulding HR: Extracellular
superoxide dismutase, a molecular transducer of health benefits of
exercise. Redox Biol. 32:1015082020. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Ansari FA, Ali SN and Mahmood R:
P-28-Protective effect of carnosine on sodium nitrite-induced
oxidative stress and DNA damage in rat intestine. Free Radic Biol
Med. 96(Suppl 1): S442016. View Article : Google Scholar
|
|
39
|
Husain N and Mahmood R: P
013-Copper(II)-induced cytotoxicity and oxidative stress in human
blood cells and its attenuation by carnosine. Free Radic Biol Med.
108(Suppl 1): S212017. View Article : Google Scholar
|
|
40
|
Di Giulio T, Barca A, Verri T, De Gennaro
M, Giancane G, Giancane E and Mazzotta C: Molecular imprinting
based on metal-ion mediated recognition: Electrosynthesis of
artificial receptors for the selective detection of peptides. Sens
Actuators B Chem. 383:1335892023. View Article : Google Scholar
|
|
41
|
Jukić I, Kolobarić N, Stupin A, Matić A,
Kozina N, Mihaljević Z, Mihalj M, Šušnjara P, Stupin M, Ćurić ŽB,
et al: Carnosine, small but mighty-prospect of use as functional
ingredient for functional food formulation. Antioxidants (Basel).
10:10372021. View Article : Google Scholar
|
|
42
|
Pasternack RF and Kustin K: The reactions
of L-carnosine with metal ions. Copper(II). J Am Chem Soc.
90:2295–2299. 1968. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Velez S, Nair NG and Reddy VP: Transition
metal ion binding studies of carnosine and histidine: Biologically
relevant antioxidants. Colloids Surf B Biointerfaces. 66:291–294.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Berdaweel I, Mahoney J, Alowaisi A, Berns
K and Anderson E: Oral carnosine supplementation restores insulin
sensitivity but not glucose tolerance in mice with glutathione
peroxidase-4 deficiency. Physiology. 38:S57959842023. View Article : Google Scholar
|
|
45
|
Kopec W, Jamroz D, Wiliczkiewicz A, Biazik
E, Pudlo A, Korzeniowska M, Hikawczuk T and Skiba T: Antioxidative
characteristics of chicken breast meat and blood after diet
supplementation with carnosine, L-histidine, and β-alanine.
Antioxidants (Basel). 9:10932020. View Article : Google Scholar
|
|
46
|
Zhao J, Shi L and Zhang LR:
Neuroprotective effect of carnosine against salsolinol-induced
Parkinson's disease. Exp Ther Med. 14:664–670. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Chatham JC and Patel RP: Protein
glycosylation in cardiovascular health and disease. Nat Rev
Cardiol. 21:525–544. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Liu YT, Che Y, Qiu HL, Feng YZ, Deng JY,
Yuan Y and Tang QZ: ADP-ribosylation: An emerging direction for
disease treatment. Ageing Res Rev. 94:1021762024. View Article : Google Scholar
|
|
49
|
Ng BG and Freeze HH: Perspectives on
glycosylation and its congenital disorders. Trends Genet.
34:466–476. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Trujillo MN and Galligan JJ: Reconsidering
the role of protein glycation in disease. Nat Chem Biol.
19:922–927. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Hipkiss AR, Brownson C and Carrier MJ:
Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with
protein carbonyl groups. Mech Ageing Dev. 122:1431–1445. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Menini S, Iacobini C, Fantauzzi CB and
Pugliese G: L-carnosine and its derivatives as new therapeutic
agents for the prevention and treatment of vascular complications
of diabetes. Curr Med Chem. 27:1744–1763. 2020. View Article : Google Scholar
|
|
53
|
Aiello G, Rescigno F, Meloni M, Zoanni B,
Aldini G, Carini M and D'Amato A: The effect of carnosine on
UVA-induced changes in intracellular signaling of human skin
fibroblast spheroids. Antioxidants (Basel). 12:3002023. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Lavilla C Jr, Billacura MP, Hanna K,
Boocock DJ, Coveney C, Miles AK, Foulds GA, Murphy A, Tan A,
Jackisch L, et al: Carnosine protects stimulus-secretion coupling
through prevention of protein carbonyl adduction events in cells
under metabolic stress. Free Radic Biol Med. 175:65–79. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Li X, Yang K, Gao S, Zhao J, Liu G, Chen
Y, Lin H, Zhao W, Hu Z and Xu N: Carnosine stimulates
macrophage-mediated clearance of senescent skin cells through
activation of the AKT2 signaling pathway by CD36 and RAGE. Front
Pharmacol. 11:5938322020. View Article : Google Scholar :
|
|
56
|
Boldyrev AA: Carnosine and free-radical
defence mechanisms. Trends Neurosci. 17:4681994. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Liew WC, Sun S, Tang M, Sudarsono N and Li
C: 50553 Combination of retinol, carnosine, and soothing
ingredients delivers anti-aging benefits with antioxidative and
anti-glycation protection. J Am Acad Dermatol. 91(Suppl 1):
AB1622024. View Article : Google Scholar
|
|
58
|
Caruso G, Fresta CG, Fidilio A, O'Donnell
F, Musso N, Lazzarino G, Grasso M, Amorini AM, Tascedda F, Bucolo
C, et al: Carnosine decreases PMA-induced oxidative stress and
inflammation in murine macrophages. Antioxidants (Basel).
8:2812019. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Fresta CG, Hogard ML, Caruso G, Melo Costa
EE, Lazzarino G and Lunte SM: Monitoring carnosine uptake by RAW
264.7 macrophage cells using microchip electrophoresis with
fluorescence detection. Anal Methods. 9:402–408. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Husain N and Mahmood R: Mitigation of
Cu(II)-induced damage in human blood cells by carnosine: An in
vitro study. Toxicol In Vitro. 68:1049562020. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Miceli V, Pampalone M, Frazziano G, Grasso
G, Rizzarelli E, Ricordi C, Casu A, Iannolo G and Conaldi PG:
Carnosine protects pancreatic beta cells and islets against
oxidative stress damage. Mol Cell Endocrinol. 474:105–118. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Ooi TC, Chan KM and Sharif R: Zinc
carnosine inhibits lipopolysaccharide-induced inflammatory
mediators by suppressing NF-κb activation in raw 264.7 macrophages,
independent of the MAPKs signaling pathway. Biol Trace Elem Res.
172:458–464. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Caruso G, Fresta CG, Musso N, Giambirtone
M, Grasso M, Spampinato SF, Merlo S, Drago F, Lazzarino G, Sortino
MA, et al: Carnosine prevents Aβ-induced oxidative stress and
inflammation in microglial cells: A key role of TGF-β1. Cells.
8:642019. View Article : Google Scholar
|
|
64
|
Diniz F, Parmeggiani B, Brandão G,
Ferreira BK, Teixeira MF, Streck EL, Olivera-Bravo S, Barbeito LH,
Schuck PF, de Melo Reis RA and Ferreira GC: Dual effect of
carnosine on ROS formation in rat cultured cortical astrocytes. Mol
Neurobiol. 61:4908–4922. 2024. View Article : Google Scholar
|
|
65
|
Shen J, Xu J, Wen Y, Tang Z, Li J and Sun
J: Carnosine ameliorates postoperative cognitive dysfunction of
aged rats by limiting astrocytes pyroptosis. Neurotherapeutics.
21:e003592024. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Trombley PQ, Horning MS and Blakemore LJ:
Carnosine modulates zinc and copper effects on amino acid receptors
and synaptic transmission. Neuroreport. 9:3503–3507. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Andersen JV, Schousboe A and Verkhratsky
A: Astrocyte energy and neurotransmitter metabolism in Alzheimer's
disease: Integration of the glutamate/GABA-glutamine cycle. Prog
Neurobiol. 217:1023312022. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Chern H, Caruso G, Desaire H and Jarosova
R: Carnosine mitigates cognitive impairment and dopamine release in
an okadaic acid-induced zebrafish model with Alzheimer's
disease-like symptoms. ACS Chem Neurosci. 16:790–801. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Shen Y, He P, Fan YY, Zhang JX, Yan HJ, Hu
WW, Ohtsu H and Chen Z: Carnosine protects against permanent
cerebral ischemia in histidine decarboxylase knockout mice by
reducing glutamate excitotoxicity. Free Radic Biol Med. 48:727–735.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Banerjee S, Mukherjee B, Poddar MK and
Dunbar GL: Carnosine improves aging-induced cognitive impairment
and brain regional neurodegeneration in relation to the
neuropathological alterations in the secondary structure of amyloid
beta (Aβ). J Neurochem. 158:710–723. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Brown JM, Baker LS, Seroogy KB and Genter
MB: Intranasal carnosine mitigates α-synuclein pathology and motor
dysfunction in the Thy1-aSyn mouse model of Parkinson's disease.
ACS Chem Neurosci. 12:2347–2359. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Naletova I, Greco V, Sciuto S, Attanasio F
and Rizzarelli E: Ionophore ability of carnosine and its trehalose
conjugate assists copper signal in triggering brain-derived
neurotrophic factor and vascular endothelial growth factor
activation in vitro. Int J Mol Sci. 22:135042021. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Odashima M, Otaka M, Jin M, Wada I,
Horikawa Y, Matsuhashi T, Ohba R, Hatakeyama N, Oyake J and
Watanabe S: Zinc L-carnosine protects colonic mucosal injury
through induction of heat shock protein 72 and suppression of
NF-kappaB activation. Life Sci. 79:2245–2250. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Fresta CG, Fidilio A, Lazzarino G, Musso
N, Grasso M, Merlo S, Amorini AM, Bucolo C, Tavazzi B, Lazzarino G,
et al: Modulation of pro-oxidant and pro-inflammatory activities of
M1 macrophages by the natural dipeptide carnosine. Int J Mol Sci.
21:7762020. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Trushina EN, Riger NA, Mustafina OK,
Timonin AN, Aksenov IV, Guseva GV and Tutelyan VA: Effect of
carnosine and α-lipoic acid on hepatocyte apoptosis and the
cytokine profile in induced fatty liver disease in Wistar rats.
Vopr Pitan. 89:6–16. 2020.In Russian.
|
|
76
|
Meng C, Zhi X, Li C, Li C, Chen Z, Qiu X,
Ding C, Ma L, Lu H, Chen D, et al: Graphene oxides decorated with
carnosine as an adjuvant to modulate innate immune and improve
adaptive immunity in vivo. ACS Nano. 10:2203–2213. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Aldini G, de Courten B, Regazzoni L,
Gilardoni E, Ferrario G, Baron G, Altomare A, D'Amato A, Vistoli G
and Carini M: Understanding the antioxidant and carbonyl
sequestering activity of carnosine: direct and indirect mechanisms.
Free Radic Res. 55:321–330. 2021. View Article : Google Scholar
|
|
78
|
Jamshidzadeh A, Heidari R, Latifpour Z,
Ommati MM, Abdoli N, Mousavi S, Azarpira N, Zarei A, Zarei M, Asadi
B, et al: Carnosine ameliorates liver fibrosis and hyperammonemia
in cirrhotic rats. Clin Res Hepatol Gastroenterol. 41:424–434.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Creighton JV, de Souza Gonçalves L,
Artioli GG, Tan D, Elliott-Sale KJ, Turner MD, Doig CL and Sale C:
Physiological roles of carnosine in myocardial function and health.
Adv Nutr. 13:1914–1929. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Caruso G, Fresta CG, Martinez-Becerra F,
Antonio L, Johnson RT, de Campos RPS, Siegel JM, Wijesinghe MB,
Lazzarino G and Lunte SM: Carnosine modulates nitric oxide in
stimulated murine RAW 264.7 macrophages. Mol Cell Biochem.
431:197–210. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Park IG, Jin SH, An S, Ki MW, Park WS, Kim
HJ, Na Y and Noh M: Carnosine and retinol synergistically inhibit
UVB-induced PGE2 synthesis in human keratinocytes
through the up-regulation of hyaluronan synthase 2. Biomol Ther
(Seoul). 32:635–639. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Impellizzeri D, Siracusa R, Cordaro M,
Peritore AF, Gugliandolo E, D'amico R, Fusco R, Crupi R, Rizzarelli
E, Cuzzocrea S, et al: Protective effect of a new hyaluronic
acid-carnosine conjugate on the modulation of the inflammatory
response in mice subjected to collagen-induced arthritis. Biomed
Pharmacother. 125:1100232020. View Article : Google Scholar
|
|
83
|
Scheltens P, De Strooper B, Kivipelto M,
Holstege H, Chételat G, Teunissen CE, Cummings J and van der Flier
WM: Alzheimer's disease. Lancet. 397:1577–1590. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Zhang H, Dong X and Sun Y:
Carnosine-LVFFARK-NH2 conjugate: A moderate chelator but
potent inhibitor of Cu2+-mediated amyloid β-protein
aggregation. ACS Chem Neurosci. 9:2689–2700. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Kalia LV and Lang AE: Parkinson's disease.
Lancet. 386:896–912. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Kulikova O, Troshev D, Berezhnoy D,
Stvolinsky S, Timoshina Y, Abaimov D, Muzychuk O, Latanov A and
Fedorova T: Neuroprotective efficacy of a nanomicellar complex of
carnosine and lipoic acid in a rat model of rotenone-induced
Parkinson's disease. Antioxidants (Basel). 12:12152023. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Kubota M, Kobayashi N, Sugizaki T, Shimoda
M, Kawahara M and Tanaka KI: Carnosine suppresses neuronal cell
death and inflammation induced by 6-hydroxydopamine in an in vitro
model of Parkinson's disease. PLoS One. 15:e02404482020. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Kulikova OI, Berezhnoy DS, Stvolinsky SL,
Lopachev AV, Orlova VS and Fedorova TN: Neuroprotective effect of
the carnosine-α-lipoic acid nanomicellar complex in a model of
early-stage Parkinson's disease. Regul Toxicol Pharmacol.
95:254–259. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Cole JB and Florez JC: Genetics of
diabetes mellitus and diabetes complications. Nat Rev Nephrol.
16:377–390. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Houjeghani S, Kheirouri S, Faraji E and
Jafarabadi MA: l-Carnosine supplementation attenuated fasting
glucose, triglycerides, advanced glycation end products, and tumor
necrosis factor-α levels in patients with type 2 diabetes: a
double-blind placebo-controlled randomized clinical trial. Nutr
Res. 49:96–106. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Shi Y and Zhang CJ: The effects of
carnosine on high glucose-induced apoptosis of human umbilical vein
endothelial cells. Adv Mat Res. 345:365–369. 2011.
|
|
92
|
Kanwar YS, Sun L, Xie P, Liu FY and Chen
S: A glimpse of various pathogenetic mechanisms of diabetic
nephropathy. Annu Rev Pathol. 6:395–423. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Yay A, Akkuş D, Yapıslar H, Balcıoglu E,
Sonmez MF and Ozdamar S: Antioxidant effect of carnosine treatment
on renal oxidative stress in streptozotocin-induced diabetic rats.
Biotech Histochem. 89:552–557. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Peters V, Yard B and Schmitt CP: Carnosine
and diabetic nephropathy. Curr Med Chem. 27:1801–1812. 2020.
View Article : Google Scholar
|
|
95
|
Albrecht T, Schilperoort M, Zhang S, Braun
JD, Qiu J, Rodriguez A, Pastene DO, Krämer BK, Köppel H, Baelde H,
et al: Carnosine attenuates the development of both type 2 diabetes
and diabetic nephropathy in BTBR ob/ob mice. Sci Rep. 7:444922017.
View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Zhu W, Li YY, Zeng HX, Liu XQ, Sun YT,
Jiang L, Xia LL and Wu YG: Carnosine alleviates podocyte injury in
diabetic nephropathy by targeting caspase-1-mediated pyroptosis.
Int Immunopharmacol. 101:1082362021. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Zhang S, Li Y, Liu X, Guo S, Jiang L,
Huang Y and Wu Y: Carnosine alleviates kidney tubular epithelial
injury by targeting NRF2 mediated ferroptosis in diabetic
nephropathy. Amino Acids. 55:1141–1155. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Liu XQ, Jiang L, Lei L, Nie ZY, Zhu W,
Wang S, Zeng HX, Zhang SQ, Zhang Q, Yard B and Wu YG: Carnosine
alleviates diabetic nephropathy by targeting GNMT, a key enzyme
mediating renal inflammation and fibrosis. Clin Sci (Lond).
134:3175–3193. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Falk E: Pathogenesis of atherosclerosis. J
Am Coll Cardiol. 47(Suppl 8): C7–C12. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Feehan J, Hariharan R, Buckenham T,
Handley C, Bhatnagar A, Baba SP and de Courten B: Carnosine as a
potential therapeutic for the management of peripheral vascular
disease. Nutr Metab Cardiovasc Dis. 32:2289–2296. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Hwang B, Song JH, Park SL, Kim JT, Kim WJ
and Moon SK: Carnosine impedes PDGF-stimulated proliferation and
migration of vascular smooth muscle cells in vitro and sprout
outgrowth ex vivo. Nutrients. 12:26972020. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Algoet M, Janssens S, Himmelreich U, Gsell
W, Pusovnik M, Van den Eynde J and Oosterlinck W: Myocardial
ischemia-reperfusion injury and the influence of inflammation.
Trends Cardiovasc Med. 33:357–366. 2023. View Article : Google Scholar
|
|
103
|
Lee JW, Miyawaki H, Bobst EV, Hester JD,
Ashraf M and Bobst AM: Improved functional recovery of ischemic rat
hearts due to singlet oxygen scavengers histidine and carnosine. J
Mol Cell Cardiol. 31:113–121. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Toufektsian MC, Morel S, Tanguy S, Jeunet
A, de Leiris J and Boucher F: Involvement of reactive oxygen
species in cardiac preconditioning in rats. Antioxid Redox Signal.
5:115–122. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Zhao J, Conklin DJ, Guo Y, Zhang X, Obal
D, Guo L, Jagatheesan G, Katragadda K, He L, Yin X, et al:
Cardiospecific overexpression of ATPGD1 (carnosine synthase)
increases histidine dipeptide levels and prevents myocardial
ischemia reperfusion injury. J Am Heart Assoc. 9:e0152222020.
View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Moloney JN and Cotter TG: ROS signalling
in the biology of cancer. Semin Cell Dev Biol. 80:50–64. 2018.
View Article : Google Scholar
|
|
107
|
Turner MD, Sale C, Garner AC and Hipkiss
AR: Anti-cancer actions of carnosine and the restoration of normal
cellular homeostasis. Biochim Biophys Acta Mol Cell Res.
1868:1191172021. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Ooi TC, Chan KM and Sharif R: Antioxidant,
anti-inflammatory, and genomic stability enhancement effects of
zinc l-carnosine: A potential cancer chemopreventive agent? Nutr
Cancer. 69:201–210. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Guney Y, Turkcu UO, Hicsonmez A, Andrieu
MN, Guney HZ, Bilgihan A and Kurtman C: Carnosine may reduce lung
injury caused by radiation therapy. Med Hypotheses. 66:957–959.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Yanase K, Funaguchi N, Iihara H, Yamada M,
Kaito D, Endo J, Ito F, Ohno Y, Tanaka H, Itoh Y, et al: Prevention
of radiation esophagitis by polaprezinc (zinc L-carnosine) in
patients with non-small cell lung cancer who received
chemoradiotherapy. Int J Clin Exp Med. 8:16215–16222.
2015.PubMed/NCBI
|
|
111
|
Gaafar PME, El-Salamouni NS, Farid RM,
Hazzah HA, Helmy MW and Abdallah OY: Pegylated liquisomes: A novel
combined passive targeting nanoplatform of L-carnosine for breast
cancer. Int J Pharm. 602:1206662021. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Aggarwal N, Singh G, Panda HS and Panda
JJ: Unravelling the potential of L-carnosine analog-based
nano-assemblies as pH-responsive therapeutics in treating glioma:
An in vitro perspective. J Mater Chem B. 12:10665–10681. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Chuang CH and Hu ML: L-carnosine inhibits
metastasis of SK-Hep-1 cells by inhibition of matrix
metaoproteinase-9 expression and induction of an antimetastatic
gene, nm23-H1. Nutr Cancer. 60:526–533. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Wu CC, Lai PY, Hsieh S, Cheng CC and Hsieh
SL: Suppression of carnosine on adhesion and extravasation of human
colorectal cancer cells. Anticancer Res. 39:6135–6144. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Lei L, Nan B, Yang F, Xu L, Guan G, Xu J,
Yue R, Wang Y, Huan S, Yin X, et al: Zinc-Carnosine metallodrug
network as dual metabolism inhibitor overcoming metabolic
reprogramming for efficient cancer therapy. Nano Lett.
23:2659–2668. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Lee J, Park JR, Lee H, Jang S, Ryu SM, Kim
H, Kim D, Jang A and Yang SR: L-carnosine induces apoptosis/cell
cycle arrest via suppression of NF-κB/STAT1 pathway in HCT116
colorectal cancer cells. In Vitro Cell Dev Biol Anim. 54:505–512.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Asbell PA, Dualan I, Mindel J, Brocks D,
Ahmad M and Epstein S: Age-related cataract. Lancet. 365:599–609.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Dubois VD and Bastawrous A:
N-acetylcarnosine (NAC) drops for age-related cataract. Cochrane
Database Syst Rev. 2:CD0094932017.PubMed/NCBI
|
|
119
|
Babizhayev MA, Guiotto A and Kasus-Jacobi
A: N-Acetylcarnosine and histidyl-hydrazide are potent agents for
multitargeted ophthalmic therapy of senile cataracts and diabetic
ocular complications. J Drug Target. 17:36–63. 2009. View Article : Google Scholar
|
|
120
|
Liao JH, Lin IL, Huang KF, Kuo PT, Wu SH
and Wu TH: Carnosine ameliorates lens protein turbidity formations
by inhibiting calpain proteolysis and ultraviolet C-induced
degradation. J Agric Food Chem. 62:5932–5938. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Guymer RH and Campbell TG: Age-related
macular degeneration. Lancet. 401:1459–1472. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Caruso G, Fresta CG, Fidilio A, Lazzara F,
Musso N, Cardaci V, Drago F, Caraci F and Bucolo C: Carnosine
counteracts the molecular alterations Aβ oligomers-induced in human
retinal pigment epithelial cells. Molecules. 28:33242023.
View Article : Google Scholar
|
|
123
|
Kim HG, Heo H, Sung MS and Park SW:
Carnosine decreases retinal ganglion cell death in a mouse model of
optic nerve crushing. Neurosci Lett. 711:1344312019. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Li S, Li H, Bennewitz K, Poschet G,
Buettner M, Hausser I, Szendroedi J, Nawroth PP and Kroll J:
Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1
amplifies dicarbonyl stress, impairs proteasome activity resulting
in hyperglycemia and activated retinal angiogenesis. Metabolism.
165:1561492025. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Pfister F, Riedl E, Wang Q, vom Hagen F,
Deinzer M, Harmsen MC, Molema G, Yard B, Feng Y and Hammes HP: Oral
carnosine supplementation prevents vascular damage in experimental
diabetic retinopathy. Cell Physiol Biochem. 28:125–136. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Hariharan R, Cameron J, Menon K, Mesinovic
J, Jansons P, Scott D, Lu ZX, de Courten M, Feehan J and de Courten
B: Carnosine supplementation improves glucose control in adults
with pre-diabetes and type 2 diabetes: A randomised controlled
trial. Nutr Metab Cardiovasc Dis. 34:485–496. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
de Courten B, Jakubova M, de Courten MP,
Kukurova IJ, Vallova S, Krumpolec P, Valkovic L, Kurdiova T, Garzon
D, Barbaresi S, et al: Effects of carnosine supplementation on
glucose metabolism: Pilot clinical trial. Obesity (Silver Spring).
24:1027–1034. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Saadati S, de Courten M, Deceneux C,
Plebanski M, Scott D, Mesinovic J, Jansons P, Aldini G, Cameron J,
Feehan J, et al: Carnosine supplementation Has No effect on
inflammatory markers in adults with prediabetes and type 2
diabetes: A randomised controlled trial. Nutrients. 16:39002024.
View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Siriwattanasit N, Satirapoj B and
Supasyndh O: Effect of Oral carnosine supplementation on urinary
TGF-β in diabetic nephropathy: A randomized controlled trial. BMC
Nephrol. 22:2362021. View Article : Google Scholar
|
|
130
|
Saadati S, Jansons P, Scott D, de Courten
M, Mousa A, Feehan J, Mesinovic J and de Courten B: The effect of
carnosine supplementation on musculoskeletal health in adults with
prediabetes and type 2 diabetes: A secondary analysis of a
randomized controlled trial. Nutrients. 16:43282024. View Article : Google Scholar :
|
|
131
|
Saadati S, Cameron J, Menon K, Hodge A, Lu
ZX, de Courten M, Feehan J and de Courten B: Carnosine did not
affect vascular and metabolic outcomes in patients with prediabetes
and type 2 diabetes: A 14-week randomized controlled trial.
Nutrients. 15:48352023. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Baye E, Ukropec J, de Courten MPJ, Mousa
A, Kurdiova T, Johnson J, Wilson K, Plebanski M, Aldini G,
Ukropcova B and de Courten B: Carnosine supplementation improves
serum resistin concentrations in overweight or obese otherwise
healthy adults: A pilot randomized trial. Nutrients. 10:12582018.
View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Baye E, Ukropec J, de Courten MP, Vallova
S, Krumpolec P, Kurdiova T, Aldini G, Ukropcova B and de Courten B:
Effect of carnosine supplementation on the plasma lipidome in
overweight and obese adults: A pilot randomised controlled trial.
Sci Rep. 7:174582017. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Abraham DA, Narasimhan U, Mahalingam VT,
Krishnan M, Ganesan RM, Goh KW, Tan CS, Ming LC and Ardianto C:
Estimation of plasma concentration of L-carnosine and its
correlation with core symptoms of autism spectrum disorder
children: A pilot clinical trial. Front Biosci (Landmark Ed).
29:3652024. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Mehrazad-Saber Z, Kheirouri S and Noorazar
SG: Effects of l-carnosine supplementation on sleep disorders and
disease severity in autistic children: A randomized, controlled
clinical trial. Basic Clin Pharmacol Toxicol. 123:72–77. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
136
|
O'Toole TE, Amraotkar AR, Gao H, Sears CG,
Rai SN, Basner M and Bhatnagar A: Carnosine supplementation
improves cognitive outcomes in younger participants of the NEAT
trial. Neurotherapeutics. 22:e005412025. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Zanini D, Jezdimirovic T, Stajer V,
Ostojic J, Maksimovic N and Ostojic SM: Dietary supplementation
with L-carnosine improves patient-reported outcomes, autonomic
nervous system performance, and brain metabolism in 3 adult
patients with multiple sclerosis. Nutr Res. 84:63–69. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Tharoor H, Maran S, Chandan AK, Pari M,
Rao S and Durairaj J: Cognitive and negative symptoms in
schizophrenia with L-Carnosine adjuvant therapy-A randomized
double-blind placebo-controlled study. Pharmacol Res Perspect.
11:e010742023. View Article : Google Scholar
|
|
139
|
Slowinska-Lisowska M, Zembron-Lacny A,
Rynkiewicz M, Rynkiewicz T and Kopec W: Influence of l-carnosine on
pro-antioxidant status in elite kayakers and canoeists. Acta
Physiol Hung. 101:461–470. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Yehia R, Saleh S, El Abhar H, Saad AS and
Schaalan M: L-Carnosine protects against Oxaliplatin-induced
peripheral neuropathy in colorectal cancer patients: A perspective
on targeting Nrf-2 and NF-κB pathways. Toxicol Appl Pharmacol.
365:41–50. 2019. View Article : Google Scholar
|
|
141
|
Rondanelli M, Gasparri C, Cavioni A,
Sivieri C, Barrile GC, Mansueto F and Perna S: A Patented dietary
supplement (hydroxy-methyl-butyrate, carnosine, magnesium,
butyrate, lactoferrin) is a promising therapeutic target for
age-related sarcopenia through the regulation of gut permeability:
A randomized controlled trial. Nutrients. 16:13692024. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Masuoka N, Yoshimine C, Hori M, Tanaka M,
Asada T, Abe K and Hisatsune T: Effects of anserine/carnosine
supplementation on mild cognitive impairment with APOE4. Nutrients.
11:16262019. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Saldi S, Perrucci E, Fulcheri CPL,
Mariucci C, Chierchini S, Ingrosso G, Falcinelli L, Podlesko AM,
Merluzzi M, Bini V and Aristei C: Zinc-L-carnosine prevented
dysphagia in breast cancer patients undergoing adjuvant
radiotherapy: Results of a phase III randomized trial. Breast J.
26:1882–1884. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Itagaki M, Saruta M, Saijo H, Mitobe J,
Arihiro S, Matsuoka M, Kato T, Ikegami M and Tajiri H: Efficacy of
zinc-carnosine chelate compound, Polaprezinc, enemas in patients
with ulcerative colitis. Scand J Gastroenterol. 49:164–172. 2014.
View Article : Google Scholar
|
|
145
|
Sakae K, Agata T, Kamide R and Yanagisawa
H: Effects of L-carnosine and its zinc complex (Polaprezinc) on
pressure ulcer healing. Nutr Clin Pract. 28:609–616. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Mutolo MG, Albanese G, Rusciano D and
Pescosolido N: Oral administration of forskolin, homotaurine,
carnosine, and folic acid in patients with primary open angle
glaucoma: Changes in intraocular pressure, pattern
electroretinogram amplitude, and foveal sensitivity. J Ocul
Pharmacol Ther. 32:178–183. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Elbarbary NS, Ismail EAR, El-Naggar AR,
Hamouda MH and El-Hamamsy M: The effect of 12 weeks carnosine
supplementation on renal functional integrity and oxidative stress
in pediatric patients with diabetic nephropathy: A randomized
placebo-controlled trial. Pediatr Diabetes. 19:470–477. 2018.
View Article : Google Scholar
|
|
148
|
Lombardi C, Carubelli V, Lazzarini V,
Vizzardi E, Bordonali T, Ciccarese C, Castrini AI, Dei Cas A,
Nodari S and Metra M: Effects of oral administration of
orodispersible levo-carnosine on quality of life and exercise
performance in patients with chronic heart failure. Nutrition.
31:72–78. 2015. View Article : Google Scholar
|
|
149
|
Araminia B, Shalbafan M, Mortezaei A,
Shirazi E, Ghaffari S, Sahebolzamani E, Mortazavi SH, Shariati B,
Ardebili ME, Aqamolaei A, et al: L-Carnosine combination therapy
for major depressive disorder: A randomized, double-blind,
placebo-controlled trial. J Affect Disord. 267:131–136. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Arabzadeh S, Shahhossenie M, Mesgarpour B,
Rezaei F, Shalbafan MR, Ghiasi Z and Akhondzadeh S: L-carnosine as
an adjuvant to fluvoxamine in treatment of obsessive compulsive
disorder: A randomized double-blind study. Hum Psychopharmacol.
32:2017. View Article : Google Scholar : PubMed/NCBI
|
|
151
|
Ghajar A, Khoaie-Ardakani MR, Shahmoradi
Z, Alavi AR, Afarideh M, Shalbafan MR, Ghazizadeh-Hashemi M and
Akhondzadeh S: L-carnosine as an add-on to risperidone for
treatment of negative symptoms in patients with stable
schizophrenia: A double-blind, randomized placebo-controlled trial.
Psychiatry Res. 262:94–101. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Chengappa KN, Turkin SR, DeSanti S, Bowie
CR, Brar JS, Schlicht PJ, Murphy SL, Hetrick ML, Bilder R and Fleet
D: A preliminary, randomized, double-blind, placebo-controlled
trial of L-carnosine to improve cognition in schizophrenia.
Schizophr Res. 142:145–152. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Ghajar A, Aghajan-Nashtaei F, Afarideh M,
Mohammadi MR and Akhondzadeh S: l-Carnosine as adjunctive therapy
in children and adolescents with attention-deficit/hyperactivity
disorder: a randomized, double-blind, placebo-controlled clinical
trial. J Child Adolesc Psychopharmacol. 28:331–338. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Hajizadeh-Zaker R, Ghajar A, Mesgarpour B,
Afarideh M, Mohammadi MR and Akhondzadeh S: l-Carnosine as an
adjunctive therapy to risperidone in children with autistic
disorder: A randomized, double-blind, placebo-controlled trial. J
Child Adolesc Psychopharmacol. 28:74–81. 2018. View Article : Google Scholar
|
|
155
|
Ann Abraham D, Narasimhan U, Christy S and
Muhasaparur Ganesan R: Effect of L-Carnosine as adjunctive therapy
in the management of children with autism spectrum disorder: A
randomized controlled study. Amino Acids. 52:1521–1528. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
156
|
Hu X, Fukui Y, Feng T, Bian Z, Yu H,
Morihara R, Hu X, Bian Y, Sun H, Takemoto M, et al: Neuroprotective
effects of carnosine in a mice stroke model concerning oxidative
stress and inflammatory response. J Neurol Sci. 447:1206082023.
View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Wu T, Tao Y, Tsang F, Abe K, Xu L, Jiang
Q, Xu L, Fu H and Fu Z: The effect of L-carnosine on the circadian
resetting of clock genes in the heart of rats. Mol Biol Rep.
42:87–94. 2015. View Article : Google Scholar
|
|
158
|
Dai Z, Lu XY, Zhu WL, Liu XQ, Li BY, Song
L, Liu HF, Cai WW, Deng YX, Xu TT, et al: Carnosine ameliorates
age-related dementia via improving mitochondrial dysfunction in
SAMP8 mice. Food Funct. 11:2489–2497. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
159
|
Afshin-Majd S, Khalili M, Roghani M,
Mehranmehr N and Baluchnejadmojarad T: Carnosine exerts
neuroprotective effect against 6-hydroxydopamine toxicity in
hemiparkinsonian rat. Mol Neurobiol. 51:1064–1070. 2015. View Article : Google Scholar
|
|
160
|
Evran B, Karpuzoğlu H, Develi S, Kalaz EB,
Soluk-Tekkeşin M, Olgaç V, Doğru-Abbasoğlu S and Uysal M: Effects
of carnosine on prooxidant-antioxidant status in heart tissue,
plasma and erythrocytes of rats with isoproterenol-induced
myocardial infarction. Pharmacol Rep. 66:81–86. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Holeček M: Side effects of amino acid
supplements. Physiol Res. 71:29–45. 2022. View Article : Google Scholar
|
|
162
|
Bae ON, Serfozo K, Baek SH, Lee KY,
Dorrance A, Rumbeiha W, Fitzgerald SD, Farooq MU, Naravelta B,
Bhatt A and Majid A: Safety and efficacy evaluation of carnosine,
an endogenous neuroprotective agent for ischemic stroke. Stroke.
44:205–212. 2013. View Article : Google Scholar :
|
