|
1
|
Ahmadzadeh E, Polglase GR, Stojanovska V,
Herlenius E, Walker DW, Miller SL and Allison BJ: Does fetal growth
restriction induce neuropathology within the developing brainstem?
J Physiol. 601:4667–4689. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Lawn JE, Ohuma EO, Bradley E, Idueta LS,
Hazel E, Okwaraji YB, Erchick DJ, Yargawa J, Katz J, Lee ACC, et
al: Small babies, big risks: Global estimates of prevalence and
mortality for vulnerable newborns to accelerate change and improve
counting. Lancet. 401:1707–1719. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Jardine J, Walker K, Gurol-Urganci I,
Webster K, Muller P, Hawdon J, Khalil A, Harris T and van der
Meulen J; National Maternity Perinatal Audit Project Team: Adverse
pregnancy outcomes attributable to socioeconomic and ethnic
inequalities in England: A national cohort study. Lancet.
398:1905–1912. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Reynolds LP, Borowicz PP, Caton JS, Crouse
MS, Dahlen CR and Ward AK: Developmental programming of fetal
growth and development. Vet Clin North Am Food Anim Pract.
35:229–247. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Hendrix MLE, Bons JA, Alers NO,
Severens-Rijvers CAH, Spaanderman MEA and Al-Nasiry S: Maternal
vascular malformation in the placenta is an indicator for fetal
growth restriction irrespective of neonatal birthweight. Placenta.
87:8–15. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Zur RL, Kingdom JC, Parks WT and Hobson
SR: The placental basis of fetal growth restriction. Obstet Gynecol
Clin North Am. 47:81–98. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
D'Agostin M, Di Sipio Morgia C, Vento G
and Nobile S: Long-term implications of fetal growth restriction.
World J Clin Cases. 11:2855–2863. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Perez M, Robbins ME, Revhaug C and
Saugstad OD: Oxygen radical disease in the newborn, revisited:
Oxidative stress and disease in the newborn period. Free Radic Biol
Med. 142:61–72. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Joo EH, Kim YR, Kim N, Jung JE, Han SH and
Cho HY: Effect of endogenic and exogenic oxidative stress triggers
on adverse pregnancy outcomes: Preeclampsia, fetal growth
restriction, gestational diabetes mellitus and preterm birth. Int J
Mol Sci. 22:101222021. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Lee C, Zeng J, Drew BG, Sallam T,
Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R
and Cohen P: The mitochondrial-derived peptide MOTS-c promotes
metabolic homeostasis and reduces obesity and insulin resistance.
Cell Metab. 21:443–454. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kim KH, Son JM, Benayoun BA and Lee C: The
mitochondrial-encoded peptide MOTS-c translocates to the nucleus to
regulate nuclear gene expression in response to metabolic stress.
Cell Metab. 28:516–524.e7. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Shen C, Wang J, Feng M, Peng J, Du X, Chu
H and Chen X: The mitochondrial-derived peptide MOTS-c attenuates
oxidative stress injury and the inflammatory response of H9c2 cells
through the Nrf2/ARE and NF-κB pathways. Cardiovasc Eng Technol.
13:651–661. 2022. View Article : Google Scholar
|
|
13
|
Xiao J, Zhang Q, Shan Y, Ye F, Zhang X,
Cheng J, Wang X, Zhao Y, Dan G, Chen M and Sai Y: The
mitochondrial-derived peptide (MOTS-c) interacted with Nrf2 to
defend the antioxidant system to protect dopaminergic neurons
against rotenone exposure. Mol Neurobiol. 60:5915–5930. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kim SJ, Miller B, Kumagai H, Silverstein
AR, Flores M and Yen K: Mitochondrial-derived peptides in aging and
age-related diseases. Geroscience. 43:1113–1121. 2021. View Article : Google Scholar :
|
|
15
|
Li Y, Li Z, Ren Y, Lei Y, Yang S, Shi Y,
Peng H, Yang W, Guo T, Yu Y and Xiong Y: Mitochondrial-derived
peptides in cardiovascular disease: Novel insights and therapeutic
opportunities. J Adv Res. 64:99–115. 2024. View Article : Google Scholar :
|
|
16
|
Wu N, Shen C, Wang J, Chen X and Zhong P:
MOTS-c peptide attenuated diabetic cardiomyopathy in STZ-induced
type 1 diabetic mouse model. Cardiovasc Drugs Ther. 39:491–498.
2025. View Article : Google Scholar
|
|
17
|
Yang M, Chen W, He L, Wang X, Liu D, Xiao
L and Sun L: The role of mitokines in diabetic nephropathy. Curr
Med Chem. 32:1276–1287. 2025. View Article : Google Scholar
|
|
18
|
Itoh K, Chiba T, Takahashi S, Ishii T,
Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K and Hatayama I: An
Nrf2/small Maf heterodimer mediates the induction of phase II
detoxifying enzyme genes through antioxidant response elements.
Biochem Biophys Res Commun. 236:313–322. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Ulasov AV, Rosenkranz AA, Georgiev GP and
Sobolev AS: Nrf2/Keap1/ARE signaling: Towards specific regulation.
Life Sci. 291:1201112022. View Article : Google Scholar
|
|
20
|
Fasipe B, Li S and Laher I: Exercise and
vascular function in sedentary lifestyles in humans. Pflugers Arch.
475:845–856. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wang DD, Xu B, Sun JJ, Sui M, Li SP, Chen
YJ, Zhang YL, Wu JB, Teng SY, Pang QF and Hu CX: MOTS-c mimics
remote ischemic preconditioning in protecting against lung
ischemia-reperfusion injury by alleviating endothelial barrier
dysfunction. Free Radic Biol Med. 229:127–138. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Zhang Y, Huang J, Zhang Y, Jiang F, Li S,
He S, Sun J, Chen D, Tong Y, Pang Q and Wu Y: The
mitochondrial-derived peptide MOTS-c alleviates radiation
pneumonitis via an Nrf2-dependent mechanism. Antioxidants (Basel).
13:6132024. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Lamberto F, Peral-Sanchez I, Muenthaisong
S, Zana M, Willaime-Morawek S and Dinnyés A: Environmental
alterations during embryonic development: Studying the impact of
stressors on pluripotent stem cell-derived cardiomyocytes. Genes
(Basel). 12:15642021. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Kweider N, Huppertz B, Rath W, Lambertz J,
Caspers R, ElMoursi M, Pecks U, Kadyrov M, Fragoulis A, Pufe T and
Wruck CJ: The effects of Nrf2 deletion on placental morphology and
exchange capacity in the mouse. J Matern Fetal Neonatal Med.
30:2068–2073. 2017. View Article : Google Scholar
|
|
25
|
The American Association for:
Accreditation of Laboratory Animal Care. JAMA. 207:17071969.
View Article : Google Scholar
|
|
26
|
Wang KCW, Larcombe AN, Berry LJ, Morton
JS, Davidge ST, James AL and Noble PB: Foetal growth restriction in
mice modifies postnatal airway responsiveness in an age and
sex-dependent manner. Clin Sci (Lond). 132:273–284. 2018.
View Article : Google Scholar
|
|
27
|
Kalotas JO, Wang CJ, Noble PB and Wang
KCW: Intrauterine growth restriction promotes postnatal airway
hyperresponsiveness independent of allergic disease. Front Med
(Lausanne). 8:6743242021. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Chen D, Wang YY, Li SP, Zhao HM, Jiang FJ,
Wu YX, Tong Y and Pang QF: Maternal propionate supplementation
ameliorates glucose and lipid metabolic disturbance in
hypoxia-induced fetal growth restriction. Food Funct.
13:10724–10736. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Chen D, Man LY, Wang YY, Zhu WY, Zhao HM,
Li SP, Zhang YL, Li SC, Wu YX, Ling-Ai and Pang QF: Nrf2 deficiency
exacerbated pulmonary pyroptosis in maternal hypoxia-induced
intrauterine growth restriction offspring mice. Reprod Toxicol.
129:1086712024. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Lu H, Tang S, Xue C, Liu Y, Wang J, Zhang
W, Luo W and Chen J: Mitochondrial-derived peptide MOTS-c increases
adipose thermogenic activation to promote cold adaptation. Int J
Mol Sci. 20:24562019. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tang M, Su Q, Duan Y, Fu Y, Liang M, Pan
Y, Yuan J, Wang M, Pang X, Ma J, et al: The role of MOTS-c-mediated
antioxidant defense in aerobic exercise alleviating diabetic
myocardial injury. Sci Rep. 13:197812023. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Li Z, LoBue A, Heuser SK, Li J, Engelhardt
E, Papapetropoulos A, Patel HH, Lilley E, Ferdinandy P, Schulz R
and Cortese-Krott MM: Best practices for blood collection and
anaesthesia in mice: Selection, application and reporting. Br J
Pharmacol. 182:2337–2353. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Mohamed AS, Hosney M, Bassiony H,
Hassanein SS, Soliman AM, Fahmy SR and Gaafar K: Sodium
pentobarbital dosages for exsanguination affect biochemical,
molecular and histological measurements in rats. Sci Rep.
10:3782020. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Chen D, Qiu YB, Gao ZQ, Wu YX, Wan BB, Liu
G, Chen JL, Zhou Q, Yu RQ and Pang QF: Sodium propionate attenuates
the lipopolysaccharide-induced epithelial-mesenchymal transition
via the PI3K/Akt/mTOR signaling pathway. J Agric Food Chem.
68:6554–6563. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Xia Y, Liu C, Li R, Zheng M, Feng B, Gao
J, Long X, Li L, Li S, Zuo X and Li Y: Lactobacillus-derived
indole-3-lactic acid ameliorates colitis in cesarean-born offspring
via activation of aryl hydrocarbon receptor. iScience.
26:1082792023. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Chen Y, Wu Q, Wei J, Hu J and Zheng S:
Effects of aspirin, vitamin D3, and progesterone on pregnancy
outcomes in an autoimmune recurrent spontaneous abortion model.
Braz J Med Biol Res. 54:e95702021. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Coin I, Beyermann M and Bienert M:
Solid-phase peptide synthesis: From standard procedures to the
synthesis of difficult sequences. Nat Protoc. 2:3247–3256. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Jia Y, Wang Q, Liang M and Huang K: KPNA2
promotes angiogenesis by regulating STAT3 phosphorylation. J Transl
Med. 20:6272022. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Chen D, Gao ZQ, Wang YY, Wan BB, Liu G,
Chen JL, Wu YX, Zhou Q, Jiang SY, Yu RQ, et al: Sodium propionate
enhances Nrf2-mediated protective defense against oxidative stress
and inflammation in lipopolysaccharide-induced neonatal mice. J
Inflamm Res. 14:803–816. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
41
|
Pérez-Gutiérrez L and Ferrara N: Biology
and therapeutic targeting of vascular endothelial growth factor A.
Nat Rev Mol Cell Biol. 24:816–834. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Vornic I, Buciu V, Furau CG, Gaje PN,
Ceausu RA, Dumitru CS, Barb AC, Novacescu D, Cumpanas AA, Latcu SC,
et al: Oxidative stress and placental pathogenesis: A contemporary
overview of potential biomarkers and emerging therapeutics. Int J
Mol Sci. 25:121952024. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Knöfler M, Haider S, Saleh L, Pollheimer
J, Gamage TKJB and James J: Human placenta and trophoblast
development: Key molecular mechanisms and model systems. Cell Mol
Life Sci. 76:3479–3496. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Murray AJ: Oxygen delivery and
fetal-placental growth: Beyond a question of supply and demand?
Placenta. 33(Suppl 2): e16–e22. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Ducsay CA, Goyal R, Pearce WJ, Wilson S,
Hu XQ and Zhang L: Gestational hypoxia and developmental
plasticity. Physiol Rev. 98:1241–1334. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Su EJ, Xin H, Yin P, Dyson M, Coon J,
Farrow KN, Mestan KK and Ernst LM: Impaired fetoplacental
angiogenesis in growth-restricted fetuses with abnormal umbilical
artery doppler velocimetry is mediated by aryl hydrocarbon receptor
nuclear translocator (ARNT). J Clin Endocrinol Metab. 100:E30–E40.
2015. View Article : Google Scholar :
|
|
47
|
Carr DJ, David AL, Aitken RP, Milne JS,
Borowicz PP, Wallace JM and Redmer DA: Placental vascularity and
markers of angiogenesis in relation to prenatal growth status in
overnourished adolescent ewes. Placenta. 46:79–86. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Hu C, Yang Y, Deng M, Yang L, Shu G, Jiang
Q, Zhang S, Li X, Yin Y, Tan C and Wu G: Placentae for low birth
weight piglets are vulnerable to oxidative stress, mitochondrial
dysfunction, and impaired angiogenesis. Oxid Med Cell Longev.
2020:87154122020. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Hu C, Wu Z, Huang Z, Hao X, Wang S, Deng
J, Yin Y and Tan C: Nox2 impairs VEGF-A-induced angiogenesis in
placenta via mitochondrial ROS-STAT3 pathway. Redox Biol.
45:1020512021. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Wu Z, Nie J, Wu D, Huang S, Chen J, Liang
H, Hao X, Feng L, Luo H and Tan C: Dietary adenosine
supplementation improves placental angiogenesis in IUGR piglets by
up-regulating adenosine A2a receptor. Anim Nutr. 13:282–288. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Lanng MB, Møller CB, Andersen ASH,
Pálsdóttir AA, Røge R, Østergaard LR and Jørgensen AS: Quality
assessment of Ki67 staining using cell line proliferation index and
stain intensity features. Cytometry A. 95:381–388. 2019. View Article : Google Scholar
|
|
52
|
Bullwinkel J, Baron-Lühr B, Lüdemann A,
Wohlenberg C, Gerdes J and Scholzen T: Ki-67 protein is associated
with ribosomal RNA transcription in quiescent and proliferating
cells. J Cell Physiol. 206:624–635. 2006. View Article : Google Scholar
|
|
53
|
Li C, Xiao N, Song W, Lam AHC, Liu F, Cui
X, Ye Z, Chen Y, Ren P, Cai J, et al: Chronic lung inflammation and
CK14+ basal cell proliferation induce persistent
alveolar-bronchiolization in SARS-CoV-2-infected hamsters.
EBioMedicine. 108:1053632024. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Devi K, Tomar MS, Barsain M, Shrivastava A
and Moharana B: Regeneration capability of neonatal lung-derived
decellularized extracellular matrix in an emphysema model. J
Control Release. 372:234–250. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Xinqiang Y, Quan C, Yuanyuan J and Hanmei
X: Protective effect of MOTS-c on acute lung injury induced by
lipopolysaccharide in mice. Int Immunopharmacol. 80:1061742020.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Wu F, Tian FJ and Lin Y: Oxidative stress
in placenta: Health and diseases. Biomed Res Int. 2015:2932712015.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Biri A, Bozkurt N, Turp A, Kavutcu M,
Himmetoglu O and Durak I: Role of oxidative stress in intrauterine
growth restriction. Gynecol Obstet Invest. 64:187–192. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Hu XQ and Zhang L: Hypoxia and
Mitochondrial dysfunction in pregnancy complications. Antioxidants
(Basel). 10:4052021. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Kaandorp JJ, Benders MJNL, Schuit E,
Rademaker CM, Oudijk MA, Porath MM, Oetomo SB, Wouters MG, van
Elburg RM, Franssen MT, et al: Maternal allopurinol administration
during suspected fetal hypoxia: A novel neuroprotective
intervention? A multicentre randomised placebo controlled trial.
Arch Dis Child Fetal Neonatal Ed. 100:F216–F223. 2015. View Article : Google Scholar
|
|
60
|
Klumper J, Kaandorp JJ, Schuit E,
Groenendaal F, Koopman-Esseboom C, Mulder EJH, Van Bel F, Benders
MJNL, Mol BWJ, van Elburg RM, et al: Behavioral and
neurodevelopmental outcome of children after maternal allopurinol
administration during suspected fetal hypoxia: 5-year follow up of
the ALLO-trial. PLoS One. 13:e02010632018. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Rashid CS, Bansal A and Simmons RA:
Oxidative stress, intrauterine growth restriction, and
developmental programming of type 2 diabetes. Physiology
(Bethesda). 33:348–359. 2018.PubMed/NCBI
|
|
62
|
Shaw P and Chattopadhyay A: Nrf2-ARE
signaling in cellular protection: Mechanism of action and the
regulatory mechanisms. J Cell Physiol. 235:3119–3130. 2020.
View Article : Google Scholar
|
|
63
|
Zhou H, Wang Y, You Q and Jiang Z: Recent
progress in the development of small molecule Nrf2 activators: A
patent review (2017-present). Expert Opin Ther Pat. 30:209–225.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Acar N, Soylu H, Edizer I, Ozbey O, Er H,
Akkoyunlu G, Gemici B and Ustunel I: Expression of nuclear factor
erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6)
proteins in healthy and pathologic placentas of human and rat. Acta
Histochem. 116:1289–1300. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Chen S, Yin Q, Hu H, Chen Q, Huang Q and
Zhong M: AOPPs induce HTR-8/SVneo cell apoptosis by downregulating
the Nrf-2/ARE/HO-1 anti-oxidative pathway: Potential implications
for preeclampsia. Placenta. 112:1–8. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J,
Liu H and Liu Z: MOTS-c functionally prevents metabolic disorders.
Metabolites. 13:1252023. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Knoop A, Thomas A and Thevis M:
Development of a mass spectrometry based detection method for the
mitochondrion-derived peptide MOTS-c in plasma samples for doping
control purposes. Rapid Commun Mass Spectrom. 33:371–380. 2019.
View Article : Google Scholar
|
