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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February-2026 Volume 57 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

  • Authors:
    • Yan Wang
    • Baowei Feng
    • Yanting Wu
    • Zongle Sun
    • Hao Yuan
    • Wei Chen
    • Chang Zhao
    • Zhi Liu

  • View Affiliations / Copyright

    Affiliations: College of Integration of Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China, College of Clinical Medicine, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China, Changchun Humanities and Sciences College, Changchun, Jilin 130118, P.R. China, College of the First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 34
    |
    Published online on: December 2, 2025
       https://doi.org/10.3892/ijmm.2025.5705
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Abstract

Ischemic heart disease remains the leading cause of global disease burden among cardiovascular disorders. In addition to cardiomyocyte injury, ischemia-reperfusion (I/R)-induced microvascular damage plays a crucial role in determining tissue dysfunction and overall prognosis. Mitochondria-associated endoplasmic reticulum membranes (MAMs), specialized contact sites between the ER and mitochondria, are now recognized as key regulators of cardiovascular pathophysiology. The present review summarized current knowledge of the structure of MAMs and their effects on endothelial cells under hypoxia/reoxygenation conditions. Particular attention was given to their role in regulating mitochondrial quality control processes, including fission, fusion, oxidative stress, mitophagy and Ca2+ homeostasis, within the context of cardiac microvascular I/R injury. Targeting MAMs may represent a promising strategy for microvascular protection in ischemic heart disease.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Feng B, Wu Y, Sun Z, Yuan H, Chen W, Zhao C and Liu Z: Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review). Int J Mol Med 57: 34, 2026.
APA
Wang, Y., Feng, B., Wu, Y., Sun, Z., Yuan, H., Chen, W. ... Liu, Z. (2026). Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review). International Journal of Molecular Medicine, 57, 34. https://doi.org/10.3892/ijmm.2025.5705
MLA
Wang, Y., Feng, B., Wu, Y., Sun, Z., Yuan, H., Chen, W., Zhao, C., Liu, Z."Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)". International Journal of Molecular Medicine 57.2 (2026): 34.
Chicago
Wang, Y., Feng, B., Wu, Y., Sun, Z., Yuan, H., Chen, W., Zhao, C., Liu, Z."Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)". International Journal of Molecular Medicine 57, no. 2 (2026): 34. https://doi.org/10.3892/ijmm.2025.5705
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Feng B, Wu Y, Sun Z, Yuan H, Chen W, Zhao C and Liu Z: Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review). Int J Mol Med 57: 34, 2026.
APA
Wang, Y., Feng, B., Wu, Y., Sun, Z., Yuan, H., Chen, W. ... Liu, Z. (2026). Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review). International Journal of Molecular Medicine, 57, 34. https://doi.org/10.3892/ijmm.2025.5705
MLA
Wang, Y., Feng, B., Wu, Y., Sun, Z., Yuan, H., Chen, W., Zhao, C., Liu, Z."Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)". International Journal of Molecular Medicine 57.2 (2026): 34.
Chicago
Wang, Y., Feng, B., Wu, Y., Sun, Z., Yuan, H., Chen, W., Zhao, C., Liu, Z."Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)". International Journal of Molecular Medicine 57, no. 2 (2026): 34. https://doi.org/10.3892/ijmm.2025.5705
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