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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February-2026 Volume 57 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

  • Authors:
    • Yiyang Pan
    • Feng Yang
    • Liucan Wang
    • Tianshu Yang
    • Guangsheng Du
    • Cong Xu
    • Hua Yang
    • Min Yu
    • Weidong Xiao

  • View Affiliations / Copyright

    Affiliations: General Surgery Laboratory, Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China, General Surgery Laboratory, Department of General Surgery, Chongqing General Hospital, Chongqing University, Chongqing 401147, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 43
    |
    Published online on: December 10, 2025
       https://doi.org/10.3892/ijmm.2025.5714
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Abstract

Inflammatory bowel disease (IBD) is a chronic idiopathic intestinal inflammatory disease with increasing incidence worldwide. However, the treatment of IBD is still limited and has not reached the expected therapeutic effect and new therapeutic targets are still to be discovered. Impaired autophagy and abnormal glycolysis levels were observed both in the in vivo and in vitro intestinal inflammation models, suggesting a relationship between autophagy and glycolysis in IBD. Subsequently, it demonstrated that autophagy negatively regulated the glycolysis of IECs by degradation of the key glycolytic enzyme 6‑phosphofructo‑2‑kinase/fructose‑2,6‑bisphosphatase 3 (PFKFB3). Co‑immunoprecipitation was employed to demonstrate that PFKFB3 ubiquitinated by fizzy and cell division cycle 20 related 1 E3 ligase and was then recognized by P62 autophagy receptor for degradation. Notably, increased PFKFB3 expression was detected both in patients with CD and DSS‑induced colitis. Inhibiting PFKFB3 enzyme activity relieved DSS‑induced intestinal inflammation and intestinal epithelial barrier damage. The present study proposed a combined therapy targeting autophagy and glycolysis might become a new choice for clinical treatment of IBD.

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Copy and paste a formatted citation
Spandidos Publications style
Pan Y, Yang F, Wang L, Yang T, Du G, Xu C, Yang H, Yu M and Xiao W: Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease. Int J Mol Med 57: 43, 2026.
APA
Pan, Y., Yang, F., Wang, L., Yang, T., Du, G., Xu, C. ... Xiao, W. (2026). Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease. International Journal of Molecular Medicine, 57, 43. https://doi.org/10.3892/ijmm.2025.5714
MLA
Pan, Y., Yang, F., Wang, L., Yang, T., Du, G., Xu, C., Yang, H., Yu, M., Xiao, W."Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease". International Journal of Molecular Medicine 57.2 (2026): 43.
Chicago
Pan, Y., Yang, F., Wang, L., Yang, T., Du, G., Xu, C., Yang, H., Yu, M., Xiao, W."Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease". International Journal of Molecular Medicine 57, no. 2 (2026): 43. https://doi.org/10.3892/ijmm.2025.5714
Copy and paste a formatted citation
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Spandidos Publications style
Pan Y, Yang F, Wang L, Yang T, Du G, Xu C, Yang H, Yu M and Xiao W: Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease. Int J Mol Med 57: 43, 2026.
APA
Pan, Y., Yang, F., Wang, L., Yang, T., Du, G., Xu, C. ... Xiao, W. (2026). Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease. International Journal of Molecular Medicine, 57, 43. https://doi.org/10.3892/ijmm.2025.5714
MLA
Pan, Y., Yang, F., Wang, L., Yang, T., Du, G., Xu, C., Yang, H., Yu, M., Xiao, W."Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease". International Journal of Molecular Medicine 57.2 (2026): 43.
Chicago
Pan, Y., Yang, F., Wang, L., Yang, T., Du, G., Xu, C., Yang, H., Yu, M., Xiao, W."Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease". International Journal of Molecular Medicine 57, no. 2 (2026): 43. https://doi.org/10.3892/ijmm.2025.5714
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