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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March-2026 Volume 57 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

  • Authors:
    • Li Zhang
    • Yongpeng Cheng
    • Lulu Tang
    • Jiaxing Zhu
    • Biguang Tuo

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China, Department of Hepatobiliary Surgery, Liupanshui Municipal People's Hospital, Liupanshui, Guizhou, 553000, P.R. China, Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 56
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    Published online on: January 2, 2026
       https://doi.org/10.3892/ijmm.2026.5727
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Abstract

In cells, copper levels are tightly regulated because copper deficiency leads to Menkes disease, anemia and neurodegeneration, whereas copper overload is associated with Wilson disease, liver injury, neurodegeneration and several cancers. Cuproptosis, a form of regulated cell death, depends on the intracellular accumulation of excessive copper. This process induces mitochondrial dysfunction and cell death by disrupting the stability of mitochondrial lipoylated proteins and iron‑sulfur cluster proteins. The present review aimed to summarize the mechanisms underlying cuproptosis in gastrointestinal cancer, with a focus on the relationship between copper metabolism imbalance and tumor initiation and progression, as well as the potential therapeutic applications of cuproptosis‑associated agents in oncology. The application prospects of cuproptosis in gastrointestinal tumor therapy are broad, offering novel therapeutic options that may improve prognosis in patients and survival outcomes.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Cheng Y, Tang L, Zhu J and Tuo B: Role of cuproptosis in digestive system tumors (Review). Int J Mol Med 57: 56, 2026.
APA
Zhang, L., Cheng, Y., Tang, L., Zhu, J., & Tuo, B. (2026). Role of cuproptosis in digestive system tumors (Review). International Journal of Molecular Medicine, 57, 56. https://doi.org/10.3892/ijmm.2026.5727
MLA
Zhang, L., Cheng, Y., Tang, L., Zhu, J., Tuo, B."Role of cuproptosis in digestive system tumors (Review)". International Journal of Molecular Medicine 57.3 (2026): 56.
Chicago
Zhang, L., Cheng, Y., Tang, L., Zhu, J., Tuo, B."Role of cuproptosis in digestive system tumors (Review)". International Journal of Molecular Medicine 57, no. 3 (2026): 56. https://doi.org/10.3892/ijmm.2026.5727
Copy and paste a formatted citation
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Spandidos Publications style
Zhang L, Cheng Y, Tang L, Zhu J and Tuo B: Role of cuproptosis in digestive system tumors (Review). Int J Mol Med 57: 56, 2026.
APA
Zhang, L., Cheng, Y., Tang, L., Zhu, J., & Tuo, B. (2026). Role of cuproptosis in digestive system tumors (Review). International Journal of Molecular Medicine, 57, 56. https://doi.org/10.3892/ijmm.2026.5727
MLA
Zhang, L., Cheng, Y., Tang, L., Zhu, J., Tuo, B."Role of cuproptosis in digestive system tumors (Review)". International Journal of Molecular Medicine 57.3 (2026): 56.
Chicago
Zhang, L., Cheng, Y., Tang, L., Zhu, J., Tuo, B."Role of cuproptosis in digestive system tumors (Review)". International Journal of Molecular Medicine 57, no. 3 (2026): 56. https://doi.org/10.3892/ijmm.2026.5727
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